Anette Müllertz

Anette Müllertz

Professor


  1. Published

    In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration

    Butler, J., Hens, B., Vertzoni, M., Brouwers, J., Berben, P., Dressman, J., Andreas, C. J., Schaefer, K. J., Mann, J., McAllister, M., Jamei, M., Kostewicz, E., Kesisoglou, F., Langguth, P., Minekus, M., Mullertz, Anette , Schilderink, R., Koziolek, M., Jedamzik, P., Weitschies, W., Reppas, C. & Augustijns, P., Mar 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 136, p. 70-83

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    In vitro-in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networks

    Fatouros, D. G., Nielsen, F. S., Douroumis, D., Hadjileontiadis, L. J. & Mullertz, Anette , 2008, In : European Journal of Pharmaceutics and Biopharmaceutics. 69, 3, p. 887-898

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    In vivo anesthetic effect and mechanism of action of active compounds from Alpinia galanga oil on Cyprinus carpio (koi carp)

    Khumpirapang, N., Chaichit, S., Jiranusornkul, S., Pikulkaew, S., Mullertz, Anette & Okonogi, S., 1 Nov 2018, In : Aquaculture. 496, p. 176-184

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media

    Sunesen, V. H., Pedersen, B. L., Kristensen, H. G. & Mullertz, Anette , 2005, In : European Journal of Pharmaceutical Sciences. 24, 4, p. 305-13 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    In vivo models and decision trees for formulation development in early drug development: A review of current practices and recommendations for biopharmaceutical development

    Zane, P., Gieschen, H., Kersten, E., Mathias, N., Ollier, C., Johansson, P., Van den Bergh, A., Van Hemelryck, S., Reichel, A., Rotgeri, A., Schäfer, K., Mullertz, Anette & Langguth, P., 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 142, p. 222-231 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Influence of bile on the absorption of halofantrine from lipid-based formulations

    Holm, R., Tønsberg, H., Jørgensen, E. B., Abedinpour, P., Farsad, S. & Mullertz, Anette , 2012, In : European Journal of Pharmaceutics and Biopharmaceutics. 81, 2, p. 281-287

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Influence of drug load and physical form of cinnarizine in new SNEDDS dosing regimens: in vivo and in vitro evaluations

    Siqueira Jørgensen, Scheyla Daniela, Mullertz, Anette , Gräeser, K., Kasten, G., Mu, Huiling & Rades, Thomas, Mar 2017, In : A A P S Journal. 19, 2, p. 587-594 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Influence of lipid composition and drug load on the in vitro performance of self-nanoemulsifying drug delivery systems

    Thomas, N., Mullertz, Anette , Graf, A. & Rades, T., 2012, In : Journal of Pharmaceutical Sciences. 101, 5, p. 1721-1731

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Influence of the solid form of siramesine hydrochloride on its behaviour in aqueous environments

    Zimmermann, A., Tian, F., Lopez de Diego, H., Ringkjøbing Elema, M., Rantanen, Jukka, Mullertz, Anette & Hovgaard, L., 2009, In : Pharmaceutical Research. 26, 4, p. 846-854

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Influence of the type of surfactant and the degree of dispersion on the lymphatic transport of halofantrine in conscious rats

    Karpf, D. M., Holm, R., Kristensen, H. G. & Mullertz, Anette , 2004, In : Pharmaceutical Research. 21, 8, p. 1413-8 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Insights into intermediate phases of human intestinal fluids visualized by atomic force microscopy and cryo-transmission electron microscopy ex vivo

    Mullertz, Anette , Fatouros, D. G., Smith, J. R., Vertzoni, M. & Reppas, C., 2012, In : Molecular Pharmaceutics. 9, 2, p. 237-247

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Insights into the early dissolution events of amlodipine using UV imaging and Raman spectroscopy

    Bøtker, Johan Peter, Savolainen, M., Koradia, V., Tian, F., Rades, Thomas, Mullertz, Anette , Cornett, Claus, Rantanen, Jukka & Østergaard, Jesper, 2011, In : Molecular Pharmaceutics. 8, 4, p. 1372-1380 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Insights into the ultrastructure of human intestinal fluids in the fed state by electron microscopy analysis

    Mullertz, Anette , Fatouros, D., Smith, J. R., Vertzoni, M. & Rappas, C., Nov 2010.

    Research output: Contribution to conferencePosterResearch

  14. Published

    Interlaboratory validation of small-scale solubility and dissolution measurements of poorly water-soluble drugs

    Andersson, S. B. E., Alvebratt, C., Bevernage, J., Bonneau, D., Mathews, C. D. C., Dattani, R., Edueng, K., He, Y., Holm, R., Madsen, C. M., Müller, T., Muenster, U., Mullertz, Anette , Ojala, K., Rades, Thomas, Sieger, P. & Bergström, C. A. S., Sep 2016, In : Journal of Pharmaceutical Sciences. 105, 9, p. 2864-72 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80

    Lind, M. L., Jacobsen, Jette, Holm, R. & Mullertz, Anette , 2008, In : European Journal of Pharmaceutical Sciences. 35, 3, p. 211-218

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Investigating the correlation between in vivo absorption and in vitro release of fenofibrate from lipid matrix particles in biorelevant medium

    Borkar, N. N., Xia, D., Holm, R., Gan, Y., Mullertz, Anette , Yang, Mingshi & Mu, Huiling, 2014, In : European Journal of Pharmaceutical Sciences. 51, p. 204-10 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery

    Abid, Z., Dalskov Mosgaard, M., Manfroni, G., Singh Petersen, R., Hagner Nielsen, L., Mullertz, Anette , Boisen, A. & Sylvest Keller, S., Nov 2019, In : Polymers. 11, 10 p., 1828.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Investigation of the Intra- and Interlaboratory Reproducibility of a Small Scale Standardized Supersaturation and Precipitation Method

    Plum, J., Madsen, C. M., Teleki, A., Bevernage, J., da Costa Mathews, C., Karlsson, E. M., Carlert, S., Holm, R., Müller, T., Matthews, W., Sayers, A., Ojala, K., Tsinsman, K., Lingamaneni, R., Bergström, C. A., Rades, Thomas & Mullertz, Anette , 7 Nov 2017, In : Molecular Pharmaceutics. 14, 12, p. 4161-4169

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Kolliphor surfactants affect solubilization and bioavailability of fenofibrate. Studies of in vitro digestion and absorption in rats.

    Berthelsen, Ragna, Holm, R., Jacobsen, Jette, Kristensen, J., Abrahamsson, B. & Mullertz, Anette , 6 Apr 2015, In : Molecular Pharmaceutics. 12, 4, p. 1062-1071 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Lipid-based formulations for danazol containing a digestible surfactant, labrafil M2125CS: In vivo bioavailability and dynamic in vitro lipolysis

    Larsen, A., Holm, R., Pedersen, M. L. & Mullertz, Anette , 2008, In : Pharmaceutical Research. 25, 12, p. 2769-2777

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Lipid-based formulations for oral administration of poorly water-soluble drugs

    Mu, Huiling, Holm, R. & Mullertz, Anette , 30 Aug 2013, In : International Journal of Pharmaceutics. 453, 1, p. 215-24 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Lipophilic prodrugs of apomorphine I: Preparation, characterisation, and in vitro enzymatic hydrolysis in biorelevant media.

    Borkar, N. N., Li, B., Holm, R., Håkansson, A., Mullertz, Anette , Yang, Mingshi & Mu, Huiling, 2015, In : European Journal of Pharmaceutics and Biopharmaceutics. 89, p. 216-223 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Liquid self-microemulsifying drug delivery

    Mullertz, Anette & Grove, M., 2007, Oral lipid-based formulations: enhancing the bioavailability of poor water-soluble drugs. Hauss, D. J. (ed.). New York: Informa Healthcare, p. 107-128

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  24. Published

    Lymphatic fatty acids in canines dosed with pharmaceutical formulations containing structured triacylglycerols

    Holm, R., Porsgaard, T., Porter, H., Høy, C., Edwards, G. A., Mullertz, Anette , Kristensen, H. G. & Charman, W. N., 2006, In : European Journal of Lipid Science and Technology. 108, 9, p. 714-722 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Mapping the intermediate digestion phases of human healthy intestinal contents from distal ileum and caecum at fasted and fed state conditions

    Tran, T., Fatouros, D. G., Vertzoni, M., Reppas, C. & Mullertz, Anette , Mar 2017, In : The Journal of pharmacy and pharmacology. 69, 3, p. 265-273 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Marine lipids and the bioavailability of omega-3 fatty acids

    Mu, Huiling & Mullertz, Anette , 2015, In : Current Nutrition and Food Science. 11, 3, p. 177-187 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  27. Published

    Meeting report: applied biopharmaceutics and quality by design for dissolution/release specification setting: product quality for patient benefit

    Selen, A., Cruanes, M. T., Mullertz, Anette , Dicikinsion, P. A., Cook, J. A., Polli, J. E., Kesisoglou, F., Crison, J., Johnson, K. C., Muirhead, G. T., Schofield, T. & Tsong, Y., 2010, In : The AAPS Journal. 12, 3, p. 465-472

    Research output: Contribution to journalReviewResearch

  28. Published

    Microcontainers for oral insulin delivery - in vitro studies of permeation enhancement

    Jørgensen, Jacob Rune, Leth Jepsen, M., Hagner Nielsen, L., Dufva, M., Nielsen, Hanne Mørck, Rades, Thomas, Boisen, A. & Mullertz, Anette , 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 143, p. 98-105

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Milk osteopontin retains integrin-binding activity after in vitro gastrointestinal transit

    Christensen, B., Karlsen, N. J., Siqueira Jørgensen, Scheyla Daniela, Jacobsen, L. N., Ostenfeld, M. S., Petersen, S. V., Mullertz, Anette & Sorensen, E. S., Jan 2020, In : Journal of Dairy Science. 103, 1, p. 42-51

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Miniaturized approach for excipient selection during the development of oral solid dosage form

    Raijada, D. K., Mullertz, Anette , Cornett, Claus, Munk, T., Sonnergaard, J. & Rantanen, Jukka, Mar 2014, In : Journal of Pharmaceutical Sciences. 103, 3, p. 900-8 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Monoacyl phosphatidylcholine inhibits the formation of lipid multilamellar structures during in vitro lipolysis of self-emulsifying drug delivery systems

    Tran, T., Siqueira Jørgensen, Scheyla Daniela, Amenitsch, H., Rades, Thomas & Mullertz, Anette , 15 Oct 2017, In : European Journal of Pharmaceutical Sciences. 108, p. 62-70

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Morphological observations on a lipid-based drug delivery system during in vitro digestion

    Fatouros, D. G., Bergenstahl, B. & Mullertz, Anette , 2007, In : European Journal of Pharmaceutical Sciences. 31, 2, p. 85-94

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Mucosal drug delivery: barriers, in vitro models and formulation strategies

    Bøgh, M., Foged, Camilla, Mullertz, Anette & Nielsen, Hanne Mørck, 2013, In : Journal of Drug Delivery Science and Technology. 23, 4, p. 383-391

    Research output: Contribution to journalReviewResearchpeer-review

  34. Published

    New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs

    Mullertz, Anette , Ogbonna, A., Ren, S. & Rades, Thomas, 2010, In : Journal of Pharmacy and Pharmacology. 62, 11, p. 1622-1636 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Optimization of self nanoemulsifying drug delivery system for poorly water-soluble drug using response surface methodology

    Ren, S., Mu, Huiling, Alchaer, F., Chtatou, A. & Mullertz, Anette , May 2013, In : Drug Development and Industrial Pharmacy. 39, 5, p. 799-806 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Optimization of the in vitro lipolysis rate of SMEDDS containing cinnarizine

    Ulmann, C., Figueriedo-Larsen, M., Refsgaard, L., Hellekilde, J., Larsen, A., Nielsen, C., Olesen, P. & Mullertz, Anette , 2009.

    Research output: Contribution to conferencePosterResearch

  37. Published

    Optimizing clinical drug product performance: applying Biopharmaceutics Risk Assessment Roadmap (BioRAM) and the BioRAM Scoring Grid

    Dickinson, P. A., Kesisoglou, F., Flanagan, T., Martinez, M. N., Mistry, H. B., Crison, J. R., Polli, J. E., Cruañes, M. T., Serajuddin, A. T. M., Mullertz, Anette , Cook, J. A. & Selen, A., Nov 2016, In : Journal of Pharmaceutical Sciences. 105, 11, p. 3243-3255 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Oral bioavailability of cinnarizine in dogs: relation to SNEDDS droplet size, drug solubility and in vitro precipitation

    Larsen, A. T., Ohlsson, A. G., Polentarutti, B., Barker, R. A., Phillips, A. R., Abu-Rmaileh, R., Dickinson, P. A., Abrahamsson, B., Østergaard, Jesper & Mullertz, Anette , 2013, In : European Journal of Pharmaceutical Sciences. 48, 1-2, p. 339-50 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Oral delivery of peptides and proteins using lipid-based drug delivery systems

    Li, P., Nielsen, Hanne Mørck & Mullertz, Anette , 2012, In : Expert Opinion on Drug Delivery. 9, 10, p. 1289-304 16 p.

    Research output: Contribution to journalReviewResearchpeer-review

  40. Published

    Phase transformations of amlodipine besylate solid forms

    Koradia, V. S., Lemos, A. F. F. D., Allesø, M., Diego, H. L. D., Ringkjøbing-Elema, M., Mullertz, Anette & Rantanen, Jukka, 2011, In : Journal of Pharmaceutical Sciences. 100, 7, p. 2896-2910

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Physicochemical characterization of simulated intestinal fed-state fluids containing lyso-phosphatidylcholine and cholesterol

    Fatouros, D., Walrand, I., Bergenstahl, B. & Mullertz, Anette , 2009, In : Dissolution Technologies. 16, 3, p. 47-50

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Polymer selection for simulation of rheological properties of human gastric fluid

    Pedersen, P. B., Vilmann, P., Bar-Shalom, Daniel, Mullertz, Anette & Baldursdottir, S. G., 2013, In : Nordic Rheology Society Annual Transactions. 21, p. 241-247

    Research output: Contribution to journalConference articleResearch

  43. Published

    Polymer-filled microcontainers for oral delivery loaded using supercritical impregnation

    Marizza, P., Keller, S. S., Mullertz, Anette & Boisen, A., 10 Jan 2014, In : Journal of controlled release : official journal of the Controlled Release Society. 173, p. 1-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Polymeric Lids for Microcontainers for Oral Protein Delivery

    Mazzoni, C., Jacobsen, R. D., Mortensen, J., Jørgensen, Jacob Rune, Vaut, L., Jacobsen, Jette, Gundlach, C., Mullertz, Anette , Nielsen, L. H. & Boisen, A., 2019, In : Macromolecular Bioscience. 19, 5, 1900004.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Polymeric microcontainers improve oral bioavailability of furosemide

    Nielsen, L. H., Melero, A., Keller, S. S., Jacobsen, Jette, Garrigues, T., Rades, Thomas, Mullertz, Anette & Boisen, A., 17 May 2016, In : International Journal of Pharmaceutics. 504, 1-2, p. 98-109 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Poorly soluble drugs

    Siepmann, J., Rades, Thomas, Mullertz, Anette & Loftsson, T., 15 Mar 2020, In : International Journal of Pharmaceutics. 577, 119055.

    Research output: Contribution to journalEditorialResearchpeer-review

  47. Published

    Precipitation of a poorly soluble model drug during in vitro lilpolysis: characterization and dissolution of the precipitate

    Sassene, P. J., Knopp, M. M., Hesselkilde, J. Z., Koradia, V. S., Larsen, A. T., Rades, T. & Mullertz, Anette , 2010, In : Journal of Pharmaceutical Sciences. 99, 12, p. 4982-4991

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Preparation and characterization of insulin-surfactant complexes for loading into lipid-based drug delivery systems

    Li, P., Nielsen, Hanne Mørck, Fano, M. & Mullertz, Anette , Aug 2013, In : Journal of Pharmaceutical Sciences. 102, 8, p. 2689-98 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to rats

    Nielsen, L. H., Gordon, S., Holm, R., Selen, A., Rades, Thomas & Mullertz, Anette , Nov 2013, In : European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 85, 3 Pt B, p. 942-51 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Property profiling of biosimilar mucus in a novel mucus-containing in vitro model for assessment of intestinal drug absorption

    Bøgh, M., Baldursdóttir, S. G., Mullertz, Anette & Nielsen, Hanne Mørck, 8 Jan 2014, In : European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 87, p. 227-235 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Real-time dissolution behavior of furosemide in biorelevant media as determined by UV imaging

    Gordon, S., Naelapää, K., Rantanen, Jukka, Selen, A., Mullertz, Anette & Østergaard, Jesper, 2013, In : Pharmaceutical Development and Technology. 18, 6, p. 1407-16 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Recent developments in oral lipid-based drug delivery

    Thomas, N., Rades, Thomas & Mullertz, Anette , 1 Jul 2013, In : Journal of Drug Delivery Science and Technology. 23, 4, p. 375-382 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Redissolution and polymorphic characterization of a poorly water-soluble drug precipitated during in vitro lipolysis from a lipid-based formulation

    Ren, S., Ogbonna, A., Koradia, V. S., Sassene, P. J., Rades, T. & Mullertz, Anette , Nov 2010.

    Research output: Contribution to conferencePosterResearch

  54. Published

    Refining stability and dissolution rate of amorphous drug formulations

    Grohganz, Holger, Priemel, P. A., Löbmann, Korbinian, Nielsen, L. H., Laitinen, R., Mullertz, Anette , Van den Mooter, G. & Rades, Thomas, Jun 2014, In : Expert Opinion on Drug Delivery. 11, 6, p. 977-89 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Rhamnogalacturonan-I based microcapsules for targeted drug release

    Svagan, A. J., Kusic, A., De Gobba, Cristian, Larsen, F. H., Sassene, P., Zhou, Q., van de Weert, Marco, Mullertz, Anette , Jørgensen, Bodil & Ulvskov, Peter, 2016, In : P L o S One. 11, 12, 13 p., e0168050.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    SEDDS for intestinal absorption of insulin: Application of Caco-2 and Caco-2/HT29 co-culture monolayers and intra-jejunal instillation in rats

    Liu, Jingying, Werner, U., Funke, M., Besenius, M., Saaby, L., Fano, M., Mu, Huiling & Mullertz, Anette , 5 Apr 2019, In : International Journal of Pharmaceutics. 560, p. 377-384

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    SNEDDS containing poorly water soluble cinnarizine; development and in Vitro characterization of dispersion, digestion and solubilization

    Larsen, A. T., Ogbonna, A., Abu-Rmaileh, R., Abrahmsson, B., Østergaard, Jesper & Mullertz, Anette , 2012, In : Pharmaceutics. 4, 4, p. 641-665

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Selection of a lipase for development of an in vitro gastric lipid digestion model

    Larsen, A. T., Jensen, L. G., Hansen, K. K. & Mullertz, Anette , Nov 2010.

    Research output: Contribution to conferencePosterResearch

  59. Published

    Self-emulsifying drug delivery systems (SEDDS) – The splendid comeback of an old technology

    Bernkop-Schnürch, A., Mullertz, Anette & Rades, Thomas, 2019, In : Advanced Drug Delivery Reviews. 142, p. 1-2 2 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  60. Published

    Self-microemulsifying drug delivery system and nanoemulsion for enhancing aqueous miscibility of Alpinia galanga oil

    Khumpirapang, N., Pikulkaew, S., Mullertz, Anette , Rades, Thomas & Okonogi, S., 2017, In : PLOS ONE. 12, 11, 18 p., e0188848.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading

    Li, P., Tan, A., Prestidge, C. A., Nielsen, Hanne Mørck & Mullertz, Anette , 30 Dec 2014, In : International Journal of Pharmaceutics. 477, 1-2, p. 390-8 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Solid Lipid Particles for Oral Delivery of Peptide and Protein Drugs II - The Digestion of Trilaurin Protects Desmopressin from Proteolytic Degradation

    Christophersen, P. C., Zhang, L., Mullertz, Anette , Nielsen, Hanne Mørck, Yang, Mingshi & Mu, Huiling, 13 Mar 2014, In : Pharmaceutical Research. 31, 9, p. 2420-28 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    Solid cellulose nanofiber based foams - Towards facile design of sustained drug delivery systems

    Svagan, A. J., Benjamins, J., Al-Ansari, Z., Bar-Shalom, Daniel, Mullertz, Anette , Wågberg, L. & Löbmann, Korbinian, 12 Nov 2016, In : Journal of controlled release : official journal of the Controlled Release Society. 244 , Part A, p. 74–82 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    Solid forms of amlodipine besylate: Physiochemical, structural, and thermodynamic characterization

    Koradia, V. S., Lopez de Diego, H., Frydenvang, Karla Andrea, Ringkjøbing-Elema, M., Mullertz, Anette , Bond, A. D. & Rantanen, Jukka, 28 Oct 2010, In : Crystal Growth & Design. 10, 12, p. 5279-5290

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Solid lipid particles for oral delivery of peptide and protein drugs I - Elucidating the release mechanism of lysozyme during lipolysis

    Christophersen, P. C. B., Zhang, L., Yang, Mingshi, Nielsen, Hanne Mørck, Mullertz, Anette & Mu, Huiling, 2 Aug 2013, In : European Journal of Pharmaceutics and Biopharmaceutics. 85, 3, part A, p. 473-480

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published

    Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin

    Christophersen, P. C., Vaghela, D., Mullertz, Anette , Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, Jul 2014, In : A A P S Journal. 16, 4, p. 875-83 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols

    Christensen, J. Ø., Schultz, K., Mollgaard, B., Kristensen, H. G. & Mullertz, Anette , 2004, In : European Journal of Pharmaceutical Sciences. 23, 3, p. 287-96 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    Solution or suspension - Does it matter for lipid based systems? In vivo studies of chase dosing lipid vehicles with aqueous suspensions of a poorly soluble drug

    Larsen, A. T., Holm, R. & Mullertz, Anette , Aug 2017, In : European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 117, p. 308-314 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. Published

    Spatial confinement can lead to increased stability of amorphous indomethacin

    Nielsen, L. H., Keller, S. S., Gordon, K. C., Boisen, A., Rades, Thomas & Mullertz, Anette , 2012, In : European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 81, 2, p. 418-25 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. Published

    Stabilisation of amorphous furosemide increases the oral drug bioavailability in rats

    Nielsen, L. H., Rades, Thomas & Mullertz, Anette , 25 Jul 2015, In : International Journal of Pharmaceutics. 490, 1-2, p. 334-40 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. Published

    Steric and interactive barrier properties of intestinal mucus elucidated by particle diffusion and peptide permeation

    Bøgh, M., García-Díaz, M., Mullertz, Anette & Nielsen, Hanne Mørck, Sep 2015, In : European Journal of Pharmaceutics and Biopharmaceutics. 94, Part A, p. 136–143 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Published

    Structural development of self nano emulsifying drug delivery systems (SNEDDS) during in vitro lipid digestion monitored by small-angle X-ray scattering

    Fatouros, D. G., Deen, R., Arleth, Lise, Bergenstahl, B., Nielsen, F. S., Pedersen, J. S. & Mullertz, Anette , 2007, In : Pharmaceutical Research. 24, 10, p. 1844-1853 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    Structural features of colloidal species in the human fasted upper small intestine

    Mullertz, Anette , Reppas, C., Psachoulias, D., Vertzoni, M. & Fatouros, D. G., Apr 2015, In : Journal of Pharmacy and Pharmacology. 67, 4, p. 486-492 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Published

    Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats

    Holm, R., Porter, C. J. H., Mullertz, Anette , Kristensen, H. G. & Charman, W. N., 2002, In : Pharmaceutical Research. 19, 9, p. 1354-61 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    Studying furosemide solubilization using an in vitro model simulating gastrointestinal digestion and drug solubilization in neonates and young infants

    Klitgaard, Mette, Sassene, P. J., Selen, A., Mullertz, Anette & Berthelsen, Ragna, 15 Nov 2017, In : European Journal of Pharmaceutical Sciences. 109, p. 191-199 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    Studying the propensity of compounds to supersaturate: a practical and broadly applicable approach

    Palmelund, Henrik, Madsen, C. M., Christensen, J. P., Mullertz, Anette & Rades, Thomas, Oct 2016, In : Journal of Pharmaceutical Sciences. 105, 10, p. 3021-3029 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

    Boyd, B. J., Bergström, C. A. S., Vinarov, Z., Kuentz, M., Brouwers, J., Augustijns, P., Brandl, M., Bernkop-Schnürch, A., Shrestha, N., Préat, V., Mullertz, Anette , Bauer-Brandl, A. & Jannin, V., 2019, In : European Journal of Pharmaceutical Sciences. 137, 27 p., 104967.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    Supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS) enhance the bioavailability of the poorly water-soluble drug Simvastatin in dogs

    Thomas, N., Holm, R., Garmer, M., Karlsson, J. J., Mullertz, Anette & Rades, Thomas, 2013, In : A A P S Journal. 15, 1, p. 219-27 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    Supersaturation of zafirlukast in fasted and fed state intestinal media with and without precipitation inhibitors

    Madsen, C. M., Boyd, B., Rades, Thomas & Mullertz, Anette , 25 Aug 2016, In : European Journal of Pharmaceutical Sciences. 91, p. 31-39 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  80. Published

    Survival of Lactobacillus acidophilus NCFM® and Bifidobacterium lactis HN019 encapsulated in chocolate during in vitro simulated passage of the upper gastrointestinal tract

    Klindt-Toldam, S., Larsen, S. K., Saaby, L., Olsen, L. R., Svenstrup, G., Mullertz, Anette , Knøchel, Susanne, Heimdal, H., Nielsen, Dennis Sandris & Zielińska, D., 2016, In : Lebensmittel - Wissenschaft und Technologie. 74, p. 404-410 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  81. Published

    Tabletter med "løse ender" giver forsinket afgift af lægemiddelstof

    Naelapaa, K., Mullertz, Anette , Jacobsen, Jette, Rømsing, Janne & Bar-Shalom, Daniel, 2009, In : Lægemiddelforskning. p. 4-6 3 p.

    Research output: Contribution to journalJournal articleResearch

  82. Published

    Tabletter med løse ender

    Naelapaa, K., Mullertz, Anette , Jacobsen, Jette, Rømsing, Janne & Bar-Shalom, Daniel, 2009, In : Lægemiddelforskning. p. 4-6

    Research output: Contribution to journalJournal articleResearch

  83. Published

    The Effect of Digestion and Drug Load on Halofantrine Absorption from Self-nanoemulsifying Drug Delivery System (SNEDDS)

    Michaelsen, M. H., Wasan, K. M., Sivak, O., Mullertz, Anette & Rades, Thomas, Jan 2016, In : The A A P S Journal. 18, 1, p. 180-186 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. Published

    The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers

    Blaabjerg, L. I., Grohganz, Holger, Lindenberg, E., Löbmann, Korbinian, Mullertz, Anette & Rades, Thomas, 21 Sep 2018, In : Pharmaceutics. 10, 4, 14 p., 164.

    Research output: Contribution to journalJournal articleResearchpeer-review

  85. Published

    The ability of two in vitro lipolysis models reflecting the human and rat gastro-intestinal conditions to predict the in vivo performance of SNEDDS dosing regimens

    Siqueira Jørgensen, Scheyla Daniela, Al Sawaf, M., Graeser, K., Mu, Huiling, Mullertz, Anette & Rades, Thomas, Mar 2018, In : European Journal of Pharmaceutics and Biopharmaceutics. 124, p. 116-124

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. Published

    The use of biorelevant dissolution media in determining the region of microemulsion: Implications for in vitro lipid formulation assessment

    Ogbonna, A., Ren, S., Olesen, P. & Mullertz, Anette , 2009.

    Research output: Contribution to conferencePosterResearch

  87. Published

    Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase

    Bakala-N'Goma, J., Williams, H. D., Sassene, P. J., Kleberg, K., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Mullertz, Anette , Pouton, C. W., Porter, C. J. H. & Carriere, F., Apr 2015, In : Pharmaceutical Research. 32, 4, p. 1279-1287 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  88. Published

    Toward the Establishment of Standardized in Vitro Tests for Lipid-Based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I, II, IIIA, IIIB, and IV Formulations during in Vitro Digestion

    Williams, H. D., Anby, M. U., Sassene, P., Kleberg, K., Bakala-N’Goma, J., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Carrière, F., Mullertz, Anette , Pouton, C. W. & Porter, C. J. H., 2012, In : Molecular Pharmaceutics. 9, 11, p. 3286-3300 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: Method parameterization and comparison of in vitro digestion profiles across a range of representative formulations

    Williams, H. D., Sassene, P., Kleberg, K., Bakala-N'Goma, J., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Carrière, F., Mullertz, Anette , Porter, C. J. H. & Pouton, C. W., 2012, In : Journal of Pharmaceutical Sciences. 101, 9, p. 3360-3380

    Research output: Contribution to journalJournal articleResearchpeer-review

  90. Published

    Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in vitro digestion of type I, II, IIIA, IIIB and IV lipid-based formulations

    Williams, H. D., Sassene, P., Kleberg, K., Calderone, M., Igonin, A., Jule, E., Vertommen, J., Blundell, R., Benameur, H., Mullertz, Anette , Pouton, C. W., Porter, C. J. H. & LFCS Consortium, L. C., Dec 2013, In : Pharmaceutical Research. 30, 12, p. 3059-76 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system

    Williams, H. D., Sassene, P., Kleberg, K., Calderone, M., Igonin, A., Jule, E., Vertommen, J., Blundell, R., Benameur, H., Mullertz, Anette , Porter, C. J. H., Pouton, C. W. & Communicated on Behalf of the LFCS Consortium, C. O. B. O. T. L. C., Aug 2014, In : Journal of Pharmaceutical Sciences. 103, 8, p. 2441-55 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published

    Towards the understanding of complex fluids in pharmaceutical sciences

    Pedersen, P. B., Pekka Pajander, J., Mullertz, Anette , Vilmann, Peter, Jørgensen, Lene & Baldursdottir, S. G., 2013, In : Journal of Drug Delivery Science and Technology. 23, 4, p. 393 401 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. Published

    Trilaurin diminishes food effect on the release of desmopressin from solid lipid microparticles

    Christophersen, P., Vaghela, D., Mullertz, Anette , Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, 2014.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  94. Published

    Unravelling the ultrastructure of ascending colon fluids from patients with ulcerative colitis by cryogenic transmission electron microscopy

    Mullertz, Anette , Fatouros, D. G., Vertzoni, M. & Reppas, C., Oct 2013, In : The Journal of pharmacy and pharmacology. 65, 10, p. 1482-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. Published

    Using Potentiometric Free Drug Sensors to Determine the Free Concentration of Ionizable Drugs in Colloidal Systems

    Tran, T., Chakraborty, A., Xi, X., Bohets, H., Cornett, Claus, Tsinman, K., Rades, Thomas & Mullertz, Anette , Jan 2018, In : Journal of Pharmaceutical Sciences. 107, 1, p. 103-112

    Research output: Contribution to journalJournal articleResearchpeer-review

  96. Published

    Using biorelevant dissolution to obtain IVIVC of solid dosage forms containing a poorly-soluble model compound

    Lue, B., Nielsen, F. S., Magnussen, T., Schou, H. M., Kristensen, K., Jacobsen, L. O. & Mullertz, Anette , 2008, In : European Journal of Pharmaceutics and Biopharmaceutics. 69, 2, p. 648-657

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    Using in vitro dynamic lipolysis modeling as a tool for exploring IVIVC relationships for oral lipid-based formulations

    Mullertz, Anette & Fatourus, D. G., 2007, Oral lipid-based formulations: enhancing the bioviabillity of poorly water-soluble drugs. Hauss, D. J. (ed.). New York: Informa healtcare, p. 257-272

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  98. Published

    Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems

    Tran, T., Bonlokke, P., Rodriguez-Rodriguez, C., Nosrati, Z., Esquinas, P. L., Borkar, N., Plum, J., Strindberg, Sophie , Karagiozov, S., Rades, Thomas, Mullertz, Anette , Saatchi, K. & Häfeli, Urs Otto, 2020, In : Journal of Controlled Release. 317, p. 375-384

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessful

    Holm, R., Hesselkilde, J. Z., Jørgensen, E. B. & Mullertz, Anette , 2012, In : European Journal of Pharmaceutical Sciences. 47, p. 347-351

    Research output: Contribution to journalJournal articleResearchpeer-review

  100. Published

    pH-triggered drug release from biodegradable microwells for oral drug delivery

    Nielsen, L. H., Nagstrup, J., Gordon, S., Keller, S. S., Østergaard, Jesper, Rades, Thomas, Mullertz, Anette & Boisen, A., Jun 2015, In : Biomedical Microdevices. 17, 7 p., 55.

    Research output: Contribution to journalJournal articleResearchpeer-review

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