Antibacterial Nanomaterials: Mechanisms, Impacts on Antimicrobial Resistance and Design Principles
Research output: Contribution to journal › Review › Research › peer-review
Standard
Antibacterial Nanomaterials : Mechanisms, Impacts on Antimicrobial Resistance and Design Principles. / Xie, Maomao; Gao, Meng; Yun, Yang; Malmsten, Martin; Rotello, Vincent M. M.; Zboril, Radek; Akhavan, Omid; Kraskouski, Aliaksandr; Amalraj, John; Cai, Xiaoming; Lu, Jianmei; Zheng, Huizhen; Li, Ruibin.
In: Angewandte Chemie International Edition, Vol. 62, No. 17, e202217345, 2023.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Antibacterial Nanomaterials
T2 - Mechanisms, Impacts on Antimicrobial Resistance and Design Principles
AU - Xie, Maomao
AU - Gao, Meng
AU - Yun, Yang
AU - Malmsten, Martin
AU - Rotello, Vincent M. M.
AU - Zboril, Radek
AU - Akhavan, Omid
AU - Kraskouski, Aliaksandr
AU - Amalraj, John
AU - Cai, Xiaoming
AU - Lu, Jianmei
AU - Zheng, Huizhen
AU - Li, Ruibin
PY - 2023
Y1 - 2023
N2 - Antimicrobial resistance (AMR) is one of the biggest threats to the environment and health. AMR rapidly invalidates conventional antibiotics, and antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several antimicrobial nanomaterials show AMR-independent antimicrobial effects without detectable new resistance and have therefore been suggested to prevent AMR evolution. In contrast, some are found to trigger the evolution of AMR. Given these seemingly conflicting findings, a timely discussion of the two faces of antimicrobial nanomaterials is urgently needed. This review systematically compares the killing mechanisms and structure-activity relationships of antibiotics and antimicrobial nanomaterials. We then focus on nano-microbe interactions to elucidate the impacts of molecular initiating events on AMR evolution. Finally, we provide an outlook on future antimicrobial nanomaterials and propose design principles for the prevention of AMR evolution.
AB - Antimicrobial resistance (AMR) is one of the biggest threats to the environment and health. AMR rapidly invalidates conventional antibiotics, and antimicrobial nanomaterials have been increasingly explored as alternatives. Interestingly, several antimicrobial nanomaterials show AMR-independent antimicrobial effects without detectable new resistance and have therefore been suggested to prevent AMR evolution. In contrast, some are found to trigger the evolution of AMR. Given these seemingly conflicting findings, a timely discussion of the two faces of antimicrobial nanomaterials is urgently needed. This review systematically compares the killing mechanisms and structure-activity relationships of antibiotics and antimicrobial nanomaterials. We then focus on nano-microbe interactions to elucidate the impacts of molecular initiating events on AMR evolution. Finally, we provide an outlook on future antimicrobial nanomaterials and propose design principles for the prevention of AMR evolution.
KW - Antibacterial Nanomaterials
KW - Antimicrobial Resistance
KW - Killing Mechanism
KW - Nano-Bio Interaction
KW - Structure-Activity Relationship
KW - SNAPSHOT ANTIBIOTIC INHIBITION
KW - BACTERIAL-CELL DIVISION
KW - GRAPHENE OXIDE
KW - SILVER NANOPARTICLES
KW - GOLD NANOPARTICLES
KW - DEPENDENT ANTIBACTERIAL
KW - ENHANCED ANTIBACTERIAL
KW - HORIZONTAL TRANSFER
KW - ZNO NANOPARTICLES
KW - COPPER NANOPARTICLES
U2 - 10.1002/anie.202217345
DO - 10.1002/anie.202217345
M3 - Review
C2 - 36718001
VL - 62
JO - Angewandte Chemie International Edition
JF - Angewandte Chemie International Edition
SN - 1433-7851
IS - 17
M1 - e202217345
ER -
ID: 339617669