Binder jetting 3D printing in fabricating pharmaceutical solid products for precision medicine
Research output: Contribution to journal › Review › Research › peer-review
Standard
Binder jetting 3D printing in fabricating pharmaceutical solid products for precision medicine. / Wang, Yingya; Genina, Natalja; Müllertz, Anette; Rantanen, Jukka.
In: Basic & clinical pharmacology & toxicology, Vol. 134, No. 3, 2024, p. 325-332.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Binder jetting 3D printing in fabricating pharmaceutical solid products for precision medicine
AU - Wang, Yingya
AU - Genina, Natalja
AU - Müllertz, Anette
AU - Rantanen, Jukka
N1 - Publisher Copyright: © 2023 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). Published by John Wiley & Sons Ltd.
PY - 2024
Y1 - 2024
N2 - Current treatment strategies are moving towards patient-centricity, which emphasizes the need for new solutions allowing for medication tailored to a patient. This can be realized by precision medicine where patient diversity is considered during treatment. However, the broader use of precision medicine is restricted by the current technological solutions and rigid manufacturing of pharmaceutical products by mass production principles. Additive manufacturing of pharmaceutical products can provide a feasible solution to this challenge. In this review, a particular subtype of additive manufacturing, that is, binder jetting 3D printing, is introduced as a solution for fabricating pharmaceutical solid products that can be considered as precision medicine. Technical aspects, practical applications, unique advantages and challenges related to this technique are discussed, indicating that binder jetting 3D printing possesses the potential for fabricating already new product prototypes, where diversity in patient treatment in terms of the needs for specific drug type, dose and drug release can be accounted. To further advance this type of mass customization of pharmaceuticals, multidisciplinary research initiatives are needed not only to cover the engineering aspects but also to bridge these innovations with patient-centric perspectives.
AB - Current treatment strategies are moving towards patient-centricity, which emphasizes the need for new solutions allowing for medication tailored to a patient. This can be realized by precision medicine where patient diversity is considered during treatment. However, the broader use of precision medicine is restricted by the current technological solutions and rigid manufacturing of pharmaceutical products by mass production principles. Additive manufacturing of pharmaceutical products can provide a feasible solution to this challenge. In this review, a particular subtype of additive manufacturing, that is, binder jetting 3D printing, is introduced as a solution for fabricating pharmaceutical solid products that can be considered as precision medicine. Technical aspects, practical applications, unique advantages and challenges related to this technique are discussed, indicating that binder jetting 3D printing possesses the potential for fabricating already new product prototypes, where diversity in patient treatment in terms of the needs for specific drug type, dose and drug release can be accounted. To further advance this type of mass customization of pharmaceuticals, multidisciplinary research initiatives are needed not only to cover the engineering aspects but also to bridge these innovations with patient-centric perspectives.
KW - binder jetting 3D printing
KW - innovative technology
KW - pharmaceutical manufacturing
KW - precision medicine
KW - solid products
U2 - 10.1111/bcpt.13974
DO - 10.1111/bcpt.13974
M3 - Review
C2 - 38105694
AN - SCOPUS:85184835326
VL - 134
SP - 325
EP - 332
JO - Basic and Clinical Pharmacology and Toxicology
JF - Basic and Clinical Pharmacology and Toxicology
SN - 1742-7835
IS - 3
ER -
ID: 383087921