TY - JOUR

T1 - Application of UV dissolution imaging to pharmaceutical systems

AU - Brown, Benedict

AU - Ward, Adam

AU - Fazili, Zayeem

AU - Østergaard, Jesper

AU - Asare-Addo, Kofi

N1 - Funding Information: The authors acknowledge the EPSRC DTP centre at the University of Huddersfield for funding Benedict Brown and the University of Huddersfield for funding Adam Ward and Zayeem Fazili. JØ would like to thank Professor David Goodall, Paraytec Ltd. for sharing his insights and the stimulating discussions. Publisher Copyright: © 2021 Elsevier B.V.

PY - 2021

Y1 - 2021

N2 - UV–vis spectrometry is widely used in the pharmaceutical sciences for compound quantification, alone or in conjunction with separation techniques, due to most drug entities possessing a chromophore absorbing light in the range 190–800 nm. UV dissolution imaging, the scope of this review, generates spatially and temporally resolved absorbance maps by exploiting the UV absorbance of the analyte. This review aims to give an introduction to UV dissolution imaging and its use in the determination of intrinsic dissolution rates and drug release from whole dosage forms. Applications of UV imaging to non-oral formulations have started to emerge and are reviewed together with the possibility of utilizing UV imaging for physical chemical characterisation of drug substances. The benefits of imaging drug diffusion and transport processes are also discussed.

AB - UV–vis spectrometry is widely used in the pharmaceutical sciences for compound quantification, alone or in conjunction with separation techniques, due to most drug entities possessing a chromophore absorbing light in the range 190–800 nm. UV dissolution imaging, the scope of this review, generates spatially and temporally resolved absorbance maps by exploiting the UV absorbance of the analyte. This review aims to give an introduction to UV dissolution imaging and its use in the determination of intrinsic dissolution rates and drug release from whole dosage forms. Applications of UV imaging to non-oral formulations have started to emerge and are reviewed together with the possibility of utilizing UV imaging for physical chemical characterisation of drug substances. The benefits of imaging drug diffusion and transport processes are also discussed.

KW - Diffusion

KW - Dissolution testing

KW - In-vitro release

KW - Intrinsic dissolution rate

KW - Parenterals

KW - UV imaging

U2 - 10.1016/j.addr.2021.113949

DO - 10.1016/j.addr.2021.113949

M3 - Review

C2 - 34461199

AN - SCOPUS:85114689322

VL - 177

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

M1 - 113949

ER -