Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus

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Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus. / Nielsen, S. E.; Breinholt, V.; Cornett, Claus; Dragsted, L. O.

In: Food and Chemical Toxicology, Vol. 38, No. 9, 2000, p. 739-746.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Nielsen, SE, Breinholt, V, Cornett, C & Dragsted, LO 2000, 'Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus', Food and Chemical Toxicology, vol. 38, no. 9, pp. 739-746.

APA

Nielsen, S. E., Breinholt, V., Cornett, C., & Dragsted, L. O. (2000). Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus. Food and Chemical Toxicology, 38(9), 739-746.

Vancouver

Nielsen SE, Breinholt V, Cornett C, Dragsted LO. Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus. Food and Chemical Toxicology. 2000;38(9):739-746.

Author

Nielsen, S. E. ; Breinholt, V. ; Cornett, Claus ; Dragsted, L. O. / Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus. In: Food and Chemical Toxicology. 2000 ; Vol. 38, No. 9. pp. 739-746.

Bibtex

@article{41b38597064047069903501a89b7f5e6,
title = "Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus",
abstract = "The present study mas carried out in order to investigate the in vivo biotransformation and excretion of the flavone, tangeretin, found in citrus fruits, by analysing urine and faeces samples from rats after repeated administration of 100 mg/kg body weight/day tangeretin. The formed metabolites were separated and identified by HPLC and the structures elucidated by LC/MS and H-1 NMR. Ten new, major metabolites with intact flavonoid structure were identified. The metabolites identified were either demethylated or hydroxylated derivatives of the parent compound and metabolic changes were found primarily to occur in the 4' position of the B-ring. The total urinary excretion of tangeretin metabolites with intact flavan nucleus sas about 11{\%} of the administered daily dose. (C) 2000 Elsevier Science Ltd. All rights reserved.",
keywords = "tangeretin rat citrus flavone metabolism HPLC liver epithelial-cells intercellular communication inhibition microsomes quercetin apigenin antioxidants biomarkers excretion enzymes",
author = "Nielsen, {S. E.} and V. Breinholt and Claus Cornett and Dragsted, {L. O.}",
year = "2000",
language = "Udefineret/Ukendt",
volume = "38",
pages = "739--746",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Pergamon Press",
number = "9",

}

RIS

TY - JOUR

T1 - Biotransformation of the citrus flavone tangeretin in rats. Identification of metabolites with intact flavane nucleus

AU - Nielsen, S. E.

AU - Breinholt, V.

AU - Cornett, Claus

AU - Dragsted, L. O.

PY - 2000

Y1 - 2000

N2 - The present study mas carried out in order to investigate the in vivo biotransformation and excretion of the flavone, tangeretin, found in citrus fruits, by analysing urine and faeces samples from rats after repeated administration of 100 mg/kg body weight/day tangeretin. The formed metabolites were separated and identified by HPLC and the structures elucidated by LC/MS and H-1 NMR. Ten new, major metabolites with intact flavonoid structure were identified. The metabolites identified were either demethylated or hydroxylated derivatives of the parent compound and metabolic changes were found primarily to occur in the 4' position of the B-ring. The total urinary excretion of tangeretin metabolites with intact flavan nucleus sas about 11% of the administered daily dose. (C) 2000 Elsevier Science Ltd. All rights reserved.

AB - The present study mas carried out in order to investigate the in vivo biotransformation and excretion of the flavone, tangeretin, found in citrus fruits, by analysing urine and faeces samples from rats after repeated administration of 100 mg/kg body weight/day tangeretin. The formed metabolites were separated and identified by HPLC and the structures elucidated by LC/MS and H-1 NMR. Ten new, major metabolites with intact flavonoid structure were identified. The metabolites identified were either demethylated or hydroxylated derivatives of the parent compound and metabolic changes were found primarily to occur in the 4' position of the B-ring. The total urinary excretion of tangeretin metabolites with intact flavan nucleus sas about 11% of the administered daily dose. (C) 2000 Elsevier Science Ltd. All rights reserved.

KW - tangeretin rat citrus flavone metabolism HPLC liver epithelial-cells intercellular communication inhibition microsomes quercetin apigenin antioxidants biomarkers excretion enzymes

M3 - Tidsskriftartikel

VL - 38

SP - 739

EP - 746

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

IS - 9

ER -

ID: 38061998