Atomic pairwise distribution function analysis of the amorphous phase prepared by different manufacturing routes

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Atomic pairwise distribution function analysis of the amorphous phase prepared by different manufacturing routes. / Boetker, Johan P.; Koradia, Vishal; Rades, Thomas; Rantanen, Jukka; Savolainen, Marja.

In: Pharmaceutics, Vol. 4, No. 1, 28.08.2012, p. 93-103.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Boetker, JP, Koradia, V, Rades, T, Rantanen, J & Savolainen, M 2012, 'Atomic pairwise distribution function analysis of the amorphous phase prepared by different manufacturing routes', Pharmaceutics, vol. 4, no. 1, pp. 93-103. https://doi.org/10.3390/pharmaceutics4010093

APA

Boetker, J. P., Koradia, V., Rades, T., Rantanen, J., & Savolainen, M. (2012). Atomic pairwise distribution function analysis of the amorphous phase prepared by different manufacturing routes. Pharmaceutics, 4(1), 93-103. https://doi.org/10.3390/pharmaceutics4010093

Vancouver

Boetker JP, Koradia V, Rades T, Rantanen J, Savolainen M. Atomic pairwise distribution function analysis of the amorphous phase prepared by different manufacturing routes. Pharmaceutics. 2012 Aug 28;4(1):93-103. https://doi.org/10.3390/pharmaceutics4010093

Author

Boetker, Johan P. ; Koradia, Vishal ; Rades, Thomas ; Rantanen, Jukka ; Savolainen, Marja. / Atomic pairwise distribution function analysis of the amorphous phase prepared by different manufacturing routes. In: Pharmaceutics. 2012 ; Vol. 4, No. 1. pp. 93-103.

Bibtex

@article{03c5ca27582e4e01ace36913d53498c8,
title = "Atomic pairwise distribution function analysis of the amorphous phase prepared by different manufacturing routes",
abstract = "Amlodipine besilate, a calcium channel antagonist, exists in several solid forms. Processing of anhydrate and dihydrate forms of this drug may lead to solid state changes, and is therefore the focus of this study. Milling was performed for the anhydrate form, whereas the dihydrate form was subjected to quench cooling thereby creating an amorphous form of the drug from both starting materials. The milled and quench cooled samples were, together with the crystalline starting materials, analyzed with X-ray powder diffraction (XRPD), Raman spectroscopy and atomic pair-wise distribution function (PDF) analysis of the XRPD pattern. When compared to XRPD and Raman spectroscopy, the PDF analysis was superior in displaying the difference between the amorphous samples prepared by milling and quench cooling approaches of the two starting materials.",
keywords = "biology, chemistry",
author = "Boetker, {Johan P.} and Vishal Koradia and Thomas Rades and Jukka Rantanen and Marja Savolainen",
year = "2012",
month = "8",
day = "28",
doi = "10.3390/pharmaceutics4010093",
language = "English",
volume = "4",
pages = "93--103",
journal = "Pharmaceutics",
issn = "1999-4923",
publisher = "MDPI AG",
number = "1",

}

RIS

TY - JOUR

T1 - Atomic pairwise distribution function analysis of the amorphous phase prepared by different manufacturing routes

AU - Boetker, Johan P.

AU - Koradia, Vishal

AU - Rades, Thomas

AU - Rantanen, Jukka

AU - Savolainen, Marja

PY - 2012/8/28

Y1 - 2012/8/28

N2 - Amlodipine besilate, a calcium channel antagonist, exists in several solid forms. Processing of anhydrate and dihydrate forms of this drug may lead to solid state changes, and is therefore the focus of this study. Milling was performed for the anhydrate form, whereas the dihydrate form was subjected to quench cooling thereby creating an amorphous form of the drug from both starting materials. The milled and quench cooled samples were, together with the crystalline starting materials, analyzed with X-ray powder diffraction (XRPD), Raman spectroscopy and atomic pair-wise distribution function (PDF) analysis of the XRPD pattern. When compared to XRPD and Raman spectroscopy, the PDF analysis was superior in displaying the difference between the amorphous samples prepared by milling and quench cooling approaches of the two starting materials.

AB - Amlodipine besilate, a calcium channel antagonist, exists in several solid forms. Processing of anhydrate and dihydrate forms of this drug may lead to solid state changes, and is therefore the focus of this study. Milling was performed for the anhydrate form, whereas the dihydrate form was subjected to quench cooling thereby creating an amorphous form of the drug from both starting materials. The milled and quench cooled samples were, together with the crystalline starting materials, analyzed with X-ray powder diffraction (XRPD), Raman spectroscopy and atomic pair-wise distribution function (PDF) analysis of the XRPD pattern. When compared to XRPD and Raman spectroscopy, the PDF analysis was superior in displaying the difference between the amorphous samples prepared by milling and quench cooling approaches of the two starting materials.

KW - biology

KW - chemistry

U2 - 10.3390/pharmaceutics4010093

DO - 10.3390/pharmaceutics4010093

M3 - Journal article

VL - 4

SP - 93

EP - 103

JO - Pharmaceutics

JF - Pharmaceutics

SN - 1999-4923

IS - 1

ER -

ID: 40380746