Are phytosomes a superior nanodelivery system for the antioxidant rutin?

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Are phytosomes a superior nanodelivery system for the antioxidant rutin? / Vu, Hanh T.H.; Hook, Sarah M.; Siqueira, Scheyla D.; Müllertz, Anette; Rades, Thomas; McDowell, Arlene.

In: International Journal of Pharmaceutics, Vol. 548, No. 1, 2018, p. 82-91.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Vu, HTH, Hook, SM, Siqueira, SD, Müllertz, A, Rades, T & McDowell, A 2018, 'Are phytosomes a superior nanodelivery system for the antioxidant rutin?', International Journal of Pharmaceutics, vol. 548, no. 1, pp. 82-91. https://doi.org/10.1016/j.ijpharm.2018.06.042

APA

Vu, H. T. H., Hook, S. M., Siqueira, S. D., Müllertz, A., Rades, T., & McDowell, A. (2018). Are phytosomes a superior nanodelivery system for the antioxidant rutin? International Journal of Pharmaceutics, 548(1), 82-91. https://doi.org/10.1016/j.ijpharm.2018.06.042

Vancouver

Vu HTH, Hook SM, Siqueira SD, Müllertz A, Rades T, McDowell A. Are phytosomes a superior nanodelivery system for the antioxidant rutin? International Journal of Pharmaceutics. 2018;548(1):82-91. https://doi.org/10.1016/j.ijpharm.2018.06.042

Author

Vu, Hanh T.H. ; Hook, Sarah M. ; Siqueira, Scheyla D. ; Müllertz, Anette ; Rades, Thomas ; McDowell, Arlene. / Are phytosomes a superior nanodelivery system for the antioxidant rutin?. In: International Journal of Pharmaceutics. 2018 ; Vol. 548, No. 1. pp. 82-91.

Bibtex

@article{a4a151f1ebd9492593c2c7413c2e11e5,
title = "Are phytosomes a superior nanodelivery system for the antioxidant rutin?",
abstract = "Rutin, a strong antioxidant, has been implicated in the prevention of liver inflammation. However, low solubility and permeability through the gut wall limit development of rutin as a therapeutic agent for oral administration. Phytosomes are described as lipid nanocarriers with a complexation between the phospholipid headgroups and entrapped phytochemicals. The aim of this research was to compare the structure of rutin liposomes to rutin phytosomes. FT-IR, DSC and NMR were employed to investigate the presence of any molecular interactions between the formulation components. The FT-IR spectra showed that a new –OH bond had formed in the rutin phytosomes, suggesting the formation of a molecular complex. 31 P NMR experiments revealed that the DPPC molecule is altered when formulated as liposomes but that these changes were greater for samples from the phytosome formulation. DSC data revealed that when rutin was added to DPPC there was a significant shift in the transition temperature of DPPC. Further, the shift was greater in the THF solvent used to produce phytosomes compared to CHCl 3 used to produce liposomes. 1 H NMR spectra of the phytosome samples indicated three additional peaks that were greater than in the liposome formulation. ROESY NMR spectra provided evidence supporting the interaction between rutin and DPPC in both liposomes and phytosomes. The apparent differences in molecular interaction between liposomes and phytosomes did not however impact rutin release in biorelevant media or during in vitro small intestinal lipolysis.",
keywords = "Antioxidant, DPPC, Liposome, Phytosome, Rutin",
author = "Vu, {Hanh T.H.} and Hook, {Sarah M.} and Siqueira, {Scheyla D.} and Anette M{\"u}llertz and Thomas Rades and Arlene McDowell",
year = "2018",
doi = "10.1016/j.ijpharm.2018.06.042",
language = "English",
volume = "548",
pages = "82--91",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Are phytosomes a superior nanodelivery system for the antioxidant rutin?

AU - Vu, Hanh T.H.

AU - Hook, Sarah M.

AU - Siqueira, Scheyla D.

AU - Müllertz, Anette

AU - Rades, Thomas

AU - McDowell, Arlene

PY - 2018

Y1 - 2018

N2 - Rutin, a strong antioxidant, has been implicated in the prevention of liver inflammation. However, low solubility and permeability through the gut wall limit development of rutin as a therapeutic agent for oral administration. Phytosomes are described as lipid nanocarriers with a complexation between the phospholipid headgroups and entrapped phytochemicals. The aim of this research was to compare the structure of rutin liposomes to rutin phytosomes. FT-IR, DSC and NMR were employed to investigate the presence of any molecular interactions between the formulation components. The FT-IR spectra showed that a new –OH bond had formed in the rutin phytosomes, suggesting the formation of a molecular complex. 31 P NMR experiments revealed that the DPPC molecule is altered when formulated as liposomes but that these changes were greater for samples from the phytosome formulation. DSC data revealed that when rutin was added to DPPC there was a significant shift in the transition temperature of DPPC. Further, the shift was greater in the THF solvent used to produce phytosomes compared to CHCl 3 used to produce liposomes. 1 H NMR spectra of the phytosome samples indicated three additional peaks that were greater than in the liposome formulation. ROESY NMR spectra provided evidence supporting the interaction between rutin and DPPC in both liposomes and phytosomes. The apparent differences in molecular interaction between liposomes and phytosomes did not however impact rutin release in biorelevant media or during in vitro small intestinal lipolysis.

AB - Rutin, a strong antioxidant, has been implicated in the prevention of liver inflammation. However, low solubility and permeability through the gut wall limit development of rutin as a therapeutic agent for oral administration. Phytosomes are described as lipid nanocarriers with a complexation between the phospholipid headgroups and entrapped phytochemicals. The aim of this research was to compare the structure of rutin liposomes to rutin phytosomes. FT-IR, DSC and NMR were employed to investigate the presence of any molecular interactions between the formulation components. The FT-IR spectra showed that a new –OH bond had formed in the rutin phytosomes, suggesting the formation of a molecular complex. 31 P NMR experiments revealed that the DPPC molecule is altered when formulated as liposomes but that these changes were greater for samples from the phytosome formulation. DSC data revealed that when rutin was added to DPPC there was a significant shift in the transition temperature of DPPC. Further, the shift was greater in the THF solvent used to produce phytosomes compared to CHCl 3 used to produce liposomes. 1 H NMR spectra of the phytosome samples indicated three additional peaks that were greater than in the liposome formulation. ROESY NMR spectra provided evidence supporting the interaction between rutin and DPPC in both liposomes and phytosomes. The apparent differences in molecular interaction between liposomes and phytosomes did not however impact rutin release in biorelevant media or during in vitro small intestinal lipolysis.

KW - Antioxidant

KW - DPPC

KW - Liposome

KW - Phytosome

KW - Rutin

U2 - 10.1016/j.ijpharm.2018.06.042

DO - 10.1016/j.ijpharm.2018.06.042

M3 - Journal article

C2 - 29933062

AN - SCOPUS:85049335353

VL - 548

SP - 82

EP - 91

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1

ER -

ID: 220848873