Thomas Rades

Thomas Rades

Professor


  1. 2013
  2. Published

    Amino acids as co-amorphous stabilizers for poorly water-soluble drugs - Part 2: Molecular interactions

    Löbmann, Korbinian, Laitinen, R., Strachan, C., Rades, Thomas & Grohganz, Holger, 1 Jan 2013, In: European Journal of Pharmaceutics and Biopharmaceutics. 85, 3, Part B, p. 882-888

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A theoretical and spectroscopic study of co-amorphous naproxen and indomethacin

    Löbmann, Korbinian, Laitinen, R., Grohganz, Holger, Strachan, C. J., Rades, Thomas & Gordon, K. C., 30 Aug 2013, In: International Journal of Pharmaceutics. 453, 1, p. 80-87 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Amino acids as co-amorphous stabilizers for poorly water soluble drugs--Part 1: preparation, stability and dissolution enhancement

    Löbmann, Korbinian, Grohganz, Holger, Laitinen, R., Strachan, C. & Rades, Thomas, Nov 2013, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 85, 3 Pt B, p. 873-81 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen

    Madsen, F. & Rades, Thomas, Jul 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 289-290 2 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  6. Published

    Investigation of the phase separation of PNIPAM using infrared spectroscopy together with multivariate data analysis

    Munk, T., Baldursdottir, S. G., Hietala, S., Rades, Thomas, Nuopponen, M., Kalliomäki, K., Tenhu, H., Rantanen, Jukka & Strachan, C. S., 2013, In: Polymer. 54, 26, p. 6947-6953 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Biorelevant characterisation of amorphous furosemide salt exhibits conversion to a furosemide hydrate during dissolution

    Nielsen, L. H., Gordon, S., Pajander, J. P., Østergaard, Jesper, Rades, Thomas & Mullertz, Anette , 30 Nov 2013, In: International Journal of Pharmaceutics. 457, 1, p. 14-24 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Characterization during storage and dissolution of Solid dispersions containing furosemide and hydroxypropyl methylcellulose

    Nielsen, L. H., Rades, Thomas & Mullertz, Anette , 1 Jul 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 409-415 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to rats

    Nielsen, L. H., Gordon, S., Holm, R., Selen, A., Rades, Thomas & Mullertz, Anette , Nov 2013, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 85, 3 Pt B, p. 942-51 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Application of an online post-column derivatization HPLC-DPPH assay to detect compounds responsible for antioxidant activity in Sonchus oleraceus L. leaf extracts

    Ou, Z., Schmierer, D. M., Rades, Thomas, Larsen, L. & McDowell, A., 2013, In: Journal of Pharmacy and Pharmacology. 65, 2, p. 271-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Quantification of the types of water in Eudragit RLPO polymer and the kinetics of water loss using FTIR

    Pirayavaraporn, C., Rades, Thomas, Gordon, K. C. & Tucker, I. G., 15 Dec 2013, In: International Journal of Pharmaceutics. 458, 1, p. 90-98 9 p.

    Research output: Contribution to journalJournal articleResearch

  12. Published

    Characterization of chitosan-magnesium aluminum silicate nanocomposite films for buccal delivery of nicotine

    Pongjanyakul, T., Khunawattanakul, W., Strachan, C. J., Gordon, K. C., Puttipipatkhachorn, S. & Rades, Thomas, 2013, In: International Journal of Biological Macromolecules. 55, p. 24-31 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    In situ amorphisation of indomethacin with Eudragit® E during dissolution

    Priemel, P. A., Laitinen, R., Grohganz, Holger, Rades, Thomas & Strachan, C. J., Nov 2013, In: European Journal of Pharmaceutics and Biopharmaceutics. 85, 3 Pt B, p. 1259-65 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Inhibition of surface crystallisation of amorphous indomethacin particles in physical drug-polymer mixtures

    Priemel, P. A., Laitinen, R., Barthold, S., Grohganz, Holger, Lehto, V., Rades, Thomas & Strachan, C. J., 18 Nov 2013, In: International Journal of Pharmaceutics. 456, 2, p. 301-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Transcutaneous immunization using microneedles and cubosomes: Mechanistic investigations using Optical Coherence Tomography and Two-Photon Microscopy

    Rattanapak, T., Birchall, J., Young, K., Ishii, M., Meglinski, I., Rades, Thomas & Hook, S., 28 Dec 2013, In: Journal of controlled release : official journal of the Controlled Release Society. 172, 3, p. 894-903 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    A case study of real-time monitoring of solid-state phase transformations in acoustically levitated particles using near infrared and Raman spectroscopy

    Rehder, S., Wu, J., Laackmann, J., Moritz, H., Rantanen, Jukka, Rades, Thomas & Leopold, C. S., 2013, In: European Journal of Pharmaceutical Sciences. 48, 1-2, p. 97-103 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    High-shear granulation as a manufacturing method for cocrystal granules

    Rehder, S., Christensen, N. P. A., Rantanen, Jukka, Rades, Thomas & Leopold, C. S., Nov 2013, In: European Journal of Pharmaceutics and Biopharmaceutics. 85, 3, Part B, p. 1019-30 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Cubosomes contaning the adjuvants imiquimod and monophosphryl lipid A stimulate robust cellular and humoral immune respones

    Rizwan, S. B., McBurney, W. T., Young, K., Boyd, B. J., Rades, Thomas & Hook, B., 2013, In: Journal of Controlled Release. 165, 1, p. 16-21

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    in vivo evaluation of chitosan as an adjuvant in subcutaneous vaccine formulations

    Scherließ, R., Buske, S., Young, K., Weber, B., Rades, Thomas & Hook, S., 1 Oct 2013, In: Vaccine. 31, 42, p. 4812-9 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Studies on the lipase-induced degradation of lipid-based drug delivery systems. Part II - Investigations on the mechanisms leading to collapse of the lipid structure

    Schwab, M., McGoverin, C. M., Gordon, K. C., Winter, G., Rades, Thomas, Myschik, J. & Strachan, C. J., Aug 2013, In: European Journal of Pharmaceutics and Biopharmaceutics. 84, 3, p. 456-63 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Recent developments in oral lipid-based drug delivery

    Thomas, N., Rades, Thomas & Mullertz, Anette , 1 Jul 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 375-382 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS) enhance the bioavailability of the poorly water-soluble drug Simvastatin in dogs

    Thomas, N., Holm, R., Garmer, M., Karlsson, J. J., Mullertz, Anette & Rades, Thomas, 2013, In: A A P S Journal. 15, 1, p. 219-27 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. 2012
  24. Published

    Determination of methylphenidate in Calliphorid larvae by liquid-liquid extraction and liquid chromatography mass spectrometry - Forensic entomotoxicology using an in vivo rat brain model

    Bushby, S. K., Thomas, N., Priemel, P. A., Coulter, C. V., Rades, Thomas & Kieser, J. A., 2012, In: Journal of Pharmaceutical and Biomedical Analysis. 70, p. 456-61 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Structural elucidationof rapid solution-mediatedPhase transitions in pharmaceutical solids using in situ synchrotron SAXS/WAXS

    Bøtker, Johan Peter, Rades, Thomas, Rantanen, Jukka, Hawley, A. & Boyd, B. J., 1 Aug 2012, In: Molecular Pharmaceutics. 9, 9, p. 2787-2791

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Report from working group on developing a communication and PR strategy for the Department of Pharmacy, Copenhagen University

    Gammelgaard, Bente, Rades, Thomas, K, H., Nørgaard, Lotte Stig & Nielsen, C. U., Oct 2012, Rapport fra arbejdsgruppe nedsat mhp. etablering af kommunikations- og PR-strategi for Institut for Farmaci. 15 p.

    Research output: Chapter in Book/Report/Conference proceedingReport chapterCommissioned

  27. Published

    Chitosan hydrogels containing liposomes and cubosomes as particulate sustained release vaccine delivery systems

    Gordon, S., Young, K., Wilson, R., Rizwan, S., Kemp, R., Rades, Thomas & Hook, S., Sep 2012, In: Journal of Liposome Research. 22, 3, p. 193-204 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Measurement of amorphous indomethacin stability with NIR and Raman spectroscopy

    Kao, J. Y., McGoverin, C. M., Graeser, K. A., Rades, Thomas & Gordon, K. C., Jan 2012, In: Vibrational Spectroscopy. 58, p. 19-26 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Effect of different preparation methods on the dissolution behaviour of amorphous indomethacin

    Karmwar, P., Graeser, K., Gordon, K. C., Strachan, C. J. & Rades, Thomas, Feb 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 80, 2, p. 459-464 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions

    Löbmann, Korbinian, Strachan, C., Grohganz, Holger, Rades, Thomas, Korhonen, O. & Laitinen, R., 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 81, 1, p. 159-69 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Ordnung muss (nicht) sein

    Löbmann, Korbinian, Jensen, K. B. T., Grohganz, Holger & Rades, Thomas, 2012, In: Lægemiddelforskning. 2012, p. 34-36

    Research output: Contribution to journalJournal articleCommunication

  32. Published

    Crystal morphology modification by the addition of tailor-made stereocontrolled poly(N-isopropyl acrylamide)

    Munk, T., Baldursdottir, S., Hietala, S., Rades, Thomas, Kapp, S., Nuopponen, M., Kalliomäki, K., Tenhu, H. & Rantanen, Jukka, 2012, In: Molecular Pharmaceutics. 9, 7, p. 1932-1941

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Polymorphic form of piroxicam influences the performance of armorphous material prepared by ball-milling

    Naelapaa, K., Bøtker, Johan Peter, Veski, P., Rantanen, Jukka, Rades, Thomas & Kogermann, K., 2012, In: International Journal of Pharmaceutics. 429, 1-2, p. 69-77

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Spatial confinement can lead to increased stability of amorphous indomethacin

    Nielsen, L. H., Keller, S. S., Gordon, K. C., Boisen, A., Rades, Thomas & Mullertz, Anette , 2012, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 81, 2, p. 418-25 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Exploring the fate of liposomes in the intestine by dynamic in vitro lipolysis

    Parmentier, J., Thomas, N., Mullertz, Anette , Fricker, G. & Rades, Thomas, 2012, In: International Journal of Pharmaceutics. 437, 1-2, p. 253-63 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Quality of generic medicines in South Africa: perceptions versus reality - a qualitative study

    Patel, A., Gauld, R., Norris, P. & Rades, Thomas, 2012, In: B M C Health Services Research. 12, p. 297

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Determination of moisture content in relation to thermal behaviour and plasticization of Eudragit RLPO

    Pirayavaraporn, C., Rades, Thomas & Tucker, I. G., 17 Jan 2012, In: International Journal of Pharmaceutics. 422, 1-2, p. 68-74 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    The impact of surface- and nano-crystallisation on the detected amorphous content and the dissolution behaviour of amorphous indomethacin

    Priemel, P. A., Grohganz, Holger, Gordon, K. C., Rades, Thomas & Strachan, C., 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 82, 1, p. 187-193

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Pharmaceutics: drug delivery and targeting

    Rades, Thomas & Perrie, Y., 2012, 2. ed. London: Pharmaceutical Press. 239 p. (FASTtrack).

    Research output: Book/ReportBookResearchpeer-review

  40. Published

    Comparative study of liposomes, transfersomes, ethosomes and cubosomes for transcutaneous immunisation: characterisation and in vitro skin penetration

    Rattanapak, T., Young, K., Rades, Thomas & Hook, S., 2012, In: Journal of Pharmacy and Pharmacology. 64, 11, p. 1560-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Thermal degradation of amorphous glibenclamide

    Rehder, S., Sakmann, A., Rades, Thomas & Leopold, C. S., Jan 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 80, 1, p. 203-208 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Dry hybrid lipid-silica microcapsules engineered from submicron lipid droplets and nanoparticles as a novel delivery system for poorly soluble drugs

    Simovic, S., Heard, P., Hui, H., Song, Y., Peddie, F., Davey, A. K., Lewis, A., Rades, Thomas & Prestidge, C. A., 2012, In: Molecular Pharmaceutics. 6, 3, p. 861-72 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Effect of intra- and extra-liposomal distribution of sodium chloride on the stability of large unilamellar vesicles

    Siow, L. F., Rades, Thomas & Lim, M. H., 2012, In: Cryo-Letters. 28, 6, p. 429-44 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Characterising lipid lipolysis and its implication in lipid-based formulation development

    Thomas, N., Holm, R., Rades, Thomas & Mullertz, Anette , 2012, In: The AAPS journal. 14, 4, p. 860-71 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    A novel image analysis methodology for online monitoring of nucleation and crystal growth during solid state phase transformations

    Wu, J., Xia, D., van der Berg, Franciscus Winfried J, Amigo Rubio, J. M., Rades, Thomas, Yang, Mingshi & Rantanen, Jukka, 2012, In: International Journal of Pharmaceutics. 433, 1-2, p. 60-70

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Solvent-mediated amorphous-to-crystalline transformation of nitrendipine in amorphous particle suspensions containing polymers

    Xia, D., Wu, J., Cui, F., Qu, H., Rades, Thomas, Rantanen, Jukka & Yang, Mingshi, 15 Aug 2012, In: European Journal of Pharmaceutical Sciences. 46, 5, p. 446-454 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Quantification of process induced disorder in milled samples using different analytical techniques

    Zimper, U., Aaltonen, J., McGoverin, C. M., Gordon, K. C., Krauel-Goellner, K. & Rades, Thomas, 28 Aug 2012, In: Pharmaceutics. 2, 1, p. 30-49 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    The influence of milling on the dissolution performance of simvastatin

    Zimper, U., Aaltonen, J., Krauel-Goellner, K., Gordon, K. C., Strachan, C. J. & Rades, Thomas, 28 Aug 2012, In: Pharmaceutics. 2, 4, p. 419-431 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. 2011
  50. Published

    Insights into the early dissolution events of amlodipine using UV imaging and Raman spectroscopy

    Bøtker, Johan Peter, Savolainen, M., Koradia, V., Tian, F., Rades, Thomas, Mullertz, Anette , Cornett, Claus, Rantanen, Jukka & Østergaard, Jesper, 2011, In: Molecular Pharmaceutics. 8, 4, p. 1372-1380 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Assessment of crystalline disorder in cryo-milled samples of indomethacin using atomic pair-wise distribution functions

    Bøtker, Johan Peter, Karmwar, P., Strachan, C. J., Cornett, Claus, Tian, F., Zujovic, Z., Rantanen, Jukka & Rades, Thomas, 2011, In: International Journal of Pharmaceutics. 417, 1-2, p. 112-119 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. An overview of recent studies on the analysis of pharmaceutical polymorphs

    Chieng, N., Rades, Thomas & Aaltonen, J., 2011, In: Journal of Pharmaceutical and Biomedical Analysis. 55, 4, p. 618-44 27 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Analysis of matrix dosage forms during dissolution testing using raman microscopy

    Haaser, M., Windbergs, M., McGoverin, C. M., Kleinebudde, P., Rades, Thomas, Gordon, K. C. & Strachan, C. J., 2011, In: Al Azhar Journal of Pharmaceutical Sciences.

    Research output: Contribution to journalJournal articleResearchpeer-review

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