Anette Müllertz
Anette Müllertz

Professor


  1. 2002
  2. Published

    Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats

    Holm, R., Porter, C. J. H., Mullertz, Anette , Kristensen, H. G. & Charman, W. N., 2002, In : Pharmaceutical Research. 19, 9, p. 1354-61 7 p.

    Research output: Contribution to journalJournal article

  3. 2003
  4. Published

    Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides

    Holm, R., Porter, C. J. H., Edwards, G. A., Mullertz, Anette , Kristensen, H. G. & Charman, W. N., 2003, In : European Journal of Pharmaceutical Sciences. 20, 1, p. 91-7 6 p.

    Research output: Contribution to journalJournal article

  5. 2004
  6. Published

    Influence of the type of surfactant and the degree of dispersion on the lymphatic transport of halofantrine in conscious rats

    Karpf, D. M., Holm, R., Kristensen, H. G. & Mullertz, Anette , 2004, In : Pharmaceutical Research. 21, 8, p. 1413-8 5 p.

    Research output: Contribution to journalJournal article

  7. Published

    Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols

    Christensen, J. Ø., Schultz, K., Mollgaard, B., Kristensen, H. G. & Mullertz, Anette , 2004, In : European Journal of Pharmaceutical Sciences. 23, 3, p. 287-96 9 p.

    Research output: Contribution to journalJournal article

  8. 2005
  9. Published

    Bioavailability of seocalcitol I: Relating solubility in biorelevant media with oral bioavailability in rats--effect of medium and long chain triglycerides

    Grove, M., Pedersen, G. P., Nielsen, J. L. & Mullertz, Anette , 2005, In : Journal of Pharmaceutical Sciences. 94, 8, p. 1830-8 8 p.

    Research output: Contribution to journalJournal article

  10. Published

    Development of  in vitro methods for the evaluation of formulation performance

    Mullertz, Anette & Nielsen, F. S., 2005. 12 p.

    Research output: Contribution to conferencePaperResearchpeer-review

  11. Published

    Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug

    Sunesen, V. H., Vedelsdal, R., Kristensen, H. G., Christrup, Lona Louring & Mullertz, Anette , 2005, In : European Journal of Pharmaceutical Sciences. 24, 4, p. 297-303 6 p.

    Research output: Contribution to journalJournal article

  12. Published

    Enzymatic characterization of lipid-based drug delivery systems

    Ljusberg-Wahren, H., Seier Nielsen, F., Brogård, M., Troedsson, E. & Mullertz, Anette , 2005, In : Internation Journal of Pharmaceutics. 298, 2, p. 328-32 4 p.

    Research output: Contribution to journalJournal article

  13. Published

    In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media

    Sunesen, V. H., Pedersen, B. L., Kristensen, H. G. & Mullertz, Anette , 2005, In : European Journal of Pharmaceutical Sciences. 24, 4, p. 305-13 8 p.

    Research output: Contribution to journalJournal article

  14. 2006
  15. Published

    Bioavailability of seocalcitol IV: evaluation of lymphatic transport in conscious rats

    Grove, M., Nielsen, J. L., Pedersen, G. P. & Mullertz, Anette , 2006, In : Pharmaceutical Research. 23, 11, p. 2681-8 7 p.

    Research output: Contribution to journalJournal article

  16. Published

    Biorelevant dissolution media: aggregation of amphiphiles and solubility of estradiol

    Ilardia-Arana, D., Kristensen, H. G. & Mullertz, Anette , 2006, In : Journal of Pharmaceutical Sciences. 95, 2, p. 248-55 7 p.

    Research output: Contribution to journalJournal article

  17. Published

    Effect of different surfactants in biorelevant medium on the secretion of a lipophilic compound in lipoproteins using Caco-2 cell culture

    Karpf, D. M., Holm, R., Garafalo, C., Levy, E., Jacobsen, Jette & Mullertz, Anette , 2006, In : Journal of Pharmaceutical Sciences. 95, 1, p. 45-55 10 p.

    Research output: Contribution to journalJournal article

  18. Published

    Lymphatic fatty acids in canines dosed with pharmaceutical formulations containing structured triacylglycerols

    Holm, R., Porsgaard, T., Porter, H., Høy, C., Edwards, G. A., Mullertz, Anette , Kristensen, H. G. & Charman, W. N., 2006, In : European Journal of Lipid Science and Technology. 108, 9, p. 714-722 8 p.

    Research output: Contribution to journalJournal article

  19. 2007
  20. Published

    Bioavailability of seocalcitol III: administration of lipid-based formulations to minipigs in the fasted and fed state

    Grove, M., Mullertz, Anette , Pedersen, G. P. & Nielsen, J. L., 2007, In : European Journal of Pharmaceutical Sciences. 31, 1, p. 8-15

    Research output: Contribution to journalJournal article

  21. Published

    Biorelevant dissolution media

    Mullertz, Anette , 2007, Solvent systems and their selection in pharmaceutics and biopharmaceutics: Biotechnology: Pharmaceutical aspects. Augustijns, P. & Brewster, M. E. (eds.). New York: Springer Science+Business Media, Vol. 6. p. 107-177

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  22. Published

    Characterization of prototype self-nanoemulsifying formulations of lipophilic compounds

    Nielsen, F. S., Gibault, E., Ljusberg-Wahren, H., Arleth, Lise, Pedersen, J. S. & Mullertz, Anette , 2007, In : Journal of Pharmaceutical Sciences. 96, 4, p. 876-892 17 p.

    Research output: Contribution to journalJournal article

  23. Published

    Clinical studies with oral lipid based formulations of poorly soluble compounds

    Fatouros, D., Karpf, D. M., Nielsen, Flemming Steen & Mullertz, Anette , 2007, In : Therapeutics and Clinical Risk Management. 3, 4, p. 591-604 13 p.

    Research output: Contribution to journalJournal article

  24. Published

    Determination of surface-adsorbed excipients of various types on drug particles prepared by antisolvent precipitation using HPLC with evaporative light scattering detection

    Zimmermann, A., Elema, M. R., Hansen, T., Mullertz, Anette & Hovgaard, L., 2007, In : Journal of Pharmaceutical and Biomedical Analysis. 44, 4, p. 874-880

    Research output: Contribution to journalJournal article

  25. Published
  26. Published

    Dynamisk model for fordøjelse af lipidbaserede lægemidler i tarmen

    Fatouros, D., Larsen, A., Pedersen, B. L., Jacobsen, Jette & Mullertz, Anette , 2007, In : Lægemiddelforskning. p. 20-21

    Research output: Contribution to journalJournal article

  27. Published

    Effect of labrafil 2125CS on the oral bioavailability of danazol, a poorly soluble drug compound

    Larsen, A., Holm, R., Pedersen, M. & Mullertz, Anette , 2007.

    Research output: Contribution to conferencePosterResearch

  28. Published

    Liquid self-microemulsifying drug delivery

    Mullertz, Anette & Grove, M., 2007, Oral lipid-based formulations: enhancing the bioavailability of poor water-soluble drugs. Hauss, D. J. (ed.). New York: Informa Healthcare, p. 107-128

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  29. Published

    Morphological observations on a lipid-based drug delivery system during in vitro digestion

    Fatouros, D. G., Bergenstahl, B. & Mullertz, Anette , 2007, In : European Journal of Pharmaceutical Sciences. 31, 2, p. 85-94

    Research output: Contribution to journalJournal article

  30. Published

    Structural development of self nano emulsifying drug delivery systems (SNEDDS) during in vitro lipid digestion monitored by small-angle X-ray scattering

    Fatouros, D. G., Deen, R., Arleth, Lise, Bergenstahl, B., Nielsen, F. S., Pedersen, J. S. & Mullertz, Anette , 2007, In : Pharmaceutical Research. 24, 10, p. 1844-1853 10 p.

    Research output: Contribution to journalJournal article

  31. Published

    Using in vitro dynamic lipolysis modeling as a tool for exploring IVIVC relationships for oral lipid-based formulations

    Mullertz, Anette & Fatourus, D. G., 2007, Oral lipid-based formulations: enhancing the bioviabillity of poorly water-soluble drugs. Hauss, D. J. (ed.). New York: Informa healtcare, p. 257-272

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  32. 2008
  33. Published

    In vitro lipid digestion models in design of drug delivery systems for enhancing oral bioavailability

    Fatouros, D. & Mullertz, Anette , 2008, In : Expert Opinion on Drug Metabolism & Toxicology. 4, 1, p. 65-76

    Research output: Contribution to journalReview

  34. Published

    Bioavailability of probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state

    Nielsen, F. S., Petersen, K. & Mullertz, Anette , 2008, In : European Journal of Pharmaceutics and Biopharmaceutics. 69, 2, p. 553-562

    Research output: Contribution to journalJournal article

  35. Published

    Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30

    Thybo, P., Pedersen, B. L., Hovgaard, L., Holm, R. & Mullertz, Anette , 2008, In : Pharmaceutical Development and Technology. 13, 5, p. 375-86 11 p.

    Research output: Contribution to journalJournal article

  36. Published

    Colloid structures in media simulating intestinal fed state conditions with and without lipolysis products

    Fatourus, D., Walrand, I., Bergenstahl, B. & Mullertz, Anette , 2008.

    Research output: Contribution to conferencePosterResearch

  37. Published

    Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

    Hayeshi, R., Hilgendorf, C., Arthursson, P., Augustijns, P., Brodin, Birger, Dehertogh, P., Fisher, K., Fossati, L., Hovenkamp, E., Korjamo, T., Masungi, C., Maubon, N., Mols, R., Mullertz, Anette , Mönkkönen, J., O´Driscoll, C., Oppers-Tiemissen, H. M., Ragnarsson, E. G. E., Rooseboom, M. & Ungell, A., 2008, In : European Journal of Pharmaceutical Sciences. 35, 5, p. 383-396

    Research output: Contribution to journalJournal article

  38. Published

    Dynamisk model for fordøjelse af lipidbaserede lægemidler i tarmen

    Larsen, A., Fatourous, D., Jacobsen, Jette & Mullertz, Anette , 2008, In : Dansk Kemi. 89, 8, p. 30-33

    Research output: Contribution to journalJournal article

  39. Published

    In vitro-in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networks

    Fatouros, D. G., Nielsen, F. S., Douroumis, D., Hadjileontiadis, L. J. & Mullertz, Anette , 2008, In : European Journal of Pharmaceutics and Biopharmaceutics. 69, 3, p. 887-898

    Research output: Contribution to journalJournal article

  40. Published

    Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80

    Lind, M. L., Jacobsen, Jette, Holm, R. & Mullertz, Anette , 2008, In : European Journal of Pharmaceutical Sciences. 35, 3, p. 211-218

    Research output: Contribution to journalJournal article

  41. Published

    Lipid-based formulations for danazol containing a digestible surfactant, labrafil M2125CS: In vivo bioavailability and dynamic in vitro lipolysis

    Larsen, A., Holm, R., Pedersen, M. L. & Mullertz, Anette , 2008, In : Pharmaceutical Research. 25, 12, p. 2769-2777

    Research output: Contribution to journalJournal article

  42. Published

    Using biorelevant dissolution to obtain IVIVC of solid dosage forms containing a poorly-soluble model compound

    Lue, B., Nielsen, F. S., Magnussen, T., Schou, H. M., Kristensen, K., Jacobsen, L. O. & Mullertz, Anette , 2008, In : European Journal of Pharmaceutics and Biopharmaceutics. 69, 2, p. 648-657

    Research output: Contribution to journalJournal article

  43. 2009
  44. Published

    Adsorption of pharmaceutical excipients onto microcrystals of siramesine hydrochloride: Effects on physicochemical properties

    Zimmermann, A., Millqvist-Fureby, A., Elema, M. R., Hansen, T., Mullertz, Anette & Hovgaard, L., 2009, In : European Journal of Pharmaceutics and Biopharmaceutics. 71, 1, p. 109-116

    Research output: Contribution to journalJournal article

  45. Published

    Colloidal structures in media simulating intestinal fed state conditions with and without lipolysis products

    Fatouros, D., Walrand, I., Bergenstahl, B. & Mullertz, Anette , 2009, In : Pharmaceutical Research. 26, 2, p. 361-374

    Research output: Contribution to journalJournal article

  46. Published

    Effects of polysorbate 80 on the in-vitro precipitation and oral bioavailability of halofantrine from polyethylene glycol 400 formulations in rats

    Tønsberg, H., Holm, R., Boll, J. B., Jacobsen, Jette & Mullertz, Anette , 2009, In : Journal of Pharmacy and Pharmacology. 62, 1, p. 63-70

    Research output: Contribution to journalJournal article

  47. Published

    Influence of the solid form of siramesine hydrochloride on its behaviour in aqueous environments

    Zimmermann, A., Tian, F., Lopez de Diego, H., Ringkjøbing Elema, M., Rantanen, Jukka, Mullertz, Anette & Hovgaard, L., 2009, In : Pharmaceutical Research. 26, 4, p. 846-854

    Research output: Contribution to journalJournal article

  48. Published

    Optimization of the in vitro lipolysis rate of SMEDDS containing cinnarizine

    Ulmann, C., Figueriedo-Larsen, M., Refsgaard, L., Hellekilde, J., Larsen, A., Nielsen, C., Olesen, P. & Mullertz, Anette , 2009.

    Research output: Contribution to conferencePosterResearch

  49. Published

    Physicochemical characterization of simulated intestinal fed-state fluids containing lyso-phosphatidylcholine and cholesterol

    Fatouros, D., Walrand, I., Bergenstahl, B. & Mullertz, Anette , 2009, In : Dissolution Technologies. 16, 3, p. 47-50

    Research output: Contribution to journalJournal article

  50. Published

    Tabletter med "løse ender" giver forsinket afgift af lægemiddelstof

    Naelapaa, K., Mullertz, Anette , Jacobsen, Jette, Rømsing, Janne & Bar-Shalom, Daniel, 2009, In : Lægemiddelforskning. p. 4-6 3 p.

    Research output: Contribution to journalJournal article

  51. Published

    Tabletter med løse ender

    Naelapaa, K., Mullertz, Anette , Jacobsen, Jette, Rømsing, Janne & Bar-Shalom, Daniel, 2009, In : Lægemiddelforskning. p. 4-6

    Research output: Contribution to journalJournal article

  52. Published

    The use of biorelevant dissolution media in determining the region of microemulsion: Implications for in vitro lipid formulation assessment

    Ogbonna, A., Ren, S., Olesen, P. & Mullertz, Anette , 2009.

    Research output: Contribution to conferencePosterResearch

  53. 2010
  54. Published

    An updated and simplified method for bile duct cannulation of rats

    Tønsberg, H., Holm, R., Bjerregaaard, T. G., Jacobsen, Jette & Mullertz, Anette , 2010, In : Laboratory Animals. 44, 4, p. 373-376

    Research output: Contribution to journalJournal article

  55. Published

    Biorelevant media simulating fed state intestinal fluids: colloid phase characterization and impact on solubilization capacity

    Kleberg, K., Jacobsen, F., Fatouros, D. G. & Mullertz, Anette , 2010, In : Journal of Pharmaceutical Sciences. 99, 8, p. 3522-3532 11 p.

    Research output: Contribution to journalJournal article

  56. Published

    Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studies

    Kleberg, K., Jacobsen, Jette & Mullertz, Anette , 2010, In : Journal of Pharmacy and Pharmacology. 62, 11, p. 1656-1668 13 p.

    Research output: Contribution to journalJournal article

  57. Published

    Meeting report: applied biopharmaceutics and quality by design for dissolution/release specification setting: product quality for patient benefit

    Selen, A., Cruanes, M. T., Mullertz, Anette , Dicikinsion, P. A., Cook, J. A., Polli, J. E., Kesisoglou, F., Crison, J., Johnson, K. C., Muirhead, G. T., Schofield, T. & Tsong, Y., 2010, In : The AAPS Journal. 12, 3, p. 465-472

    Research output: Contribution to journalReview

  58. Published

    New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs

    Mullertz, Anette , Ogbonna, A., Ren, S. & Rades, Thomas, 2010, In : Journal of Pharmacy and Pharmacology. 62, 11, p. 1622-1636 15 p.

    Research output: Contribution to journalJournal article

  59. Published

    Precipitation of a poorly soluble model drug during in vitro lilpolysis: characterization and dissolution of the precipitate

    Sassene, P. J., Knopp, M. M., Hesselkilde, J. Z., Koradia, V. S., Larsen, A. T., Rades, T. & Mullertz, Anette , 2010, In : Journal of Pharmaceutical Sciences. 99, 12, p. 4982-4991

    Research output: Contribution to journalJournal article

  60. Published

    Solid forms of amlodipine besylate: Physiochemical, structural, and thermodynamic characterization

    Koradia, V. S., Lopez de Diego, H., Frydenvang, Karla Andrea, Ringkjøbing-Elema, M., Mullertz, Anette , Bond, A. D. & Rantanen, Jukka, 28 Oct 2010, In : Crystal Growth & Design. 10, 12, p. 5279-5290

    Research output: Contribution to journalJournal article

  61. Published

    Impact of lipolysis on absorption of a poorly soluble model drug formulated in SMEDDS - an in vitro study

    Eriksson, A. H., Refsgaard, L., Larsen, A. T., Mullertz, Anette & Olesen, P. H., Nov 2010.

    Research output: Contribution to conferencePosterResearch

  62. Published

    Insights into the ultrastructure of human intestinal fluids in the fed state by electron microscopy analysis

    Mullertz, Anette , Fatouros, D., Smith, J. R., Vertzoni, M. & Rappas, C., Nov 2010.

    Research output: Contribution to conferencePosterResearch

  63. Published

    Redissolution and polymorphic characterization of a poorly water-soluble drug precipitated during in vitro lipolysis from a lipid-based formulation

    Ren, S., Ogbonna, A., Koradia, V. S., Sassene, P. J., Rades, T. & Mullertz, Anette , Nov 2010.

    Research output: Contribution to conferencePosterResearch

  64. Published

    Selection of a lipase for development of an in vitro gastric lipid digestion model

    Larsen, A. T., Jensen, L. G., Hansen, K. K. & Mullertz, Anette , Nov 2010.

    Research output: Contribution to conferencePosterResearch

  65. 2011
  66. Published

    A novel excipient, 1-perfluorohexyloctane shows limited utility for the oral delivery of poorly water-soluble drugs

    Holm, R., Jørgensen, E. B., Harborg, M., Larsen, R. S., Holm, P., Mullertz, Anette & Jacobsen, Jette, 2011, In : European Journal of Pharmaceutical Sciences. 42, p. 416-422

    Research output: Contribution to journalJournal article

  67. Published

    Effect of bile on the oral absorption of halofantrine in polyethylene glycol 400 and polysorbate 80 formulations dosed to bile duct cannulated rats

    Tønsberg, H., Holm, R., Mu, Huiling, Boll, J. B., Jacobsen, Jette & Mullertz, Anette , 2011, In : Journal of Pharmacy and Pharmacology. 63, p. 817-824

    Research output: Contribution to journalJournal article

  68. Published

    In vitro lipolysis models as a tool for the characterization of oral lilpid and surfactant based drug delivery systems

    Larsen, A. T., Sassene, P. & Mullertz, Anette , 2011, In : International Journal of Pharmaceutics. 417, 1-2, p. 245-255

    Research output: Contribution to journalJournal article

  69. Published

    Insights into the early dissolution events of amlodipine using UV imaging and Raman spectroscopy

    Bøtker, Johan Peter, Savolainen, M., Koradia, V., Tian, F., Rades, Thomas, Mullertz, Anette , Cornett, Claus, Rantanen, Jukka & Østergaard, Jesper, 2011, In : Molecular Pharmaceutics. 8, 4, p. 1372-1380 9 p.

    Research output: Contribution to journalJournal article

  70. Published

    Phase transformations of amlodipine besylate solid forms

    Koradia, V. S., Lemos, A. F. F. D., Allesø, M., Diego, H. L. D., Ringkjøbing-Elema, M., Mullertz, Anette & Rantanen, Jukka, 2011, In : Journal of Pharmaceutical Sciences. 100, 7, p. 2896-2910

    Research output: Contribution to journalJournal article

  71. 2012
  72. Published

    Characterising lipid lipolysis and its implication in lipid-based formulation development

    Thomas, N., Holm, R., Rades, Thomas & Mullertz, Anette , 2012, In : The AAPS journal. 14, 4, p. 860-71 12 p.

    Research output: Contribution to journalJournal article

  73. Published

    Exploring the fate of liposomes in the intestine by dynamic in vitro lipolysis

    Parmentier, J., Thomas, N., Mullertz, Anette , Fricker, G. & Rades, Thomas, 2012, In : International Journal of Pharmaceutics. 437, 1-2, p. 253-63 11 p.

    Research output: Contribution to journalJournal article

  74. Published

    In vitro digestion testing of lipid-based delivery systems: calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the solubilization capacity of colloidal digestion products

    Devraj, R., Williams, H. D., Warren, D. B., Mullertz, Anette , Porter, C. J. H. & Pouton, C. W., 2012, In : International Journal of Pharmaceutics. 441, 1-2, p. 323-333

    Research output: Contribution to journalJournal article

  75. Published

    Influence of bile on the absorption of halofantrine from lipid-based formulations

    Holm, R., Tønsberg, H., Jørgensen, E. B., Abedinpour, P., Farsad, S. & Mullertz, Anette , 2012, In : European Journal of Pharmaceutics and Biopharmaceutics. 81, 2, p. 281-287

    Research output: Contribution to journalJournal article

  76. Published

    Influence of lipid composition and drug load on the in vitro performance of self-nanoemulsifying drug delivery systems

    Thomas, N., Mullertz, Anette , Graf, A. & Rades, T., 2012, In : Journal of Pharmaceutical Sciences. 101, 5, p. 1721-1731

    Research output: Contribution to journalJournal article

  77. Published

    Insights into intermediate phases of human intestinal fluids visualized by atomic force microscopy and cryo-transmission electron microscopy ex vivo

    Mullertz, Anette , Fatouros, D. G., Smith, J. R., Vertzoni, M. & Reppas, C., 2012, In : Molecular Pharmaceutics. 9, 2, p. 237-247

    Research output: Contribution to journalJournal article

  78. Published

    Oral delivery of peptides and proteins using lipid-based drug delivery systems

    Li, P., Nielsen, Hanne Mørck & Mullertz, Anette , 2012, In : Expert Opinion on Drug Delivery. 9, 10, p. 1289-304 16 p.

    Research output: Contribution to journalReview

  79. Published

    SNEDDS containing poorly water soluble cinnarizine; development and in Vitro characterization of dispersion, digestion and solubilization

    Larsen, A. T., Ogbonna, A., Abu-Rmaileh, R., Abrahmsson, B., Østergaard, Jesper & Mullertz, Anette , 2012, In : Pharmaceutics. 4, 4, p. 641-665

    Research output: Contribution to journalJournal article

  80. Published

    Spatial confinement can lead to increased stability of amorphous indomethacin

    Nielsen, L. H., Keller, S. S., Gordon, K. C., Boisen, A., Rades, Thomas & Mullertz, Anette , 2012, In : European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 81, 2, p. 418-25 8 p.

    Research output: Contribution to journalJournal article

  81. Published

    Toward the Establishment of Standardized in Vitro Tests for Lipid-Based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I, II, IIIA, IIIB, and IV Formulations during in Vitro Digestion

    Williams, H. D., Anby, M. U., Sassene, P., Kleberg, K., Bakala-N’Goma, J., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Carrière, F., Mullertz, Anette , Pouton, C. W. & Porter, C. J. H., 2012, In : Molecular Pharmaceutics. 9, 11, p. 3286-3300 15 p.

    Research output: Contribution to journalJournal article

  82. Published

    Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: Method parameterization and comparison of in vitro digestion profiles across a range of representative formulations

    Williams, H. D., Sassene, P., Kleberg, K., Bakala-N'Goma, J., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Carrière, F., Mullertz, Anette , Porter, C. J. H. & Pouton, C. W., 2012, In : Journal of Pharmaceutical Sciences. 101, 9, p. 3360-3380

    Research output: Contribution to journalJournal article

  83. Published

    Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessful

    Holm, R., Hesselkilde, J. Z., Jørgensen, E. B. & Mullertz, Anette , 2012, In : European Journal of Pharmaceutical Sciences. 47, p. 347-351

    Research output: Contribution to journalJournal article

  84. 2013
  85. Published

    A new approach to dissolution testing by UV imaging and finite element simulations

    Bøtker, Johan Peter, Rantanen, Jukka, Rades, Thomas, Mullertz, Anette , Østergaard, Jesper & Jensen, Henrik, 2013, In : Pharmaceutical Research. 30, 5, p. 1328-1337

    Research output: Contribution to journalJournal article

  86. Published

    Development and rheological profiling of biosimilar mucus

    Bøgh, M., Baldursdottir, S. G., Nielsen, M. H., Mullertz, Anette & Nielsen, Hanne Mørck, 2013, In : Nordic Rheology Society Annual Transactions. 21, p. 233-240

    Research output: Contribution to journalConference article

  87. Published

    Mucosal drug delivery: barriers, in vitro models and formulation strategies

    Bøgh, M., Foged, Camilla, Mullertz, Anette & Nielsen, Hanne Mørck, 2013, In : Journal of Drug Delivery Science and Technology. 23, 4, p. 383-391

    Research output: Contribution to journalReview

  88. Published

    Oral bioavailability of cinnarizine in dogs: relation to SNEDDS droplet size, drug solubility and in vitro precipitation

    Larsen, A. T., Ohlsson, A. G., Polentarutti, B., Barker, R. A., Phillips, A. R., Abu-Rmaileh, R., Dickinson, P. A., Abrahamsson, B., Østergaard, Jesper & Mullertz, Anette , 2013, In : European Journal of Pharmaceutical Sciences. 48, 1-2, p. 339-50 12 p.

    Research output: Contribution to journalJournal article

  89. Published

    Polymer selection for simulation of rheological properties of human gastric fluid

    Pedersen, P. B., Vilmann, P., Bar-Shalom, Daniel, Mullertz, Anette & Baldursdottir, S. G., 2013, In : Nordic Rheology Society Annual Transactions. 21, p. 241-247

    Research output: Contribution to journalConference article

  90. Published

    Real-time dissolution behavior of furosemide in biorelevant media as determined by UV imaging

    Gordon, S., Naelapää, K., Rantanen, Jukka, Selen, A., Mullertz, Anette & Østergaard, Jesper, 2013, In : Pharmaceutical Development and Technology. 18, 6, p. 1407-16 10 p.

    Research output: Contribution to journalJournal article

  91. Published

    Supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS) enhance the bioavailability of the poorly water-soluble drug Simvastatin in dogs

    Thomas, N., Holm, R., Garmer, M., Karlsson, J. J., Mullertz, Anette & Rades, Thomas, 2013, In : A A P S Journal. 15, 1, p. 219-27 9 p.

    Research output: Contribution to journalJournal article

  92. Published

    Towards the understanding of complex fluids in pharmaceutical sciences

    Pedersen, P. B., Pekka Pajander, J., Mullertz, Anette , Vilmann, Peter, Jørgensen, Lene & Baldursdottir, S. G., 2013, In : Journal of Drug Delivery Science and Technology. 23, 4, p. 393 401 p.

    Research output: Contribution to journalJournal article

  93. Published

    Ex vivo - correlation of the absorption of metoprolol through human and porcine buccal mucosa at varying pH.

    Meng-Lund, E., Marxen, E., Pedersen, Anne Marie Lynge, Mullertz, Anette , Holm, R., Hyrup, B. & Jacobsen, Jette, 4 Mar 2013.

    Research output: Contribution to conferencePosterResearchpeer-review

  94. Published

    Optimization of self nanoemulsifying drug delivery system for poorly water-soluble drug using response surface methodology

    Ren, S., Mu, Huiling, Alchaer, F., Chtatou, A. & Mullertz, Anette , May 2013, In : Drug Development and Industrial Pharmacy. 39, 5, p. 799-806 8 p.

    Research output: Contribution to journalJournal article

  95. Published

    Characterization during storage and dissolution of Solid dispersions containing furosemide and hydroxypropyl methylcellulose

    Nielsen, L. H., Rades, Thomas & Mullertz, Anette , 1 Jul 2013, In : Journal of Drug Delivery Science and Technology. 23, 4, p. 409-415 7 p.

    Research output: Contribution to journalJournal article

  96. Published

    Recent developments in oral lipid-based drug delivery

    Thomas, N., Rades, Thomas & Mullertz, Anette , 1 Jul 2013, In : Journal of Drug Delivery Science and Technology. 23, 4, p. 375-382 8 p.

    Research output: Contribution to journalJournal article

  97. Published

    Preparation and characterization of insulin-surfactant complexes for loading into lipid-based drug delivery systems

    Li, P., Nielsen, Hanne Mørck, Fano, M. & Mullertz, Anette , Aug 2013, In : Journal of Pharmaceutical Sciences. 102, 8, p. 2689-98 10 p.

    Research output: Contribution to journalJournal article

  98. Published

    Solid lipid particles for oral delivery of peptide and protein drugs I - Elucidating the release mechanism of lysozyme during lipolysis

    Christophersen, P. C. B., Zhang, L., Yang, Mingshi, Nielsen, Hanne Mørck, Mullertz, Anette & Mu, Huiling, 2 Aug 2013, In : European Journal of Pharmaceutics and Biopharmaceutics. 85, 3, part A, p. 473-480

    Research output: Contribution to journalJournal article

  99. Published

    Bile salts and their importance for drug absorption

    Holm, R., Mullertz, Anette & Mu, Huiling, 30 Aug 2013, In : International Journal of Pharmaceutics. 453, 1, p. 44-55 12 p.

    Research output: Contribution to journalReview

  100. Published

    Lipid-based formulations for oral administration of poorly water-soluble drugs

    Mu, Huiling, Holm, R. & Mullertz, Anette , 30 Aug 2013, In : International Journal of Pharmaceutics. 453, 1, p. 215-24 10 p.

    Research output: Contribution to journalJournal article

  101. Published

    Unravelling the ultrastructure of ascending colon fluids from patients with ulcerative colitis by cryogenic transmission electron microscopy

    Mullertz, Anette , Fatouros, D. G., Vertzoni, M. & Reppas, C., Oct 2013, In : The Journal of pharmacy and pharmacology. 65, 10, p. 1482-7 6 p.

    Research output: Contribution to journalJournal article

  102. Published

    Characterization of fasted human gastric fluid for relevant rheological parameters and gastric lipase activities

    Pedersen, P. B., Vilmann, Peter, Bar-Shalom, Daniel, Mullertz, Anette & Baldursdottir, S., Nov 2013, In : European Journal of Pharmaceutics and Biopharmaceutics. 85, 3, Pt B, p. 958-65 8 p.

    Research output: Contribution to journalJournal article

  103. Published

    Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to rats

    Nielsen, L. H., Gordon, S., Holm, R., Selen, A., Rades, Thomas & Mullertz, Anette , Nov 2013, In : European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 85, 3 Pt B, p. 942-51 10 p.

    Research output: Contribution to journalJournal article

  104. Published

    Biorelevant characterisation of amorphous furosemide salt exhibits conversion to a furosemide hydrate during dissolution

    Nielsen, L. H., Gordon, S., Pajander, J. P., Østergaard, Jesper, Rades, Thomas & Mullertz, Anette , 30 Nov 2013, In : International Journal of Pharmaceutics. 457, 1, p. 14-24 11 p.

    Research output: Contribution to journalJournal article

  105. Published

    Bioavailability of cinnarizine in dogs: effect of SNEDDS loading level and correlation with cinnarizine solubilization during in vitro lipolysis

    Larsen, A. T., Åkesson, P., Juréus, A., Saaby, L., Abu-Rmaileh, R., Abrahamsson, B., Østergaard, Jesper & Mullertz, Anette , Dec 2013, In : Pharmaceutical Research. 30, 12, p. 3101-13 13 p.

    Research output: Contribution to journalJournal article

  106. Published

    Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in vitro digestion of type I, II, IIIA, IIIB and IV lipid-based formulations

    Williams, H. D., Sassene, P., Kleberg, K., Calderone, M., Igonin, A., Jule, E., Vertommen, J., Blundell, R., Benameur, H., Mullertz, Anette , Pouton, C. W., Porter, C. J. H. & LFCS Consortium, L. C., Dec 2013, In : Pharmaceutical Research. 30, 12, p. 3059-76 18 p.

    Research output: Contribution to journalJournal article

  107. 2014
  108. Published

    Cinnarizine food-effects in beagle dogs can be avoided by administration in a Self Nano Emulsifying Drug Delivery System (SNEDDS)

    Christiansen, M. L., Holm, R., Kristensen, J., Kreilgaard, M., Jacobsen, Jette, Abrahamsson, B. & Mullertz, Anette , 2014, In : European Journal of Pharmaceutical Sciences. 57, p. 164-172

    Research output: Contribution to journalJournal article

  109. Published

    Fed and fasted state gastro-intestinal in vitro lipolysis: In vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS

    Christophersen, P. C. B., Christiansen, M. L., Holm, R., Kristensen, J., Jacobsen, Jette, Abrahamsson, B. & Mullertz, Anette , 2014, In : European Journal of Pharmaceutical Sciences. 57, p. 232-239

    Research output: Contribution to journalJournal article

  110. Published

    Investigating the correlation between in vivo absorption and in vitro release of fenofibrate from lipid matrix particles in biorelevant medium

    Borkar, N. N., Xia, D., Holm, R., Gan, Y., Mullertz, Anette , Yang, Mingshi & Mu, Huiling, 2014, In : European Journal of Pharmaceutical Sciences. 51, p. 204-10 7 p.

    Research output: Contribution to journalJournal article

  111. Published

    Trilaurin diminishes food effect on the release of desmopressin from solid lipid microparticles

    Christophersen, P., Vaghela, D., Mullertz, Anette , Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, 2014.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  112. Published

    Property profiling of biosimilar mucus in a novel mucus-containing in vitro model for assessment of intestinal drug absorption

    Bøgh, M., Baldursdóttir, S. G., Mullertz, Anette & Nielsen, Hanne Mørck, 8 Jan 2014, In : European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 87, p. 227-235 9 p.

    Research output: Contribution to journalJournal article

  113. Published

    Polymer-filled microcontainers for oral delivery loaded using supercritical impregnation

    Marizza, P., Keller, S. S., Mullertz, Anette & Boisen, A., 10 Jan 2014, In : Journal of controlled release : official journal of the Controlled Release Society. 173, p. 1-9 9 p.

    Research output: Contribution to journalJournal article

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