Anette Müllertz

Anette Müllertz

Professor


  1. 2020
  2. Published

    Formulation of co-amorphous systems from naproxen and naproxen sodium and in situ monitoring of physicochemical state changes during dissolution testing by Raman spectroscopy

    Ueda, H., Bøtker, Johan Peter, Edinger, M., Löbmann, Korbinian, Grohganz, Holger, Mullertz, Anette , Rades, Thomas & Østergaard, Jesper, 25 Sep 2020, In : International Journal of Pharmaceutics. 587, 119662.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. E-pub ahead of print
  4. Published

    Effect of supersaturation on absorption of indomethacin and tadalafil in a single pass intestinal perfusion rat model, in the absence and presence of a precipitation inhibitor

    Strindberg, Sophie , Plum, J., Stie, Mai Bay, Christiansen, M. L., Nielsen, L. H., Rades, Thomas & Mullertz, Anette , Jun 2020, In : European Journal of Pharmaceutics and Biopharmaceutics. 151, p. 108-115

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Towards the development of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) containing trimethyl chitosan for the oral delivery of amphotericin B: In vitro assessment and cytocompatibility studies

    Kontogiannidou, E., Meikopoulos, T., Virgiliou, C., Bouropoulos, N., Gika, H., Vizirianakis, I. S., Mullertz, Anette & Fatouros, D. G., Apr 2020, In : Journal of Drug Delivery Science and Technology. 56, 9 p., 101524.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Poorly soluble drugs

    Siepmann, J., Rades, Thomas, Mullertz, Anette & Loftsson, T., 15 Mar 2020, In : International Journal of Pharmaceutics. 577, 119055.

    Research output: Contribution to journalEditorialResearchpeer-review

  7. Published

    In Vitro, Ex Vivo and In Vivo Evaluation of Microcontainers for Oral Delivery of Insulin

    Jørgensen, Jacob Rune, Yu, F., Ramakrishnan, Venkatasubramanian, Nielsen, L. H., Nielsen, Hanne Mørck, Boisen, A., Rades, Thomas & Mullertz, Anette , 7 Jan 2020, In : Pharmaceutics. 12, 1, 14 p., 48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Comparison of induction methods for supersaturation: pH shift versus solvent shift

    Plum, J., Bavnhoj, C., Palmelund, Henrik Brogaard, Perez-Alos, L., Mullertz, Anette & Rades, Thomas, 5 Jan 2020, In : International Journal of Pharmaceutics. 573, 8 p., 118862.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Milk osteopontin retains integrin-binding activity after in vitro gastrointestinal transit

    Christensen, B., Karlsen, N. J., Siqueira Jørgensen, Scheyla Daniela, Jacobsen, L. N., Ostenfeld, M. S., Petersen, S. V., Mullertz, Anette & Sorensen, E. S., Jan 2020, In : Journal of Dairy Science. 103, 1, p. 42-51

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Evaluating side-by-side diffusion models for studying drug supersaturation in an absorptive environment: a case example of fenofibrate and felodipine

    Eliasen, J. N., Berthelsen, Ragna, Slot, A. L. & Mullertz, Anette , 2020, In : Journal of Pharmacy and Pharmacology. 72, 3, p. 371-384

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Evaluation of self -emulsifying drug delivery systems for oral insulin delivery using an in vitro model simulating the intestinal proteolysis

    Liu, J., Hirschberg, C., Fano, M., Mu, Huiling & Mullertz, Anette , 2020, In : European Journal of Pharmaceutical Sciences. 147, 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Impact of gastrointestinal physiology on drug absorption in special populations??An UNGAP review

    Stillhart, C., Vucicevic, K., Augustijns, P., Basit, A. W., Batchelor, H., Flanagan, T. R., Gesquiere, I., Greupink, R., Keszthelyi, D., Koskinen, M., Madla, C. M., Matthys, C., Miljus, G., Mooij, M. G., Parrott, N., Ungell, A. -., de Wildt, S. N., Orlu, M., Klein, S. & Mullertz, Anette , 2020, In : European Journal of Pharmaceutical Sciences. 147, 28 p., 105280.

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    Improving the drug load and in vitro performance of supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS) using polymeric precipitation inhibitors

    Bannow, Jacob, Yorulmaz, Y., Löbmann, Korbinian, Mullertz, Anette & Rades, Thomas, 2020, In : International Journal of Pharmaceutics. 575, 1188960.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B

    Kontogiannidou, E., Meikopoulos, T., Gika, H., Panteris, E., Vizirianakis, I. S., Mullertz, Anette & Fatouros, D. G., 2020, In : Pharmaceutics. 12, 8, 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Integrated Multi-stakeholder Systems Thinking Strategy: Decision-making with Biopharmaceutics Risk Assessment Roadmap (BioRAM) to Optimize Clinical Performance of Drug Products

    Selen, A., Mullertz, Anette , Kesisoglou, F., Ho, R. J. Y., Cook, J. A., Dickinson, P. A. & Flanagan, T., 2020, In : AAPS Journal. 22, 5, 20 p., 97.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. E-pub ahead of print

    Towards analyzing the potential of exosomes to deliver microRNA therapeutics

    Giassafaki, L. N., Siqueira, S., Panteris, E., Psatha, K., Chatzopoulou, F., Aivaliotis, M., Tzimagiorgis, G., Mullertz, Anette , Fatouros, D. G. & Vizirianakis, I. S., 2020, In : Journal of Cellular Physiology. 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems

    Tran, T., Bonlokke, P., Rodriguez-Rodriguez, C., Nosrati, Z., Esquinas, P. L., Borkar, N., Plum, J., Strindberg, Sophie , Karagiozov, S., Rades, Thomas, Mullertz, Anette , Saatchi, K. & Häfeli, Urs Otto, 2020, In : Journal of Controlled Release. 317, p. 375-384

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. 2019
  19. Published

    Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery

    Abid, Z., Dalskov Mosgaard, M., Manfroni, G., Singh Petersen, R., Hagner Nielsen, L., Mullertz, Anette , Boisen, A. & Sylvest Keller, S., Nov 2019, In : Polymers. 11, 10 p., 1828.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    In vitro digestion models to evaluate lipid based drug delivery systems; present status and current trends

    Berthelsen, Ragna, Klitgaard, Mette, Rades, Thomas & Mullertz, Anette , 29 Jun 2019, In : Advanced Drug Delivery Reviews. 142, p. 35-49 15 p.

    Research output: Contribution to journalReviewResearchpeer-review

  21. Published

    Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects

    Bergstrom, C. A. S., Box, K., Holm, R., Matthews, W., McAllister, M., Mullertz, Anette , Rades, Thomas, Schaefer, K. J. & Teleki, A., Jun 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 139, p. 101-114

    Research output: Contribution to journalReviewResearchpeer-review

  22. Published

    SEDDS for intestinal absorption of insulin: Application of Caco-2 and Caco-2/HT29 co-culture monolayers and intra-jejunal instillation in rats

    Liu, J., Werner, U., Funke, M., Besenius, M., Saaby, L., Fano, M., Mu, Huiling & Mullertz, Anette , 5 Apr 2019, In : International Journal of Pharmaceutics. 560, p. 377-384

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration

    Butler, J., Hens, B., Vertzoni, M., Brouwers, J., Berben, P., Dressman, J., Andreas, C. J., Schaefer, K. J., Mann, J., McAllister, M., Jamei, M., Kostewicz, E., Kesisoglou, F., Langguth, P., Minekus, M., Mullertz, Anette , Schilderink, R., Koziolek, M., Jedamzik, P., Weitschies, W., Reppas, C. & Augustijns, P., Mar 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 136, p. 70-83

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Exploring the utility of the Chasing-rinciple: influence of drug-free SNEDDS composition on solubilization of carvedilol, cinnarizine and R3040 in aqueous suspension

    Siqueira Jørgensen, Scheyla Daniela, Rades, Thomas, Mu, Huiling, Graeser, K. & Mullertz, Anette , Jan 2019, In : Acta Pharmaceutica Sinica B. 9, 1, p. 194-201

    Research output: Contribution to journalLetterResearchpeer-review

  25. Published

    Biodegradable microcontainers-towards real life applications of microfabricated systems for oral drug delivery

    Abid, Z., Strindberg, Sophie , Javed, M. M., Mazzoni, C., Vaut, L., Nielsen, L. H., Gundlach, C., Petersen, R. S., Mullertz, Anette , Boisen, A. & Keller, S. S., 2019, In : Lab on a Chip. 19, 17, p. 2905-2914 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Developing a predictive in vitro dissolution model based on gastrointestinal fluid characterisation in rats

    Christfort, J. F., Strindberg, Sophie , Plum, J., Hall-Andersen, J., Janfelt, Christian, Nielsen, L. H. & Mullertz, Anette , 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 142, p. 307-314 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Ex vivo intestinal perfusion model for investigating mucoadhesion of microcontainers

    Dalskov Mosgaard, M., Strindberg, Sophie , Abid, Z., Singh Petersen, R., Højlund Eklund Thamdrup, L., Joukainen Andersen, A., Sylvest Keller, S., Mullertz, Anette , Hagner Nielsen, L. & Boisen, A., 2019, In : International Journal of Pharmaceutics. 570, 118658.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Fenofibrate oral absorption from SNEDDS and super-SNEDDS is not significantly affected by lipase inhibition in rats

    Michaelsen, M. H., Siqueira Jørgensen, Scheyla Daniela, Abdi, I. M., Wasan, K. M., Rades, Thomas & Mullertz, Anette , 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 142, p. 258-264 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    In vivo models and decision trees for formulation development in early drug development: A review of current practices and recommendations for biopharmaceutical development

    Zane, P., Gieschen, H., Kersten, E., Mathias, N., Ollier, C., Johansson, P., Van den Bergh, A., Van Hemelryck, S., Reichel, A., Rotgeri, A., Schäfer, K., Mullertz, Anette & Langguth, P., 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 142, p. 222-231 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Microcontainers for oral insulin delivery - in vitro studies of permeation enhancement

    Jørgensen, Jacob Rune, Leth Jepsen, M., Hagner Nielsen, L., Dufva, M., Nielsen, Hanne Mørck, Rades, Thomas, Boisen, A. & Mullertz, Anette , 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 143, p. 98-105

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Polymeric Lids for Microcontainers for Oral Protein Delivery

    Mazzoni, C., Jacobsen, R. D., Mortensen, J., Jørgensen, Jacob Rune, Vaut, L., Jacobsen, Jette, Gundlach, C., Mullertz, Anette , Nielsen, L. H. & Boisen, A., 2019, In : Macromolecular Bioscience. 19, 5, 1900004.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Self-emulsifying drug delivery systems (SEDDS) – The splendid comeback of an old technology

    Bernkop-Schnürch, A., Mullertz, Anette & Rades, Thomas, 2019, In : Advanced Drug Delivery Reviews. 142, p. 1-2 2 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  33. Published

    Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

    Boyd, B. J., Bergström, C. A. S., Vinarov, Z., Kuentz, M., Brouwers, J., Augustijns, P., Brandl, M., Bernkop-Schnürch, A., Shrestha, N., Préat, V., Mullertz, Anette , Bauer-Brandl, A. & Jannin, V., 2019, In : European Journal of Pharmaceutical Sciences. 137, 27 p., 104967.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. 2018
  35. Published

    In vivo anesthetic effect and mechanism of action of active compounds from Alpinia galanga oil on Cyprinus carpio (koi carp)

    Khumpirapang, N., Chaichit, S., Jiranusornkul, S., Pikulkaew, S., Mullertz, Anette & Okonogi, S., 1 Nov 2018, In : Aquaculture. 496, p. 176-184

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers

    Blaabjerg, L. I., Grohganz, Holger, Lindenberg, E., Löbmann, Korbinian, Mullertz, Anette & Rades, Thomas, 21 Sep 2018, In : Pharmaceutics. 10, 4, 14 p., 164.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    A fast and novel internal calibration method for quantitative Raman measurements on aqueous solutions

    Duraipandian, S., Knopp, M. M., Pollard, M. R., Kerdoncuff, H., Petersen, J. C. & Mullertz, Anette , 7 Aug 2018, In : Analytical Methods. 10, 29, p. 3589-3593

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and L-Arginine

    Ueda, H., Wu, W., Löbmann, Korbinian, Grohganz, Holger, Mullertz, Anette & Rades, Thomas, May 2018, In : Molecular Pharmaceutics. 15, 5, p. 2036-2044

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    The ability of two in vitro lipolysis models reflecting the human and rat gastro-intestinal conditions to predict the in vivo performance of SNEDDS dosing regimens

    Siqueira Jørgensen, Scheyla Daniela, Al Sawaf, M., Graeser, K., Mu, Huiling, Mullertz, Anette & Rades, Thomas, Mar 2018, In : European Journal of Pharmaceutics and Biopharmaceutics. 124, p. 116-124

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Effect of composition of simulated intestinal media on the solubility of poorly soluble compounds investigated by design of experiments

    Madsen, C. M., Feng, K., Leithead, A., Canfield, N., Jørgensen, S. A., Mullertz, Anette & Rades, Thomas, Jan 2018, In : European Journal of Pharmaceutical Sciences. 111, p. 311-319 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Using Potentiometric Free Drug Sensors to Determine the Free Concentration of Ionizable Drugs in Colloidal Systems

    Tran, T., Chakraborty, A., Xi, X., Bohets, H., Cornett, Claus, Tsinman, K., Rades, Thomas & Mullertz, Anette , Jan 2018, In : Journal of Pharmaceutical Sciences. 107, 1, p. 103-112

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Are phytosomes a superior nanodelivery system for the antioxidant rutin?

    Vu, H. T. H., Hook, S. M., Siqueira Jørgensen, Scheyla Daniela, Mullertz, Anette , Rades, Thomas & McDowell, A., 2018, In : International Journal of Pharmaceutics. 548, 1, p. 82-91 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Characterization of the hydrodynamics in a miniaturized dissolution apparatus

    Johansson, Kristoffer Enøe, Plum, J., Mosleh, M., Madsen, C. M., Rades, Thomas & Mullertz, Anette , 2018, In : Journal of Pharmaceutical Sciences. 107, 4, p. 1095-1103 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Development and characterization of clove oil nanoemulsions and self-microemulsifying drug delivery systems

    Kheawfu, K., Pikulkaew, S., Rades, Thomas, Mullertz, Anette & Okonogi, S., 2018, In : Journal of Drug Delivery Science and Technology. 46, p. 330-338 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Formulation of self-nanoemulsifying drug delivery systems containing monoacyl phosphatidylcholine and Kolliphor® RH40 using experimental design

    Tran, T., Rades, Thomas & Mullertz, Anette , 2018, In : Asian Journal of Pharmaceutical Sciences. 13, p. 536-545

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Hydrolysed pea proteins mitigate in vitro wheat starch digiestibility

    López-Barón , N., Sagnelli, D., Blennow, Andreas, Holse, M., Gao, J., Saaby, L., Mullertz, Anette , Jespersen, Birthe P Møller & Vasanthan, T., 2018, In : Food Hydrocolloids. 79, p. 117-126 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. 2017
  48. Published

    From concept to in vivo testing: Microcontainers for oral drug delivery

    Mazzoni, C., Tentor, F., Strindberg, Sophie , Nielsen, L. H., Keller, S. S., Alstrøm, T. S., Gundlach, C., Mullertz, Anette , Marizza, P. & Boisen, A., 28 Dec 2017, In : Journal of Controlled Release. 268, p. 343-351 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Studying furosemide solubilization using an in vitro model simulating gastrointestinal digestion and drug solubilization in neonates and young infants

    Klitgaard, Mette, Sassene, P. J., Selen, A., Mullertz, Anette & Berthelsen, Ragna, 15 Nov 2017, In : European Journal of Pharmaceutical Sciences. 109, p. 191-199 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Investigation of the Intra- and Interlaboratory Reproducibility of a Small Scale Standardized Supersaturation and Precipitation Method

    Plum, J., Madsen, C. M., Teleki, A., Bevernage, J., da Costa Mathews, C., Karlsson, E. M., Carlert, S., Holm, R., Müller, T., Matthews, W., Sayers, A., Ojala, K., Tsinsman, K., Lingamaneni, R., Bergström, C. A., Rades, Thomas & Mullertz, Anette , 7 Nov 2017, In : Molecular Pharmaceutics. 14, 12, p. 4161-4169

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide

    Svagan, A. J., Mullertz, Anette & Löbmann, Korbinian, Nov 2017, In : The Journal of pharmacy and pharmacology. 69, 11, p. 1477-1484 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Monoacyl phosphatidylcholine inhibits the formation of lipid multilamellar structures during in vitro lipolysis of self-emulsifying drug delivery systems

    Tran, T., Siqueira Jørgensen, Scheyla Daniela, Amenitsch, H., Rades, Thomas & Mullertz, Anette , 15 Oct 2017, In : European Journal of Pharmaceutical Sciences. 108, p. 62-70

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Efficacy of oral lipid-based formulations of apomorphine and its diester in a Parkinson's disease rat model

    Borkar, N., Andersson, D. R., Yang, Mingshi, Mullertz, Anette , Holm, R. & Mu, Huiling, Sep 2017, In : Journal of Pharmacy and Pharmacology. 69, 9, p. 1110-1115

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Solution or suspension - Does it matter for lipid based systems? In vivo studies of chase dosing lipid vehicles with aqueous suspensions of a poorly soluble drug

    Larsen, A. T., Holm, R. & Mullertz, Anette , Aug 2017, In : European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 117, p. 308-314 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    In vitro and in vivo performance of monoacyl phospholipid-based self-emulsifying drug delivery systems

    Tran, T., Siqueira Jørgensen, Scheyla Daniela, Amenitsch, H., Mullertz, Anette & Rades, Thomas, 10 Jun 2017, In : Journal of Controlled Release. 255, p. 45-53 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Dissolution enhancement of griseofulvin from griseofulvin-sodium dodecyl sulfate discs investigated by UV imaging

    Madelung, P., Bertelsen, P., Jacobsen, Jette, Mullertz, Anette & Østergaard, Jesper, Jun 2017, In : Journal of Drug Delivery Science and Technology. 39, p. 516-522

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Cellulose Nanopaper and Nanofoam for Patient-Tailored Drug Delivery

    Löbmann, Korbinian, Wohlert, J., Mullertz, Anette , Wågberg, L. & Svagan, A. J., May 2017, In : Advanced Materials Interfaces. 4, 9, 11 p., 1600655.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Amorphous is not always better—A dissolution study on solid state forms of carbamazepine

    Jensen, L. G., Skautrup, F. B., Mullertz, Anette , Abrahamsson, B., Rades, Thomas & Priemel, P. A., 30 Apr 2017, In : International Journal of Pharmaceutics. 522, 1-2, p. 74-79 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Bioinspired Layer-by-Layer Microcapsules Based on Cellulose Nanofibers with Switchable Permeability

    Paulraj, T., Riazanova, A. V., Yao, K., Andersson, R. L., Mullertz, Anette & Svagan, A. J., 10 Apr 2017, In : Biomacromolecules. 18, 4, p. 1401-1410 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    High-Throughput Lipolysis in 96-Well Plates for Rapid Screening of Lipid-Based Drug Delivery Systems

    Mosgaard, M. D., Sassene, P. J., Mu, Huiling, Rades, Thomas & Mullertz, Anette , Apr 2017, In : Journal of Pharmaceutical Sciences. 106, 4, p. 1183-1186 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Influence of drug load and physical form of cinnarizine in new SNEDDS dosing regimens: in vivo and in vitro evaluations

    Siqueira Jørgensen, Scheyla Daniela, Mullertz, Anette , Gräeser, K., Kasten, G., Mu, Huiling & Rades, Thomas, Mar 2017, In : A A P S Journal. 19, 2, p. 587-594 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Mapping the intermediate digestion phases of human healthy intestinal contents from distal ileum and caecum at fasted and fed state conditions

    Tran, T., Fatouros, D. G., Vertzoni, M., Reppas, C. & Mullertz, Anette , Mar 2017, In : The Journal of pharmacy and pharmacology. 69, 3, p. 265-273 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    In Vitro Model Simulating Gastro-Intestinal Digestion in the Pediatric Population (Neonates and Young Infants)

    Kamstrup, D., Berthelsen, Ragna, Sassene, P. J., Selen, A. & Mullertz, Anette , Feb 2017, In : A A P S PharmSciTech. 18, 2, p. 317-329 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    Analysis of 3D Prints by X-ray Computed Microtomography and Terahertz Pulsed Imaging

    Markl, D., Zeitler, J. A., Rasch, C., Michaelsen, M. H., Mullertz, Anette , Rantanen, Jukka, Rades, Thomas & Bøtker, Johan Peter, 2017, In : Pharmaceutical Research. 34, 5, p. 1037–1052 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Development of a Video-Microscopic Tool To Evaluate the Precipitation Kinetics of Poorly Water Soluble Drugs: A Case Study with Tadalafil and HPMC

    Fjelrad Christfort, J., Christensen, J. P., Madsen, C. M., Nielsen, L. H., Sandau, M., Andersen, K., Mullertz, Anette & Rades, Thomas, 2017, In : Molecular Pharmaceutics. 14, 12, p. 4154-4160

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published

    Self-microemulsifying drug delivery system and nanoemulsion for enhancing aqueous miscibility of Alpinia galanga oil

    Khumpirapang, N., Pikulkaew, S., Mullertz, Anette , Rades, Thomas & Okonogi, S., 2017, In : PLOS ONE. 12, 11, 18 p., e0188848.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. 2016
  68. Published

    Solid cellulose nanofiber based foams - Towards facile design of sustained drug delivery systems

    Svagan, A. J., Benjamins, J., Al-Ansari, Z., Bar-Shalom, Daniel, Mullertz, Anette , Wågberg, L. & Löbmann, Korbinian, 12 Nov 2016, In : Journal of controlled release : official journal of the Controlled Release Society. 244 , Part A, p. 74–82 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. Published

    Optimizing clinical drug product performance: applying Biopharmaceutics Risk Assessment Roadmap (BioRAM) and the BioRAM Scoring Grid

    Dickinson, P. A., Kesisoglou, F., Flanagan, T., Martinez, M. N., Mistry, H. B., Crison, J. R., Polli, J. E., Cruañes, M. T., Serajuddin, A. T. M., Mullertz, Anette , Cook, J. A. & Selen, A., Nov 2016, In : Journal of Pharmaceutical Sciences. 105, 11, p. 3243-3255 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. Published

    In Vivo Precipitation of Poorly Soluble Drugs from Lipid-Based Drug Delivery Systems

    Sassene, P. J., Michaelsen, M. H., Mosgaard, M. D., Klitgaard, Mette, Van Den Broek, E., Wasan, K. M., Mu, Huiling, Rades, Thomas & Mullertz, Anette , 3 Oct 2016, In : Molecular Pharmaceutics. 13, 10, p. 3417-3426 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. Published

    Development of a μDissolution-Permeation model with in situ drug concentration monitoring

    Berthelsen, Ragna, Byrialsen, J. P., Holm, R., Jacobsen, Jette, Abrahamsson, B., Saabye, L., Madelung, P. & Mullertz, Anette , 1 Oct 2016, In : Journal of Drug Delivery Science and Technology. 35, p. 223-233 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Published

    Studying the propensity of compounds to supersaturate: a practical and broadly applicable approach

    Palmelund, Henrik Brogaard, Madsen, C. M., Christensen, J. P., Mullertz, Anette & Rades, Thomas, Oct 2016, In : Journal of Pharmaceutical Sciences. 105, 10, p. 3021-3029 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    Buccal absorption of diazepam is improved when administered in bioadhesive tablets-An in vivo study in conscious Göttingen mini-pigs

    Meng-Lund, E., Jacobsen, Jette, Mullertz, Anette , Jørgensen, E. B. & Holm, R., 30 Sep 2016, In : International Journal of Pharmaceutics. 515, 1-2, p. 125-131 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Published

    Comparison of lipases for in vitro models of gastric digestion: lipolysis using two infant formulas as model substrates

    Sassene, P. J., Fanø, M., Mu, Huiling, Rades, Thomas, Aquistapace, S., Schmitt, B., Cruz-Hernandez, C., Wooster, T. J. & Mullertz, Anette , 14 Sep 2016, In : Food & Function. 7, 9, p. 3989-3998 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    In vivo evaluation of lipid-based formulations for oral delivery of apomorphine and its diester prodrugs

    Borkar, N. N., Holm, R., Yang, Mingshi, Mullertz, Anette & Mu, Huiling, 9 Sep 2016, In : International Journal of Pharmaceutics. 513, 1-2, p. 211-217 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    Impact of lipid-based drug delivery systems on the transport and uptake of insulin across Caco-2 Cell monolayers

    Li, P., Nielsen, Hanne Mørck & Mullertz, Anette , Sep 2016, In : Journal of Pharmaceutical Sciences. 105, 9, p. 2743-51 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    Interlaboratory validation of small-scale solubility and dissolution measurements of poorly water-soluble drugs

    Andersson, S. B. E., Alvebratt, C., Bevernage, J., Bonneau, D., Mathews, C. D. C., Dattani, R., Edueng, K., He, Y., Holm, R., Madsen, C. M., Müller, T., Muenster, U., Mullertz, Anette , Ojala, K., Rades, Thomas, Sieger, P. & Bergström, C. A. S., Sep 2016, In : Journal of Pharmaceutical Sciences. 105, 9, p. 2864-72 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    Supersaturation of zafirlukast in fasted and fed state intestinal media with and without precipitation inhibitors

    Madsen, C. M., Boyd, B., Rades, Thomas & Mullertz, Anette , 25 Aug 2016, In : European Journal of Pharmaceutical Sciences. 91, p. 31-39 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    Apomorphine and its esters: Differences in Caco-2 cell permeability and chylomicron affinity

    Borkar, N., Chen, Z., Saaby, L., Mullertz, Anette , Håkansson, A. E., Schönbeck, C., Yang, Mingshi, Holm, R. & Mu, Huiling, 6 Jun 2016, In : International Journal of Pharmaceutics. 509, 1-2, p. 499–506 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  80. Published

    Polymeric microcontainers improve oral bioavailability of furosemide

    Nielsen, L. H., Melero, A., Keller, S. S., Jacobsen, Jette, Garrigues, T., Rades, Thomas, Mullertz, Anette & Boisen, A., 17 May 2016, In : International Journal of Pharmaceutics. 504, 1-2, p. 98-109 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  81. Published

    Formulation and characterization of self-nanoemulsifying drug delivery systems containing monoacyl phosphatidylcholine

    Tran, T., Xi, X., Rades, Thomas & Mullertz, Anette , 11 Apr 2016, In : International Journal of Pharmaceutics. 502, 1-2, p. 151-60 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  82. Published

    Anhydrate to hydrate solid-state transformations of carbamazepine and nitrofurantoin in biorelevant media studied in situ using time-resolved synchrotron X-ray diffraction

    Bøtker, Johan Peter, Rantanen, Jukka, Arnfast, L., Doreth, M., Raijada, D. K., Löbmann, Korbinian, Madsen, C. M., Khan, J., Rades, Thomas, Mullertz, Anette , Hawley, A., Thomas, D. & Boyd, B. J., Mar 2016, In : European Journal of Pharmaceutics and Biopharmaceutics. 100, p. 119-127 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  83. Published

    Dissolution Model Development: Formulation Effects and Filter Complications

    Berthelsen, Ragna, Holm, R., Jacobsen, Jette, Kristensen, J., Abrahamsson, B. & Mullertz, Anette , Feb 2016, In : Dissolution Technologies. 23, 1, p. 6-12 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. Published

    The Effect of Digestion and Drug Load on Halofantrine Absorption from Self-nanoemulsifying Drug Delivery System (SNEDDS)

    Michaelsen, M. H., Wasan, K. M., Sivak, O., Mullertz, Anette & Rades, Thomas, Jan 2016, In : The A A P S Journal. 18, 1, p. 180-186 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  85. Published

    Effect of food intake and co-administration of placebo self-nanoemulsifying drug delivery systems on the absorption of cinnarizine in healthy human volunteers

    Christiansen, M. L., Holm, R., Abrahamsson, B., Jacobsen, Jette, Kristensen, J., Andersen, Jens Rikardt & Mullertz, Anette , 2016, In : European Journal of Pharmaceutical Sciences. 84, p. 77-82 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. Published

    Evaluating Oral Drug Delivery Systems: Digestion Models.

    Berthelsen, Ragna, Sassene, P., Rades, Thomas & Mullertz, Anette , 2016, Analytical Techniques in the Pharmaceutical Sciences. Springer, p. 753-771

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  87. Published

    Evaluating Oral Drug Delivery Systems: Dissolution Models.

    Berthelsen, Ragna, Mullertz, Anette & Rades, Thomas, 2016, Analytical Techniques in the Pharmaceutical Sciences. Springer, p. 753-771

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  88. Published

    Rhamnogalacturonan-I based microcapsules for targeted drug release

    Svagan, A. J., Kusic, A., De Gobba, Cristian, Larsen, F. H., Sassene, P., Zhou, Q., van de Weert, Marco, Mullertz, Anette , Jørgensen, Bodil & Ulvskov, Peter, 2016, In : P L o S One. 11, 12, 13 p., e0168050.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    Survival of Lactobacillus acidophilus NCFM® and Bifidobacterium lactis HN019 encapsulated in chocolate during in vitro simulated passage of the upper gastrointestinal tract

    Klindt-Toldam, S., Larsen, S. K., Saaby, L., Olsen, L. R., Svenstrup, G., Mullertz, Anette , Knøchel, Susanne, Heimdal, H., Nielsen, Dennis Sandris & Zielińska, D., 2016, In : Lebensmittel - Wissenschaft und Technologie. 74, p. 404-410 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  90. 2015
  91. Published

    Steric and interactive barrier properties of intestinal mucus elucidated by particle diffusion and peptide permeation

    Bøgh, M., García-Díaz, M., Mullertz, Anette & Nielsen, Hanne Mørck, Sep 2015, In : European Journal of Pharmaceutics and Biopharmaceutics. 94, Part A, p. 136–143 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published

    Development of a high-throughput in vitro intestinal lipolysis model for rapid screening of lipid-based drug delivery systems

    Mosgaard, M. D., Sassene, P., Mu, Huiling, Rades, Thomas & Mullertz, Anette , Aug 2015, In : European Journal of Pharmaceutics and Biopharmaceutics. 94, p. 493-500 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. Published

    Stabilisation of amorphous furosemide increases the oral drug bioavailability in rats

    Nielsen, L. H., Rades, Thomas & Mullertz, Anette , 25 Jul 2015, In : International Journal of Pharmaceutics. 490, 1-2, p. 334-40 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  94. Published

    pH-triggered drug release from biodegradable microwells for oral drug delivery

    Nielsen, L. H., Nagstrup, J., Gordon, S., Keller, S. S., Østergaard, Jesper, Rades, Thomas, Mullertz, Anette & Boisen, A., Jun 2015, In : Biomedical Microdevices. 17, 7 p., 55.

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. Published

    Kolliphor surfactants affect solubilization and bioavailability of fenofibrate. Studies of in vitro digestion and absorption in rats.

    Berthelsen, Ragna, Holm, R., Jacobsen, Jette, Kristensen, J., Abrahamsson, B. & Mullertz, Anette , 6 Apr 2015, In : Molecular Pharmaceutics. 12, 4, p. 1062-1071 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  96. Published

    Structural features of colloidal species in the human fasted upper small intestine

    Mullertz, Anette , Reppas, C., Psachoulias, D., Vertzoni, M. & Fatouros, D. G., Apr 2015, In : Journal of Pharmacy and Pharmacology. 67, 4, p. 486-492 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase

    Bakala-N'Goma, J., Williams, H. D., Sassene, P. J., Kleberg, K., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Mullertz, Anette , Pouton, C. W., Porter, C. J. H. & Carriere, F., Apr 2015, In : Pharmaceutical Research. 32, 4, p. 1279-1287 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    Evaluation of the use of Göttingen minipigs to predict food effects on the oral absorption of drugs in humans

    Christiansen, M. L., Mullertz, Anette , Garmer, M., Kristensen, J., Jacobsen, Jette, Abrahamsson, B. & Holm, R., Jan 2015, In : Journal of Pharmaceutical Sciences. 104, 1, p. 135-143 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    Elucidating the molecular interactions occurring during drug precipitation of weak bases from lipid-based formulations: a case study with cinnarizine and a long chain self-nanoemulsifying drug delivery system

    Sassene, P. J., Mosgaard, M. D., Löbmann, Korbinian, Mu, Huiling, Larsen, F. H., Rades, Thomas & Mullertz, Anette , 2015, In : Molecular Pharmaceutics. 12, 11, p. 4067-4076 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  100. Published

    Lipophilic prodrugs of apomorphine I: Preparation, characterisation, and in vitro enzymatic hydrolysis in biorelevant media.

    Borkar, N. N., Li, B., Holm, R., Håkansson, A., Mullertz, Anette , Yang, Mingshi & Mu, Huiling, 2015, In : European Journal of Pharmaceutics and Biopharmaceutics. 89, p. 216-223 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  101. Published

    Marine lipids and the bioavailability of omega-3 fatty acids

    Mu, Huiling & Mullertz, Anette , 2015, In : Current Nutrition and Food Science. 11, 3, p. 177-187 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  102. 2014
  103. Published

    Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading

    Li, P., Tan, A., Prestidge, C. A., Nielsen, Hanne Mørck & Mullertz, Anette , 30 Dec 2014, In : International Journal of Pharmaceutics. 477, 1-2, p. 390-8 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  104. Published

    Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system

    Williams, H. D., Sassene, P., Kleberg, K., Calderone, M., Igonin, A., Jule, E., Vertommen, J., Blundell, R., Benameur, H., Mullertz, Anette , Porter, C. J. H., Pouton, C. W. & Communicated on Behalf of the LFCS Consortium, C. O. B. O. T. L. C., Aug 2014, In : Journal of Pharmaceutical Sciences. 103, 8, p. 2441-55 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  105. Published

    Combining in vitro and in silico methods for better prediction of surfactant effects on the absorption of poorly water soluble drugs-a fenofibrate case example

    Berthelsen, Ragna, Sjögren, E., Jacobsen, Jette, Kristensen, J., Holm, R., Abrahamsson, B. & Mullertz, Anette , 2 Jul 2014, In : International Journal of Pharmaceutics. 473, 1-2, p. 356-365 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  106. Published

    Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin

    Christophersen, P. C., Vaghela, D., Mullertz, Anette , Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, Jul 2014, In : A A P S Journal. 16, 4, p. 875-83 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  107. Published

    In vitro and in vivo evaluations of the performance of an indirubin derivative, formulated in four different self-emulsifying drug delivery systems

    Heshmati, N., Cheng, X., Dapat, E., Sassene, P., Eisenbrand, G., Fricker, G. & Mullertz, Anette , 24 Jun 2014, In : The Journal of pharmacy and pharmacology. 66, 11, p. 1567-75 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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