Kasper Dyrberg Rand

Kasper Dyrberg Rand

Professor


  1. Published

    Unusual Self-Assembly of the Recombinant Chlamydia trachomatis Major Outer Membrane Protein-Based Fusion Antigen CTH522 Into Protein Nanoparticles

    Rose, F., Karlsen, K., Jensen, P. R., Jakobsen, R. U., Wood, G. K., Rand, Kasper Dyrberg, Godiksen, H., Andersen, P., Follmann, F. & Foged, Camilla, Jun 2018, In: Journal of Pharmaceutical Sciences. 107, 6, p. 1690-1700 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    UV Photodissociation Mass Spectrometry Accurately Localize Sites of Backbone Deuteration in Peptides

    Mistarz, U. H., Bellina, B., Jensen, P. F., Brown, J. M., Barran, P. E. & Rand, Kasper Dyrberg, 2018, In: Analytical Chemistry. 90, 2, p. 1077-1080 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Thiol-ene microfluidic chip for performing hydrogen/deuterium exchange of proteins at sub-second timescales

    Svejdal, R. R., Dickinson, E. R., Sticker, Drago, Kutter, Jörg P. & Rand, Kasper Dyrberg, 15 Jan 2019, In: Analytical Chemistry. 91, 2, p. 1309-1317

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Thiol-ene microfluidic chip for fast on-chip sample clean-up, separation and ESI mass spectrometry of peptides and proteins

    Svejdal, R. R., Sticker, Drago, Sønderby, C., Kutter, Jörg P. & Rand, Kasper Dyrberg, 2020, In: Analytica Chimica Acta. 1140, p. 168-177 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Thiol-ene Monolithic Pepsin Microreactor with a 3D-Printed Interface for Efficient UPLC-MS Peptide Mapping Analyses

    Jönsson, A., Svejdal, R. R., Bøgelund, N., Nguyen, T. T. T. N., Flindt, H., Kutter, Jörg P., Rand, Kasper Dyrberg & Lafleur, J. P., 21 Mar 2017, In: Analytical Chemistry. 89, 8, p. 4573-4580 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. The origins of enhanced activity in factor VIIa analogs and the interplay between key allosteric sites revealed by hydrogen exchange mass spectrometry

    Rand, Kasper Dyrberg, Andersen, M., Olsen, O. H., Jørgensen, T., Ostergaard, H., Jensen, O., Stennicke, H. R. & Persson, E., 2008, In: Journal of Biological Chemistry. 283, 19, p. 13378-87 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The extraordinary thermal stability of EstA from S. islandicus is independent of post translational modifications

    Stiefler-Jensen, D., Schwarz-Linnet, T., de Lichtenberg, C., Nguyen, T. T. T. N., Rand, Kasper Dyrberg, Huang, L., She, Q. & Teilum, Kaare, Sep 2017, In: Protein Science. 26, 9, p. 1819-1827 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    The dopamine transporter antiports potassium to increase the uptake of dopamine

    Schmidt, S. G., Malle, M. G., Nielsen, A. K., Bohr, S. S., Pugh, Ciara Frances, Nielsen, Jeppe Cederholm, Poulsen, I. H., Rand, Kasper Dyrberg, Hatzakis, Nikos & Loland, Claus Juul, 2022, In: Nature Communications. 13, 1, 12 p., 2446.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed β2-Microglobulin through Distinct Binding Sites

    Merkle, P. S., Irving, M., Hongjian, S., Ferber, M., Jørgensen, T. J. D., Scholten, K., Luescher, I., Coukos, G., Zoete, V., Cuendet, M. A., Michielin, O. & Rand, Kasper Dyrberg, 1 Aug 2017, In: Biochemistry. 56, 30, p. 3945-3961 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    The Impact of the ‘Austrian’ Mutation of the Amyloid Precursor Protein Transmembrane Helix is Communicated to the Hinge Region

    Stelzer, W., Scharnagl, C., Leurs, U., Rand, Kasper Dyrberg & Langosch, D., 2016, In: ChemistrySelect. 1, 15, p. 4408-4412 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The First Community-Wide, Comparative Cross-linking Mass Spectrometry Study

    Iacobucci, C., Piotrowski, C., Aebersold, R., Amaral, B. C., Andrews, P. C., Bernfur, K., Borchers, C. H., Brodie, N. I., Bruce, J. E., Cao, Y., Chaignepain, S., Chavez, J. D., Claverol, S., Cox, J., Davis, T. N., Degliesposti, G., Dong, M-Q., Edinger, N., Emanuelsson, C., Gay, M. & 53 others, Gomes-Neto, F., Gozzo, F. C., Gutierrez, C. B., Haupt, C., Heck, A. J. R., Herzog, F., Huang, L., Hoopmann, M. R., Kalisman, N., Klykov, O., Kukačka, Z., Liu, F., MacCoss, M. J., Mechtler, K., Mesika, R., Moritz, R. L., Nagaraj, N., Nesati, V., Neves-Fereira, A. G. C., Ninnis, R., Novák, P., O'Reilly, F. J., Pelzing, M., Petrotchenko, E. V., Piersimoni, L., Plasencia, M., Pukala, T. L., Rand, Kasper Dyrberg, Rappsilber, J., Reichman, D., Sailer, C., Sarnowski, C. P., Scheltema, R. A., Schmidt, C., Schriemer, D. C., Shi, Y., Skehel, J. M., Slavin, M., Sobott, F., Solis-Mezarino, V., Stephanowitz, H., Stengel, F., Stieger, C. E., Trabjerg, Esben, Trnka, M. J., Vilaseca, M., Viner, R., Xiang, Y., Yılmaz, Ş., Zelter, A., Ziemianowicz, D. S., Leitner, A. & Sinz, A., 2 May 2019, In: Analytical Chemistry. 91, 11, p. 6953-6961

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT: Recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Robert Vandenberg

    Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 2018, In: Science Advances. 4, 5, 12 p., eaar6179.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Substrate-induced conformational dynamics of the dopamine transporter

    Nielsen, A. K., Möller, I. R., Wang, Y., Rasmussen, Søren Gøgsig Faarup, Lindorff-Larsen, Kresten, Rand, Kasper Dyrberg & Loland, Claus Juul, 2019, In: Nature Communications. 10, 14 p., 2714.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Substrate-Induced Conformational Dynamics of the Dopamine Transporter

    Nielsen, A. K., Moller, I. R., Rasmussen, Søren Gøgsig Faarup, Rand, Kasper Dyrberg & Loland, Claus Juul, 2019, In: Biophysical Society. Annual Meeting. Abstracts. 116, 3, p. 346A 1 p., 1714-Pos.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  15. Published

    Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C

    Leurs, U., Lohse, B., Rand, Kasper Dyrberg, Ming, S., Riise, E. S., Cole, P. A., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 11 Jul 2014, In: A C S Chemical Biology. 9, 9, p. 2131-2138 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Structure and Dynamics of a Promiscuous Xanthan Lyase from Paenibacillus nanensis and the Design of Variants with Increased Stability and Activity

    Jensen, P. F., Kadziola, Anders, Comamala, G., Segura, D. R., Anderson, L., Poulsen, Jens-Christian Navarro, Rasmussen, K. K., Agarwal, S., Sainathan, R. K., Monrad, R. N., Svendsen, A., Nielsen, J. E., Lo Leggio, Leila & Rand, Kasper Dyrberg, 2019, In: Cell Chemical Biology. 26, 2, p. 191-202.e1-e6 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Structural Dynamics and Catalytic Properties of a Multimodular Xanthanase

    Moroz, O. V., Jensen, P. F., Mcdonald, S. P., Mcgregor, N., Blagova, E., Comamala, G., Segura, D. R., Anderson, L., Vasu, S. M., Rao, V. P., Giger, L., Sørensen, T. H., Monrad, R. N., Svendsen, A., Nielsen, J. E., Henrissat, B., Davies, G. J., Brumer, H., Rand, Kasper Dyrberg & Wilson, K. S., 6 Jul 2018, In: ACS Catalysis. 8, 7, p. 6021-6034

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Spatially resolved protein hydrogen exchange measured by matrix-assisted laser desorption ionization in-source decay

    Rand, Kasper Dyrberg, Bache, N., Nedertoft, M. M. & Jørgensen, T., 2011, In: Analytical Chemistry. 83, 23, p. 8859-62 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Sites involved in intra- and interdomain allostery associated with the activation of factor VIIa pinpointed by hydrogen-deuterium exchange and electron transfer dissociation mass spectrometry

    Song, H., Olsen, O. H., Persson, E. & Rand, Kasper Dyrberg, 24 Oct 2014, In: The Journal of Biological Chemistry. 289, p. 35388-96 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Site-specific analysis of gas-phase hydrogen/deuterium exchange of peptides and proteins by electron transfer dessociation

    Rand, Kasper Dyrberg, Pringle, S. D., Morris, M. & Brown, J. M., 2012, In: Analytical Chemistry. 84, 4, p. 1931-1940

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Simple setup for gas-phase H/D exchange mass spectrometry coupled to electron transfer dissociation and ion mobility for analysis of polypeptide structure on a liquid chromatographic time scale

    Mistarz, U. H., Brown, J. M., Haselmann, K. F. & Rand, Kasper Dyrberg, 2 Dec 2014, In: Analytical Chemistry. 86, 23, p. 11868-76 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Side-chain moieties from the N-terminal region of Aβ are Involved in an oligomer-stabilizing network of interactions

    Przygońska, K., Poznański, J., Mistarz, U. H., Rand, Kasper Dyrberg & Dadlez, M., 6 Aug 2018, In: PLoS One. 13, 8, p. 1-25 25 p., e0201761.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Revealing the dynamic allosteric changes required for formation of the cysteine synthase complex by hydrogen-deuterium exchange mass spectrometry

    Rosa, B., Dickinson, E. R., Marchetti, M., Campanini, B., Pioselli, B., Bettati, S. & Rand, Kasper Dyrberg, 2021, In: Molecular and Cellular Proteomics. 20, 12 p., 100098.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Removal of N-Linked Glycosylations at Acidic pH by PNGase A Facilitates Hydrogen/Deuterium Exchange Mass Spectrometry Analysis of N-Linked Glycoproteins

    Jensen, P. F., Comamala Grau, G., Trelle, M. B., Madsen, J. B., Jorgensen, T. J. D. & Rand, Kasper Dyrberg, 20 Dec 2016, In: Analytical Chemistry. 88, 24, p. 12479-12488 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

    Masson, G. R., Burke, J. E., Ahn, N. G., Anand, G. S., Borchers, C., Brier, S., Bou-Assaf, G. M., Engen, J. R., Englander, S. W., Faber, J., Garlish, R., Griffin, P. R., Gross, M. L., Guttman, M., Hamuro, Y., Heck, A. J. R., Houde, D., Iacob, R. E., Jorgensen, T. J. D., Kaltashov, I. A. & 20 others, Klinman, J. P., Konermann, L., Man, P., Mayne, L., Pascal, B. D., Reichmann, D., Skehel, M., Snijder, J., Strutzenberg, T. S., Underbakke, E. S., Wagner, C., Wales, T. E., Walters, B. T., Weis, D. D., Wilson, D. J., Wintrode, P. L., Zhang, Z., Zheng, J., Schriemer, D. C. & Rand, Kasper Dyrberg, Jul 2019, In: Nature Methods. 16, 7, p. 595-602

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Rapid and simple preparation of thiol-ene emulsion-templated monoliths and their application as enzymatic microreactors

    Lafleur, J. P., Senkbeil, S., Novotny, J., Nys, G., Bøgelund, N., Rand, Kasper Dyrberg, Foret, F. & Kutter, Jörg P., 2015, In: Lab On a Chip. 15, 10, p. 2162-72 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Rapid Conformational Analysis of Protein Drugs in Formulation by Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS)

    Esmail Nazari, Z., van de Weert, Marco, Bou-Assaf, G., Houde, D., Weiskopf, A. & Rand, Kasper Dyrberg, 1 Jul 2016, In: Journal of Pharmaceutical Sciences. 105, 11, p. 3269–3277 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Protein hydrogen exchange measured at single-residue resolution by electron transfer dissociation mass spectrometry

    Rand, Kasper Dyrberg, Zehl, M., Jensen, O. & Jørgensen, T., 2009, In: Analytical Chemistry. 81, 14, p. 5577-84 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Probing the impact of temperature and substrates on the conformational dynamics of the Neurotransmitter:Sodium symporter LeuT

    Calugareanu, D., Möller, I. R., Schmidt, S. G., Loland, Claus Juul & Rand, Kasper Dyrberg, 2022, In: Journal of Molecular Biology. 434, 2, 15 p., 167356.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Probing the conformational impact of detergents on the integral membrane protein LeuT by global HDX-MS

    Möller, I. R., Merkle, P. S., Calugareanu, D., Comamala, G., Schmidt, S. G., Loland, Claus Juul & Rand, Kasper Dyrberg, 2020, In: Journal of Proteomics. 225, 103845.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Probing the Dissociation of Protein Complexes by Means of Gas-Phase H/D Exchange Mass Spectrometry

    Mistarz, U. H., Chandler, S. A., Brown, J. M., Benesch, J. L. P. & Rand, Kasper Dyrberg, 15 Jan 2019, In: Journal of the American Society for Mass Spectrometry. 30, 1, p. 45-57 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Probing the Conformational and Functional Consequences of Disulfide Bond Engineering in Growth Hormone by Hydrogen-Deuterium Exchange Mass Spectrometry Coupled to Electron Transfer Dissociation

    Seger, S. T., Breinholt, J., Faber, J. H., Andersen, M. D., Wiberg, C., Schjødt, C. B. & Rand, Kasper Dyrberg, 16 Jun 2015, In: Analytical Chemistry. 87, 12, p. 5973-80 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Probing the Conformational Dynamics of Affinity-Enhanced T Cell Receptor Variants upon Binding the Peptide-Bound Major Histocompatibility Complex by Hydrogen/Deuterium Exchange Mass Spectrometry

    Merkle, P. S., Trabjerg, Esben, Hongjian, S., Ferber, M., Cuendet, M. A., Jorgensen, T. J. D., Luescher, I., Irving, M., Zoete, V., Michielin, O. & Rand, Kasper Dyrberg, 2021, In: Biochemistry. 60, 11, p. 859-872

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Probing the Binding Interfaces of Protein Complexes Using Gas-Phase H/D Exchange Mass Spectrometry

    Mistarz, U. H., Brown, J. M., Haselmann, K. F. & Rand, Kasper Dyrberg, 2 Feb 2016, In: Structure. 24, 2, p. 310-318 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Pinpointing changes in higher-order protein structure by hydrogen/deuterium exchange coupled to electron transfer dissociation mass spectrometry

    Rand, Kasper Dyrberg, 15 Mar 2013, In: International Journal of Mass Spectrometry. 338, p. 2-10 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  36. Published

    Photodissociation Mass Spectrometry Accurately Localizes Sites of Backbone Deuteration in Peptides

    Mistarz, U. H., Bellina, B., Jensen, P. F., Brown, J. M., Barran, P. E. & Rand, Kasper Dyrberg, 14 Nov 2017

    Research output: Other contributionResearch

  37. Published

    Partial Unwinding of Transmembrane Helices Facilitates Alternating Access in the Neurotransmitter: Sodium Symporter LeuT

    Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 28 Jun 2017

    Research output: Other contributionResearch

  38. Published

    PNGase H+ variant from Rudaea cellulosilytica with improved deglycosylation efficiency for rapid analysis of eukaryotic N‐glycans and HDX‐MS analysis of glycoproteins.

    Guo, R., Zhang, T., Lambert, Thomas Ole Tandrup, Wang, T., Voglmeir, J., Rand, Kasper Dyrberg & Liu, L., 2022, In: Rapid Communications in Mass Spectrometry. 36, 21, 9 p., e9376.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Molecular architecture of the Jumonji C family histone demethylase KDM5B

    Dorosz, J., Kristensen, L. H., Aduri, N. G., Mirza, Osman Asghar, Lousen, R., Bucciarelli, S., Mehta, V., Sellés Baiget, Selene, Solbak, Sara Marie Øie, Bach, Anders, Mesa, Pablo, Hernandez, P. A., Montoya, Guillermo, Nguyen, T. T. T. N., Rand, Kasper Dyrberg, Boesen, T. & Gajhede, Michael, 2019, In: Scientific Reports. 9, 13 p., 4019.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Molecular analysis of the interaction between the hematopoietic master transcription factors GATA-1 and PU.1.

    Liew, C. W., Rand, Kasper Dyrberg, Simpson, R. J. Y., Yung, W. W., Mansfield, R. E., Crossley, M., Proetorius-Ibba, M., Nerlov, C., Poulsen, F. M. & Mackay, J. P., 2006, In: Journal of Biological Chemistry. 281, 38, p. 28296-306 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Molecular Basis of the Mechanisms Controlling MASTL

    Hermida, D., Mortuza, G. B., Pedersen, A., Pozdnyakova, I., Nguyen, T. T. T. N., Maroto, M., Williamson, M., Ebersole, T., Cazzamali, G., Rand, Kasper Dyrberg, Olsen, Jesper Velgaard, Malumbres, M. & Montoya, Guillermo, 2020, In: Molecular & Cellular Proteomics. 19, 2, p. 326-343

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Measuring the hydrogen/deuterium exchange of proteins at high spatial resolution by mass spectrometry: overcoming gas-phase hydrogen/deuterium scrambling

    Rand, Kasper Dyrberg, Zehl, M. & Jørgensen, T. J. D., 21 Oct 2014, In: Accounts of Chemical Research. 47, 10, p. 3018-27 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Measuring the binding interfaces of protein complexes by gas-phase hydrogen/deuterium exchange mass spectrometry (gas-phase HDX-MS)

    Mistarz, U. H., Brown, J. M., Haselmann, K. F. & Rand, Kasper Dyrberg, 2015.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  44. Published

    Massespektrometri viser vejen til forbedrede proteinlægemidler

    Song, H. & Rand, Kasper Dyrberg, 2012, In: Lægemiddelforskning. 2012, p. 43-46

    Research output: Contribution to journalJournal articleCommunication

  45. Published

    Mapping the interactions of selective biochemical probes of antibody conformation by hydrogen-deuterium exchange mass spectrometry

    Leurs, U., Beck, H., Bonnington, L., Lindner, I., Pol, E. & Rand, Kasper Dyrberg, 1 Jun 2017, In: ChemBioChem. 18, 11, p. 1016-1021

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Loss of ammonia during electron-transfer dissociation of deuterated peptides as an inherent gauge of gas-phase hydrogen scrambling

    Rand, Kasper Dyrberg, Zehl, M., Jensen, O. & Jørgensen, T., 2010, In: Analytical Chemistry. 82, 23, p. 9755-62 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Investigation of amide hydrogen back-exchange in Asp and His repeats measured by hydrogen (1H/2H) exchange mass spectrometry

    Rand, Kasper Dyrberg, Lund, F. W., Amon, S. & Jørgensen, Thomas, Apr 2011, In: International Journal of Mass Spectrometry.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Investigating the utility of minimized sample preparation and high-resolution mass spectrometry for quantification of monoclonal antibody drugs

    Nguyen, T. T. T. N., Mistarz, U. H., Costa, N., Herbet, A., Boquet, D., Becher, F. & Rand, Kasper Dyrberg, 10 Sep 2018, In: Journal of Pharmaceutical and Biomedical Analysis. 159, p. 384-392

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Investigating the Role of Artemin Glycosylation

    Danwen, Q., Code, C., Quan, C., Gong, B., Arndt, J., Pepinsky, B., Rand, Kasper Dyrberg & Houde, D., Jun 2016, In: Pharmaceutical Research. 33, 6, p. 1383-1398 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Investigating the Interaction between the Neonatal Fc Receptor and Monoclonal Antibody Variants by Hydrogen/Deuterium Exchange Mass Spectrometry

    Jensen, P. F., Larraillet, V., Schlothauer, T., Kettenberger, H., Hilger, M. & Rand, Kasper Dyrberg, Jan 2015, In: Molecular and Cellular Proteomics. 14, 1, p. 148-61 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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ID: 34783804