Biopolymer-drug conjugates as biomaterials

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Over the years, several biopolymers have widely been exploited for the delivery of small-molecule drugs, particularly owing to their outstanding biocompatible and biodegradable characteristics. In this context an array of drug molecules has been chemically conjugated with various biopolymers and the resulting conjugates could slowly elute their cargos following cleavage of the biopolymer-drug linkages under physiological conditions. These conjugates offer numerous advantages over their therapeutic precursors. For instance, the conjugates could enhance water solubility and bioavailability of the drugs, improve their pharmacokinetic and biodistribution profiles, protect them from deactivation, and facilitate their transport to the targeted sites, which eventually augment the bio-performances of the drugs. The present chapter reviews recently reported covalent conjugates based on biopolymers and small-molecule drugs and their therapeutic benefits.

Original languageEnglish
Title of host publicationTailor-Made and Functionalized Biopolymer Systems : For Drug Delivery and Biomedical Applications
Number of pages32
Publication date2021
ISBN (Electronic)9780128214374
Publication statusPublished - 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Ltd All rights reserved.

    Research areas

  • Covalent conjugates, Drug delivery, Polypeptides, Polysaccharides, Small-molecule drugs

ID: 305570712