A calorimetric study of phosphocholine membranes mixed with desmopressin and its diacylated prodrug derivative (DPP)

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Standard

A calorimetric study of phosphocholine membranes mixed with desmopressin and its diacylated prodrug derivative (DPP). / Pedersen, Tina B.; Frokjaer, Sven; Mouritsen, Ole G.; Jørgensen, Kent.

In: International Journal of Pharmaceutics, Vol. 233, No. 1-2, 21.02.2002, p. 199-206.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Pedersen, TB, Frokjaer, S, Mouritsen, OG & Jørgensen, K 2002, 'A calorimetric study of phosphocholine membranes mixed with desmopressin and its diacylated prodrug derivative (DPP)', International Journal of Pharmaceutics, vol. 233, no. 1-2, pp. 199-206. https://doi.org/10.1016/S0378-5173(01)00946-2

APA

Pedersen, T. B., Frokjaer, S., Mouritsen, O. G., & Jørgensen, K. (2002). A calorimetric study of phosphocholine membranes mixed with desmopressin and its diacylated prodrug derivative (DPP). International Journal of Pharmaceutics, 233(1-2), 199-206. https://doi.org/10.1016/S0378-5173(01)00946-2

Vancouver

Pedersen TB, Frokjaer S, Mouritsen OG, Jørgensen K. A calorimetric study of phosphocholine membranes mixed with desmopressin and its diacylated prodrug derivative (DPP). International Journal of Pharmaceutics. 2002 Feb 21;233(1-2):199-206. https://doi.org/10.1016/S0378-5173(01)00946-2

Author

Pedersen, Tina B. ; Frokjaer, Sven ; Mouritsen, Ole G. ; Jørgensen, Kent. / A calorimetric study of phosphocholine membranes mixed with desmopressin and its diacylated prodrug derivative (DPP). In: International Journal of Pharmaceutics. 2002 ; Vol. 233, No. 1-2. pp. 199-206.

Bibtex

@article{9b31707b0e2c4395a7dad83e43816ab7,
title = "A calorimetric study of phosphocholine membranes mixed with desmopressin and its diacylated prodrug derivative (DPP)",
abstract = "The influence of the water-soluble peptide, desmopressin (DDAVP) and its dipalmitoylated prodrug derivative (DPP) on the thermal behaviour of three different saturated phosphatidylcholine lipid membranes was investigated by differential scanning calorimetry. For lipid membranes composed of dimyristoyl, dipalmitoyl and distearoyl phosphatidylcholines the addition of DDAVP at concentrations of up to 10 mol% resulted in an insignificant change in the thermodynamic phase behaviour. In contrast, the dipalmitoylated DPP prodrug caused major changes on the lipid membrane phase behaviour manifested as a drastic decrease in the heat capacity peak height and a concomitant broadening of the main phase transition as well as a decrease in the transition enthalpy. In addition, the main phase transition temperature was slightly decreased and the pre-transition of the three phosphatidylcholines was abolished when DPP was present.",
keywords = "Acylated peptide, Differential scanning calorimetry, Peptide-membrane interaction",
author = "Pedersen, {Tina B.} and Sven Frokjaer and Mouritsen, {Ole G.} and Kent J{\o}rgensen",
year = "2002",
month = feb,
day = "21",
doi = "10.1016/S0378-5173(01)00946-2",
language = "English",
volume = "233",
pages = "199--206",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - A calorimetric study of phosphocholine membranes mixed with desmopressin and its diacylated prodrug derivative (DPP)

AU - Pedersen, Tina B.

AU - Frokjaer, Sven

AU - Mouritsen, Ole G.

AU - Jørgensen, Kent

PY - 2002/2/21

Y1 - 2002/2/21

N2 - The influence of the water-soluble peptide, desmopressin (DDAVP) and its dipalmitoylated prodrug derivative (DPP) on the thermal behaviour of three different saturated phosphatidylcholine lipid membranes was investigated by differential scanning calorimetry. For lipid membranes composed of dimyristoyl, dipalmitoyl and distearoyl phosphatidylcholines the addition of DDAVP at concentrations of up to 10 mol% resulted in an insignificant change in the thermodynamic phase behaviour. In contrast, the dipalmitoylated DPP prodrug caused major changes on the lipid membrane phase behaviour manifested as a drastic decrease in the heat capacity peak height and a concomitant broadening of the main phase transition as well as a decrease in the transition enthalpy. In addition, the main phase transition temperature was slightly decreased and the pre-transition of the three phosphatidylcholines was abolished when DPP was present.

AB - The influence of the water-soluble peptide, desmopressin (DDAVP) and its dipalmitoylated prodrug derivative (DPP) on the thermal behaviour of three different saturated phosphatidylcholine lipid membranes was investigated by differential scanning calorimetry. For lipid membranes composed of dimyristoyl, dipalmitoyl and distearoyl phosphatidylcholines the addition of DDAVP at concentrations of up to 10 mol% resulted in an insignificant change in the thermodynamic phase behaviour. In contrast, the dipalmitoylated DPP prodrug caused major changes on the lipid membrane phase behaviour manifested as a drastic decrease in the heat capacity peak height and a concomitant broadening of the main phase transition as well as a decrease in the transition enthalpy. In addition, the main phase transition temperature was slightly decreased and the pre-transition of the three phosphatidylcholines was abolished when DPP was present.

KW - Acylated peptide

KW - Differential scanning calorimetry

KW - Peptide-membrane interaction

UR - http://www.scopus.com/inward/record.url?scp=0037148677&partnerID=8YFLogxK

U2 - 10.1016/S0378-5173(01)00946-2

DO - 10.1016/S0378-5173(01)00946-2

M3 - Journal article

C2 - 11897424

AN - SCOPUS:0037148677

VL - 233

SP - 199

EP - 206

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 230986957