Cellulose nanofibers as excipient for the delivery of poorly soluble drugs

Department of Pharmacy

Cellulose nanofibers as excipient for the delivery of poorly soluble drugs

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Cellulose nanofibers as excipient for the delivery of poorly soluble drugs. / Löbmann, Korbinian; Svagan, Anna J.

In: International Journal of Pharmaceutics, Vol. 533, No. 1, 23.09.2017, p. 285-297.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Löbmann, K & Svagan, AJ 2017, 'Cellulose nanofibers as excipient for the delivery of poorly soluble drugs', International Journal of Pharmaceutics, vol. 533, no. 1, pp. 285-297. https://doi.org/10.1016/j.ijpharm.2017.09.064

APA

Löbmann, K., & Svagan, A. J. (2017). Cellulose nanofibers as excipient for the delivery of poorly soluble drugs. International Journal of Pharmaceutics, 533(1), 285-297. https://doi.org/10.1016/j.ijpharm.2017.09.064

Vancouver

Löbmann K, Svagan AJ. Cellulose nanofibers as excipient for the delivery of poorly soluble drugs. International Journal of Pharmaceutics. 2017 Sep 23;533(1):285-297. https://doi.org/10.1016/j.ijpharm.2017.09.064

Author

Löbmann, Korbinian ; Svagan, Anna J. / Cellulose nanofibers as excipient for the delivery of poorly soluble drugs. In: International Journal of Pharmaceutics. 2017 ; Vol. 533, No. 1. pp. 285-297.

Bibtex

@article{fe2177ab88994a87b8e063fdca137bd8,

title = "Cellulose nanofibers as excipient for the delivery of poorly soluble drugs",

abstract = "Poor aqueous solubility of drugs is becoming an increasingly pronounced challenge in the formulation and development of drug delivery systems. To overcome the limitations associated with these problematic drugs, formulation scientists are required to use enabling strategies which often demands the use of new excipients. Cellulose nanofibers (CNFs) is such an excipient and it has only recently been described in the pharmaceutical field. In this review, the use of CNF in drug formulation with a focus on poorly soluble drugs is featured. In particular, the aim is to describe and discuss the many unique properties of CNFs, which make CNFs attractive as excipients in pharmaceutical sciences. Furthermore, the use of CNF as stabilizers for crystalline drug nanoparticles, as a matrix former to obtain a long-lasting sustained drug release over several weeks and as a film former with immediate release properties for poorly soluble drug are reported. Finally, the preparation of pharmaceutical CNF foams together with poorly soluble drugs is highlighted; foams, which offer a sustained drug delivery system with positive buoyancy.",

keywords = "Journal Article",

author = "Korbinian L{\"o}bmann and Svagan, {Anna J}",

year = "2017",

month = sep,

day = "23",

doi = "10.1016/j.ijpharm.2017.09.064",

language = "English",

volume = "533",

pages = "285--297",

journal = "International Journal of Pharmaceutics",

issn = "0378-5173",

publisher = "Elsevier",

number = "1",

}

RIS

TY - JOUR

T1 - Cellulose nanofibers as excipient for the delivery of poorly soluble drugs

AU - Löbmann, Korbinian

AU - Svagan, Anna J

PY - 2017/9/23

Y1 - 2017/9/23

N2 - Poor aqueous solubility of drugs is becoming an increasingly pronounced challenge in the formulation and development of drug delivery systems. To overcome the limitations associated with these problematic drugs, formulation scientists are required to use enabling strategies which often demands the use of new excipients. Cellulose nanofibers (CNFs) is such an excipient and it has only recently been described in the pharmaceutical field. In this review, the use of CNF in drug formulation with a focus on poorly soluble drugs is featured. In particular, the aim is to describe and discuss the many unique properties of CNFs, which make CNFs attractive as excipients in pharmaceutical sciences. Furthermore, the use of CNF as stabilizers for crystalline drug nanoparticles, as a matrix former to obtain a long-lasting sustained drug release over several weeks and as a film former with immediate release properties for poorly soluble drug are reported. Finally, the preparation of pharmaceutical CNF foams together with poorly soluble drugs is highlighted; foams, which offer a sustained drug delivery system with positive buoyancy.

AB - Poor aqueous solubility of drugs is becoming an increasingly pronounced challenge in the formulation and development of drug delivery systems. To overcome the limitations associated with these problematic drugs, formulation scientists are required to use enabling strategies which often demands the use of new excipients. Cellulose nanofibers (CNFs) is such an excipient and it has only recently been described in the pharmaceutical field. In this review, the use of CNF in drug formulation with a focus on poorly soluble drugs is featured. In particular, the aim is to describe and discuss the many unique properties of CNFs, which make CNFs attractive as excipients in pharmaceutical sciences. Furthermore, the use of CNF as stabilizers for crystalline drug nanoparticles, as a matrix former to obtain a long-lasting sustained drug release over several weeks and as a film former with immediate release properties for poorly soluble drug are reported. Finally, the preparation of pharmaceutical CNF foams together with poorly soluble drugs is highlighted; foams, which offer a sustained drug delivery system with positive buoyancy.

KW - Journal Article

U2 - 10.1016/j.ijpharm.2017.09.064

DO - 10.1016/j.ijpharm.2017.09.064

M3 - Journal article

C2 - 28951349

VL - 533

SP - 285

EP - 297

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1

ER -

ID: 184414010