Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30

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Standard

Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30. / Thybo, Pia; Pedersen, Betty L; Hovgaard, Lars; Holm, Rene; Mullertz, Anette.

In: Pharmaceutical Development and Technology, Vol. 13, No. 5, 2008, p. 375-86.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Thybo, P, Pedersen, BL, Hovgaard, L, Holm, R & Mullertz, A 2008, 'Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30', Pharmaceutical Development and Technology, vol. 13, no. 5, pp. 375-86. https://doi.org/10.1080/10837450802244843

APA

Thybo, P., Pedersen, B. L., Hovgaard, L., Holm, R., & Mullertz, A. (2008). Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30. Pharmaceutical Development and Technology, 13(5), 375-86. https://doi.org/10.1080/10837450802244843

Vancouver

Thybo P, Pedersen BL, Hovgaard L, Holm R, Mullertz A. Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30. Pharmaceutical Development and Technology. 2008;13(5):375-86. https://doi.org/10.1080/10837450802244843

Author

Thybo, Pia ; Pedersen, Betty L ; Hovgaard, Lars ; Holm, Rene ; Mullertz, Anette. / Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30. In: Pharmaceutical Development and Technology. 2008 ; Vol. 13, No. 5. pp. 375-86.

Bibtex

@article{8e2b77b0c5ec11dd9473000ea68e967b,
title = "Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30",
abstract = "The main purpose of this study was to obtain stable, well-characterized solid dispersions (SDs) of amorphous probucol and polyvinylpyrrolidone K-30 (PVP-K30) with improved dissolution rates. A secondary aim was to investigate the flow-through dissolution method for in-vitro dissolution measurements of small-sized amorphous powders dispersed in a hydrophilic polymer. SDs were prepared by spray drying solutions of probucol and different amounts of PVP-K30. The obtained SDs were characterized by dissolution rate measurements in a flow-through apparatus, X-ray Powder Diffraction (XRPD), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), particle sizing (laser diffraction) and Brunauer-Emmett-Teller Method (BET) and results were compared with starting material and a physical mixture. The physical stability was monitored after storage at 25 degrees C and 60{\%} RH for up to 12 weeks. The flow-through method was found suitable as dissolution method. All SDs showed improved in-vitro dissolution rates when compared to starting material and physical mixtures. The greatest improvement in the in-vitro dissolution rate was observed for the highest polymer to drug ratio. By means of the results from XRPD and DSC, it was argued that the presence of amorphous probucol improved the dissolution rate, but the amorphous state could not fully account for the difference in dissolution profiles between the SDs. It was suggested that the increase in surface area due to the reduction in particle size contributed to an increased dissolution rate as well as the presence of PVP-K30 by preventing aggregation and drug re-crystallization and by improving wettability during dissolution. The stabilizing effect of the polymer was verified in the solid state, as all the SDs retained probucol in the amorphous state throughout the entire length of the stability study.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Pia Thybo and Pedersen, {Betty L} and Lars Hovgaard and Rene Holm and Anette Mullertz",
note = "Keywords: Anticholesteremic Agents; Chemistry, Pharmaceutical; Crystallization; Drug Stability; Drug Storage; Excipients; Humidity; Particle Size; Povidone; Powders; Probucol; Solubility; Wettability",
year = "2008",
doi = "10.1080/10837450802244843",
language = "English",
volume = "13",
pages = "375--86",
journal = "Pharmaceutical Development and Technology",
issn = "1083-7450",
publisher = "Taylor & Francis",
number = "5",

}

RIS

TY - JOUR

T1 - Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30

AU - Thybo, Pia

AU - Pedersen, Betty L

AU - Hovgaard, Lars

AU - Holm, Rene

AU - Mullertz, Anette

N1 - Keywords: Anticholesteremic Agents; Chemistry, Pharmaceutical; Crystallization; Drug Stability; Drug Storage; Excipients; Humidity; Particle Size; Povidone; Powders; Probucol; Solubility; Wettability

PY - 2008

Y1 - 2008

N2 - The main purpose of this study was to obtain stable, well-characterized solid dispersions (SDs) of amorphous probucol and polyvinylpyrrolidone K-30 (PVP-K30) with improved dissolution rates. A secondary aim was to investigate the flow-through dissolution method for in-vitro dissolution measurements of small-sized amorphous powders dispersed in a hydrophilic polymer. SDs were prepared by spray drying solutions of probucol and different amounts of PVP-K30. The obtained SDs were characterized by dissolution rate measurements in a flow-through apparatus, X-ray Powder Diffraction (XRPD), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), particle sizing (laser diffraction) and Brunauer-Emmett-Teller Method (BET) and results were compared with starting material and a physical mixture. The physical stability was monitored after storage at 25 degrees C and 60% RH for up to 12 weeks. The flow-through method was found suitable as dissolution method. All SDs showed improved in-vitro dissolution rates when compared to starting material and physical mixtures. The greatest improvement in the in-vitro dissolution rate was observed for the highest polymer to drug ratio. By means of the results from XRPD and DSC, it was argued that the presence of amorphous probucol improved the dissolution rate, but the amorphous state could not fully account for the difference in dissolution profiles between the SDs. It was suggested that the increase in surface area due to the reduction in particle size contributed to an increased dissolution rate as well as the presence of PVP-K30 by preventing aggregation and drug re-crystallization and by improving wettability during dissolution. The stabilizing effect of the polymer was verified in the solid state, as all the SDs retained probucol in the amorphous state throughout the entire length of the stability study.

AB - The main purpose of this study was to obtain stable, well-characterized solid dispersions (SDs) of amorphous probucol and polyvinylpyrrolidone K-30 (PVP-K30) with improved dissolution rates. A secondary aim was to investigate the flow-through dissolution method for in-vitro dissolution measurements of small-sized amorphous powders dispersed in a hydrophilic polymer. SDs were prepared by spray drying solutions of probucol and different amounts of PVP-K30. The obtained SDs were characterized by dissolution rate measurements in a flow-through apparatus, X-ray Powder Diffraction (XRPD), Differential Scanning Calorimetry (DSC), Scanning Electron Microscopy (SEM), particle sizing (laser diffraction) and Brunauer-Emmett-Teller Method (BET) and results were compared with starting material and a physical mixture. The physical stability was monitored after storage at 25 degrees C and 60% RH for up to 12 weeks. The flow-through method was found suitable as dissolution method. All SDs showed improved in-vitro dissolution rates when compared to starting material and physical mixtures. The greatest improvement in the in-vitro dissolution rate was observed for the highest polymer to drug ratio. By means of the results from XRPD and DSC, it was argued that the presence of amorphous probucol improved the dissolution rate, but the amorphous state could not fully account for the difference in dissolution profiles between the SDs. It was suggested that the increase in surface area due to the reduction in particle size contributed to an increased dissolution rate as well as the presence of PVP-K30 by preventing aggregation and drug re-crystallization and by improving wettability during dissolution. The stabilizing effect of the polymer was verified in the solid state, as all the SDs retained probucol in the amorphous state throughout the entire length of the stability study.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1080/10837450802244843

DO - 10.1080/10837450802244843

M3 - Journal article

C2 - 18720236

VL - 13

SP - 375

EP - 386

JO - Pharmaceutical Development and Technology

JF - Pharmaceutical Development and Technology

SN - 1083-7450

IS - 5

ER -

ID: 9013117