Pharmaceutical Physical and Analytical Chemistry
Universitetsparken 2, Building: 17-3-315c
2100 København Ø
Primary fields of research
My main research interest is the application of advanced analytical chemistry for the investigation of fate, biotransformation and cytotoxicity of metal-based drugs (e.g. cisplatin, oxaliplatin or new drug candidates) in biological systems. The research involves application of in vitro cancer cell systems as model systems. In terms of instrumentation this entails application of Inductively Coupled Plasma Mass Spectrometry (ICPMS) often coupled to separation techniques such as Capillary Electrophoresis (CE), Size Exclusion Chromatography (SEC) or High Pressure Liquid Chromatography (HPLC)
Other research interests are the application of ICPMS/ICPOES based instrumentation for determination of trace elements in drugs in the Pharmaceutical industry and the compliance of the techniques with current pharmacopeia requirements.
Papers with peer-review: 74; h-factor: 23
Development of ICP-MS methods for determination of trace element impurities in drug products. Development and validation of new methods to comply with Pharmacopeia requirements. Collaboration with Novo Nordic.
Intracellular distribution of platinum following administration of cisplatin/oxaliplatin. Development of protocols for precise and accurate determination of platinum in cytosol, nucleus and mitochondria by ICPMS. Collaboration with Ian H. Lambert, Science, University of Copenhagen
The correlation between intracellular glutathione levels and cisplatin resistance. Development of analytical protocols to measure GSH and cisplatin in sensitive and resistant cancer cell models. Collaboration with Ian H. Lambert, Science, University of Copenhagen.
Instrumental Analytical Chemistry (A26, Bachelor): Responsible for management of the laboratory course (A26-2)
Kemiske Principper (Bachelor)
7 PhD students and 12 master students, most recent master students are:
Theodosia Tsolakou: Stability and Cellular Uptale of novel metal-based anticancer drugs.
Louise Moe: Determination of trace elements in ironoxides by ICP-OES.
Celina Støving Jensen: Development and validation of ICP-OES and ICP-MS methods for the determination of elemental impurities in drug substances according to the newly revised U.S. Pharmacopeia.