Birger Brodin Larsen

Birger Brodin Larsen

Professor


  1. Published

    5-Hydroxy-L-tryptohan alters gaboxadol pharmacokinetics in rats: involvement of PAT1 and rOat1 in gaboxadol absorption and elimination

    Broberg, M. L., Holm, R., Jensen, K. G., Sveigaard, C., Larsen, Birger Brodin & Nielsen, C. U., 2010, In: European Journal of Pharmaceutical Sciences. 39, 1-3, p. 68-75

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    In Vitro cutaneous application of ISCOMs on human skin enhances delivery of hydrophobic model compounds through the stratum corneum

    Madsen, H. B., Ifversen, P., Madsen, F., Larsen, Birger Brodin, Hausser, I. & Nielsen, Hanne Mørck, 2009, In: The AAPS Journal. 11, 4, p. 728-739

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A Critical View on In Vitro Analysis of P-glycoprotein (P-gp) Transport Kinetics

    Saaby, Lasse & Larsen, Birger Brodin, Sep 2017, In: Journal of Pharmaceutical Sciences. 106, 9, p. 2257-2264 8 p.

    Research output: Contribution to journalReviewResearchpeer-review

  4. Published

    A Tight Blood-Brain Barrier Model Displays Brain-to-Blood Efflux of Substrates for the ABC-Transporters, P-gp, BCRP and MRP-1

    Helms, H. C. C., Hersom, M. N. S., Kuhlmann, L. B., Badolo, L., Nielsen, C. U. & Larsen, Birger Brodin, 11 Sep 2014. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  5. Published

    A bovine in vitro blood-brain barrier model under oxygenglucose deprivation (OGD) condition

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig, Waagepetersen, Helle S. & Larsen, Birger Brodin, 2016.

    Research output: Contribution to conferencePosterResearch

  6. Published

    A quantitative structure-activity relationship for translocation of tripeptides via the human proton-coupled peptide transporter, hPEPT1 (SLC15A1)

    Omkvist, D. H., Larsen, S. B., Nielsen, C. U., Steffansen, B., Olsen, L., Jørgensen, Flemming Steen & Larsen, Birger Brodin, 2010, In: The AAPS Journal. 12, 3, p. 385-396

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    ATP induce an increase in intracellular Ca2+ in pericytes of the blood-brain barrier

    Jensen, S. H., Helms, H. C. C., Jessen, S. B., Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, 2 Nov 2015.

    Research output: Contribution to conferencePosterResearchpeer-review

  8. Published

    ATP induce intracellular calcium rises in cultures of primary brain pericytes

    Jensen, S. H., Helms, H. C. C., Jessen, S. B., Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, Jun 2016.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  9. Published

    ATP induces contraction of cultured brain capillary pericytes, via activation of P2Y type purinergic receptors

    Hørlyck, S., Cai, Changsi, Helms, H. C., Lauritzen, Martin & Larsen, Birger Brodin, 2021, In: American Journal of Physiology: Heart and Circulatory Physiology. 320, p. H699–H712 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Absorptive transporters

    Nielsen, C. U., Steffansen, B. & Larsen, Birger Brodin, 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage from evaluation. Steffansen, B., Brodin, B. & Uhd Nielsen, C. (eds.). London: Pharmaceutical Press, p. 193-211 (ULLA Pharmacy Series).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  11. Published

    Acid/base properties, solubility and distribution of drug candidates

    Steffansen, B., Nielsen, C. U. & Larsen, Birger Brodin, 2010, Molecular Biopharmaceutics: Aspects of drug characterization drug delivery and dosage form evaluation. Pharmaceutical Press, p. 5-31

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  12. Published

    Affinity and translocation relationships via hPEPT1 of H-Xaa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs

    Omkvist, D. H., Trangbæk, D. J., Mildon, J., Paine, J. S., Larsen, Birger Brodin, Begtrup, M. & Nielsen, C. U., 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 77, 2, p. 327-331

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    An Electrically Tight In Vitro Blood-Brain Barrier Model Displays Net Brain-to-Blood Efflux of Substrates for the ABC Transporters, P-gp, Bcrp and Mrp-1

    Helms, H. C., Hersom, M., Kuhlmann, L. B., Badolo, L., Nielsen, C. U. & Larsen, Birger Brodin, 17 Jun 2014, In: A A P S Journal. 16, 5, p. 1046-1055 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    An increase in [Ca2+]i activates basolateral chloride channels and inhibits apical sodium channels in frog skin epithelium

    Larsen, Birger Brodin, Rytved, K. A. & Nielsen, Rasmus, 1996, In: Pflügers Archiv - European Journal of Physiology. 433, 1-2, p. 16-25 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Application of Cell Culture and Tissue Models for Assessing Drug Transport

    Nielsen, C. U. & Larsen, Birger Brodin, 2016, Analytical Techniques in the Pharmaceutical Sciences. Müllertz, A., Perrie, Y. & Rades, T. (eds.). Springer, p. 791-821 30 p. (Advances in Delivery Science and Technology; No. 1).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  16. Published

    Basolateral glycylsarcosine (Gly-Sar) transport in Caco-2 cell monolayers is pH dependent

    Berthelsen, Ragna, Nielsen, C. U. & Larsen, Birger Brodin, Jul 2013, In: Journal of Pharmacy and Pharmacology. 65, 7, p. 970-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Basolateral peptid etransport in the human intestinal cell line Caco-2 is proton-coupled

    Nielsen, M. J., Nielsen, C. U. & Larsen, Birger Brodin, 2008. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  18. Published

    Basolateral peptide transport in intestinal cells is pH dependent

    Juul Nielsen, M., Nielsen, C. U. & Larsen, Birger Brodin, 2007. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  19. Published

    Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells

    Siupka, P., Hersom, M. N., Lykke-Hartmann, K., Johnsen, K. B., Thomsen, L. B., Andresen, T. L., Moos, T., Abbott, N. J. & Larsen, Birger Brodin, 1 Jan 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 7, p. 2598-2613

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Bovine endothelial/rat astrocyte co-cultures cultured in highly buffered media functionally express MDR1 and BCRP

    Helms, H. C. C., Badolo, L., Kuhlmann, L. B. & Larsen, Birger Brodin, 21 Jun 2011.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  21. Published

    Brain endothelial cells metabolize glutamate via glutamate dehydrogenase to replenish TCA-intermediates and produce ATP under hypoglycemic conditions

    Hinca, S. B., Salcedo, C., Wagner, A., Goldeman, C., Sadat, E., Aibar, M. M. D., Maechler, P., Larsen, Birger Brodin, Aldana, Blanca & Helms, H. C. C., 2021, In: Journal of Neurochemistry. 157, 6, p. 1861-1875

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Calu-3 cells grown under AIC and LCC conditions: implications for dipeptide uptake and transepithelial transport of substances

    Stentebjerg-Andersen, A., Notlevesen, I. V., Larsen, Birger Brodin & Nielsen, C. U., 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 78, 1, p. 19-26

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Carbonic anhydrase imhibitors. Transepithelial transport of novel anticancer sulfonamide inhibitors of the cancer-associated isozyme CA IX is dependent on the p.gp efflux transporter

    Vullo, D., Steffansen, B., Larsen, Birger Brodin, Supuran, C. T., Scozzafava, A. & Nielsen, C. U., 2006, In: Bioorganic & Medicinal Chemistry Letters. 14, 7, p. 2418-2427

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Carrier-mediated dipeptide transport in a human lung epithelial cell line, Calu-3

    Nielsen, C. U., Søndergaard, H. B. & Larsen, Birger Brodin, 2006. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  25. Published

    Carrier-mediated transport kinetics

    Nielsen, C. U., Steffansen, B. & Larsen, Birger Brodin, 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage form evaluation. Pharmaceutical Press, p. 153-173

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  26. Published

    Carrier-mediated ¿-aminobutyric acid transport across the basolateral membrane of human intestinal Caco-2 cell monolayers

    Nielsen, C. U., Carstensen, M. & Larsen, Birger Brodin, 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 81, 2, p. 458-462

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Cellemodel af blodhjernebarrieren kan mindske brugen af forsøgsdyr

    Larsen, Birger Brodin, Helms, H. C. C., Hersom, M. N. S., Nielsen, C. U. & Waagepetersen, Helle S., 2013, In: Lægemiddelforskning. 2013, p. 47-49 3 p.

    Research output: Contribution to journalJournal articleCommunication

  28. Published

    Changes in barrier properties and protein expression levels of bovine brain endothelial cells during oxygen-glucose deprivation (OGD)

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 27 Aug 2015.

    Research output: Contribution to conferenceConference abstract for conferenceCommunication

  29. Published

    Changes in protein expression levels, Claudin-5 localization and barrier function in bovine brain endothelial cells during oxygen-glucose deprivation (OGD)

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 4 Jul 2015.

    Research output: Contribution to conferenceConference abstract for conferenceCommunication

  30. Published

    Characterisation of in-vitro blood-brain barrier models

    Helms, H. C., Eriksson, A. H., Waagepetersen, Helle S. & Larsen, Birger Brodin, 2009.

    Research output: Contribution to conferencePosterResearch

  31. Published

    Characterization of in vitro blood-brain barrier models

    Helms, H. C. C., Eriksson, A. H., Nielsen, C. U., Waagepetersen, Helle S., Walls, Anne Byriel & Larsen, Birger Brodin, 9 Aug 2009. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  32. Published

    Characterization of in-vitro blood-brain barrier models

    Helms, H. C. C., Eriksson, A. H., Nielsen, C. U., Waagepetersen, Helle S. & Larsen, Birger Brodin, Aug 2009.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  33. Published

    Characterization of rPEPT2-mediated Gly-Sar transport parameters in the rat kidney proximal tubule cell line SKPT-0193 cl.2 cultured in basic growth media

    Bravo, S. A., Nielsen, C. U., Frøkjær, Sven & Larsen, Birger Brodin, 2005, In: Molecular Pharmaceutics. 2, 2, p. 98-108 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates

    Ozgür, Burak, Saaby, Lasse, Langthaler, K. & Larsen, Birger Brodin, 2018, In: European Journal of Pharmaceutical Sciences. 112, p. 112-121 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model

    Helms, H. C., Aldana, Blanca, Groth, S., Jensen, M. M., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 12, p. 3744–3758

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Claudin-5 mRNA expression and transendothelial electrical resistance (TEER) correlate in the BCEC/astrocyte blood-brain barrier model

    Helms, H. C. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2010. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  37. Published

    Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D

    Bräuner-Osborne, Hans, Jensen, Anders A., Sheppard, P. O., Larsen, Birger Brodin, Krogsgaard-Larsen, Povl & O'Hara, P., 2001, In: BBA General Subjects. 1518, 3, p. 237-48 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Cloning of the pig PEPT2 (pPEPT2) and characterization of the effects of epidermal growth factor (EGF) on pPEPT2-mediated peptide uptake in the renal porcine cell line LLC-PK1

    Søndergaard, H. B., Bravo, S. A., Nielsen, C. U., Frøkjær, Sven & Larsen, Birger Brodin, 2008, In: European Journal of Pharmaceutical Sciences. 33, 4-5, p. 332-342

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

    Hayeshi, R., Hilgendorf, C., Arthursson, P., Augustijns, P., Larsen, Birger Brodin, Dehertogh, P., Fisher, K., Fossati, L., Hovenkamp, E., Korjamo, T., Masungi, C., Maubon, N., Mols, R., Mullertz, Anette , Mönkkönen, J., O´Driscoll, C., Oppers-Tiemissen, H. M., Ragnarsson, E. G. E., Rooseboom, M. & Ungell, A., 2008, In: European Journal of Pharmaceutical Sciences. 35, 5, p. 383-396

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation

    Kristensen, Mie, Kucharz, Krzysztof, Alves Fernandes, Eduardo Felipe, Strømgaard, Kristian, Schallburg Nielsen, M., Cederberg Helms, H. C., Bach, Anders, Ulrikkaholm Tofte-Hansen, M., Aldana, Blanca, Lauritzen, Martin & Larsen, Birger Brodin, 2020, In: Pharmaceutics. 12, 7, 24 p., 661.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Culture of brain capillary pericytes for cytosolic calcium measurements and calcium imaging studies

    Hørlyck, S., Helms, H. C. C. & Larsen, Birger Brodin, May 2020, In: Journal of Visualized Experiments. 159, p. 1-9 9 p., e61253.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Culture-induced changes in mRNA expression levels of efflux and SLC-transporters in brain endothelial cells

    Goldeman, C., Ozgür, Burak & Larsen, Birger Brodin, 22 Apr 2020, In: Fluids and Barriers of the CNS. 17, 32, 12 p., 32.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017

    Greenwood, J., Hammarlund-Udenaes, M., Jones, H. C., Stitt, A. W., Vandenbrouke, R. E., Romero, I. A., Campbell, M., Fricker, G., Larsen, Birger Brodin, Manninga, H., Gaillard, P. J., Schwaninger, M., Webster, C., Wicher, K. B. & Khrestchatisky, M., 7 Nov 2017, In: Fluids and Barriers of the CNS. 14, 11 p., 31.

    Research output: Contribution to journalReviewResearchpeer-review

  44. Published

    Current status of rational design of prodrugs targeting the intestinal di/tri-peptide transporter hPEPT1 (SLC15A1)

    Saaby, Lasse, Nielsen, C. U., Steffansen, B., Larsen, Birger Brodin & Larsen, S. B. L., 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 307–314

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Cypris ultrastructure, metamorphosis and sex in seven families of parasitic barnacles (Crustacea: Cirripedia: Rhizocephala)

    Larsen, Birger Brodin, 1989, In: Acta Zoologica (Stockholm). 70, p. 229-242 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Data demonstrating the challenges of determining the kinetic parameters of P-gp mediated transport of low-water soluble substrates

    Ozgür, Burak, Saaby, Lasse, Langthaler, K. & Larsen, Birger Brodin, 2018, In: Data in Brief. 16, p. 655-659 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Design of prodrugs targeting the intestinal di/tri‐peptide transporter hPEPT1 (SLC15A1

    Omkvist, D. H., Nielsen, C. U., Steffansen, B., Larsen, S. B., Olsen, L., Jørgensen, Flemming Steen & Larsen, Birger Brodin, 4 Apr 2014. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  48. Published

    Development and Characterization of a Brain Endothelial Cell Phenotype using Human Induced Pluripotent Stem Cells

    Goldeman, C., Saaby, L., Holst, B., Hall, Vanessa Jane, Hyttel, P. & Larsen, Birger Brodin, 2 Nov 2017.

    Research output: Contribution to conferencePosterResearchpeer-review

  49. Published

    Di/tri-peptide transporters as drug delivery targets: regulation of transport under physiological and patho-physiological conditions

    Nielsen, C. U. & Larsen, Birger Brodin, 2003, In: Current Drug Targets. 4, 5, p. 373-88 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line

    Nielsen, C. U., Andersen, R., Larsen, Birger Brodin, Frøkjær, Sven, Taub, M. E. & Steffansen, B., 2001, In: Journal of Controlled Release. 76, 1-2, p. 129-38 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Discovery of ligands for the human intestinal di-/tripeptide transporter (hPEPT1) using af QSAR-assisted virtual screening strategy

    Larsen, S. B., Omkvist, D. H., Larsen, Birger Brodin, Nielsen, C. U., Steffansen, B., Olsen, L. & Jørgensen, Flemming Steen, 2009, In: ChemMedChem. 4, 9, p. 1439-1445

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Down-regulation of selected Blood-brain Barrier Specific Genes from Capillaries to Bovine In Vitro Models

    Goldeman, C., Saaby, L. & Larsen, Birger Brodin, 14 Sep 2016. 1 p.

    Research output: Contribution to conferencePosterResearchpeer-review

  53. Published

    Drug Delivery Strategies to Overcome the Blood-Brain Barrier (BBB)

    Helms, H. C. C., Kristensen, Mie, Saaby, L., Fricker, G. & Larsen, Birger Brodin, 2020, Handbook of Experimental Pharmacology. Springer, p. 1-33

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  54. Published

    Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures

    Tornabene, E., Helms, H. C. C., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 2019, In: PLoS ONE. 14, 8, 20 p., e0221103.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Efflux transporter expression in a tight in vitro model of the blood brain barrier

    Helms, H. C. C., Hersom, M. N. S., Kuhlmann, L. B., Badolo, L., Nielsen, C. U. & Larsen, Birger Brodin, 10 Dec 2014. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  56. Published

    Efflux transporters

    Nielsen, C. U., Larsen, Birger Brodin & Steffansen, B., 2010, Molecular biopharmaceutics: Aspects of drug characterisation, drug delivery and dosage form evaluation. Steffansen, B., Brodin, B. & Uhd Nielsen, C. (eds.). Pharmaceutical Press, p. 213-22

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  57. Published

    Electrophysiological evidence for an ATP-gated ion channel in the principal cells of the frog skin epithelium

    Larsen, Birger Brodin & Nielsen, R., 2000, In: Pflügers Archiv: European Journal of Physiology. 439, p. 227-233

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Endothelial cell phenotype differs strongly between in viro BCEC monocultures and BCEC/rat astrocyte co-cultures, a phenomenon which may contribute to the differences in barrier tightness

    Helms, H. C. C. & Larsen, Birger Brodin, 2013. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  59. Published

    Epidermal growth factor and insulin short-term increase hPEPT1-mediated glycylsarcosine uptake in Caco-2 cells

    Larsen, Birger Brodin, Amstrup, J., Nielsen, C. U., Steffansen, B. & Frøkjær, S., 2003, In: Acta Physiol. Scandinavia. 178, p. 139-148

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Epidermal growth factor decreases PEPT2 transport capacity and expression in the rat kidney proximal tubule cell line SKPT0193 cl.2

    Bravo, S. A., Nielsen, C. U., Amstrup, J., Frøkjær, Sven & Larsen, Birger Brodin, 2004, In: American Journal of Physiology - Renal Physiology. 286, 2, p. 385-393

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line

    Nielsen, C. U., Amstrup, J., Steffansen, B., Frøkjær, Sven & Larsen, Birger Brodin, 2001, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 281, 1, p. G191-9

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Erratum: Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: Affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism (Journal of Controlled Release (2003) 86 (279-292) PII: S0168365902004133)

    Thomsen, A. E., Friedrichsen, G. M., Sørensen, A. H., Andersen, R., Nielsen, C. U., Larsen, Birger Brodin, Begtrup, M., Frøkjær, Sven & Steffansen, B., 7 Mar 2003, In: Journal of Controlled Release. 88, 2

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    Evaluating the involvement of cerebral microvascular endothelial Na+/K+-ATPase and Na+-K+-2Cl- co-transporter in electrolyte fluxes in an in vitro blood-brain barrier model of dehydration

    Lykke, K., Assentoft, M., Hørlyck, S., Helms, H. C. C., Stoica, A., Toft, Trine Lisberg, Tritsaris, Katerina, Vilhardt, Frederik, Larsen, Birger Brodin & MacAulay, Nanna, 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 3, p. 497-512

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    Evidence for P2Y-type ATP receptors on the serosal membrane of frog skin eipthelium

    Larsen, Birger Brodin & Nielsen, R., 2000, In: Pflügers Arch. (Eur. J. Physiol.). 439, p. 234-239

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Evidence for P2Y-type ATP receptors on the serosal membrane of frog skin epithelium

    Larsen, Birger Brodin & Nielsen, R., 1 Jan 2000, In: Pflugers Archiv European Journal of Physiology. 439, 3, p. 234-239 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published

    Evidence for a Na+/Ca2+ exchange mechanism in frog skin epithelium

    Madsen, K. H., Larsen, Birger Brodin & Nielsen, Rasmus, 1999, In: Pflügers Archiv - European Journal of Physiology. 437, 2, p. 175-81 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    Excitatory amino acid transporter-1 (EAAT1) is the main transporter responsible for abluminal uptake of L-glutamate in bovine brain endothelial cells

    Helms, H. C. C., Groth, S., Mikél, M., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 27 May 2013.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  68. Published

    Expression and functional activity of the efflux transporters BCRP and P-gp in bovine endothelial cells, co-cultured with rat astrocytes

    Hersom, M. N. S., Helms, H. C. C., Kuhlmann, L. B., Badolo, L. & Larsen, Birger Brodin, 2013. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  69. Published

    Expression profiles of selected receptor systems in a bovine in vitro blood-brain barrier model

    Hersom, M. N. S., Helms, H. C. C., Nielsen, M. S., Holm, R. & Larsen, Birger Brodin, 10 Dec 2014. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  70. Published

    Function and expression of the proton-coupled amino acid transporter Slc36a1 along the rat gastrointestinal tract: Implications for intestinal absorption of gaboxadol

    Broberg, M. L., Holm, R. K., Tønsberg, H., Frølund, S. B., Ewon, K. B., Nielsen, A. L., Larsen, Birger Brodin, Jensen, A., Kall, M. A., Nielsen, C. U. & Christensen, K. V., 2012, In: British Journal of Pharmacology. 167, 3, p. 654-665

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. Published

    Functional Insulin Receptor expression does not facilitate transendothelial passage of insulin in a bovine in vitro blood-brain barrier model

    Hersom, M. N. S., Helms, H. C. C., Pedersen, T., Buckley, S. & Larsen, Birger Brodin, 3 Mar 2016.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  72. Published

    GABA transport across the basolateral membrane of intestinal cells

    Nielsen, C. U., Carstensen, M. & Larsen, Birger Brodin, 2010. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  73. Published

    Gaboxadol bliver absorberet via en aminosyretransportør

    Broberg, M. L., Holm, R., Jensen, K. G., Larsen, Birger Brodin & Nielsen, C. U., 2009, In: Lægemiddelforskning. p. 22-24

    Research output: Contribution to journalJournal articleCommunication

  74. Published

    Generation of a rat in-vitro blood-brain barrier model and initial insights on excitatory amino acid transporter expression

    Groth, S., Moos, T., Helms, H. C. C. & Larsen, Birger Brodin, 2012. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  75. Published

    Generation of primary cultures of bovine brain endothelial cells and setup of cocultures with rat astrocytes

    Helms, H. C. & Larsen, Birger Brodin, 2014, In: Methods in molecular biology (Clifton, N.J.). 1135, p. 365-82 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    Genetic variants of the human dipeptide transporter PEPT1

    Anderle, P., Nielsen, C. U., Pinsonneault, J., Krog, P. L., Larsen, Birger Brodin & Sadée, W., 1 Feb 2006, In: Journal of Pharmacology and Experimental Therapeutics. 316, 2, p. 636-646 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    Glutamate Efflux at the Blood-Brain Barrier: Cellular Mechanisms and Potential Clinical Relevance

    Cederberg-Helms, H. C., Uhd-Nielsen, C. & Larsen, Birger Brodin, 15 Nov 2014, In: Archives of Medical Research. 45, 8, p. 639-645 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    Glutamate Transporters in the Blood-Brain Barrier

    Helms, H. C. C., Nielsen, C. U., Waagepetersen, Helle S. & Larsen, Birger Brodin, 2017, Glial Amino Acid Transporters. Vol. 16. p. 297-314 18 p. (Advances in Neurobiology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  79. Published

    Glutamate efflux from brain to blood - Studies in an in vitro blood-brain barrier model

    Helms, H. C. C., Madelung, R., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2012.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  80. Published

    Gly-Sar is a substrate for the human proton-coupled amino acid transporter, hPAT1 (SLC36A1)

    Frølund, S. B., Holm, R., Larsen, Birger Brodin & Nielsen, C. U., Mar 2010.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  81. Published

    Gly-sar is a substrate for the human proton coupled amino acid trasporter 1, hPAT1 (SLC36A1)

    Frølund, S. B., Holm, R., Larsen, Birger Brodin & Nielsen, C. U., 2010.

    Research output: Contribution to conferencePosterResearch

  82. Published

    Highly cationic cell-penetrating peptides affect the barrier integrity and facilitates mannitol permeation in a human stem cell-based blood-brain barrier model

    Frøslev, Patrick, Franzyk, Henrik, Ozgür, Burak, Larsen, Birger Brodin & Kristensen, Mie, 2022, In: European Journal of Pharmaceutical Sciences. 168, 10 p., 106054.

    Research output: Contribution to journalJournal articleResearchpeer-review

  83. Published

    Hjernens forsvarsmur kortlagt og kopieret

    Helms, H. C., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2010, In: Lægemiddelforskning. 2010, p. 22-24

    Research output: Contribution to journalJournal articleCommunication

  84. Published

    Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5)

    Goldeman, C., Andersen, M., Al-Robai, A., Buchholtz, T., Svane, N., Ozgür, Burak, Holst, B., Shusta, E., Hall, Vanessa Jane, Saaby, Lasse, Hyttel, P. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutical Sciences. 156, 14 p., 105577.

    Research output: Contribution to journalJournal articleResearchpeer-review

  85. Published

    Human peptide transporters: Therapeutic applications

    Nielsen, C. U., Larsen, Birger Brodin, Jørgensen, Flemming Steen, Frøkjær, Sven & Steffansen, B., 1 Sep 2002, In: Expert Opinion on Therapeutic Patents. 12, 9, p. 1329-1350 22 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. Published

    Hypoxia increases expression of selected blood–brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers

    Ozgür, Burak, Helms, H. C. C., Tornabene, E. & Larsen, Birger Brodin, 2022, In: Fluids and Barriers of the CNS. 19, 1, 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    IN VITRO MEMBRANE PERMEATION STUDIES AND IN VIVO ANTINOCICEPTION OF GLYCOSYLATED Dmt1-DALDA ANALOGUES

    Betti, C., Novoa, A., Tömböly, C., Nielsen, C. U., Helms, H. C. C., Lesniak, A., Klecskowska, P., Chung, N. N., Chung, N. N., Lipkowski, A. W., Larsen, Birger Brodin, Tourwé, D., Schiller, P. W. & Ballet, S., 31 Aug 2014. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  88. Published

    IPEC-J2 MDR1, a Novel High-Resistance Cell Line with Functional Expression of Human P-glycoprotein (ABCB1) for Drug Screening Studies

    Saaby, Lasse, Helms, H. C. C. & Larsen, Birger Brodin, 1 Feb 2016, In: Molecular Pharmaceutics. 13, 2, p. 640-52 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    IPEC-J2 rMdr1a, a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes

    Saaby, L., Trasborg, J., Rasmussen, M. A., Holst, B. & Larsen, Birger Brodin, 17 Jul 2020, In: Pharmaceutics. 12, 7, 17 p., 673.

    Research output: Contribution to journalJournal articleResearchpeer-review

  90. Published

    Ibuprofen is a non-competitive inhibitor of the peptide transporter hPEPT1 (SLC15A1): possible interactions between hPEPT1 substrates and ibuprofen

    Omkvist, D. H., Larsen, Birger Brodin & Nielsen, C. U., 2010, In: British Journal of Pharmacology. 161, 8, p. 1793-1805

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    Ibuprofen is an inhibitor of hPEPT1: Implications for drug-drug interactions at the level of drug absorption

    Omkvist, D. H., Larsen, Birger Brodin & Nielsen, C. U., Mar 2010. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  92. Published

    Ibuprofen is an inhibitor of hPEPT1: Implications for drug-drug interactions at the level of drug absorption

    Omkvist, D. H., Larsen, Birger Brodin & Nielsen, C. U., 2010.

    Research output: Contribution to conferencePosterResearch

  93. Published

    Identification and Characterization of a Novel Nontranslated Sequence Variant of the Human Intestinal Di-/Tripeptide Transporter, hPEPT1

    Søndergaard, H. B., Nielsen, C. U. & Larsen, Birger Brodin, 31 Dec 2012, In: International Journal of Peptides. 2012, 2012, 7 p., 743472.

    Research output: Contribution to journalJournal articleResearchpeer-review

  94. Published

    In Vitro Blood-Brain Barrier Models-An Overview of Established Models and New Microfluidic Approaches

    Wolff, A., Antfolk, M., Larsen, Birger Brodin & Tenje, M., 28 Jan 2015, In: Journal of Pharmaceutical Sciences. 104, 9, p. 2727-2746 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. Published

    In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt(1)-DALDA Analogues

    Ballet, S., Betti, C., Novoa, A., Tömböly, C., Nielsen, C. U., Helms, H. C., Lesniak, A., Kleczkowska, P., Chung, N. N., Lipkowski, A. W., Larsen, Birger Brodin, Tourwé, D. & Schiller, P. W., 10 Apr 2014, In: ACS Medicinal Chemistry Letters. 5, 4, p. 352-357 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  96. Published

    In vitro blood-brain barrier models

    Helms, H. C. C., Eriksson, A. H., Nielsen, C. U., Waagepetersen, Helle S. & Larsen, Birger Brodin, 18 Jul 2009.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  97. Published

    In vitro blood-brain barrier permeability predictions for GABAA receptor modulating piperine analogs

    Eigenmann, D. E., Dürig, C., Jähne, E. A., Smieško, M., Culot, M., Gosselet, F., Cecchelli, R., Helms, H. C. C., Larsen, Birger Brodin, Wimmer, L., Mihovilovic, M. D., Hamburger, M. & Oufir, M., Jun 2016, In: European Journal of Pharmaceutics and Biopharmaceutics. 103, p. 118-26 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    In vitro evaluation of N-methyl amide tripeptidomimetics as substrates for the human intestinal di-/tri-peptide transporter hPEPT1

    Andersen, R., Nielsen, C. U., Begtrup, M., Jørgensen, Flemming Steen, Larsen, Birger Brodin, Frøkjær, Sven & Steffansen, B., 2006, In: European Journal of Pharmaceutical Sciences. 28, 4, p. 325-35 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate

    Helms, H. C., Madelung, R., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2012, In: Glia. 60, 6, p. 882-893

    Research output: Contribution to journalJournal articleResearchpeer-review

  100. Published

    In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells co-cultured with astrocytes display a polarized brain-to-blood transport of glutamate

    Helms, H. C. C., Madelung, R., Groth, S., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 13 Sep 2012. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

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