Birger Brodin Larsen

Birger Brodin Larsen

Professor


  1. 2021
  2. Published

    Tanycytes Control the Hypothalamic Uptake and Metabolic Actions of Liraglutide

    Imbernon, M., Saponaro, C., Helms, H. C. C., Zubiaga, L., Bitsi, S., Duquenne, M., Tomas, A., Chen, S., Salem, V., Deligia, E., Gmyr, V., Denis, R., Kerr-Conte, J., Chao, D. H. M., Beiroa, D., Steals, B., Pattou, F., Pfrieger, F., Larsen, Birger Brodin, Jones, B., Luquet, S., Bonner, C. & Prevot, V., Jul 2021, In: Glia. 69, p. E237 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  3. Published

    Transendothelial electrical resistance measurement across the blood–brain barrier: A critical review of methods

    Vigh, J. P., Kincses, A., Ozgür, Burak, Walter, F. R., Santa-Maria, A. R., Valkai, S., Vastag, M., Neuhaus, W., Larsen, Birger Brodin, Dér, A. & Deli, M. A., Jun 2021, In: Micromachines. 12, 6, 685.

    Research output: Contribution to journalReviewResearchpeer-review

  4. Published

    ATP induces contraction of cultured brain capillary pericytes, via activation of P2Y type purinergic receptors

    Hørlyck, S., Cai, Changsi, Helms, H. C., Lauritzen, Martin & Larsen, Birger Brodin, 2021, In: A J P: Heart and Circulatory Physiology (Online). 320, p. H699–H712 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. E-pub ahead of print

    Brain endothelial cells metabolize glutamate via glutamate dehydrogenase to replenish TCA-intermediates and produce ATP under hypoglycemic conditions

    Hinca, S. B., Salcedo, C., Wagner, A., Goldeman, C., Sadat, E., Aibar, M. M. D., Maechler, P., Larsen, Birger Brodin, Aldana Garcia, Blanca Irene & Helms, H. C. C., 2021, (E-pub ahead of print) In: Journal of Neurochemistry.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5)

    Goldeman, C., Andersen, M., Al-Robai, A., Buchholtz, T., Svane, N., Ozgür, Burak, Holst, B., Shusta, E., Hall, Vanessa Jane, Saaby, L., Hyttel, P. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutical Sciences. 156, 14 p., 105577.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. E-pub ahead of print

    Nitric oxide, KATP channels and endothelin-1 modulate brain pericyte function, vascular tone and neurovascular coupling

    Zambach, Stefan Andreas, Cai, Changsi, Helms, H. C. C., Hald, B. O., Fordsmann, J. C., Nielsen, R. M., Lønstrup, M., Larsen, Birger Brodin & Lauritzen, Martin, 2021, (E-pub ahead of print)

    Research output: Other contributionResearch

  8. Published

    Precapillary sphincters and pericytes at first-order capillaries as key regulators for brain capillary perfusion

    Zambach, Stefan Andreas, Cai, Changsi, Helms, H. C. C., Hald, B. O., Dong, Y., Fordsmann, J. C., Nielsen, R. M., Hu, J., Lønstrup, M., Larsen, Birger Brodin & Lauritzen, Martin, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 26, e2023749118.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. 2020
  10. Published

    IPEC-J2 rMdr1a, a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes

    Saaby, L., Trasborg, J., Rasmussen, M. A., Holst, B. & Larsen, Birger Brodin, 17 Jul 2020, In: Pharmaceutics. 12, 7, 17 p., 673.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Culture of brain capillary pericytes for cytosolic calcium measurements and calcium imaging studies

    Hørlyck, S., Helms, H. C. C. & Larsen, Birger Brodin, May 2020, In: Journal of Visualized Experiments. 159, p. 1-9 9 p., e61253.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Culture-induced changes in mRNA expression levels of efflux and SLC-transporters in brain endothelial cells

    Goldeman, C., Ozgür, Burak & Larsen, Birger Brodin, 22 Apr 2020, In: Fluids and Barriers of the CNS. 17, 32, 12 p., 32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP

    Ambjørner, Sophie Emilie Blomgren, Wiese, M., Köhler, S. C., Svindt, J., Lund, X. L., Gajhede, Michael, Saaby, L., Larsen, Birger Brodin, Rump, S., Weigt, H., Brünner, Nils & Stenvang, Jan, 4 Mar 2020, In: Cells. 9, 3, 22 p., 613.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation

    Kristensen, Mie, Kucharz, Krzysztof, Felipe Alves Fernandes, E., Strømgaard, Kristian, Schallburg Nielsen, M., Cederberg Helms, H. C., Bach, Anders, Ulrikkaholm Tofte-Hansen, M., Aldana Garcia, Blanca Irene, Lauritzen, Martin & Larsen, Birger Brodin, 2020, In: Pharmaceutics. 12, 7, 24 p., 661.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Drug Delivery Strategies to Overcome the Blood-Brain Barrier (BBB)

    Helms, H. C. C., Kristensen, Mie, Saaby, L., Fricker, G. & Larsen, Birger Brodin, 2020, Handbook of Experimental Pharmacology. Springer, p. 1-33

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  16. 2019
  17. Published

    miRNA-27a-3p and miRNA-222-3p as Novel Modulators of Phosphodiesterase 3a (PDE3A) in Cerebral Microvascular Endothelial Cells

    Yasmeen, S., Kaur, S., Mirza, A. H., Larsen, Birger Brodin, Pociot, Flemming & Kruuse, Christina Rostrup, Aug 2019, In: Molecular Neurobiology. 56, 8, p. 5304–5314

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures

    Tornabene, E., Helms, H. C. C., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 2019, In: PLoS ONE. 14, 8, 20 p., e0221103.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Evaluating the involvement of cerebral microvascular endothelial Na+/K+-ATPase and Na+-K+-2Cl- co-transporter in electrolyte fluxes in an in vitro blood-brain barrier model of dehydration

    Lykke, K., Assentoft, M., Hørlyck, S., Helms, H. C. C., Stoica, A., Toft-Bertelsen, Trine Lisberg, Tritsaris, Katerina, Vilhardt, Frederik, Larsen, Birger Brodin & MacAulay, Nanna, 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 3, p. 497-512

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Two-photon fluorescence imaging: a platform to investigate cell-penetrating peptides and liposome-based nanocarriers for drug delivery across the heterogeneous BBB in vivo

    Kucharz, K., Kristensen, K., Kristensen, Mie, Lund, M., Andresen, T., Larsen, Birger Brodin & Lauritzen, M., 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, p. 60 1 p.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  21. 2018
  22. Published

    Validation of reference genes for normalization of real-time quantitative PCR studies of gene expression in brain capillary endothelial cells cultured in vitro

    Hersom, M., Goldeman, C., Pretzer, N. & Larsen, Birger Brodin, Dec 2018, In: Molecular and Cellular Neuroscience. 93, p. 27-35 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    The iP-gp cell model is an improved tool for predicting the in vivo relevance of P-gp mediated efflux at the blood-brain barrier

    Ozgür, Burak, Saaby, L., Eneberg, E., Langthaler, K., Jacobsen, A., Janfelt, Christian, Badolo, L., Montanari, D. & Larsen, Birger Brodin, 22 Jun 2018.

    Research output: Contribution to conferencePosterResearchpeer-review

  24. Published

    Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates

    Ozgür, Burak, Saaby, L., Langthaler, K. & Larsen, Birger Brodin, 2018, In: European Journal of Pharmaceutical Sciences. 112, p. 112-121 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Data demonstrating the challenges of determining the kinetic parameters of P-gp mediated transport of low-water soluble substrates

    Ozgür, Burak, Saaby, L., Langthaler, K. & Larsen, Birger Brodin, 2018, In: Data in Brief. 16, p. 655-659 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Stimulation-induced increases in cerebral blood flow and local capillary vasoconstriction depend on conducted vascular responses

    Cai, Changsi, Fordsmann, J. C., Jensen, S. H., Gesslein, B., Lønstrup, M., Hald, B. O., Zambach, Stefan Andreas, Larsen, Birger Brodin & Lauritzen, Martin, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 25, p. E5796-E5804 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells, but does not mediate insulin entry from blood-to-brain

    Hersom, M., Helms, H. C., Schmalz, C., Pedersen, T. Å., Buckley, S. T. & Larsen, Birger Brodin, 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 315, 4, p. E531-E542

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. 2017
  29. Published

    Substrate-Dependent Inhibition of P-glycoprotein Mediated Efflux Transport of Digoxin

    Saaby, L., Ozgür, Burak & Larsen, Birger Brodin, 14 Nov 2017, p. T7089.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  30. Published

    Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017

    Greenwood, J., Hammarlund-Udenaes, M., Jones, H. C., Stitt, A. W., Vandenbrouke, R. E., Romero, I. A., Campbell, M., Fricker, G., Larsen, Birger Brodin, Manninga, H., Gaillard, P. J., Schwaninger, M., Webster, C., Wicher, K. B. & Khrestchatisky, M., 7 Nov 2017, In: Fluids and Barriers of the CNS. 14, 11 p., 31.

    Research output: Contribution to journalReviewResearchpeer-review

  31. Published

    Development and Characterization of a Brain Endothelial Cell Phenotype using Human Induced Pluripotent Stem Cells

    Goldeman, C., Saaby, L., Holst, B., Hall, Vanessa Jane, Hyttel, P. & Larsen, Birger Brodin, 2 Nov 2017.

    Research output: Contribution to conferencePosterResearchpeer-review

  32. Published

    A Critical View on In Vitro Analysis of P-glycoprotein (P-gp) Transport Kinetics

    Saaby, L. & Larsen, Birger Brodin, Sep 2017, In: Journal of Pharmaceutical Sciences. 106, 9, p. 2257-2264 8 p.

    Research output: Contribution to journalReviewResearchpeer-review

  33. Published

    Routes for drug translocation across the blood-brain barrier: Exploiting peptides as delivery vectors

    Kristensen, Mie & Larsen, Birger Brodin, Sep 2017, In: Journal of Pharmaceutical Sciences. 106, 9, p. 2326-2334

    Research output: Contribution to journalReviewResearchpeer-review

  34. Published

    iP-gp , a novel cell line with tight barrier function and expression of human P-glycoprotein (ABCB1) for drug screening

    Larsen, Birger Brodin, Ozgür, Burak & Saaby, L., 23 May 2017.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  35. Published

    Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells

    Siupka, P., Hersom, M. N., Lykke-Hartmann, K., Johnsen, K. B., Thomsen, L. B., Andresen, T. L., Moos, T., Abbott, N. J. & Larsen, Birger Brodin, 1 Jan 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 7, p. 2598-2613

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model

    Helms, H. C., Aldana Garcia, Blanca Irene, Groth, S., Jensen, M. M., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 12, p. 3744–3758

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Glutamate Transporters in the Blood-Brain Barrier

    Helms, H. C. C., Nielsen, C. U., Waagepetersen, Helle S. & Larsen, Birger Brodin, 2017, Glial Amino Acid Transporters. Vol. 16. p. 297-314 18 p. (Advances in Neurobiology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  38. 2016
  39. Published

    Initial Attempts of Development and Characterization of an In Vitro Blood Brain Barrier Model Derived from Human Pluripotent Stem Cells

    Goldeman, C., Saaby, L., Hall, Vanessa Jane, Hyttel, P. & Larsen, Birger Brodin, 8 Dec 2016. 1 p.

    Research output: Contribution to conferencePosterResearchpeer-review

  40. Published

    Down-regulation of selected Blood-brain Barrier Specific Genes from Capillaries to Bovine In Vitro Models

    Goldeman, C., Saaby, L. & Larsen, Birger Brodin, 14 Sep 2016. 1 p.

    Research output: Contribution to conferencePosterResearchpeer-review

  41. Published

    The insulin receptor is expressed and functional in blood-brain barrier endothelial cells, but does not mediate insulin entry from blood-to-brain

    Hersom, M. N. S., Helms, H. C. C., Pedersen, T., Buckley, S. & Larsen, Birger Brodin, 14 Sep 2016.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  42. Published

    Transferrin receptor expression and role in transendothelial transport of transferrin in cultured brain endothelial monolayers

    Hersom, M., Helms, H. C., Pretzer, N., Andersen, C. G., Jensen, A. I., Severin, G., Nielsen, M. S., Holm, R. & Larsen, Birger Brodin, 24 Aug 2016, In: Molecular and Cellular Neuroscience. 76, p. 59-67 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Modeling the ischemic blood-brain barrier; the effects of oxygen-glucose deprivation (OGD) on endothelial cells in culture

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig, Waagepetersen, Helle S. & Larsen, Birger Brodin, 19 Jun 2016.

    Research output: Contribution to conferenceConference abstract for conferenceCommunication

  44. Published

    ATP induce intracellular calcium rises in cultures of primary brain pericytes

    Jensen, S. H., Helms, H. C. C., Jessen, S. B., Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, Jun 2016.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  45. Published

    In vitro blood-brain barrier permeability predictions for GABAA receptor modulating piperine analogs

    Eigenmann, D. E., Dürig, C., Jähne, E. A., Smieško, M., Culot, M., Gosselet, F., Cecchelli, R., Helms, H. C. C., Larsen, Birger Brodin, Wimmer, L., Mihovilovic, M. D., Hamburger, M. & Oufir, M., Jun 2016, In: European Journal of Pharmaceutics and Biopharmaceutics. 103, p. 118-26 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

    Helms, H. C. C., Abbott, N. J., Burek, M., Cecchelli, R., Couraud, P., Deli, M. A., Förster, C., Galla, H. J., Romero, I. A., Shusta, E. V., Stebbins, M. J., Vandenhaute, E., Weksler, B. & Larsen, Birger Brodin, May 2016, In: Journal of Cerebral Blood Flow and Metabolism. 36, 5, p. 862-90 29 p.

    Research output: Contribution to journalReviewResearchpeer-review

  47. Published

    Functional Insulin Receptor expression does not facilitate transendothelial passage of insulin in a bovine in vitro blood-brain barrier model

    Hersom, M. N. S., Helms, H. C. C., Pedersen, T., Buckley, S. & Larsen, Birger Brodin, 3 Mar 2016.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  48. Published

    IPEC-J2 MDR1, a Novel High-Resistance Cell Line with Functional Expression of Human P-glycoprotein (ABCB1) for Drug Screening Studies

    Saaby, L., Helms, H. C. C. & Larsen, Birger Brodin, 1 Feb 2016, In: Molecular Pharmaceutics. 13, 2, p. 640-52 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Stroke and Drug Delivery--In Vitro Models of the Ischemic Blood-Brain Barrier

    Tornabene, E. & Larsen, Birger Brodin, Feb 2016, In: Journal of Pharmaceutical Sciences. 105, 2, p. 398-405 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    A bovine in vitro blood-brain barrier model under oxygenglucose deprivation (OGD) condition

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig, Waagepetersen, Helle S. & Larsen, Birger Brodin, 2016.

    Research output: Contribution to conferencePosterResearch

  51. Published

    Application of Cell Culture and Tissue Models for Assessing Drug Transport

    Nielsen, C. U. & Larsen, Birger Brodin, 2016, Analytical Techniques in the Pharmaceutical Sciences. Müllertz, A., Perrie, Y. & Rades, T. (eds.). Springer, p. 791-821 30 p. (Advances in Delivery Science and Technology; No. 1).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  52. Published

    Rises in intracellular calcium in primary brain pericytes are caused by ATP

    Jensen, S. H., Helms, H. C. C., Cai, Changsi, Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, 2016. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  53. 2015
  54. Published

    ATP induce an increase in intracellular Ca2+ in pericytes of the blood-brain barrier

    Jensen, S. H., Helms, H. C. C., Jessen, S. B., Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, 2 Nov 2015.

    Research output: Contribution to conferencePosterResearchpeer-review

  55. Published

    The in vitro blood-brain barrier model under OGD condition

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 2 Nov 2015.

    Research output: Contribution to conferenceConference abstract for conferenceCommunication

  56. Published

    Changes in barrier properties and protein expression levels of bovine brain endothelial cells during oxygen-glucose deprivation (OGD)

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 27 Aug 2015.

    Research output: Contribution to conferenceConference abstract for conferenceCommunication

  57. Published

    Changes in protein expression levels, Claudin-5 localization and barrier function in bovine brain endothelial cells during oxygen-glucose deprivation (OGD)

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 4 Jul 2015.

    Research output: Contribution to conferenceConference abstract for conferenceCommunication

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