Birger Brodin Larsen

Birger Brodin Larsen

Professor


  1. 2024
  2. Published

    Application of a new MDCKII-MDR1 cell model to measure the extent of drug distribution in vitro at equilibrium for prediction of in vivo unbound brain-to-plasma drug distribution

    Langthaler, Kristine, Jones, C. R., Saaby, Lasse, Bundgaard, C. & Larsen, Birger Brodin, 2024, In: Fluids and Barriers of the CNS. 21, 1, 15 p., 11.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Generation of an iPSC-line (BIONi010C-48) with restored P-glycoprotein functionality following transfection with the human MDR1 gene in the AAVS1 locus

    Nielsen, A. K. R., Lilieholm-Røngren, L., Schmid, B., Holst, B., Larsen, Birger Brodin & Saaby, Lasse, 2024, In: Stem Cell Research. 76, 5 p., 103348.

    Research output: Contribution to journalJournal articlepeer-review

  4. 2023
  5. Published

    Subcellular trafficking and transcytosis efficacy of different receptor types for therapeutic antibody delivery at the blood‒brain barrier

    Holst, M. R., de Wit, N. M., Ozgür, Burak, Brachner, A., Hyldig, K., Appelt-Menzel, A., Sleven, H., Cader, Z., de Vries, H. E., Neuhaus, W., Jensen, A., Larsen, Birger Brodin & Nielsen, M. S., 2023, In: Fluids and Barriers of the CNS. 20, 1, 17 p., 82.

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    Assessing extent of brain penetration in vivo (Kp,uu,brain) in Göttingen minipig using a diverse set of reference drugs

    Langthaler, Kristine, Jones, C. R., Larsen, Birger Brodin & Bundgaard, C., 2023, In: European Journal of Pharmaceutical Sciences. 190, 11 p., 106554.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells

    Nielsen, S. S. E., Holst, M. R., Langthaler, Kristine, Bruun, E. H., Larsen, Birger Brodin & Nielsen, M. S., 2023, In: Fluids and Barriers of the CNS. 20, 1, 15 p., 2.

    Research output: Contribution to journalJournal articlepeer-review

  8. Published

    Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line

    Ozgür, Burak, Puris, E., Brachner, A., Appelt-Menzel, A., Oerter, S., Balzer, V., Holst, M. R., Christiansen, R. F., Hyldig, K., Buckley, S. T., Kristensen, Mie, Auriola, S., Jensen, A., Fricker, G., Nielsen, M. S., Neuhaus, W. & Larsen, Birger Brodin, 2023, In: Fluids and Barriers of the CNS. 20, 1, 15 p., 96.

    Research output: Contribution to journalJournal articlepeer-review

  9. 2022
  10. Published

    Highly cationic cell-penetrating peptides affect the barrier integrity and facilitates mannitol permeation in a human stem cell-based blood-brain barrier model

    Frøslev, Patrick, Franzyk, Henrik, Ozgür, Burak, Larsen, Birger Brodin & Kristensen, Mie, 2022, In: European Journal of Pharmaceutical Sciences. 168, 10 p., 106054.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions

    Imbernon, M., Saponaro, C., Helms, H. C. C., Duquenne, M., Fernandois, D., Deligia, E., Denis, R. G. P., Chao, D. H. M., Rasika, S., Staels, B., Pattou, F., Pfrieger, F. W., Larsen, Birger Brodin, Luquet, S., Bonner, C. & Prevot, V., 2022, In: Cell Metabolism. 34, 7, p. 1054-1063.e7

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    Characterisation of intravenous pharmacokinetics in Göttingen minipig and clearance prediction using established in vitro to in vivo extrapolation methodologies

    Langthaler, Kristine, Jones, C. R., Christensen, R. B., Eneberg, E., Larsen, Birger Brodin & Bundgaard, C., 2022, In: Xenobiotica. 52, 6, p. 591-607

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    The Cell-Penetrating Peptide Tat Facilitates Effective Internalization of PSD-95 Inhibitors Into Blood–Brain Barrier Endothelial Cells but less Efficient Permeation Across the Blood–Brain Barrier In Vitro and In Vivo

    Lisa Al Humaidan, E., Lund Pedersen, S., Burkhart, A., Laurfelt Munch Rasmussen, C., Moos, T., Fuchs, P., Alves Fernandes, E. F., Ozgür, Burak, Strømgaard, K., Bach, Anders, Larsen, Birger Brodin & Kristensen, Mie, 2022, In: Frontiers in Drug Delivery - CNS Drug Delivery. 2, 17 p., 854703.

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    Hypoxia increases expression of selected blood–brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial monolayers

    Ozgür, Burak, Helms, H. C. C., Tornabene, E. & Larsen, Birger Brodin, 2022, In: Fluids and Barriers of the CNS. 19, 1, 17 p.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Sortilin regulates blood-brain barrier integrity

    Toth, A. E., Helms, H. C., Harazin, A., Johnsen, K. B., Goldeman, C., Burkhart, A., Thomsen, M. S., Kempen, P. J., Klepe, A., Lipka, D. V., Møller, P. L., Andresen, T. L., Nyegaard, M., Moos, T., Larsen, Birger Brodin & Nielsen, M. S., 2022, In: The FEBS Journal. 289, 4, p. 1062-1079

    Research output: Contribution to journalJournal articlepeer-review

  16. 2021
  17. Published

    Human induced pluripotent stem cells (BIONi010-C) generate tight cell monolayers with blood-brain barrier traits and functional expression of large neutral amino acid transporter 1 (SLC7A5)

    Goldeman, C., Andersen, M., Al-Robai, A., Buchholtz, T., Svane, Nana Isabella, Ozgür, Burak, Holst, B., Shusta, E., Hall, Vanessa Jane, Saaby, Lasse, Hyttel, P. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutical Sciences. 156, 14 p., 105577.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    Brain endothelial cells metabolize glutamate via glutamate dehydrogenase to replenish TCA-intermediates and produce ATP under hypoglycemic conditions

    Hinca, S. B., Salcedo, C., Wagner, A., Goldeman, C., Sadat, E., Aibar, M. M. D., Maechler, P., Larsen, Birger Brodin, Aldana, Blanca & Helms, H. C. C., 2021, In: Journal of Neurochemistry. 157, 6, p. 1861-1875

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    ATP induces contraction of cultured brain capillary pericytes, via activation of P2Y type purinergic receptors

    Hørlyck, S., Cai, Changsi, Helms, H. C., Lauritzen, Martin & Larsen, Birger Brodin, 2021, In: American Journal of Physiology: Heart and Circulatory Physiology. 320, p. H699–H712 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    Tanycytes Control the Hypothalamic Uptake and Metabolic Actions of Liraglutide

    Imbernon, M., Saponaro, C., Helms, H. C. C., Zubiaga, L., Bitsi, S., Duquenne, M., Tomas, A., Chen, S., Salem, V., Deligia, E., Gmyr, V., Denis, R., Kerr-Conte, J., Chao, D. H. M., Beiroa, D., Steals, B., Pattou, F., Pfrieger, F., Brodin, B., Jones, B. & 3 others, Luquet, S., Bonner, C. & Prevot, V., Jul 2021, In: Glia. 69, S1, p. E237-E237

    Research output: Contribution to journalConference abstract in journal

  21. Published

    Screening novel CNS drug candidates for P-glycoprotein interactions using the cell line iP-gp: In vitro efflux ratios from iP-gp and MDCK-MDR1 monolayers compared to brain distribution data from mice

    Ozgür, Burak, Saaby, Lasse, Janfelt, Christian, Langthaler, K., Eneberg, E., Jacobsen, A., Badolo, L., Montanari, D. & Larsen, Birger Brodin, 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 169, p. 211-219

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Transendothelial electrical resistance measurement across the blood–brain barrier: A critical review of methods

    Vigh, J. P., Kincses, A., Ozgür, Burak, Walter, F. R., Santa-Maria, A. R., Valkai, S., Vastag, M., Neuhaus, W., Larsen, Birger Brodin, Dér, A. & Deli, M. A., 2021, In: Micromachines. 12, 6, 18 p., 685.

    Research output: Contribution to journalReviewpeer-review

  23. Published

    Precapillary sphincters and pericytes at first-order capillaries as key regulators for brain capillary perfusion

    Zambach, S. A., Cai, Changsi, Helms, H. C. C., Hald, B. O., Dong, Y., Fordsmann, J. C., Nielsen, R. M., Hu, J., wbh615, wbh615, Larsen, Birger Brodin & Lauritzen, Martin, 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 26, e2023749118.

    Research output: Contribution to journalJournal articlepeer-review

  24. 2020
  25. Published

    The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP

    Ambjørner, S. E. B., Wiese, M., Köhler, S. C., Svindt, J., Lund, X. L., Gajhede, Michael, Saaby, Lasse, Larsen, Birger Brodin, Rump, S., Weigt, H., Brünner, N. & Stenvang, Jan, 4 Mar 2020, In: Cells. 9, 3, 22 p., 613.

    Research output: Contribution to journalJournal articlepeer-review

  26. Published

    Culture-induced changes in mRNA expression levels of efflux and SLC-transporters in brain endothelial cells

    Goldeman, C., Ozgür, Burak & Larsen, Birger Brodin, 22 Apr 2020, In: Fluids and Barriers of the CNS. 17, 32, 12 p., 32.

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Drug Delivery Strategies to Overcome the Blood-Brain Barrier (BBB)

    Helms, H. C. C., Kristensen, Mie, Saaby, Lasse, Fricker, G. & Larsen, Birger Brodin, 2020, Handbook of Experimental Pharmacology. Springer, Vol. 273. p. 151-183

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  28. Published

    Culture of brain capillary pericytes for cytosolic calcium measurements and calcium imaging studies

    Hørlyck, S., Helms, H. C. C. & Larsen, Birger Brodin, May 2020, In: Journal of Visualized Experiments. 159, p. 1-9 9 p., e61253.

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation

    Kristensen, Mie, Kucharz, Krzysztof, Alves Fernandes, Eduardo Felipe, Strømgaard, Kristian, Schallburg Nielsen, M., Cederberg Helms, H. C., Bach, Anders, Ulrikkaholm Tofte-Hansen, M., Aldana, Blanca, Lauritzen, Martin & Larsen, Birger Brodin, 2020, In: Pharmaceutics. 12, 7, 24 p., 661.

    Research output: Contribution to journalJournal articlepeer-review

  30. Published

    IPEC-J2 rMdr1a, a New Cell Line with Functional Expression of Rat P-glycoprotein Encoded by Rat Mdr1a for Drug Screening Purposes

    Saaby, Lasse, Trasborg, J., Rasmussen, M. A., Holst, B. & Larsen, Birger Brodin, 17 Jul 2020, In: Pharmaceutics. 12, 7, 17 p., 673.

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    Nitric oxide, KATP channels and endothelin-1 modulate brain pericyte function, vascular tone and neurovascular coupling

    Zambach, S. A., Cai, Changsi, Helms, H. C. C., Hald, B. O., Fordsmann, J. C., Nielsen, R. M., wbh615, wbh615, Larsen, Birger Brodin & Lauritzen, Martin, 8 Jun 2020, bioRxiv, 43 p.

    Research output: Working paperPreprintResearch

  32. 2019
  33. Published

    Two-photon fluorescence imaging: a platform to investigate cell-penetrating peptides and liposome-based nanocarriers for drug delivery across the heterogeneous BBB in vivo

    Kucharz, K., Kristensen, K., Kristensen, Mie, Lund, M., Andresen, T., Larsen, Birger Brodin & Lauritzen, M., 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, p. 60 1 p.

    Research output: Contribution to journalConference abstract in journalpeer-review

  34. Published

    Evaluating the involvement of cerebral microvascular endothelial Na+/K+-ATPase and Na+-K+-2Cl- co-transporter in electrolyte fluxes in an in vitro blood-brain barrier model of dehydration

    Lykke, K., Assentoft, M., Hørlyck, S., Helms, H. C. C., Stoica, A., Toft-Bertelsen, Trine Lisberg, Tritsaris, Katerina, Vilhardt, Frederik, Larsen, Birger Brodin & MacAulay, Nanna, 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 3, p. 497-512

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures

    Tornabene, E., Helms, H. C. C., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 2019, In: PLoS ONE. 14, 8, 20 p., e0221103.

    Research output: Contribution to journalJournal articlepeer-review

  36. Published

    miRNA-27a-3p and miRNA-222-3p as Novel Modulators of Phosphodiesterase 3a (PDE3A) in Cerebral Microvascular Endothelial Cells

    Yasmeen, S., Kaur, S., Mirza, A. H., Larsen, Birger Brodin, Pociot, Flemming & Kruuse, Christina Rostrup, Aug 2019, In: Molecular Neurobiology. 56, 8, p. 5304–5314

    Research output: Contribution to journalJournal articlepeer-review

  37. 2018
  38. Published

    Stimulation-induced increases in cerebral blood flow and local capillary vasoconstriction depend on conducted vascular responses

    Cai, Changsi, Fordsmann, J. C., Jensen, S. H., Gesslein, B., wbh615, wbh615, Hald, B. O., Zambach, S. A., Larsen, Birger Brodin & Lauritzen, Martin, 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 25, p. E5796-E5804 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  39. Published

    The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells, but does not mediate insulin entry from blood-to-brain

    Hersom, M., Helms, H. C., Schmalz, C., Pedersen, T. Å., Buckley, S. T. & Larsen, Birger Brodin, 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 315, 4, p. E531-E542

    Research output: Contribution to journalJournal articlepeer-review

  40. Published

    Validation of reference genes for normalization of real-time quantitative PCR studies of gene expression in brain capillary endothelial cells cultured in vitro

    Hersom, M., Goldeman, C., Pretzer, N. & Larsen, Birger Brodin, Dec 2018, In: Molecular and Cellular Neuroscience. 93, p. 27-35 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  41. Published

    Characterization of the IPEC-J2 MDR1 (iP-gp) cell line as a tool for identification of P-gp substrates

    Ozgür, Burak, Saaby, Lasse, Langthaler, K. & Larsen, Birger Brodin, 2018, In: European Journal of Pharmaceutical Sciences. 112, p. 112-121 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    Data demonstrating the challenges of determining the kinetic parameters of P-gp mediated transport of low-water soluble substrates

    Ozgür, Burak, Saaby, Lasse, Langthaler, K. & Larsen, Birger Brodin, 2018, In: Data in Brief. 16, p. 655-659 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published

    The iP-gp cell model is an improved tool for predicting the in vivo relevance of P-gp mediated efflux at the blood-brain barrier

    Ozgür, Burak, Saaby, Lasse, Eneberg, E., Langthaler, K., Jacobsen, A., Janfelt, Christian, Badolo, L., Montanari, D. & Larsen, Birger Brodin, 22 Jun 2018.

    Research output: Contribution to conferencePosterResearchpeer-review

  44. 2017
  45. Published

    iP-gp , a novel cell line with tight barrier function and expression of human P-glycoprotein (ABCB1) for drug screening

    Larsen, Birger Brodin, Ozgür, Burak & Saaby, Lasse, 23 May 2017.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  46. Published

    Development and Characterization of a Brain Endothelial Cell Phenotype using Human Induced Pluripotent Stem Cells

    Goldeman, C., Saaby, L., Holst, B., Hall, Vanessa Jane, Hyttel, P. & Larsen, Birger Brodin, 2 Nov 2017.

    Research output: Contribution to conferencePosterResearchpeer-review

  47. Published

    Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017

    Greenwood, J., Hammarlund-Udenaes, M., Jones, H. C., Stitt, A. W., Vandenbrouke, R. E., Romero, I. A., Campbell, M., Fricker, G., Larsen, Birger Brodin, Manninga, H., Gaillard, P. J., Schwaninger, M., Webster, C., Wicher, K. B. & Khrestchatisky, M., 7 Nov 2017, In: Fluids and Barriers of the CNS. 14, 11 p., 31.

    Research output: Contribution to journalReviewpeer-review

  48. Published

    Characterization of the L-glutamate clearance pathways across the blood-brain barrier and the effect of astrocytes in an in vitro blood-brain barrier model

    Helms, H. C., Aldana, Blanca, Groth, S., Jensen, M. M., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 12, p. 3744–3758

    Research output: Contribution to journalJournal articlepeer-review

  49. Published

    Glutamate Transporters in the Blood-Brain Barrier

    Helms, H. C. C., Nielsen, C. U., Waagepetersen, Helle S. & Larsen, Birger Brodin, 2017, Glial Amino Acid Transporters. Vol. 16. p. 297-314 18 p. (Advances in Neurobiology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  50. Published

    Routes for drug translocation across the blood-brain barrier: Exploiting peptides as delivery vectors

    Kristensen, Mie & Larsen, Birger Brodin, Sep 2017, In: Journal of Pharmaceutical Sciences. 106, 9, p. 2326-2334

    Research output: Contribution to journalReviewpeer-review

  51. Published

    A Critical View on In Vitro Analysis of P-glycoprotein (P-gp) Transport Kinetics

    Saaby, Lasse & Larsen, Birger Brodin, Sep 2017, In: Journal of Pharmaceutical Sciences. 106, 9, p. 2257-2264 8 p.

    Research output: Contribution to journalReviewpeer-review

  52. Published

    Substrate-Dependent Inhibition of P-glycoprotein Mediated Efflux Transport of Digoxin

    Saaby, L., Ozgür, Burak & Larsen, Birger Brodin, 14 Nov 2017, p. T7089.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  53. Published

    Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells

    Siupka, P., Hersom, M. N., Lykke-Hartmann, K., Johnsen, K. B., Thomsen, L. B., Andresen, T. L., Moos, T., Abbott, N. J. & Larsen, Birger Brodin, 1 Jan 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 7, p. 2598-2613

    Research output: Contribution to journalJournal articlepeer-review

  54. 2016
  55. Published

    In vitro blood-brain barrier permeability predictions for GABAA receptor modulating piperine analogs

    Eigenmann, D. E., Dürig, C., Jähne, E. A., Smieško, M., Culot, M., Gosselet, F., Cecchelli, R., Helms, H. C. C., Larsen, Birger Brodin, Wimmer, L., Mihovilovic, M. D., Hamburger, M. & Oufir, M., Jun 2016, In: European Journal of Pharmaceutics and Biopharmaceutics. 103, p. 118-26 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  56. Published

    Initial Attempts of Development and Characterization of an In Vitro Blood Brain Barrier Model Derived from Human Pluripotent Stem Cells

    Goldeman, C., Saaby, L., Hall, Vanessa Jane, Hyttel, P. & Larsen, Birger Brodin, 8 Dec 2016. 1 p.

    Research output: Contribution to conferencePosterResearchpeer-review

  57. Published

    Down-regulation of selected Blood-brain Barrier Specific Genes from Capillaries to Bovine In Vitro Models

    Goldeman, C., Saaby, L. & Larsen, Birger Brodin, 14 Sep 2016. 1 p.

    Research output: Contribution to conferencePosterResearchpeer-review

  58. Published

    In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

    Helms, H. C. C., Abbott, N. J., Burek, M., Cecchelli, R., Couraud, P., Deli, M. A., Förster, C., Galla, H. J., Romero, I. A., Shusta, E. V., Stebbins, M. J., Vandenhaute, E., Weksler, B. & Larsen, Birger Brodin, May 2016, In: Journal of Cerebral Blood Flow and Metabolism. 36, 5, p. 862-90 29 p.

    Research output: Contribution to journalReviewpeer-review

  59. Published

    Transferrin receptor expression and role in transendothelial transport of transferrin in cultured brain endothelial monolayers

    Hersom, M., Helms, H. C., Pretzer, N., Andersen, C. G., Jensen, A. I., Severin, G., Nielsen, M. S., Holm, R. & Larsen, Birger Brodin, 24 Aug 2016, In: Molecular and Cellular Neuroscience. 76, p. 59-67 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  60. Published

    Functional Insulin Receptor expression does not facilitate transendothelial passage of insulin in a bovine in vitro blood-brain barrier model

    Hersom, M. N. S., Helms, H. C. C., Pedersen, T., Buckley, S. & Larsen, Birger Brodin, 3 Mar 2016.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  61. Published

    The insulin receptor is expressed and functional in blood-brain barrier endothelial cells, but does not mediate insulin entry from blood-to-brain

    Hersom, M. N. S., Helms, H. C. C., Pedersen, T., Buckley, S. & Larsen, Birger Brodin, 14 Sep 2016.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  62. Published

    ATP induce intracellular calcium rises in cultures of primary brain pericytes

    Jensen, S. H., Helms, H. C. C., Jessen, S. B., Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, Jun 2016.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  63. Published

    Rises in intracellular calcium in primary brain pericytes are caused by ATP

    Jensen, S. H., Helms, H. C. C., Cai, Changsi, Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, 2016. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  64. Published

    Application of Cell Culture and Tissue Models for Assessing Drug Transport

    Nielsen, C. U. & Larsen, Birger Brodin, 2016, Analytical Techniques in the Pharmaceutical Sciences. Müllertz, A., Perrie, Y. & Rades, T. (eds.). Springer, p. 791-821 30 p. (Advances in Delivery Science and Technology; No. 1).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  65. Published

    IPEC-J2 MDR1, a Novel High-Resistance Cell Line with Functional Expression of Human P-glycoprotein (ABCB1) for Drug Screening Studies

    Saaby, Lasse, Helms, H. C. C. & Larsen, Birger Brodin, 1 Feb 2016, In: Molecular Pharmaceutics. 13, 2, p. 640-52 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  66. Published

    A bovine in vitro blood-brain barrier model under oxygenglucose deprivation (OGD) condition

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig, Waagepetersen, Helle S. & Larsen, Birger Brodin, 2016.

    Research output: Contribution to conferencePosterResearch

  67. Published

    Modeling the ischemic blood-brain barrier; the effects of oxygen-glucose deprivation (OGD) on endothelial cells in culture

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig, Waagepetersen, Helle S. & Larsen, Birger Brodin, 19 Jun 2016.

    Research output: Contribution to conferenceConference abstract for conferenceCommunication

  68. Published

    Stroke and Drug Delivery--In Vitro Models of the Ischemic Blood-Brain Barrier

    Tornabene, E. & Larsen, Birger Brodin, Feb 2016, In: Journal of Pharmaceutical Sciences. 105, 2, p. 398-405 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  69. 2015
  70. Published

    ATP induce an increase in intracellular Ca2+ in pericytes of the blood-brain barrier

    Jensen, S. H., Helms, H. C. C., Jessen, S. B., Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, 2 Nov 2015.

    Research output: Contribution to conferencePosterResearchpeer-review

  71. Published

    Purinergic Signaling in Pericytes of the Blood-Brain Barrier

    Jensen, S. H., Helms, H. C. C., Jessen, S. B., Lauritzen, Martin, Waagepetersen, Helle S. & Larsen, Birger Brodin, Jul 2015.

    Research output: Contribution to conferencePosterResearchpeer-review

  72. Published

    The putative P-gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P-glycoprotein expressing cell line MDCK II MDR1

    Saaby, Lasse, Tfelt-Hansen, P. & Larsen, Birger Brodin, 11 Jun 2015, In: Pharmacology Research & Perspectives. 3, 4, p. 1-9 9 p., e00151.

    Research output: Contribution to journalJournal articlepeer-review

  73. Published

    Changes in barrier properties and protein expression levels of bovine brain endothelial cells during oxygen-glucose deprivation (OGD)

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 27 Aug 2015.

    Research output: Contribution to conferenceConference abstract for conferenceCommunication

  74. Published

    Changes in protein expression levels, Claudin-5 localization and barrier function in bovine brain endothelial cells during oxygen-glucose deprivation (OGD)

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 4 Jul 2015.

    Research output: Contribution to conferenceConference abstract for conferenceCommunication

  75. Published

    The in vitro blood-brain barrier model under OGD condition

    Tornabene, E., Helms, H. C. C., Berndt, P., Blasig, I., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 2 Nov 2015.

    Research output: Contribution to conferenceConference abstract for conferenceCommunication

  76. Published

    In Vitro Blood-Brain Barrier Models-An Overview of Established Models and New Microfluidic Approaches

    Wolff, A., Antfolk, M., Larsen, Birger Brodin & Tenje, M., 28 Jan 2015, In: Journal of Pharmaceutical Sciences. 104, 9, p. 2727-2746 20 p.

    Research output: Contribution to journalJournal articlepeer-review

  77. 2014
  78. Published

    In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt(1)-DALDA Analogues

    Ballet, S., Betti, C., Novoa, A., Tömböly, C., Nielsen, C. U., Helms, H. C., Lesniak, A., Kleczkowska, P., Chung, N. N., Lipkowski, A. W., Larsen, Birger Brodin, Tourwé, D. & Schiller, P. W., 10 Apr 2014, In: ACS Medicinal Chemistry Letters. 5, 4, p. 352-357 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  79. Published

    IN VITRO MEMBRANE PERMEATION STUDIES AND IN VIVO ANTINOCICEPTION OF GLYCOSYLATED Dmt1-DALDA ANALOGUES

    Betti, C., Novoa, A., Tömböly, C., Nielsen, C. U., Helms, H. C. C., Lesniak, A., Klecskowska, P., Chung, N. N., Chung, N. N., Lipkowski, A. W., Larsen, Birger Brodin, Tourwé, D., Schiller, P. W. & Ballet, S., 31 Aug 2014. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  80. Published

    Glutamate Efflux at the Blood-Brain Barrier: Cellular Mechanisms and Potential Clinical Relevance

    Cederberg-Helms, H. C., Uhd-Nielsen, C. & Larsen, Birger Brodin, 15 Nov 2014, In: Archives of Medical Research. 45, 8, p. 639-645 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  81. Published

    Generation of primary cultures of bovine brain endothelial cells and setup of cocultures with rat astrocytes

    Helms, H. C. & Larsen, Birger Brodin, 2014, In: Methods in molecular biology (Clifton, N.J.). 1135, p. 365-82 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  82. Published

    An Electrically Tight In Vitro Blood-Brain Barrier Model Displays Net Brain-to-Blood Efflux of Substrates for the ABC Transporters, P-gp, Bcrp and Mrp-1

    Helms, H. C., Hersom, M., Kuhlmann, L. B., Badolo, L., Nielsen, C. U. & Larsen, Birger Brodin, 17 Jun 2014, In: A A P S Journal. 16, 5, p. 1046-1055 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  83. Published

    A Tight Blood-Brain Barrier Model Displays Brain-to-Blood Efflux of Substrates for the ABC-Transporters, P-gp, BCRP and MRP-1

    Helms, H. C. C., Hersom, M. N. S., Kuhlmann, L. B., Badolo, L., Nielsen, C. U. & Larsen, Birger Brodin, 11 Sep 2014. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  84. Published

    Efflux transporter expression in a tight in vitro model of the blood brain barrier

    Helms, H. C. C., Hersom, M. N. S., Kuhlmann, L. B., Badolo, L., Nielsen, C. U. & Larsen, Birger Brodin, 10 Dec 2014. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  85. Published

    Transport pathways mediating blood-to-brain L-glutamate efflux

    Helms, H. C. C., Nielsen, C. U., Waagepetersen, Helle S. & Larsen, Birger Brodin, 10 Dec 2014. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  86. Published

    Expression profiles of selected receptor systems in a bovine in vitro blood-brain barrier model

    Hersom, M. N. S., Helms, H. C. C., Nielsen, M. S., Holm, R. & Larsen, Birger Brodin, 10 Dec 2014. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  87. Published

    PAT1 (SLC36A1) shows nuclear localization and affect growth of smooth muscle cells from rats

    Jensen, A., Figueiredo-Larsen, E. M., Holm, R., Broberg, M. L., Larsen, Birger Brodin & Nielsen, C. U., Jan 2014, In: A J P: Endocrinology and Metabolism (Online). 306, p. E65-E74

    Research output: Contribution to journalJournal articlepeer-review

  88. Published

    The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers

    Nøhr, M. K., Hansen, S. H., Larsen, Birger Brodin, Holm, R. & Nielsen, C. U., 23 Jan 2014, In: European Journal of Pharmaceutical Sciences. 51, p. 1-10

    Research output: Contribution to journalJournal articlepeer-review

  89. Published

    Design of prodrugs targeting the intestinal di/tri‐peptide transporter hPEPT1 (SLC15A1

    Omkvist, D. H., Nielsen, C. U., Steffansen, B., Larsen, S. B., Olsen, L., Jørgensen, Flemming Steen & Larsen, Birger Brodin, 4 Apr 2014. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  90. Published

    Molecular mechanisms underlying potassium transport in an in vitro model of the blood-brain barrier

    Pedersen, K. L., Assentoft, M., Helms, H. C. C., Larsen, Birger Brodin & MacAulay, N., 12 May 2014. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  91. Published

    THE POSSIBLE EFFECT OF TELMISARTAN ON THE BLOOD-BRAIN BARRIER TRANSPORT OF VERAPAMIL.

    Saaby, Lasse, Tfelt-Hansen, P. & Larsen, Birger Brodin, 18 Sep 2014. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  92. Published

    VPS10P domain receptor trafficking in brain endothelial cells

    Siupka, P., Højland, A., Thomsen, L. B., Lykke-Hartmann, K., Helms, H. C. C., Larsen, Birger Brodin, Moos, T., Madsen, P. S. & Nielsen, M. S., 10 Dec 2014. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  93. 2013
  94. Published

    Basolateral glycylsarcosine (Gly-Sar) transport in Caco-2 cell monolayers is pH dependent

    Berthelsen, R., Nielsen, C. U. & Larsen, Birger Brodin, Jul 2013, In: Journal of Pharmacy and Pharmacology. 65, 7, p. 970-9 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  95. Published

    Cellemodel af blodhjernebarrieren kan mindske brugen af forsøgsdyr

    Larsen, Birger Brodin, Helms, H. C. C., Hersom, M. N. S., Nielsen, C. U. & Waagepetersen, Helle S., 2013, In: Lægemiddelforskning. 2013, p. 47-49 3 p.

    Research output: Contribution to journalJournal article

  96. Published

    Potential involvement of the proton-coupled amino acid transporter PAT1 (SLC36A1) in the delivery of pharmaceutical agents

    Frølund, S. B., Nøhr, M. K., Holm, R., Larsen, Birger Brodin & Nielsen, C. U., 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 293-306

    Research output: Contribution to journalJournal articlepeer-review

  97. Published

    Endothelial cell phenotype differs strongly between in viro BCEC monocultures and BCEC/rat astrocyte co-cultures, a phenomenon which may contribute to the differences in barrier tightness

    Helms, H. C. C. & Larsen, Birger Brodin, 2013. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  98. Published

    Excitatory amino acid transporter-1 (EAAT1) is the main transporter responsible for abluminal uptake of L-glutamate in bovine brain endothelial cells

    Helms, H. C. C., Groth, S., Mikél, M., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 27 May 2013.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  99. Published

    Expression and functional activity of the efflux transporters BCRP and P-gp in bovine endothelial cells, co-cultured with rat astrocytes

    Hersom, M. N. S., Helms, H. C. C., Kuhlmann, L. B., Badolo, L. & Larsen, Birger Brodin, 2013. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  100. Published

    Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro

    Nielsen, C. U., Frølund, S. B., Abdulhadi, S., Sari, H., Langthaler, L., Nøhr, M. K., Kall, M. A., Larsen, Birger Brodin & Holm, R., Nov 2013, In: British Journal of Pharmacology. 170, 5, p. 1041-52 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  101. Published

    Vigabatrin absorption is mediated via the proton-coupled amino acid transporter PAT1 – in vitro and in vivo

    Nøhr, M. K., Juul, R. V., Hansen, S. H., Larsen, Birger Brodin, Holm, R., Kreilgaard, M. & Nielsen, C. U., 24 Jun 2013.

    Research output: Contribution to conferencePosterResearch

  102. Published

    Current status of rational design of prodrugs targeting the intestinal di/tri-peptide transporter hPEPT1 (SLC15A1)

    Saaby, Lasse, Nielsen, C. U., Steffansen, B., Larsen, Birger Brodin & Larsen, S. B. L., 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 307–314

    Research output: Contribution to journalJournal articlepeer-review

  103. Published

    Serotonin transporter protein (SERT) and P-glycoprotein (P-gp) binding activity of montanine and coccinine from three species of Haemanthus L. (Amaryllidaceae)

    Stafford, G. I., Birer, C., Larsen, Birger Brodin, Christensen, Søren Brøgger, Eriksson, A. H., Jäger, A. & Rønsted, Nina, Sep 2013, In: South African Journal of Botany. 88, p. 101-106 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  104. Published

    Membrane Transporters in ADME

    Steffansen, B., Nielsen, C. U. & Larsen, Birger Brodin, 2013, Transporters in drug development: discovery, optimization, clinical study and regulation. Steffansen, B. & Sugiyama, Y. (eds.). Springer Publishing Company, Vol. 7. p. 1-22 (AAPS Advances in the Pharmaceutical Sciences Series).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  105. 2012
  106. Published

    Function and expression of the proton-coupled amino acid transporter Slc36a1 along the rat gastrointestinal tract: Implications for intestinal absorption of gaboxadol

    Broberg, M. L., Holm, R. K., Tønsberg, H., Frølund, S. B., Ewon, K. B., Nielsen, A. L., Larsen, Birger Brodin, Jensen, A., Kall, M. A., Nielsen, C. U. & Christensen, K. V., 2012, In: British Journal of Pharmacology. 167, 3, p. 654-665

    Research output: Contribution to journalJournal articlepeer-review

  107. Published

    In-vitro models of the blood brain barrier

    Larsen, Birger Brodin, Helms, H. C. C., Groth, S., Waagepetersen, Helle S. & Nielsen, C. U., 2012. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  108. Published

    In-vitro evaluation of the P-glycoprotein interactions of a series of potentially CNS-active Amaryllidaceae alkaloids

    Eriksson, A. H., Rønsted, Nina, Jäger, A. K., Sendra, J. R. & Larsen, Birger Brodin, 2012, In: Journal of Pharmacy and Pharmacology. 64, 11, p. 1667-1677 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  109. Published

    Generation of a rat in-vitro blood-brain barrier model and initial insights on excitatory amino acid transporter expression

    Groth, S., Moos, T., Helms, H. C. C. & Larsen, Birger Brodin, 2012. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  110. Published

    In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells cocultured with astrocytes display a polarized brain-to-blood transport of glutamate

    Helms, H. C., Madelung, R., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2012, In: Glia. 60, 6, p. 882-893

    Research output: Contribution to journalJournal articlepeer-review

  111. Published

    Glutamate efflux from brain to blood - Studies in an in vitro blood-brain barrier model

    Helms, H. C. C., Madelung, R., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 2012.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  112. Published

    In vitro evidence for the brain glutamate efflux hypothesis: brain endothelial cells co-cultured with astrocytes display a polarized brain-to-blood transport of glutamate

    Helms, H. C. C., Madelung, R., Groth, S., Waagepetersen, Helle S., Nielsen, C. U. & Larsen, Birger Brodin, 13 Sep 2012. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  113. Published

    Carrier-mediated ¿-aminobutyric acid transport across the basolateral membrane of human intestinal Caco-2 cell monolayers

    Nielsen, C. U., Carstensen, M. & Larsen, Birger Brodin, 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 81, 2, p. 458-462

    Research output: Contribution to journalJournal articlepeer-review

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