Azone® decreases the buccal mucosal permeation of Diazepam in a concentration-dependent manner via a reservoir effect

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Azone® decreases the buccal mucosal permeation of Diazepam in a concentration-dependent manner via a reservoir effect. / Meng-Lund, Emil; Jacobsen, Jette; Jin, Liang; Janfelt, Christian; Holm, René; Müllertz, Anette; Nicolazzo, Joseph A.

In: Journal of Pharmaceutical Sciences, Vol. 103, No. 4, 103, 15.02.2014, p. 1133-1141.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Meng-Lund, E, Jacobsen, J, Jin, L, Janfelt, C, Holm, R, Müllertz, A & Nicolazzo, JA 2014, 'Azone® decreases the buccal mucosal permeation of Diazepam in a concentration-dependent manner via a reservoir effect', Journal of Pharmaceutical Sciences, vol. 103, no. 4, 103, pp. 1133-1141. https://doi.org/10.1002/jps.23877

APA

Meng-Lund, E., Jacobsen, J., Jin, L., Janfelt, C., Holm, R., Müllertz, A., & Nicolazzo, J. A. (2014). Azone® decreases the buccal mucosal permeation of Diazepam in a concentration-dependent manner via a reservoir effect. Journal of Pharmaceutical Sciences, 103(4), 1133-1141. [103]. https://doi.org/10.1002/jps.23877

Vancouver

Meng-Lund E, Jacobsen J, Jin L, Janfelt C, Holm R, Müllertz A et al. Azone® decreases the buccal mucosal permeation of Diazepam in a concentration-dependent manner via a reservoir effect. Journal of Pharmaceutical Sciences. 2014 Feb 15;103(4):1133-1141. 103. https://doi.org/10.1002/jps.23877

Author

Meng-Lund, Emil ; Jacobsen, Jette ; Jin, Liang ; Janfelt, Christian ; Holm, René ; Müllertz, Anette ; Nicolazzo, Joseph A. / Azone® decreases the buccal mucosal permeation of Diazepam in a concentration-dependent manner via a reservoir effect. In: Journal of Pharmaceutical Sciences. 2014 ; Vol. 103, No. 4. pp. 1133-1141.

Bibtex

@article{7da67d174264482396a88eb7227f3e31,
title = "Azone{\textregistered} decreases the buccal mucosal permeation of Diazepam in a concentration-dependent manner via a reservoir effect",
abstract = "The purpose of this study was to examine concentration-dependent effects of Azone{\textregistered} (AZ) on the buccal absorption of diazepam (DIAZ). Porcine buccal mucosa was placed in modified Ussing chambers and pretreated with 10 μL of 0%, 5%, 20%, and 50% (w/v) AZ in ethanol. DIAZ was administered to the donor chamber either in solution or a chitosan-based gel. The donor chamber disappearance, receptor chamber appearance, and tissue retention of DIAZ were monitored over 2 h by HPLC, with AZ tissue disposition also measured by liquid chromatography-mass spectrometry profiling of tissue cryosections. DIAZ steady-state flux values significantly (p ",
author = "Emil Meng-Lund and Jette Jacobsen and Liang Jin and Christian Janfelt and Ren{\'e} Holm and Anette M{\"u}llertz and Nicolazzo, {Joseph A}",
note = "{\textcopyright} 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.",
year = "2014",
month = feb,
day = "15",
doi = "10.1002/jps.23877",
language = "English",
volume = "103",
pages = "1133--1141",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Azone® decreases the buccal mucosal permeation of Diazepam in a concentration-dependent manner via a reservoir effect

AU - Meng-Lund, Emil

AU - Jacobsen, Jette

AU - Jin, Liang

AU - Janfelt, Christian

AU - Holm, René

AU - Müllertz, Anette

AU - Nicolazzo, Joseph A

N1 - © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association.

PY - 2014/2/15

Y1 - 2014/2/15

N2 - The purpose of this study was to examine concentration-dependent effects of Azone® (AZ) on the buccal absorption of diazepam (DIAZ). Porcine buccal mucosa was placed in modified Ussing chambers and pretreated with 10 μL of 0%, 5%, 20%, and 50% (w/v) AZ in ethanol. DIAZ was administered to the donor chamber either in solution or a chitosan-based gel. The donor chamber disappearance, receptor chamber appearance, and tissue retention of DIAZ were monitored over 2 h by HPLC, with AZ tissue disposition also measured by liquid chromatography-mass spectrometry profiling of tissue cryosections. DIAZ steady-state flux values significantly (p

AB - The purpose of this study was to examine concentration-dependent effects of Azone® (AZ) on the buccal absorption of diazepam (DIAZ). Porcine buccal mucosa was placed in modified Ussing chambers and pretreated with 10 μL of 0%, 5%, 20%, and 50% (w/v) AZ in ethanol. DIAZ was administered to the donor chamber either in solution or a chitosan-based gel. The donor chamber disappearance, receptor chamber appearance, and tissue retention of DIAZ were monitored over 2 h by HPLC, with AZ tissue disposition also measured by liquid chromatography-mass spectrometry profiling of tissue cryosections. DIAZ steady-state flux values significantly (p

U2 - 10.1002/jps.23877

DO - 10.1002/jps.23877

M3 - Journal article

C2 - 24532052

VL - 103

SP - 1133

EP - 1141

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 4

M1 - 103

ER -

ID: 103025631