Anette Müllertz
Professor
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pH-triggered drug release from biodegradable microwells for oral drug delivery
Nielsen, L. H., Nagstrup, J., Gordon, S., Keller, S. S., Østergaard, Jesper, Rades, Thomas, Mullertz, Anette & Boisen, A., Jun 2015, In: Biomedical Microdevices. 17, 7 p., 55.Research output: Contribution to journal › Journal article › peer-review
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X-ray Imaging for Gastrointestinal Tracking of Microscale Oral Drug Delivery Devices
Kjeldsen, R. B., Kristensen, M. N., Gundlach, C., Thamdrup, L. H. E., Mullertz, Anette , Rades, Thomas, Nielsen, L. H., Zór, K. & Boisen, A., 2021, In: ACS Biomaterials Science and Engineering. 7, 6, p. 2538–2547Research output: Contribution to journal › Journal article › peer-review
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Visualizing the Journey of Fenofibrate through the Rat Gastrointestinal Tract by Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging
Strindberg, S., Plum, J., Bagger, C., Janfelt, Christian & Mullertz, Anette , 2021, In: Molecular Pharmaceutics. 18, 6, p. 2189–2197Research output: Contribution to journal › Journal article › peer-review
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Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessful
Holm, R., Hesselkilde, J. Z., Jørgensen, E. B. & Mullertz, Anette , 2012, In: European Journal of Pharmaceutical Sciences. 47, p. 347-351Research output: Contribution to journal › Journal article › peer-review
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Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems
Tran, T., Bonlokke, P., Rodriguez-Rodriguez, C., Nosrati, Z., Esquinas, P. L., Borkar, N., Plum, J., Strindberg, S., Karagiozov, S., Rades, Thomas, Mullertz, Anette , Saatchi, K. & Hafeli, U. O., 2020, In: Journal of Controlled Release. 317, p. 375-384Research output: Contribution to journal › Journal article › peer-review
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Using in vitro dynamic lipolysis modeling as a tool for exploring IVIVC relationships for oral lipid-based formulations
Mullertz, Anette & Fatourus, D. G., 2007, Oral lipid-based formulations: enhancing the bioviabillity of poorly water-soluble drugs. Hauss, D. J. (ed.). New York: Informa healtcare, p. 257-272Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Using biorelevant dissolution to obtain IVIVC of solid dosage forms containing a poorly-soluble model compound
Lue, B., Nielsen, F. S., Magnussen, T., Schou, H. M., Kristensen, K., Jacobsen, L. O. & Mullertz, Anette , 2008, In: European Journal of Pharmaceutics and Biopharmaceutics. 69, 2, p. 648-657Research output: Contribution to journal › Journal article › peer-review
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Using Potentiometric Free Drug Sensors to Determine the Free Concentration of Ionizable Drugs in Colloidal Systems
Tran, T., Chakraborty, A., Xi, X., Bohets, H., Cornett, Claus, Tsinman, K., Rades, Thomas & Mullertz, Anette , Jan 2018, In: Journal of Pharmaceutical Sciences. 107, 1, p. 103-112Research output: Contribution to journal › Journal article › peer-review
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Unravelling the ultrastructure of ascending colon fluids from patients with ulcerative colitis by cryogenic transmission electron microscopy
Mullertz, Anette , Fatouros, D. G., Vertzoni, M. & Reppas, C., Oct 2013, In: The Journal of pharmacy and pharmacology. 65, 10, p. 1482-7 6 p.Research output: Contribution to journal › Journal article › peer-review
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UNGAP best practice for improving solubility data quality of orally administered drugs
Vertzoni, M., Alsenz, J., Augustijns, P., Bauer-Brandl, A., Bergström, C. A. S., Brouwers, J., Mullertz, Anette , Perlovich, G., Saal, C., Sugano, K. & Reppas, C., 1 Jan 2022, In: European Journal of Pharmaceutical Sciences. 168, 21 p., 106043.Research output: Contribution to journal › Journal article › peer-review
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Trilaurin diminishes food effect on the release of desmopressin from solid lipid microparticles
Christophersen, P., Vaghela, D., Mullertz, Anette , Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, 2014.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Towards the understanding of complex fluids in pharmaceutical sciences
Pedersen, P. B., Pekka Pajander, J., Mullertz, Anette , Vilmann, Peter, Jørgensen, Lene & Baldursdottir, S. G., 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 393 401 p.Research output: Contribution to journal › Journal article › peer-review
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Towards the development of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) containing trimethyl chitosan for the oral delivery of amphotericin B: In vitro assessment and cytocompatibility studies
Kontogiannidou, E., Meikopoulos, T., Virgiliou, C., Bouropoulos, N., Gika, H., Vizirianakis, I. S., Mullertz, Anette & Fatouros, D. G., Apr 2020, In: Journal of Drug Delivery Science and Technology. 56, 9 p., 101524.Research output: Contribution to journal › Journal article › peer-review
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Towards analyzing the potential of exosomes to deliver microRNA therapeutics
Giassafaki, L. N., Siqueira, S., Panteris, E., Psatha, K., Chatzopoulou, F., Aivaliotis, M., Tzimagiorgis, G., Mullertz, Anette , Fatouros, D. G. & Vizirianakis, I. S., 2021, In: Journal of Cellular Physiology. 236, 2, p. 1529-1544 16 p.Research output: Contribution to journal › Journal article › peer-review
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Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system
Williams, H. D., Sassene, P., Kleberg, K., Calderone, M., Igonin, A., Jule, E., Vertommen, J., Blundell, R., Benameur, H., Mullertz, Anette , Porter, C. J. H., Pouton, C. W. & Communicated on Behalf of the LFCS Consortium, C. O. B. O. T. L. C., Aug 2014, In: Journal of Pharmaceutical Sciences. 103, 8, p. 2441-55 15 p.Research output: Contribution to journal › Journal article › peer-review
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Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in vitro digestion of type I, II, IIIA, IIIB and IV lipid-based formulations
Williams, H. D., Sassene, P., Kleberg, K., Calderone, M., Igonin, A., Jule, E., Vertommen, J., Blundell, R., Benameur, H., Mullertz, Anette , Pouton, C. W., Porter, C. J. H. & LFCS Consortium, L. C., Dec 2013, In: Pharmaceutical Research. 30, 12, p. 3059-76 18 p.Research output: Contribution to journal › Journal article › peer-review
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Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: Method parameterization and comparison of in vitro digestion profiles across a range of representative formulations
Williams, H. D., Sassene, P., Kleberg, K., Bakala-N'Goma, J., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Carrière, F., Mullertz, Anette , Porter, C. J. H. & Pouton, C. W., 2012, In: Journal of Pharmaceutical Sciences. 101, 9, p. 3360-3380Research output: Contribution to journal › Journal article › peer-review
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Toward the Establishment of Standardized in Vitro Tests for Lipid-Based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I, II, IIIA, IIIB, and IV Formulations during in Vitro Digestion
Williams, H. D., Anby, M. U., Sassene, P., Kleberg, K., Bakala-N’Goma, J., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Carrière, F., Mullertz, Anette , Pouton, C. W. & Porter, C. J. H., 2012, In: Molecular Pharmaceutics. 9, 11, p. 3286-3300 15 p.Research output: Contribution to journal › Journal article › peer-review
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Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase
Bakala-N'Goma, J., Williams, H. D., Sassene, P. J., Kleberg, K., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Mullertz, Anette , Pouton, C. W., Porter, C. J. H. & Carriere, F., Apr 2015, In: Pharmaceutical Research. 32, 4, p. 1279-1287 9 p.Research output: Contribution to journal › Journal article › peer-review
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The use of biorelevant dissolution media in determining the region of microemulsion: Implications for in vitro lipid formulation assessment
Ogbonna, A., Ren, S., Olesen, P. & Mullertz, Anette , 2009.Research output: Contribution to conference › Poster › Research
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The ability of two in vitro lipolysis models reflecting the human and rat gastro-intestinal conditions to predict the in vivo performance of SNEDDS dosing regimens
Jorgensen, S. D. S., Al Sawaf, M., Graeser, K., Mu, Huiling, Mullertz, Anette & Rades, Thomas, Mar 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 124, p. 116-124Research output: Contribution to journal › Journal article › peer-review
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The Influence of Solidification on the in vitro Solubilisation of Blonanserin Loaded Supersaturated Lipid-Based Oral Formulations
Moller, A., Schultz, H. B., Meola, T. R., Mullertz, Anette & Prestidge, C. A., 2021, In: European Journal of Pharmaceutical Sciences. 157, 10 p., 105640.Research output: Contribution to journal › Journal article › peer-review
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The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers
Blaabjerg, L. I., Grohganz, Holger, Lindenberg, E., Löbmann, K., Mullertz, Anette & Rades, Thomas, 21 Sep 2018, In: Pharmaceutics. 10, 4, 14 p., 164.Research output: Contribution to journal › Journal article › peer-review
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The Influence of Blonanserin Supersaturation in Liquid and Silica Stabilised Self-Nanoemulsifying Drug Delivery Systems on In Vitro Solubilisation
Møller, Amalie Lykkemark, Schultz, H. B., Meola, T. R., Joyce, P., Mullertz, Anette & Prestidge, C. A., 2023, In: Pharmaceutics. 15, 1, 14 p., 284.Research output: Contribution to journal › Journal article › peer-review
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The Effect of Digestion and Drug Load on Halofantrine Absorption from Self-nanoemulsifying Drug Delivery System (SNEDDS)
Michaelsen, M. H., Wasan, K. M., Sivak, O., Mullertz, Anette & Rades, Thomas, Jan 2016, In: The A A P S Journal. 18, 1, p. 180-186 7 p.Research output: Contribution to journal › Journal article › peer-review
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The Binding of Alpinia galanga Oil and Its Nanoemulsion to Mammal GABA(A) Receptors Using Rat Cortical Membranes and an In Silico Modeling Platform
Khumpirapang, N., Suknuntha, K., Wongrattanakamon, P., Jiranusornkul, S., Anuchapreeda, S., Wellendorph, Petrine, Mullertz, Anette , Rades, Thomas & Okonogi, S., 2022, In: Pharmaceutics. 14, 3, 15 p., 650.Research output: Contribution to journal › Journal article › peer-review
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Tabletter med løse ender
Naelapaa, K., Mullertz, Anette , Jacobsen, Jette, Rømsing, J. & Bar-Shalom, Daniel, 2009, In: Lægemiddelforskning. p. 4-6Research output: Contribution to journal › Journal article
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Tabletter med "løse ender" giver forsinket afgift af lægemiddelstof
Naelapaa, K., Mullertz, Anette , Jacobsen, Jette, Rømsing, J. & Bar-Shalom, Daniel, 2009, In: Lægemiddelforskning. p. 4-6 3 p.Research output: Contribution to journal › Journal article
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Survival of Lactobacillus acidophilus NCFM® and Bifidobacterium lactis HN019 encapsulated in chocolate during in vitro simulated passage of the upper gastrointestinal tract
Klindt-Toldam, S., Larsen, S. K., Saaby, Lasse, Olsen, L. R., Svenstrup, G., Mullertz, Anette , Knøchel, Susanne, Heimdal, H., Nielsen, Dennis Sandris & Zielińska, D., 2016, In: Lebensmittel - Wissenschaft und Technologie. 74, p. 404-410 7 p.Research output: Contribution to journal › Journal article › peer-review
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Supersaturation of zafirlukast in fasted and fed state intestinal media with and without precipitation inhibitors
Madsen, C. M., Boyd, B., Rades, Thomas & Mullertz, Anette , 25 Aug 2016, In: European Journal of Pharmaceutical Sciences. 91, p. 31-39 9 p.Research output: Contribution to journal › Journal article › peer-review
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Supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS) enhance the bioavailability of the poorly water-soluble drug Simvastatin in dogs
Thomas, N., Holm, R., Garmer, M., Karlsson, J. J., Mullertz, Anette & Rades, Thomas, 2013, In: A A P S Journal. 15, 1, p. 219-27 9 p.Research output: Contribution to journal › Journal article › peer-review
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Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
Boyd, B. J., Bergström, C. A. S., Vinarov, Z., Kuentz, M., Brouwers, J., Augustijns, P., Brandl, M., Bernkop-Schnürch, A., Shrestha, N., Préat, V., Mullertz, Anette , Bauer-Brandl, A. & Jannin, V., 2019, In: European Journal of Pharmaceutical Sciences. 137, 27 p., 104967.Research output: Contribution to journal › Journal article › peer-review
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Studying the propensity of compounds to supersaturate: a practical and broadly applicable approach
Palmelund, H., Madsen, C. M., Christensen, J. P., Mullertz, Anette & Rades, Thomas, Oct 2016, In: Journal of Pharmaceutical Sciences. 105, 10, p. 3021-3029 9 p.Research output: Contribution to journal › Journal article › peer-review
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Studying furosemide solubilization using an in vitro model simulating gastrointestinal digestion and drug solubilization in neonates and young infants
Klitgaard, Mette, Sassene, P. J., Selen, A., Mullertz, Anette & Berthelsen, R., 15 Nov 2017, In: European Journal of Pharmaceutical Sciences. 109, p. 191-199 9 p.Research output: Contribution to journal › Journal article › peer-review
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Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats
Holm, R., Porter, C. J. H., Mullertz, Anette , Kristensen, H. G. & Charman, W. N., 2002, In: Pharmaceutical Research. 19, 9, p. 1354-61 7 p.Research output: Contribution to journal › Journal article › peer-review
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Structured approach for designing drug-loaded solid products by binder jetting 3D printing
Wang, Y., Mullertz, Anette & Rantanen, Jukka, 2022, In: European Journal of Pharmaceutical Sciences. 178, 11 p., 106280.Research output: Contribution to journal › Journal article › peer-review
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Structural features of colloidal species in the human fasted upper small intestine
Mullertz, Anette , Reppas, C., Psachoulias, D., Vertzoni, M. & Fatouros, D. G., Apr 2015, In: Journal of Pharmacy and Pharmacology. 67, 4, p. 486-492 7 p.Research output: Contribution to journal › Journal article › peer-review
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Structural development of self nano emulsifying drug delivery systems (SNEDDS) during in vitro lipid digestion monitored by small-angle X-ray scattering
Fatouros, D. G., Deen, R., Arleth, Lise, Bergenstahl, B., Nielsen, F. S., Pedersen, J. S. & Mullertz, Anette , 2007, In: Pharmaceutical Research. 24, 10, p. 1844-1853 10 p.Research output: Contribution to journal › Journal article › peer-review
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Steric and interactive barrier properties of intestinal mucus elucidated by particle diffusion and peptide permeation
Bøgh, M., García-Díaz, M., Mullertz, Anette & Nielsen, Hanne Mørck, Sep 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 94, Part A, p. 136–143 8 p.Research output: Contribution to journal › Journal article › peer-review
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Stability and intrinsic dissolution of vacuum compression molded amorphous solid dispersions of efavirenz
Jørgensen, J. R., Mohr, W., Rischer, M., Sauer, A., Mistry, S., Mullertz, Anette & Rades, Thomas, 2023, In: International Journal of Pharmaceutics. 632, 8 p., 122564.Research output: Contribution to journal › Journal article › peer-review
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Stabilisation of amorphous furosemide increases the oral drug bioavailability in rats
Nielsen, L. H., Rades, Thomas & Mullertz, Anette , 25 Jul 2015, In: International Journal of Pharmaceutics. 490, 1-2, p. 334-40 7 p.Research output: Contribution to journal › Journal article › peer-review
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Spatial confinement can lead to increased stability of amorphous indomethacin
Nielsen, L. H., Keller, S. S., Gordon, K. C., Boisen, A., Rades, Thomas & Mullertz, Anette , 2012, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 81, 2, p. 418-25 8 p.Research output: Contribution to journal › Journal article › peer-review
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Solution or suspension - Does it matter for lipid based systems? In vivo studies of chase dosing lipid vehicles with aqueous suspensions of a poorly soluble drug
Larsen, A. T., Holm, R. & Mullertz, Anette , Aug 2017, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 117, p. 308-314 7 p.Research output: Contribution to journal › Journal article › peer-review
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Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols
Christensen, J. Ø., Schultz, K., Mollgaard, B., Kristensen, H. G. & Mullertz, Anette , 2004, In: European Journal of Pharmaceutical Sciences. 23, 3, p. 287-96 9 p.Research output: Contribution to journal › Journal article › peer-review
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Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin
Christophersen, P. C., Vaghela, D., Mullertz, Anette , Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, Jul 2014, In: A A P S Journal. 16, 4, p. 875-83 9 p.Research output: Contribution to journal › Journal article › peer-review
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Solid lipid particles for oral delivery of peptide and protein drugs I - Elucidating the release mechanism of lysozyme during lipolysis
Christophersen, P. C. B., Zhang, L., Yang, Mingshi, Nielsen, Hanne Mørck, Mullertz, Anette & Mu, Huiling, 2 Aug 2013, In: European Journal of Pharmaceutics and Biopharmaceutics. 85, 3, part A, p. 473-480Research output: Contribution to journal › Journal article › peer-review
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Solid forms of amlodipine besylate: Physiochemical, structural, and thermodynamic characterization
Koradia, V. S., Lopez de Diego, H., Frydenvang, Karla Andrea, Ringkjøbing-Elema, M., Mullertz, Anette , Bond, A. D. & Rantanen, Jukka, 28 Oct 2010, In: Crystal Growth & Design. 10, 12, p. 5279-5290Research output: Contribution to journal › Journal article › peer-review
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Solid cellulose nanofiber based foams - Towards facile design of sustained drug delivery systems
Svagan, A. J., Benjamins, J., Al-Ansari, Z., Bar-Shalom, Daniel, Mullertz, Anette , Wågberg, L. & Löbmann, K., 12 Nov 2016, In: Journal of controlled release : official journal of the Controlled Release Society. 244 , Part A, p. 74–82 9 p.Research output: Contribution to journal › Journal article › peer-review
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Solid Lipid Particles for Oral Delivery of Peptide and Protein Drugs II - The Digestion of Trilaurin Protects Desmopressin from Proteolytic Degradation
Christophersen, P. C., Zhang, L., Mullertz, Anette , Nielsen, Hanne Mørck, Yang, Mingshi & Mu, Huiling, 13 Mar 2014, In: Pharmaceutical Research. 31, 9, p. 2420-28 9 p.Research output: Contribution to journal › Journal article › peer-review
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Six years of progress in the oral biopharmaceutics area – A summary from the IMI OrBiTo project
Abrahamsson, B., Mcallister, M., Augustijns, P., Zane, P., Butler, J., Holm, R., Langguth, P., Lindahl, A., Mullertz, Anette , Pepin, X., Rostami-hodjegan, A., Sjögren, E., Berntsson, M. & Lennernäs, H., 1 Jul 2020, In: European Journal of Pharmaceutics and Biopharmaceutics. 152, p. 236-247 12 p.Research output: Contribution to journal › Journal article › peer-review
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Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading
Li, P., Tan, A., Prestidge, C. A., Nielsen, Hanne Mørck & Mullertz, Anette , 30 Dec 2014, In: International Journal of Pharmaceutics. 477, 1-2, p. 390-8 9 p.Research output: Contribution to journal › Journal article › peer-review
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Self-microemulsifying drug delivery system and nanoemulsion for enhancing aqueous miscibility of Alpinia galanga oil
Khumpirapang, N., Pikulkaew, S., Mullertz, Anette , Rades, Thomas & Okonogi, S., 2017, In: PLOS ONE. 12, 11, 18 p., e0188848.Research output: Contribution to journal › Journal article › peer-review
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Self-emulsifying drug delivery systems (SEDDS) – The splendid comeback of an old technology
Bernkop-Schnürch, A., Mullertz, Anette & Rades, Thomas, 2019, In: Advanced Drug Delivery Reviews. 142, p. 1-2 2 p.Research output: Contribution to journal › Editorial › peer-review
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Selection of a lipase for development of an in vitro gastric lipid digestion model
Larsen, A. T., Jensen, L. G., Hansen, K. K. & Mullertz, Anette , Nov 2010.Research output: Contribution to conference › Poster › Research
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SNEDDS containing poorly water soluble cinnarizine; development and in Vitro characterization of dispersion, digestion and solubilization
Larsen, A. T., Ogbonna, A., Abu-Rmaileh, R., Abrahmsson, B., Østergaard, Jesper & Mullertz, Anette , 2012, In: Pharmaceutics. 4, 4, p. 641-665Research output: Contribution to journal › Journal article › peer-review
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SEDDS for intestinal absorption of insulin: Application of Caco-2 and Caco-2/HT29 co-culture monolayers and intra-jejunal instillation in rats
Liu, J., Werner, U., Funke, M., Besenius, M., Saaby, Lasse, Fano, M., Mu, Huiling & Mullertz, Anette , 5 Apr 2019, In: International Journal of Pharmaceutics. 560, p. 377-384Research output: Contribution to journal › Journal article › peer-review
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Rhamnogalacturonan-I based microcapsules for targeted drug release
Svagan, A. J., Kusic, A., De Gobba, Cristian, Larsen, F. H., Sassene, P., Zhou, Q., van de Weert, Marco, Mullertz, Anette , Jørgensen, Bodil & Ulvskov, Peter, 2016, In: P L o S One. 11, 12, 13 p., e0168050.Research output: Contribution to journal › Journal article › peer-review
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Refining stability and dissolution rate of amorphous drug formulations
Grohganz, Holger, Priemel, P. A., Löbmann, K., Nielsen, L. H., Laitinen, R., Mullertz, Anette , Van den Mooter, G. & Rades, Thomas, Jun 2014, In: Expert Opinion on Drug Delivery. 11, 6, p. 977-89 13 p.Research output: Contribution to journal › Journal article › peer-review
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Redissolution and polymorphic characterization of a poorly water-soluble drug precipitated during in vitro lipolysis from a lipid-based formulation
Ren, S., Ogbonna, A., Koradia, V. S., Sassene, P. J., Rades, T. & Mullertz, Anette , Nov 2010.Research output: Contribution to conference › Poster › Research
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Recent developments in oral lipid-based drug delivery
Thomas, N., Rades, Thomas & Mullertz, Anette , 1 Jul 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 375-382 8 p.Research output: Contribution to journal › Journal article › peer-review
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Real-time dissolution behavior of furosemide in biorelevant media as determined by UV imaging
Gordon, S., Naelapää, K., Rantanen, Jukka, Selen, A., Mullertz, Anette & Østergaard, Jesper, 2013, In: Pharmaceutical Development and Technology. 18, 6, p. 1407-16 10 p.Research output: Contribution to journal › Journal article › peer-review
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Property profiling of biosimilar mucus in a novel mucus-containing in vitro model for assessment of intestinal drug absorption
Bøgh, M., Baldursdóttir, S. G., Mullertz, Anette & Nielsen, Hanne Mørck, 8 Jan 2014, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 87, p. 227-235 9 p.Research output: Contribution to journal › Journal article › peer-review
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Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to rats
Nielsen, L. H., Gordon, S., Holm, R., Selen, A., Rades, Thomas & Mullertz, Anette , Nov 2013, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 85, 3 Pt B, p. 942-51 10 p.Research output: Contribution to journal › Journal article › peer-review
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Preparation and characterization of insulin-surfactant complexes for loading into lipid-based drug delivery systems
Li, P., Nielsen, Hanne Mørck, Fano, M. & Mullertz, Anette , Aug 2013, In: Journal of Pharmaceutical Sciences. 102, 8, p. 2689-98 10 p.Research output: Contribution to journal › Journal article › peer-review
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Predicting Oral Absorption of fenofibrate in Lipid-Based Drug Delivery Systems by Combining In Vitro Lipolysis with the Mucus-PVPA Permeability Model
Falavigna, M., Klitgaard, Mette, Berthelsen, R., Mullertz, Anette & Flaten, G. E., 2021, In: Journal of Pharmaceutical Sciences. 110, 1, p. 208-216 9 p.Research output: Contribution to journal › Journal article › peer-review
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Precipitation of a poorly soluble model drug during in vitro lilpolysis: characterization and dissolution of the precipitate
Sassene, P. J., Knopp, M. M., Hesselkilde, J. Z., Koradia, V., Larsen, A., Rades, Thomas & Mullertz, Anette , 2010, In: Journal of Pharmaceutical Sciences. 99, 12, p. 4982-4991Research output: Contribution to journal › Journal article › peer-review
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Poorly soluble drugs
Siepmann, J., Rades, Thomas, Mullertz, Anette & Loftsson, T., 15 Mar 2020, In: International Journal of Pharmaceutics. 577, 119055.Research output: Contribution to journal › Editorial
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Polymeric microcontainers improve oral bioavailability of furosemide
Nielsen, L. H., Melero, A., Keller, S. S., Jacobsen, Jette, Garrigues, T., Rades, Thomas, Mullertz, Anette & Boisen, A., 17 May 2016, In: International Journal of Pharmaceutics. 504, 1-2, p. 98-109 12 p.Research output: Contribution to journal › Journal article › peer-review
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Polymeric Lids for Microcontainers for Oral Protein Delivery
Mazzoni, C., Jacobsen, R. D., Mortensen, J., Jørgensen, J. R., Vaut, L., Jacobsen, Jette, Gundlach, C., Mullertz, Anette , Nielsen, L. H. & Boisen, A., 2019, In: Macromolecular Bioscience. 19, 5, 1900004.Research output: Contribution to journal › Journal article › peer-review
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Polymer-filled microcontainers for oral delivery loaded using supercritical impregnation
Marizza, P., Keller, S. S., Mullertz, Anette & Boisen, A., 10 Jan 2014, In: Journal of controlled release : official journal of the Controlled Release Society. 173, p. 1-9 9 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Polymer selection for simulation of rheological properties of human gastric fluid
Pedersen, P. B., Vilmann, P., Bar-Shalom, Daniel, Mullertz, Anette & Baldursdottir, S. G., 2013, In: Nordic Rheology Society Annual Transactions. 21, p. 241-247Research output: Contribution to journal › Conference article
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Physicochemical characterization of simulated intestinal fed-state fluids containing lyso-phosphatidylcholine and cholesterol
Fatouros, D., Walrand, I., Bergenstahl, B. & Mullertz, Anette , 2009, In: Dissolution Technologies. 16, 3, p. 47-50Research output: Contribution to journal › Journal article › peer-review
- Published
Physico-chemical characterization of aspirated and simulated human gastric fluids to study their influence on the intrinsic dissolution rate of cinnarizine
Pedersen, P. B., Berthelsen, R., Rades, Thomas, Jørgensen, S. A., Vilmann, Peter, Bar-Shalom, Daniel, Baldursdottir, S. & Mullertz, Anette , 2022, In: International Journal of Pharmaceutics. 622, 7 p., 121856.Research output: Contribution to journal › Journal article › peer-review
- Published
Phase transformations of amlodipine besylate solid forms
Koradia, V. S., Lemos, A. F. F. D., Allesø, M., Diego, H. L. D., Ringkjøbing-Elema, M., Mullertz, Anette & Rantanen, Jukka, 2011, In: Journal of Pharmaceutical Sciences. 100, 7, p. 2896-2910Research output: Contribution to journal › Journal article › peer-review
- Published
Oral delivery of peptides and proteins using lipid-based drug delivery systems
Li, P., Nielsen, Hanne Mørck & Mullertz, Anette , 2012, In: Expert Opinion on Drug Delivery. 9, 10, p. 1289-304 16 p.Research output: Contribution to journal › Review › peer-review
- Published
Oral bioavailability of cinnarizine in dogs: relation to SNEDDS droplet size, drug solubility and in vitro precipitation
Larsen, A. T., Ohlsson, A. G., Polentarutti, B., Barker, R. A., Phillips, A. R., Abu-Rmaileh, R., Dickinson, P. A., Abrahamsson, B., Østergaard, Jesper & Mullertz, Anette , 2013, In: European Journal of Pharmaceutical Sciences. 48, 1-2, p. 339-50 12 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Optimizing clinical drug product performance: applying Biopharmaceutics Risk Assessment Roadmap (BioRAM) and the BioRAM Scoring Grid
Dickinson, P. A., Kesisoglou, F., Flanagan, T., Martinez, M. N., Mistry, H. B., Crison, J. R., Polli, J. E., Cruañes, M. T., Serajuddin, A. T. M., Mullertz, Anette , Cook, J. A. & Selen, A., Nov 2016, In: Journal of Pharmaceutical Sciences. 105, 11, p. 3243-3255 13 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Optimization of the in vitro lipolysis rate of SMEDDS containing cinnarizine
Ulmann, C., Figueriedo-Larsen, M., Refsgaard, L., Hellekilde, J., Larsen, A., Nielsen, C., Olesen, P. & Mullertz, Anette , 2009.Research output: Contribution to conference › Poster › Research
- Published
Optimization of self nanoemulsifying drug delivery system for poorly water-soluble drug using response surface methodology
Ren, S., Mu, Huiling, Alchaer, F., Chtatou, A. & Mullertz, Anette , May 2013, In: Drug Development and Industrial Pharmacy. 39, 5, p. 799-806 8 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Oligonucleotide Delivery across the Caco-2 Monolayer: The Design and Evaluation of Self-Emulsifying Drug Delivery Systems (SEDDS)
Kubackova, J., Holas, O., Zbytovska, J., Vranikova, B., Zeng, G., Pavek, P. & Mullertz, Anette , Apr 2021, In: Pharmaceutics. 13, 4, 27 p., 459.Research output: Contribution to journal › Journal article › peer-review
- Published
New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs
Mullertz, Anette , Ogbonna, A., Ren, S. & Rades, Thomas, 2010, In: Journal of Pharmacy and Pharmacology. 62, 11, p. 1622-1636 15 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Mucosal drug delivery: barriers, in vitro models and formulation strategies
Bøgh, M., Foged, Camilla, Mullertz, Anette & Nielsen, Hanne Mørck, 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 383-391Research output: Contribution to journal › Review › peer-review
- Published
Moving perfusion culture and live-cell imaging from lab to disc: proof of concept toxicity assay with AI-based image analysis
Serioli, L., Gruzinskyte, L., Zappalà, G., Hwu, E. T., Laksafoss, T. Z., Jensen, P. L., Demarchi, D., Mullertz, Anette , Boisen, A. & Zór, K., 2023, In: Lab on a Chip. 23, p. 1603-1612Research output: Contribution to journal › Journal article › peer-review
- Published
Morphological observations on a lipid-based drug delivery system during in vitro digestion
Fatouros, D. G., Bergenstahl, B. & Mullertz, Anette , 2007, In: European Journal of Pharmaceutical Sciences. 31, 2, p. 85-94Research output: Contribution to journal › Journal article › peer-review
- Published
Monoacyl phosphatidylcholine inhibits the formation of lipid multilamellar structures during in vitro lipolysis of self-emulsifying drug delivery systems
Tran, T., Siqueira, S. D. V. S., Amenitsch, H., Rades, Thomas & Mullertz, Anette , 15 Oct 2017, In: European Journal of Pharmaceutical Sciences. 108, p. 62-70Research output: Contribution to journal › Journal article › peer-review
- Published
Miniaturized approach for excipient selection during the development of oral solid dosage form
Raijada, D. K., Mullertz, Anette , Cornett, Claus, Munk, T., Møller-Sonnergaard, Jørn & Rantanen, Jukka, Mar 2014, In: Journal of Pharmaceutical Sciences. 103, 3, p. 900-8 9 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Milk osteopontin retains integrin-binding activity after in vitro gastrointestinal transit
Christensen, B., Karlsen, N. J., Jorgensen, S. D. S., Jacobsen, L. N., Ostenfeld, M. S., Petersen, S. V., Mullertz, Anette & Sorensen, E. S., Jan 2020, In: Journal of Dairy Science. 103, 1, p. 42-51Research output: Contribution to journal › Journal article › peer-review
- Published
Microcontainers for oral insulin delivery - in vitro studies of permeation enhancement
Rune Jørgensen, J., Leth Jepsen, M., Hagner Nielsen, L., Dufva, M., Nielsen, Hanne Mørck, Rades, Thomas, Boisen, A. & Mullertz, Anette , 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 143, p. 98-105Research output: Contribution to journal › Journal article › peer-review
- Published
Meeting report: applied biopharmaceutics and quality by design for dissolution/release specification setting: product quality for patient benefit
Selen, A., Cruanes, M. T., Mullertz, Anette , Dicikinsion, P. A., Cook, J. A., Polli, J. E., Kesisoglou, F., Crison, J., Johnson, K. C., Muirhead, G. T., Schofield, T. & Tsong, Y., 2010, In: The AAPS Journal. 12, 3, p. 465-472Research output: Contribution to journal › Review
- Published
Marine lipids and the bioavailability of omega-3 fatty acids
Mu, Huiling & Mullertz, Anette , 2015, In: Current Nutrition and Food Science. 11, 3, p. 177-187 11 p.Research output: Contribution to journal › Review › peer-review
- Published
Mapping the intermediate digestion phases of human healthy intestinal contents from distal ileum and caecum at fasted and fed state conditions
Tran, T., Fatouros, D. G., Vertzoni, M., Reppas, C. & Mullertz, Anette , Mar 2017, In: The Journal of pharmacy and pharmacology. 69, 3, p. 265-273 9 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Lymphatic fatty acids in canines dosed with pharmaceutical formulations containing structured triacylglycerols
Holm, R., Porsgaard, T., Porter, H., Høy, C., Edwards, G. A., Mullertz, Anette , Kristensen, H. G. & Charman, W. N., 2006, In: European Journal of Lipid Science and Technology. 108, 9, p. 714-722 8 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Liquid self-microemulsifying drug delivery
Mullertz, Anette & Grove, M., 2007, Oral lipid-based formulations: enhancing the bioavailability of poor water-soluble drugs. Hauss, D. J. (ed.). New York: Informa Healthcare, p. 107-128Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Lipophilic prodrugs of apomorphine I: Preparation, characterisation, and in vitro enzymatic hydrolysis in biorelevant media.
Borkar, N. N., Li, B., Holm, R., Håkansson, A., Mullertz, Anette , Yang, Mingshi & Mu, Huiling, 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 89, p. 216-223 8 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Lipid-based formulations for oral administration of poorly water-soluble drugs
Mu, Huiling, Holm, R. & Mullertz, Anette , 30 Aug 2013, In: International Journal of Pharmaceutics. 453, 1, p. 215-24 10 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Lipid-based formulations for danazol containing a digestible surfactant, labrafil M2125CS: In vivo bioavailability and dynamic in vitro lipolysis
Larsen, A., Holm, R., Pedersen, M. L. & Mullertz, Anette , 2008, In: Pharmaceutical Research. 25, 12, p. 2769-2777Research output: Contribution to journal › Journal article › peer-review
- Published
Kolliphor surfactants affect solubilization and bioavailability of fenofibrate. Studies of in vitro digestion and absorption in rats.
Berthelsen, R., Holm, R., Jacobsen, Jette, Kristensen, J., Abrahamsson, B. & Mullertz, Anette , 6 Apr 2015, In: Molecular Pharmaceutics. 12, 4, p. 1062-1071 10 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Investigation of the Intra- and Interlaboratory Reproducibility of a Small Scale Standardized Supersaturation and Precipitation Method
Plum, J., Madsen, C. M., Teleki, A., Bevernage, J., da Costa Mathews, C., Karlsson, E. M., Carlert, S., Holm, R., Müller, T., Matthews, W., Sayers, A., Ojala, K., Tsinsman, K., Lingamaneni, R., Bergström, C. A., Rades, Thomas & Mullertz, Anette , 7 Nov 2017, In: Molecular Pharmaceutics. 14, 12, p. 4161-4169Research output: Contribution to journal › Journal article › peer-review
- Published
Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery
Abid, Z., Dalskov Mosgaard, M., Manfroni, G., Singh Petersen, R., Hagner Nielsen, L., Mullertz, Anette , Boisen, A. & Sylvest Keller, S., Nov 2019, In: Polymers. 11, 10 p., 1828.Research output: Contribution to journal › Journal article › peer-review
- Published
Investigating the effect of graphene oxide in chitosan/alginate-based foams on the release and antifungal activity of clotrimazole in vitro
Huang, Jianfei, Jacobsen, Jette, Genina, Natalja, Larsen, Susan Weng, Nielsen, Hanne Mørck, Mullertz, Anette & Mu, Huiling, 2022, In: European Journal of Pharmaceutical Sciences. 174, 9 p., 106204.Research output: Contribution to journal › Journal article › peer-review
ID: 1302503
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Analysis of 3D Prints by X-ray Computed Microtomography and Terahertz Pulsed Imaging
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Comparison of lipases for in vitro models of gastric digestion: lipolysis using two infant formulas as model substrates
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Rhamnogalacturonan-I based microcapsules for targeted drug release
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