Anette Müllertz

Anette Müllertz

Professor

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    ORCID: 0000-0003-3020-8892

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    1. Published

      Influence of the solid form of siramesine hydrochloride on its behaviour in aqueous environments

      Zimmermann, A., Tian, F., Lopez de Diego, H., Ringkjøbing Elema, M., Rantanen, Jukka, Mullertz, Anette & Hovgaard, L., 2009, In: Pharmaceutical Research. 26, 4, p. 846-854

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Determination of surface-adsorbed excipients of various types on drug particles prepared by antisolvent precipitation using HPLC with evaporative light scattering detection

      Zimmermann, A., Elema, M. R., Hansen, T., Mullertz, Anette & Hovgaard, L., 2007, In: Journal of Pharmaceutical and Biomedical Analysis. 44, 4, p. 874-880

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Adsorption of pharmaceutical excipients onto microcrystals of siramesine hydrochloride: Effects on physicochemical properties

      Zimmermann, A., Millqvist-Fureby, A., Elema, M. R., Hansen, T., Mullertz, Anette & Hovgaard, L., 2009, In: European Journal of Pharmaceutics and Biopharmaceutics. 71, 1, p. 109-116

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      In vivo models and decision trees for formulation development in early drug development: A review of current practices and recommendations for biopharmaceutical development

      Zane, P., Gieschen, H., Kersten, E., Mathias, N., Ollier, C., Johansson, P., Van den Bergh, A., Van Hemelryck, S., Reichel, A., Rotgeri, A., Schäfer, K., Mullertz, Anette & Langguth, P., 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 142, p. 222-231 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Chitosan Alginate Nanoparticles of Protein Hydrolysate from Acheta domesticus with Enhanced Stability for Skin Delivery

      Yeerong, K., Chantawannakul, P., Anuchapreeda, S., Juntrapirom, S., Kanjanakawinkul, W., Mullertz, Anette , Rades, Thomas & Chaiyana, W., 2024, In: Pharmaceutics. 16, 6, 25 p., 724.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Acheta domesticus: A Natural Source of Anti-Skin-Aging Ingredients for Cosmetic Applications

      Yeerong, K., Chantawannakul, P., Anuchapreeda, S., Rades, Thomas, Mullertz, Anette & Chaiyana, W., 2024, In: Pharmaceuticals. 17, 3, 20 p., 346.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: Method parameterization and comparison of in vitro digestion profiles across a range of representative formulations

      Williams, H. D., Sassene, P., Kleberg, K., Bakala-N'Goma, J., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Carrière, F., Mullertz, Anette , Porter, C. J. H. & Pouton, C. W., 2012, In: Journal of Pharmaceutical Sciences. 101, 9, p. 3360-3380

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Toward the Establishment of Standardized in Vitro Tests for Lipid-Based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I, II, IIIA, IIIB, and IV Formulations during in Vitro Digestion

      Williams, H. D., Anby, M. U., Sassene, P., Kleberg, K., Bakala-N’Goma, J., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Carrière, F., Mullertz, Anette , Pouton, C. W. & Porter, C. J. H., 2012, In: Molecular Pharmaceutics. 9, 11, p. 3286-3300 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system

      Williams, H. D., Sassene, P., Kleberg, K., Calderone, M., Igonin, A., Jule, E., Vertommen, J., Blundell, R., Benameur, H., Mullertz, Anette , Porter, C. J. H., Pouton, C. W. & Communicated on Behalf of the LFCS Consortium, C. O. B. O. T. L. C., Aug 2014, In: Journal of Pharmaceutical Sciences. 103, 8, p. 2441-55 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in vitro digestion of type I, II, IIIA, IIIB and IV lipid-based formulations

      Williams, H. D., Sassene, P., Kleberg, K., Calderone, M., Igonin, A., Jule, E., Vertommen, J., Blundell, R., Benameur, H., Mullertz, Anette , Pouton, C. W., Porter, C. J. H. & LFCS Consortium, L. C., Dec 2013, In: Pharmaceutical Research. 30, 12, p. 3059-76 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Binder jetting 3D printing in fabricating pharmaceutical solid products for precision medicine

      Wang, Y., Genina, Natalja, Mullertz, Anette & Rantanen, Jukka, 2024, In: Basic & clinical pharmacology & toxicology. 134, 3, p. 325-332

      Research output: Contribution to journal › Review › Research › peer-review

    12. Published

      Structured approach for designing drug-loaded solid products by binder jetting 3D printing

      Wang, Y., Mullertz, Anette & Rantanen, Jukka, 2022, In: European Journal of Pharmaceutical Sciences. 178, 11 p., 106280.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Coating of Primary Powder Particles Improves the Quality of Binder Jetting 3D Printed Oral Solid Products

      Wang, Y., Genina, Natalja, Mullertz, Anette & Rantanen, Jukka, 2023, In: Journal of Pharmaceutical Sciences. 112, 2, p. 506-512

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Additive Manufacturing of Solid Products for Oral Drug Delivery Using Binder Jetting Three-Dimensional Printing

      Wang, Y., Mullertz, Anette & Rantanen, Jukka, 2022, In: AAPS PharmSciTech. 23, 6, 196.

      Research output: Contribution to journal › Review › Research › peer-review

    15. Published

      Are phytosomes a superior nanodelivery system for the antioxidant rutin?

      Vu, H. T. H., Hook, S. M., Siqueira, S. D., Mullertz, Anette , Rades, Thomas & McDowell, A., 2018, In: International Journal of Pharmaceutics. 548, 1, p. 82-91 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

      Vinarov, Z., Abrahamsson, B., Artursson, P., Batchelor, H., Berben, P., Bernkop-Schnurch, A., Butler, J., Ceulemans, J., Davies, N., Dupont, D., Flaten, G. E., Fotaki, N., Griffin, B. T., Jannin, V., Keemink, J., Kesisoglou, F., Koziolek, M., Kuentz, M., Mackie, A., Melendez-Martinez, A. J. & 16 others, McAllister, M., Mullertz, Anette , O'Driscoll, C. M., Parrott, N., Paszkowska, J., Pavek, P., Porter, C. J. H., Reppas, C., Stillhart, C., Sugano, K., Toader, E., Valentova, K., Vertzoni, M., De Wildt, S. N., Wilson, C. G. & Augustijns, P., 2021, In: Advanced Drug Delivery Reviews. 171, p. 289-331 43 p.

      Research output: Contribution to journal › Review › Research › peer-review

    17. Published

      UNGAP best practice for improving solubility data quality of orally administered drugs

      Vertzoni, M., Alsenz, J., Augustijns, P., Bauer-Brandl, A., Bergström, C. A. S., Brouwers, J., Mullertz, Anette , Perlovich, G., Saal, C., Sugano, K. & Reppas, C., 1 Jan 2022, In: European Journal of Pharmaceutical Sciences. 168, 21 p., 106043.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Optimization of the in vitro lipolysis rate of SMEDDS containing cinnarizine

      Ulmann, C., Figueriedo-Larsen, M., Refsgaard, L., Hellekilde, J., Larsen, A., Nielsen, C., Olesen, P. & Mullertz, Anette , 2009.

      Research output: Contribution to conference › Poster › Research

    19. Published

      Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and L-Arginine

      Ueda, H., Wu, W., Löbmann, Korbinian, Grohganz, Holger, Mullertz, Anette & Rades, Thomas, May 2018, In: Molecular Pharmaceutics. 15, 5, p. 2036-2044

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Formulation of co-amorphous systems from naproxen and naproxen sodium and in situ monitoring of physicochemical state changes during dissolution testing by Raman spectroscopy

      Ueda, H., Bøtker, Johan Peter, Edinger, M., Löbmann, Korbinian, Grohganz, Holger, Mullertz, Anette , Rades, Thomas & Østergaard, Jesper, 2020, In: International Journal of Pharmaceutics. 587, 119662.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      An updated and simplified method for bile duct cannulation of rats

      Tønsberg, H., Holm, R., Bjerregaaard, T. G., Jacobsen, Jette & Mullertz, Anette , 2010, In: Laboratory Animals. 44, 4, p. 373-376

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Effect of bile on the oral absorption of halofantrine in polyethylene glycol 400 and polysorbate 80 formulations dosed to bile duct cannulated rats

      Tønsberg, H., Holm, R., Mu, Huiling, Boll, J. B., Jacobsen, Jette & Mullertz, Anette , 2011, In: Journal of Pharmacy and Pharmacology. 63, p. 817-824

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Effects of polysorbate 80 on the in-vitro precipitation and oral bioavailability of halofantrine from polyethylene glycol 400 formulations in rats

      Tønsberg, H., Holm, R., Boll, J. B., Jacobsen, Jette & Mullertz, Anette , 2009, In: Journal of Pharmacy and Pharmacology. 62, 1, p. 63-70

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Erratum: Formulation and characterization of self-nanoemulsifying drug delivery systems containing monoacyl phosphatidylcholine (International Journal of Pharmaceutics (2016) 502:1-2 (151-160) DOI: 10.1016/j.ijpharm.2016.02.026 )

      Tran, T., Xi, X., Rades, Thomas & Mullertz, Anette , 30 Jun 2016, In: International Journal of Pharmaceutics. 507, 1-2, p. 109 1 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    25. Published

      Monoacyl phosphatidylcholine inhibits the formation of lipid multilamellar structures during in vitro lipolysis of self-emulsifying drug delivery systems

      Tran, T., Siqueira, S. D. V. S., Amenitsch, H., Rades, Thomas & Mullertz, Anette , 15 Oct 2017, In: European Journal of Pharmaceutical Sciences. 108, p. 62-70

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      In vitro and in vivo performance of monoacyl phospholipid-based self-emulsifying drug delivery systems

      Tran, T., Siqueira, S. D. V. S., Amenitsch, H., Mullertz, Anette & Rades, Thomas, 10 Jun 2017, In: Journal of Controlled Release. 255, p. 45-53 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Using Potentiometric Free Drug Sensors to Determine the Free Concentration of Ionizable Drugs in Colloidal Systems

      Tran, T., Chakraborty, A., Xi, X., Bohets, H., Cornett, Claus, Tsinman, K., Rades, Thomas & Mullertz, Anette , Jan 2018, In: Journal of Pharmaceutical Sciences. 107, 1, p. 103-112

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Formulation and characterization of self-nanoemulsifying drug delivery systems containing monoacyl phosphatidylcholine

      Tran, T., Xi, X., Rades, Thomas & Mullertz, Anette , 11 Apr 2016, In: International Journal of Pharmaceutics. 502, 1-2, p. 151-60 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Formulation of self-nanoemulsifying drug delivery systems containing monoacyl phosphatidylcholine and Kolliphor® RH40 using experimental design

      Tran, T., Rades, Thomas & Mullertz, Anette , 2018, In: Asian Journal of Pharmaceutical Sciences. 13, p. 536-545

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems

      Tran, T., Bonlokke, P., Rodriguez-Rodriguez, C., Nosrati, Z., Esquinas, P. L., Borkar, N., Plum, J., Strindberg, S., Karagiozov, S., Rades, Thomas, Mullertz, Anette , Saatchi, K. & Hafeli, U. O., 2020, In: Journal of Controlled Release. 317, p. 375-384

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Mapping the intermediate digestion phases of human healthy intestinal contents from distal ileum and caecum at fasted and fed state conditions

      Tran, T., Fatouros, D. G., Vertzoni, M., Reppas, C. & Mullertz, Anette , Mar 2017, In: The Journal of pharmacy and pharmacology. 69, 3, p. 265-273 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30

      Thybo, P., Pedersen, B. L., Hovgaard, L., Holm, R. & Mullertz, Anette , 2008, In: Pharmaceutical Development and Technology. 13, 5, p. 375-86 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS) enhance the bioavailability of the poorly water-soluble drug Simvastatin in dogs

      Thomas, N., Holm, R., Garmer, M., Karlsson, J. J., Mullertz, Anette & Rades, Thomas, 2013, In: A A P S Journal. 15, 1, p. 219-27 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      In Vitro Lipolysis Data Does Not Adequately Predict the In Vivo Performance of Lipid-Based Drug Delivery Systems Containing Fenofibrate

      Thomas, N., Richter, K., Pedersen, T. B., Holm, R., Mullertz, Anette & Rades, Thomas, 2 Apr 2014, In: A A P S Journal. 16, 3, p. 539-549

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Characterising lipid lipolysis and its implication in lipid-based formulation development

      Thomas, N., Holm, R., Rades, Thomas & Mullertz, Anette , 2012, In: The AAPS journal. 14, 4, p. 860-71 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Influence of lipid composition and drug load on the in vitro performance of self-nanoemulsifying drug delivery systems

      Thomas, N., Mullertz, Anette , Graf, A. & Rades, T., 2012, In: Journal of Pharmaceutical Sciences. 101, 5, p. 1721-1731

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Recent developments in oral lipid-based drug delivery

      Thomas, N., Rades, Thomas & Mullertz, Anette , 1 Jul 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 375-382 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide

      Svagan, A. J., Mullertz, Anette & Löbmann, Korbinian, Nov 2017, In: The Journal of pharmacy and pharmacology. 69, 11, p. 1477-1484 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Rhamnogalacturonan-I based microcapsules for targeted drug release

      Svagan, A. J., Kusic, A., De Gobba, Cristian, Larsen, F. H., Sassene, P., Zhou, Q., van de Weert, Marco, Mullertz, Anette , Jørgensen, Bodil & Ulvskov, Peter, 2016, In: P L o S One. 11, 12, 13 p., e0168050.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Solid cellulose nanofiber based foams - Towards facile design of sustained drug delivery systems

      Svagan, A. J., Benjamins, J., Al-Ansari, Z., Bar-Shalom, Daniel, Mullertz, Anette , Wågberg, L. & Löbmann, Korbinian, 12 Nov 2016, In: Journal of controlled release : official journal of the Controlled Release Society. 244 , Part A, p. 74–82 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug

      Sunesen, V. H., Vedelsdal, R., Kristensen, H. G., Christrup, Lona Louring & Mullertz, Anette , 2005, In: European Journal of Pharmaceutical Sciences. 24, 4, p. 297-303 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media

      Sunesen, V. H., Pedersen, B. L., Kristensen, H. G. & Mullertz, Anette , 2005, In: European Journal of Pharmaceutical Sciences. 24, 4, p. 305-13 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Visualizing the Journey of Fenofibrate through the Rat Gastrointestinal Tract by Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging

      Strindberg, S., Plum, J., Bagger, C., Janfelt, Christian & Mullertz, Anette , 2021, In: Molecular Pharmaceutics. 18, 6, p. 2189–2197

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Effect of supersaturation on absorption of indomethacin and tadalafil in a single pass intestinal perfusion rat model, in the absence and presence of a precipitation inhibitor

      Strindberg, S., Plum, J., Stie, Mai Bay, Christiansen, M. L., Nielsen, L. H., Rades, Thomas & Mullertz, Anette , Jun 2020, In: European Journal of Pharmaceutics and Biopharmaceutics. 151, p. 108-115

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Impact of gastrointestinal physiology on drug absorption in special populations – An UNGAP review

      Stillhart, C., Vucicevic, K., Augustijns, P., Basit, A. W., Batchelor, H., Flanagan, T. R., Gesquiere, I., Greupink, R., Keszthelyi, D., Koskinen, M., Madla, C. M., Matthys, C., Miljus, G., Mooij, M. G., Parrott, N., Ungell, A. -., de Wildt, S. N., Orlu, M., Klein, S. & Mullertz, Anette , 2020, In: European Journal of Pharmaceutical Sciences. 147, 28 p., 105280.

      Research output: Contribution to journal › Review › Research › peer-review

    46. Published

      Influence of drug load and physical form of cinnarizine in new SNEDDS dosing regimens: in vivo and in vitro evaluations

      Siqueira, S. D. V. S., Mullertz, Anette , Gräeser, K., Kasten, G., Mu, Huiling & Rades, Thomas, Mar 2017, In: A A P S Journal. 19, 2, p. 587-594 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Poorly soluble drugs

      Siepmann, J., Rades, Thomas, Mullertz, Anette & Loftsson, T., 15 Mar 2020, In: International Journal of Pharmaceutics. 577, 119055.

      Research output: Contribution to journal › Editorial › Research

    48. Published

      Moving perfusion culture and live-cell imaging from lab to disc: proof of concept toxicity assay with AI-based image analysis

      Serioli, L., Gruzinskyte, L., Zappalà, G., Hwu, E. T., Laksafoss, T. Z., Jensen, P. L., Demarchi, D., Mullertz, Anette , Boisen, A. & Zór, K., 2023, In: Lab on a Chip. 23, p. 1603-1612

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Development of a Microgram Scale Video-Microscopic Method to Investigate Dissolution Behavior of Poorly Water-Soluble Drugs

      Senniksen, M. B., Christfort, J. F., Marabini, R., Spillum, E., Matthews, W., Da Vià, L., Plum, J., Rades, Thomas & Mullertz, Anette , 2022, In: AAPS PharmSciTech. 23, 6, 173.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Meeting report: applied biopharmaceutics and quality by design for dissolution/release specification setting: product quality for patient benefit

      Selen, A., Cruanes, M. T., Mullertz, Anette , Dicikinsion, P. A., Cook, J. A., Polli, J. E., Kesisoglou, F., Crison, J., Johnson, K. C., Muirhead, G. T., Schofield, T. & Tsong, Y., 2010, In: The AAPS Journal. 12, 3, p. 465-472

      Research output: Contribution to journal › Review › Research

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