Anette Müllertz

Anette Müllertz

Professor


  1. Published

    pH-triggered drug release from biodegradable microwells for oral drug delivery

    Nielsen, L. H., Nagstrup, J., Gordon, S., Keller, S. S., Østergaard, Jesper, Rades, Thomas, Mullertz, Anette & Boisen, A., Jun 2015, In : Biomedical Microdevices. 17, 7 p., 55.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessful

    Holm, R., Hesselkilde, J. Z., Jørgensen, E. B. & Mullertz, Anette , 2012, In : European Journal of Pharmaceutical Sciences. 47, p. 347-351

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems

    Tran, T., Bonlokke, P., Rodriguez-Rodriguez, C., Nosrati, Z., Esquinas, P. L., Borkar, N., Plum, J., Strindberg, Sophie , Karagiozov, S., Rades, Thomas, Mullertz, Anette , Saatchi, K. & Häfeli, Urs Otto, 2020, In : Journal of Controlled Release. 317, p. 375-384

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Using in vitro dynamic lipolysis modeling as a tool for exploring IVIVC relationships for oral lipid-based formulations

    Mullertz, Anette & Fatourus, D. G., 2007, Oral lipid-based formulations: enhancing the bioviabillity of poorly water-soluble drugs. Hauss, D. J. (ed.). New York: Informa healtcare, p. 257-272

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  5. Published

    Using biorelevant dissolution to obtain IVIVC of solid dosage forms containing a poorly-soluble model compound

    Lue, B., Nielsen, F. S., Magnussen, T., Schou, H. M., Kristensen, K., Jacobsen, L. O. & Mullertz, Anette , 2008, In : European Journal of Pharmaceutics and Biopharmaceutics. 69, 2, p. 648-657

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Using Potentiometric Free Drug Sensors to Determine the Free Concentration of Ionizable Drugs in Colloidal Systems

    Tran, T., Chakraborty, A., Xi, X., Bohets, H., Cornett, Claus, Tsinman, K., Rades, Thomas & Mullertz, Anette , Jan 2018, In : Journal of Pharmaceutical Sciences. 107, 1, p. 103-112

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Unravelling the ultrastructure of ascending colon fluids from patients with ulcerative colitis by cryogenic transmission electron microscopy

    Mullertz, Anette , Fatouros, D. G., Vertzoni, M. & Reppas, C., Oct 2013, In : The Journal of pharmacy and pharmacology. 65, 10, p. 1482-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Trilaurin diminishes food effect on the release of desmopressin from solid lipid microparticles

    Christophersen, P., Vaghela, D., Mullertz, Anette , Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, 2014.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  9. Published

    Towards the understanding of complex fluids in pharmaceutical sciences

    Pedersen, P. B., Pekka Pajander, J., Mullertz, Anette , Vilmann, Peter, Jørgensen, Lene & Baldursdottir, S. G., 2013, In : Journal of Drug Delivery Science and Technology. 23, 4, p. 393 401 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Towards the development of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) containing trimethyl chitosan for the oral delivery of amphotericin B: In vitro assessment and cytocompatibility studies

    Kontogiannidou, E., Meikopoulos, T., Virgiliou, C., Bouropoulos, N., Gika, H., Vizirianakis, I. S., Mullertz, Anette & Fatouros, D. G., Apr 2020, In : Journal of Drug Delivery Science and Technology. 56, 9 p., 101524.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system

    Williams, H. D., Sassene, P., Kleberg, K., Calderone, M., Igonin, A., Jule, E., Vertommen, J., Blundell, R., Benameur, H., Mullertz, Anette , Porter, C. J. H., Pouton, C. W. & Communicated on Behalf of the LFCS Consortium, C. O. B. O. T. L. C., Aug 2014, In : Journal of Pharmaceutical Sciences. 103, 8, p. 2441-55 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in vitro digestion of type I, II, IIIA, IIIB and IV lipid-based formulations

    Williams, H. D., Sassene, P., Kleberg, K., Calderone, M., Igonin, A., Jule, E., Vertommen, J., Blundell, R., Benameur, H., Mullertz, Anette , Pouton, C. W., Porter, C. J. H. & LFCS Consortium, L. C., Dec 2013, In : Pharmaceutical Research. 30, 12, p. 3059-76 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: Method parameterization and comparison of in vitro digestion profiles across a range of representative formulations

    Williams, H. D., Sassene, P., Kleberg, K., Bakala-N'Goma, J., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Carrière, F., Mullertz, Anette , Porter, C. J. H. & Pouton, C. W., 2012, In : Journal of Pharmaceutical Sciences. 101, 9, p. 3360-3380

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Toward the Establishment of Standardized in Vitro Tests for Lipid-Based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I, II, IIIA, IIIB, and IV Formulations during in Vitro Digestion

    Williams, H. D., Anby, M. U., Sassene, P., Kleberg, K., Bakala-N’Goma, J., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Carrière, F., Mullertz, Anette , Pouton, C. W. & Porter, C. J. H., 2012, In : Molecular Pharmaceutics. 9, 11, p. 3286-3300 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase

    Bakala-N'Goma, J., Williams, H. D., Sassene, P. J., Kleberg, K., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Mullertz, Anette , Pouton, C. W., Porter, C. J. H. & Carriere, F., Apr 2015, In : Pharmaceutical Research. 32, 4, p. 1279-1287 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    The use of biorelevant dissolution media in determining the region of microemulsion: Implications for in vitro lipid formulation assessment

    Ogbonna, A., Ren, S., Olesen, P. & Mullertz, Anette , 2009.

    Research output: Contribution to conferencePosterResearch

  17. Published

    The ability of two in vitro lipolysis models reflecting the human and rat gastro-intestinal conditions to predict the in vivo performance of SNEDDS dosing regimens

    Siqueira Jørgensen, Scheyla Daniela, Al Sawaf, M., Graeser, K., Mu, Huiling, Mullertz, Anette & Rades, Thomas, Mar 2018, In : European Journal of Pharmaceutics and Biopharmaceutics. 124, p. 116-124

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers

    Blaabjerg, L. I., Grohganz, Holger, Lindenberg, E., Löbmann, Korbinian, Mullertz, Anette & Rades, Thomas, 21 Sep 2018, In : Pharmaceutics. 10, 4, 14 p., 164.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    The Effect of Digestion and Drug Load on Halofantrine Absorption from Self-nanoemulsifying Drug Delivery System (SNEDDS)

    Michaelsen, M. H., Wasan, K. M., Sivak, O., Mullertz, Anette & Rades, Thomas, Jan 2016, In : The A A P S Journal. 18, 1, p. 180-186 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Tabletter med løse ender

    Naelapaa, K., Mullertz, Anette , Jacobsen, Jette, Rømsing, Janne & Bar-Shalom, Daniel, 2009, In : Lægemiddelforskning. p. 4-6

    Research output: Contribution to journalJournal articleResearch

  21. Published

    Tabletter med "løse ender" giver forsinket afgift af lægemiddelstof

    Naelapaa, K., Mullertz, Anette , Jacobsen, Jette, Rømsing, Janne & Bar-Shalom, Daniel, 2009, In : Lægemiddelforskning. p. 4-6 3 p.

    Research output: Contribution to journalJournal articleResearch

  22. Published

    Survival of Lactobacillus acidophilus NCFM® and Bifidobacterium lactis HN019 encapsulated in chocolate during in vitro simulated passage of the upper gastrointestinal tract

    Klindt-Toldam, S., Larsen, S. K., Saaby, L., Olsen, L. R., Svenstrup, G., Mullertz, Anette , Knøchel, Susanne, Heimdal, H., Nielsen, Dennis Sandris & Zielińska, D., 2016, In : Lebensmittel - Wissenschaft und Technologie. 74, p. 404-410 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Supersaturation of zafirlukast in fasted and fed state intestinal media with and without precipitation inhibitors

    Madsen, C. M., Boyd, B., Rades, Thomas & Mullertz, Anette , 25 Aug 2016, In : European Journal of Pharmaceutical Sciences. 91, p. 31-39 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS) enhance the bioavailability of the poorly water-soluble drug Simvastatin in dogs

    Thomas, N., Holm, R., Garmer, M., Karlsson, J. J., Mullertz, Anette & Rades, Thomas, 2013, In : A A P S Journal. 15, 1, p. 219-27 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

    Boyd, B. J., Bergström, C. A. S., Vinarov, Z., Kuentz, M., Brouwers, J., Augustijns, P., Brandl, M., Bernkop-Schnürch, A., Shrestha, N., Préat, V., Mullertz, Anette , Bauer-Brandl, A. & Jannin, V., 2019, In : European Journal of Pharmaceutical Sciences. 137, 27 p., 104967.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Studying the propensity of compounds to supersaturate: a practical and broadly applicable approach

    Palmelund, Henrik, Madsen, C. M., Christensen, J. P., Mullertz, Anette & Rades, Thomas, Oct 2016, In : Journal of Pharmaceutical Sciences. 105, 10, p. 3021-3029 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Studying furosemide solubilization using an in vitro model simulating gastrointestinal digestion and drug solubilization in neonates and young infants

    Klitgaard, Mette, Sassene, P. J., Selen, A., Mullertz, Anette & Berthelsen, Ragna, 15 Nov 2017, In : European Journal of Pharmaceutical Sciences. 109, p. 191-199 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats

    Holm, R., Porter, C. J. H., Mullertz, Anette , Kristensen, H. G. & Charman, W. N., 2002, In : Pharmaceutical Research. 19, 9, p. 1354-61 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Structural features of colloidal species in the human fasted upper small intestine

    Mullertz, Anette , Reppas, C., Psachoulias, D., Vertzoni, M. & Fatouros, D. G., Apr 2015, In : Journal of Pharmacy and Pharmacology. 67, 4, p. 486-492 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Structural development of self nano emulsifying drug delivery systems (SNEDDS) during in vitro lipid digestion monitored by small-angle X-ray scattering

    Fatouros, D. G., Deen, R., Arleth, Lise, Bergenstahl, B., Nielsen, F. S., Pedersen, J. S. & Mullertz, Anette , 2007, In : Pharmaceutical Research. 24, 10, p. 1844-1853 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Steric and interactive barrier properties of intestinal mucus elucidated by particle diffusion and peptide permeation

    Bøgh, M., García-Díaz, M., Mullertz, Anette & Nielsen, Hanne Mørck, Sep 2015, In : European Journal of Pharmaceutics and Biopharmaceutics. 94, Part A, p. 136–143 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Stabilisation of amorphous furosemide increases the oral drug bioavailability in rats

    Nielsen, L. H., Rades, Thomas & Mullertz, Anette , 25 Jul 2015, In : International Journal of Pharmaceutics. 490, 1-2, p. 334-40 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Spatial confinement can lead to increased stability of amorphous indomethacin

    Nielsen, L. H., Keller, S. S., Gordon, K. C., Boisen, A., Rades, Thomas & Mullertz, Anette , 2012, In : European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 81, 2, p. 418-25 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Solution or suspension - Does it matter for lipid based systems? In vivo studies of chase dosing lipid vehicles with aqueous suspensions of a poorly soluble drug

    Larsen, A. T., Holm, R. & Mullertz, Anette , Aug 2017, In : European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 117, p. 308-314 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols

    Christensen, J. Ø., Schultz, K., Mollgaard, B., Kristensen, H. G. & Mullertz, Anette , 2004, In : European Journal of Pharmaceutical Sciences. 23, 3, p. 287-96 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin

    Christophersen, P. C., Vaghela, D., Mullertz, Anette , Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, Jul 2014, In : A A P S Journal. 16, 4, p. 875-83 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Solid lipid particles for oral delivery of peptide and protein drugs I - Elucidating the release mechanism of lysozyme during lipolysis

    Christophersen, P. C. B., Zhang, L., Yang, Mingshi, Nielsen, Hanne Mørck, Mullertz, Anette & Mu, Huiling, 2 Aug 2013, In : European Journal of Pharmaceutics and Biopharmaceutics. 85, 3, part A, p. 473-480

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Solid forms of amlodipine besylate: Physiochemical, structural, and thermodynamic characterization

    Koradia, V. S., Lopez de Diego, H., Frydenvang, Karla Andrea, Ringkjøbing-Elema, M., Mullertz, Anette , Bond, A. D. & Rantanen, Jukka, 28 Oct 2010, In : Crystal Growth & Design. 10, 12, p. 5279-5290

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Solid cellulose nanofiber based foams - Towards facile design of sustained drug delivery systems

    Svagan, A. J., Benjamins, J., Al-Ansari, Z., Bar-Shalom, Daniel, Mullertz, Anette , Wågberg, L. & Löbmann, Korbinian, 12 Nov 2016, In : Journal of controlled release : official journal of the Controlled Release Society. 244 , Part A, p. 74–82 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Solid Lipid Particles for Oral Delivery of Peptide and Protein Drugs II - The Digestion of Trilaurin Protects Desmopressin from Proteolytic Degradation

    Christophersen, P. C., Zhang, L., Mullertz, Anette , Nielsen, Hanne Mørck, Yang, Mingshi & Mu, Huiling, 13 Mar 2014, In : Pharmaceutical Research. 31, 9, p. 2420-28 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading

    Li, P., Tan, A., Prestidge, C. A., Nielsen, Hanne Mørck & Mullertz, Anette , 30 Dec 2014, In : International Journal of Pharmaceutics. 477, 1-2, p. 390-8 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Self-microemulsifying drug delivery system and nanoemulsion for enhancing aqueous miscibility of Alpinia galanga oil

    Khumpirapang, N., Pikulkaew, S., Mullertz, Anette , Rades, Thomas & Okonogi, S., 2017, In : PLOS ONE. 12, 11, 18 p., e0188848.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Self-emulsifying drug delivery systems (SEDDS) – The splendid comeback of an old technology

    Bernkop-Schnürch, A., Mullertz, Anette & Rades, Thomas, 2019, In : Advanced Drug Delivery Reviews. 142, p. 1-2 2 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  44. Published

    Selection of a lipase for development of an in vitro gastric lipid digestion model

    Larsen, A. T., Jensen, L. G., Hansen, K. K. & Mullertz, Anette , Nov 2010.

    Research output: Contribution to conferencePosterResearch

  45. Published

    SNEDDS containing poorly water soluble cinnarizine; development and in Vitro characterization of dispersion, digestion and solubilization

    Larsen, A. T., Ogbonna, A., Abu-Rmaileh, R., Abrahmsson, B., Østergaard, Jesper & Mullertz, Anette , 2012, In : Pharmaceutics. 4, 4, p. 641-665

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    SEDDS for intestinal absorption of insulin: Application of Caco-2 and Caco-2/HT29 co-culture monolayers and intra-jejunal instillation in rats

    Liu, J., Werner, U., Funke, M., Besenius, M., Saaby, L., Fano, M., Mu, Huiling & Mullertz, Anette , 5 Apr 2019, In : International Journal of Pharmaceutics. 560, p. 377-384

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Rhamnogalacturonan-I based microcapsules for targeted drug release

    Svagan, A. J., Kusic, A., De Gobba, Cristian, Larsen, F. H., Sassene, P., Zhou, Q., van de Weert, Marco, Mullertz, Anette , Jørgensen, Bodil & Ulvskov, Peter, 2016, In : P L o S One. 11, 12, 13 p., e0168050.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Refining stability and dissolution rate of amorphous drug formulations

    Grohganz, Holger, Priemel, P. A., Löbmann, Korbinian, Nielsen, L. H., Laitinen, R., Mullertz, Anette , Van den Mooter, G. & Rades, Thomas, Jun 2014, In : Expert Opinion on Drug Delivery. 11, 6, p. 977-89 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Redissolution and polymorphic characterization of a poorly water-soluble drug precipitated during in vitro lipolysis from a lipid-based formulation

    Ren, S., Ogbonna, A., Koradia, V. S., Sassene, P. J., Rades, T. & Mullertz, Anette , Nov 2010.

    Research output: Contribution to conferencePosterResearch

  50. Published

    Recent developments in oral lipid-based drug delivery

    Thomas, N., Rades, Thomas & Mullertz, Anette , 1 Jul 2013, In : Journal of Drug Delivery Science and Technology. 23, 4, p. 375-382 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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