Anette Müllertz

Anette Müllertz

Professor


  1. Published

    Influence of the solid form of siramesine hydrochloride on its behaviour in aqueous environments

    Zimmermann, A., Tian, F., Lopez de Diego, H., Ringkjøbing Elema, M., Rantanen, Jukka, Mullertz, Anette & Hovgaard, L., 2009, In : Pharmaceutical Research. 26, 4, p. 846-854

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Determination of surface-adsorbed excipients of various types on drug particles prepared by antisolvent precipitation using HPLC with evaporative light scattering detection

    Zimmermann, A., Elema, M. R., Hansen, T., Mullertz, Anette & Hovgaard, L., 2007, In : Journal of Pharmaceutical and Biomedical Analysis. 44, 4, p. 874-880

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Adsorption of pharmaceutical excipients onto microcrystals of siramesine hydrochloride: Effects on physicochemical properties

    Zimmermann, A., Millqvist-Fureby, A., Elema, M. R., Hansen, T., Mullertz, Anette & Hovgaard, L., 2009, In : European Journal of Pharmaceutics and Biopharmaceutics. 71, 1, p. 109-116

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    In vivo models and decision trees for formulation development in early drug development: A review of current practices and recommendations for biopharmaceutical development

    Zane, P., Gieschen, H., Kersten, E., Mathias, N., Ollier, C., Johansson, P., Van den Bergh, A., Van Hemelryck, S., Reichel, A., Rotgeri, A., Schäfer, K., Mullertz, Anette & Langguth, P., 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 142, p. 222-231 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: Method parameterization and comparison of in vitro digestion profiles across a range of representative formulations

    Williams, H. D., Sassene, P., Kleberg, K., Bakala-N'Goma, J., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Carrière, F., Mullertz, Anette , Porter, C. J. H. & Pouton, C. W., 2012, In : Journal of Pharmaceutical Sciences. 101, 9, p. 3360-3380

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Toward the Establishment of Standardized in Vitro Tests for Lipid-Based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I, II, IIIA, IIIB, and IV Formulations during in Vitro Digestion

    Williams, H. D., Anby, M. U., Sassene, P., Kleberg, K., Bakala-N’Goma, J., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Carrière, F., Mullertz, Anette , Pouton, C. W. & Porter, C. J. H., 2012, In : Molecular Pharmaceutics. 9, 11, p. 3286-3300 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system

    Williams, H. D., Sassene, P., Kleberg, K., Calderone, M., Igonin, A., Jule, E., Vertommen, J., Blundell, R., Benameur, H., Mullertz, Anette , Porter, C. J. H., Pouton, C. W. & Communicated on Behalf of the LFCS Consortium, C. O. B. O. T. L. C., Aug 2014, In : Journal of Pharmaceutical Sciences. 103, 8, p. 2441-55 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in vitro digestion of type I, II, IIIA, IIIB and IV lipid-based formulations

    Williams, H. D., Sassene, P., Kleberg, K., Calderone, M., Igonin, A., Jule, E., Vertommen, J., Blundell, R., Benameur, H., Mullertz, Anette , Pouton, C. W., Porter, C. J. H. & LFCS Consortium, L. C., Dec 2013, In : Pharmaceutical Research. 30, 12, p. 3059-76 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Are phytosomes a superior nanodelivery system for the antioxidant rutin?

    Vu, H. T. H., Hook, S. M., Siqueira Jørgensen, Scheyla Daniela, Mullertz, Anette , Rades, Thomas & McDowell, A., 2018, In : International Journal of Pharmaceutics. 548, 1, p. 82-91 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Optimization of the in vitro lipolysis rate of SMEDDS containing cinnarizine

    Ulmann, C., Figueriedo-Larsen, M., Refsgaard, L., Hellekilde, J., Larsen, A., Nielsen, C., Olesen, P. & Mullertz, Anette , 2009.

    Research output: Contribution to conferencePosterResearch

  11. Published

    Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and L-Arginine

    Ueda, H., Wu, W., Löbmann, Korbinian, Grohganz, Holger, Mullertz, Anette & Rades, Thomas, May 2018, In : Molecular Pharmaceutics. 15, 5, p. 2036-2044

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    An updated and simplified method for bile duct cannulation of rats

    Tønsberg, H., Holm, R., Bjerregaaard, T. G., Jacobsen, Jette & Mullertz, Anette , 2010, In : Laboratory Animals. 44, 4, p. 373-376

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Effect of bile on the oral absorption of halofantrine in polyethylene glycol 400 and polysorbate 80 formulations dosed to bile duct cannulated rats

    Tønsberg, H., Holm, R., Mu, Huiling, Boll, J. B., Jacobsen, Jette & Mullertz, Anette , 2011, In : Journal of Pharmacy and Pharmacology. 63, p. 817-824

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Effects of polysorbate 80 on the in-vitro precipitation and oral bioavailability of halofantrine from polyethylene glycol 400 formulations in rats

    Tønsberg, H., Holm, R., Boll, J. B., Jacobsen, Jette & Mullertz, Anette , 2009, In : Journal of Pharmacy and Pharmacology. 62, 1, p. 63-70

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems

    Tran, T., Bonlokke, P., Rodriguez-Rodriguez, C., Nosrati, Z., Esquinas, P. L., Borkar, N., Plum, J., Strindberg, Sophie , Karagiozov, S., Rades, Thomas, Mullertz, Anette , Saatchi, K. & Häfeli, Urs Otto, 2020, In : Journal of Controlled Release. 317, p. 375-384

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Monoacyl phosphatidylcholine inhibits the formation of lipid multilamellar structures during in vitro lipolysis of self-emulsifying drug delivery systems

    Tran, T., Siqueira Jørgensen, Scheyla Daniela, Amenitsch, H., Rades, Thomas & Mullertz, Anette , 15 Oct 2017, In : European Journal of Pharmaceutical Sciences. 108, p. 62-70

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    In vitro and in vivo performance of monoacyl phospholipid-based self-emulsifying drug delivery systems

    Tran, T., Siqueira Jørgensen, Scheyla Daniela, Amenitsch, H., Mullertz, Anette & Rades, Thomas, 10 Jun 2017, In : Journal of Controlled Release. 255, p. 45-53 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Using Potentiometric Free Drug Sensors to Determine the Free Concentration of Ionizable Drugs in Colloidal Systems

    Tran, T., Chakraborty, A., Xi, X., Bohets, H., Cornett, Claus, Tsinman, K., Rades, Thomas & Mullertz, Anette , Jan 2018, In : Journal of Pharmaceutical Sciences. 107, 1, p. 103-112

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Formulation and characterization of self-nanoemulsifying drug delivery systems containing monoacyl phosphatidylcholine

    Tran, T., Xi, X., Rades, Thomas & Mullertz, Anette , 11 Apr 2016, In : International Journal of Pharmaceutics. 502, 1-2, p. 151-60 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Formulation of self-nanoemulsifying drug delivery systems containing monoacyl phosphatidylcholine and Kolliphor® RH40 using experimental design

    Tran, T., Rades, Thomas & Mullertz, Anette , 2018, In : Asian Journal of Pharmaceutical Sciences. 13, p. 536-545

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Mapping the intermediate digestion phases of human healthy intestinal contents from distal ileum and caecum at fasted and fed state conditions

    Tran, T., Fatouros, D. G., Vertzoni, M., Reppas, C. & Mullertz, Anette , Mar 2017, In : The Journal of pharmacy and pharmacology. 69, 3, p. 265-273 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30

    Thybo, P., Pedersen, B. L., Hovgaard, L., Holm, R. & Mullertz, Anette , 2008, In : Pharmaceutical Development and Technology. 13, 5, p. 375-86 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS) enhance the bioavailability of the poorly water-soluble drug Simvastatin in dogs

    Thomas, N., Holm, R., Garmer, M., Karlsson, J. J., Mullertz, Anette & Rades, Thomas, 2013, In : A A P S Journal. 15, 1, p. 219-27 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    In Vitro Lipolysis Data Does Not Adequately Predict the In Vivo Performance of Lipid-Based Drug Delivery Systems Containing Fenofibrate

    Thomas, N., Richter, K., Pedersen, T. B., Holm, R., Mullertz, Anette & Rades, Thomas, 2 Apr 2014, In : A A P S Journal. 16, 3, p. 539-549

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Characterising lipid lipolysis and its implication in lipid-based formulation development

    Thomas, N., Holm, R., Rades, Thomas & Mullertz, Anette , 2012, In : The AAPS journal. 14, 4, p. 860-71 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Influence of lipid composition and drug load on the in vitro performance of self-nanoemulsifying drug delivery systems

    Thomas, N., Mullertz, Anette , Graf, A. & Rades, T., 2012, In : Journal of Pharmaceutical Sciences. 101, 5, p. 1721-1731

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Recent developments in oral lipid-based drug delivery

    Thomas, N., Rades, Thomas & Mullertz, Anette , 1 Jul 2013, In : Journal of Drug Delivery Science and Technology. 23, 4, p. 375-382 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide

    Svagan, A. J., Mullertz, Anette & Löbmann, Korbinian, Nov 2017, In : The Journal of pharmacy and pharmacology. 69, 11, p. 1477-1484 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Rhamnogalacturonan-I based microcapsules for targeted drug release

    Svagan, A. J., Kusic, A., De Gobba, Cristian, Larsen, F. H., Sassene, P., Zhou, Q., van de Weert, Marco, Mullertz, Anette , Jørgensen, Bodil & Ulvskov, Peter, 2016, In : P L o S One. 11, 12, 13 p., e0168050.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Solid cellulose nanofiber based foams - Towards facile design of sustained drug delivery systems

    Svagan, A. J., Benjamins, J., Al-Ansari, Z., Bar-Shalom, Daniel, Mullertz, Anette , Wågberg, L. & Löbmann, Korbinian, 12 Nov 2016, In : Journal of controlled release : official journal of the Controlled Release Society. 244 , Part A, p. 74–82 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug

    Sunesen, V. H., Vedelsdal, R., Kristensen, H. G., Christrup, Lona Louring & Mullertz, Anette , 2005, In : European Journal of Pharmaceutical Sciences. 24, 4, p. 297-303 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media

    Sunesen, V. H., Pedersen, B. L., Kristensen, H. G. & Mullertz, Anette , 2005, In : European Journal of Pharmaceutical Sciences. 24, 4, p. 305-13 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Influence of drug load and physical form of cinnarizine in new SNEDDS dosing regimens: in vivo and in vitro evaluations

    Siqueira Jørgensen, Scheyla Daniela, Mullertz, Anette , Gräeser, K., Kasten, G., Mu, Huiling & Rades, Thomas, Mar 2017, In : A A P S Journal. 19, 2, p. 587-594 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Poorly soluble drugs

    Siepmann, J., Rades, Thomas, Mullertz, Anette & Loftsson, T., 15 Mar 2020, In : International Journal of Pharmaceutics. 577, 119055.

    Research output: Contribution to journalEditorialResearchpeer-review

  35. Published

    Meeting report: applied biopharmaceutics and quality by design for dissolution/release specification setting: product quality for patient benefit

    Selen, A., Cruanes, M. T., Mullertz, Anette , Dicikinsion, P. A., Cook, J. A., Polli, J. E., Kesisoglou, F., Crison, J., Johnson, K. C., Muirhead, G. T., Schofield, T. & Tsong, Y., 2010, In : The AAPS Journal. 12, 3, p. 465-472

    Research output: Contribution to journalReviewResearch

  36. Published

    Elucidating the molecular interactions occurring during drug precipitation of weak bases from lipid-based formulations: a case study with cinnarizine and a long chain self-nanoemulsifying drug delivery system

    Sassene, P. J., Mosgaard, M. D., Löbmann, Korbinian, Mu, Huiling, Larsen, F. H., Rades, Thomas & Mullertz, Anette , 2015, In : Molecular Pharmaceutics. 12, 11, p. 4067-4076 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Precipitation of a poorly soluble model drug during in vitro lilpolysis: characterization and dissolution of the precipitate

    Sassene, P. J., Knopp, M. M., Hesselkilde, J. Z., Koradia, V. S., Larsen, A. T., Rades, T. & Mullertz, Anette , 2010, In : Journal of Pharmaceutical Sciences. 99, 12, p. 4982-4991

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Comparison of lipases for in vitro models of gastric digestion: lipolysis using two infant formulas as model substrates

    Sassene, P. J., Fanø, M., Mu, Huiling, Rades, Thomas, Aquistapace, S., Schmitt, B., Cruz-Hernandez, C., Wooster, T. J. & Mullertz, Anette , 14 Sep 2016, In : Food & Function. 7, 9, p. 3989-3998 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    In Vivo Precipitation of Poorly Soluble Drugs from Lipid-Based Drug Delivery Systems

    Sassene, P. J., Michaelsen, M. H., Mosgaard, M. D., Klitgaard, Mette, Van Den Broek, E., Wasan, K. M., Mu, Huiling, Rades, Thomas & Mullertz, Anette , 3 Oct 2016, In : Molecular Pharmaceutics. 13, 10, p. 3417-3426 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Microcontainers for oral insulin delivery - in vitro studies of permeation enhancement

    Jørgensen, Jacob Rune, Leth Jepsen, M., Hagner Nielsen, L., Dufva, M., Nielsen, Hanne Mørck, Rades, Thomas, Boisen, A. & Mullertz, Anette , 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 143, p. 98-105

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Optimization of self nanoemulsifying drug delivery system for poorly water-soluble drug using response surface methodology

    Ren, S., Mu, Huiling, Alchaer, F., Chtatou, A. & Mullertz, Anette , May 2013, In : Drug Development and Industrial Pharmacy. 39, 5, p. 799-806 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Redissolution and polymorphic characterization of a poorly water-soluble drug precipitated during in vitro lipolysis from a lipid-based formulation

    Ren, S., Ogbonna, A., Koradia, V. S., Sassene, P. J., Rades, T. & Mullertz, Anette , Nov 2010.

    Research output: Contribution to conferencePosterResearch

  43. Published

    Miniaturized approach for excipient selection during the development of oral solid dosage form

    Raijada, D. K., Mullertz, Anette , Cornett, Claus, Munk, T., Sonnergaard, J. & Rantanen, Jukka, Mar 2014, In : Journal of Pharmaceutical Sciences. 103, 3, p. 900-8 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Comparison of induction methods for supersaturation: pH shift versus solvent shift

    Plum, J., Bavnhoj, C., Palmelund, Henrik, Perez-Alos, L., Mullertz, Anette & Rades, Thomas, 5 Jan 2020, In : International Journal of Pharmaceutics. 573, 8 p., 118862.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Investigation of the Intra- and Interlaboratory Reproducibility of a Small Scale Standardized Supersaturation and Precipitation Method

    Plum, J., Madsen, C. M., Teleki, A., Bevernage, J., da Costa Mathews, C., Karlsson, E. M., Carlert, S., Holm, R., Müller, T., Matthews, W., Sayers, A., Ojala, K., Tsinsman, K., Lingamaneni, R., Bergström, C. A., Rades, Thomas & Mullertz, Anette , 7 Nov 2017, In : Molecular Pharmaceutics. 14, 12, p. 4161-4169

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Feasibility of Capsule Endoscopy for Direct Imaging of Drug Delivery Systems in the Fasted Upper-Gastrointestinal Tract

    Pedersen, P. B., Bar-Shalom, Daniel, Baldursdottir, S., Vilmann, Peter & Mullertz, Anette , 19 Feb 2014, In : Pharmaceutical Research. 31, 8, p. 2044-2053 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Towards the understanding of complex fluids in pharmaceutical sciences

    Pedersen, P. B., Pekka Pajander, J., Mullertz, Anette , Vilmann, Peter, Jørgensen, Lene & Baldursdottir, S. G., 2013, In : Journal of Drug Delivery Science and Technology. 23, 4, p. 393 401 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Characterization of fasted human gastric fluid for relevant rheological parameters and gastric lipase activities

    Pedersen, P. B., Vilmann, Peter, Bar-Shalom, Daniel, Mullertz, Anette & Baldursdottir, S., Nov 2013, In : European Journal of Pharmaceutics and Biopharmaceutics. 85, 3, Pt B, p. 958-65 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Polymer selection for simulation of rheological properties of human gastric fluid

    Pedersen, P. B., Vilmann, P., Bar-Shalom, Daniel, Mullertz, Anette & Baldursdottir, S. G., 2013, In : Nordic Rheology Society Annual Transactions. 21, p. 241-247

    Research output: Contribution to journalConference articleResearch

  50. Published

    Bioinspired Layer-by-Layer Microcapsules Based on Cellulose Nanofibers with Switchable Permeability

    Paulraj, T., Riazanova, A. V., Yao, K., Andersson, R. L., Mullertz, Anette & Svagan, A. J., 10 Apr 2017, In : Biomacromolecules. 18, 4, p. 1401-1410 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Exploring the fate of liposomes in the intestine by dynamic in vitro lipolysis

    Parmentier, J., Thomas, N., Mullertz, Anette , Fricker, G. & Rades, Thomas, 2012, In : International Journal of Pharmaceutics. 437, 1-2, p. 253-63 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Studying the propensity of compounds to supersaturate: a practical and broadly applicable approach

    Palmelund, Henrik, Madsen, C. M., Christensen, J. P., Mullertz, Anette & Rades, Thomas, Oct 2016, In : Journal of Pharmaceutical Sciences. 105, 10, p. 3021-3029 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    The use of biorelevant dissolution media in determining the region of microemulsion: Implications for in vitro lipid formulation assessment

    Ogbonna, A., Ren, S., Olesen, P. & Mullertz, Anette , 2009.

    Research output: Contribution to conferencePosterResearch

  54. Published

    Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to rats

    Nielsen, L. H., Gordon, S., Holm, R., Selen, A., Rades, Thomas & Mullertz, Anette , Nov 2013, In : European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 85, 3 Pt B, p. 942-51 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Characterization during storage and dissolution of Solid dispersions containing furosemide and hydroxypropyl methylcellulose

    Nielsen, L. H., Rades, Thomas & Mullertz, Anette , 1 Jul 2013, In : Journal of Drug Delivery Science and Technology. 23, 4, p. 409-415 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Spatial confinement can lead to increased stability of amorphous indomethacin

    Nielsen, L. H., Keller, S. S., Gordon, K. C., Boisen, A., Rades, Thomas & Mullertz, Anette , 2012, In : European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 81, 2, p. 418-25 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Stabilisation of amorphous furosemide increases the oral drug bioavailability in rats

    Nielsen, L. H., Rades, Thomas & Mullertz, Anette , 25 Jul 2015, In : International Journal of Pharmaceutics. 490, 1-2, p. 334-40 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    A slow cooling rate of indomethacin melt spatially confined in microcontainers increases the physical stability of the amorphous drug without influencing its biorelevant dissolution behaviour

    Nielsen, L. H., Keller, S. S., Boisen, A., Mullertz, Anette & Rades, Thomas, Jun 2014, In : Drug Delivery and Translational Research. 4, 3, p. 268-74 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Biorelevant characterisation of amorphous furosemide salt exhibits conversion to a furosemide hydrate during dissolution

    Nielsen, L. H., Gordon, S., Pajander, J. P., Østergaard, Jesper, Rades, Thomas & Mullertz, Anette , 30 Nov 2013, In : International Journal of Pharmaceutics. 457, 1, p. 14-24 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Polymeric microcontainers improve oral bioavailability of furosemide

    Nielsen, L. H., Melero, A., Keller, S. S., Jacobsen, Jette, Garrigues, T., Rades, Thomas, Mullertz, Anette & Boisen, A., 17 May 2016, In : International Journal of Pharmaceutics. 504, 1-2, p. 98-109 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    pH-triggered drug release from biodegradable microwells for oral drug delivery

    Nielsen, L. H., Nagstrup, J., Gordon, S., Keller, S. S., Østergaard, Jesper, Rades, Thomas, Mullertz, Anette & Boisen, A., Jun 2015, In : Biomedical Microdevices. 17, 7 p., 55.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Bioavailability of probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state

    Nielsen, F. S., Petersen, K. & Mullertz, Anette , 2008, In : European Journal of Pharmaceutics and Biopharmaceutics. 69, 2, p. 553-562

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    Characterization of prototype self-nanoemulsifying formulations of lipophilic compounds

    Nielsen, F. S., Gibault, E., Ljusberg-Wahren, H., Arleth, Lise, Pedersen, J. S. & Mullertz, Anette , 2007, In : Journal of Pharmaceutical Sciences. 96, 4, p. 876-892 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    Tabletter med "løse ender" giver forsinket afgift af lægemiddelstof

    Naelapaa, K., Mullertz, Anette , Jacobsen, Jette, Rømsing, Janne & Bar-Shalom, Daniel, 2009, In : Lægemiddelforskning. p. 4-6 3 p.

    Research output: Contribution to journalJournal articleResearch

  65. Published

    Tabletter med løse ender

    Naelapaa, K., Mullertz, Anette , Jacobsen, Jette, Rømsing, Janne & Bar-Shalom, Daniel, 2009, In : Lægemiddelforskning. p. 4-6

    Research output: Contribution to journalJournal articleResearch

  66. Published

    Using in vitro dynamic lipolysis modeling as a tool for exploring IVIVC relationships for oral lipid-based formulations

    Mullertz, Anette & Fatourus, D. G., 2007, Oral lipid-based formulations: enhancing the bioviabillity of poorly water-soluble drugs. Hauss, D. J. (ed.). New York: Informa healtcare, p. 257-272

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  67. Published

    Unravelling the ultrastructure of ascending colon fluids from patients with ulcerative colitis by cryogenic transmission electron microscopy

    Mullertz, Anette , Fatouros, D. G., Vertzoni, M. & Reppas, C., Oct 2013, In : The Journal of pharmacy and pharmacology. 65, 10, p. 1482-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    Development of  in vitro methods for the evaluation of formulation performance

    Mullertz, Anette & Nielsen, F. S., 2005. 12 p.

    Research output: Contribution to conferencePaperResearchpeer-review

  69. Published

    Liquid self-microemulsifying drug delivery

    Mullertz, Anette & Grove, M., 2007, Oral lipid-based formulations: enhancing the bioavailability of poor water-soluble drugs. Hauss, D. J. (ed.). New York: Informa Healthcare, p. 107-128

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  70. Published

    Insights into the ultrastructure of human intestinal fluids in the fed state by electron microscopy analysis

    Mullertz, Anette , Fatouros, D., Smith, J. R., Vertzoni, M. & Rappas, C., Nov 2010.

    Research output: Contribution to conferencePosterResearch

  71. Published

    New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs

    Mullertz, Anette , Ogbonna, A., Ren, S. & Rades, Thomas, 2010, In : Journal of Pharmacy and Pharmacology. 62, 11, p. 1622-1636 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Published

    Biorelevant dissolution media

    Mullertz, Anette , 2007, Solvent systems and their selection in pharmaceutics and biopharmaceutics: Biotechnology: Pharmaceutical aspects. Augustijns, P. & Brewster, M. E. (eds.). New York: Springer Science+Business Media, Vol. 6. p. 107-177

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  73. Published

    Insights into intermediate phases of human intestinal fluids visualized by atomic force microscopy and cryo-transmission electron microscopy ex vivo

    Mullertz, Anette , Fatouros, D. G., Smith, J. R., Vertzoni, M. & Reppas, C., 2012, In : Molecular Pharmaceutics. 9, 2, p. 237-247

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Published

    Structural features of colloidal species in the human fasted upper small intestine

    Mullertz, Anette , Reppas, C., Psachoulias, D., Vertzoni, M. & Fatouros, D. G., Apr 2015, In : Journal of Pharmacy and Pharmacology. 67, 4, p. 486-492 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    Lipid-based formulations for oral administration of poorly water-soluble drugs

    Mu, Huiling, Holm, R. & Mullertz, Anette , 30 Aug 2013, In : International Journal of Pharmaceutics. 453, 1, p. 215-24 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    Marine lipids and the bioavailability of omega-3 fatty acids

    Mu, Huiling & Mullertz, Anette , 2015, In : Current Nutrition and Food Science. 11, 3, p. 177-187 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  77. Published

    Development of a high-throughput in vitro intestinal lipolysis model for rapid screening of lipid-based drug delivery systems

    Mosgaard, M. D., Sassene, P., Mu, Huiling, Rades, Thomas & Mullertz, Anette , Aug 2015, In : European Journal of Pharmaceutics and Biopharmaceutics. 94, p. 493-500 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    High-Throughput Lipolysis in 96-Well Plates for Rapid Screening of Lipid-Based Drug Delivery Systems

    Mosgaard, M. D., Sassene, P. J., Mu, Huiling, Rades, Thomas & Mullertz, Anette , Apr 2017, In : Journal of Pharmaceutical Sciences. 106, 4, p. 1183-1186 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    Fenofibrate oral absorption from SNEDDS and super-SNEDDS is not significantly affected by lipase inhibition in rats

    Michaelsen, M. H., Siqueira Jørgensen, Scheyla Daniela, Abdi, I. M., Wasan, K. M., Rades, Thomas & Mullertz, Anette , 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 142, p. 258-264 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  80. Published

    The Effect of Digestion and Drug Load on Halofantrine Absorption from Self-nanoemulsifying Drug Delivery System (SNEDDS)

    Michaelsen, M. H., Wasan, K. M., Sivak, O., Mullertz, Anette & Rades, Thomas, Jan 2016, In : The A A P S Journal. 18, 1, p. 180-186 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  81. Published

    Ex vivo - correlation of the absorption of metoprolol through human and porcine buccal mucosa at varying pH.

    Meng-Lund, E., Marxen, E., Pedersen, Anne Marie Lynge, Mullertz, Anette , Holm, R., Hyrup, B. & Jacobsen, Jette, 4 Mar 2013.

    Research output: Contribution to conferencePosterResearchpeer-review

  82. Published

    Azone® decreases the buccal mucosal permeation of Diazepam in a concentration-dependent manner via a reservoir effect

    Meng-Lund, E., Jacobsen, Jette, Jin, L., Janfelt, Christian, Holm, R., Mullertz, Anette & Nicolazzo, J. A., 15 Feb 2014, In : Journal of Pharmaceutical Sciences. 103, 4, p. 1133-1141 103.

    Research output: Contribution to journalJournal articleResearchpeer-review

  83. Published

    Ex Vivo Correlation of the Permeability of Metoprolol Across Human and Porcine Buccal Mucosa

    Meng-Lund, E., Marxen, E., Pedersen, Anne Marie Lynge, Mullertz, Anette , Hyrup, B., Holm, R. & Jacobsen, Jette, 13 May 2014, In : Journal of Pharmaceutical Sciences. 103, 7, p. 2053-2061 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. Published

    Buccal absorption of diazepam is improved when administered in bioadhesive tablets-An in vivo study in conscious Göttingen mini-pigs

    Meng-Lund, E., Jacobsen, Jette, Mullertz, Anette , Jørgensen, E. B. & Holm, R., 30 Sep 2016, In : International Journal of Pharmaceutics. 515, 1-2, p. 125-131 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  85. Published

    Polymeric Lids for Microcontainers for Oral Protein Delivery

    Mazzoni, C., Jacobsen, R. D., Mortensen, J., Jørgensen, Jacob Rune, Vaut, L., Jacobsen, Jette, Gundlach, C., Mullertz, Anette , Nielsen, L. H. & Boisen, A., 2019, In : Macromolecular Bioscience. 19, 5, 1900004.

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. Published

    From concept to in vivo testing: Microcontainers for oral drug delivery

    Mazzoni, C., Tentor, F., Strindberg, Sophie , Nielsen, L. H., Keller, S. S., Alstrøm, T. S., Gundlach, C., Mullertz, Anette , Marizza, P. & Boisen, A., 28 Dec 2017, In : Journal of Controlled Release. 268, p. 343-351 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    Analysis of 3D Prints by X-ray Computed Microtomography and Terahertz Pulsed Imaging

    Markl, D., Zeitler, J. A., Rasch, C., Michaelsen, M. H., Mullertz, Anette , Rantanen, Jukka, Rades, Thomas & Bøtker, Johan Peter, 2017, In : Pharmaceutical Research. 34, 5, p. 1037–1052 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  88. Published

    Polymer-filled microcontainers for oral delivery loaded using supercritical impregnation

    Marizza, P., Keller, S. S., Mullertz, Anette & Boisen, A., 10 Jan 2014, In : Journal of controlled release : official journal of the Controlled Release Society. 173, p. 1-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    Effect of composition of simulated intestinal media on the solubility of poorly soluble compounds investigated by design of experiments

    Madsen, C. M., Feng, K., Leithead, A., Canfield, N., Jørgensen, S. A., Mullertz, Anette & Rades, Thomas, Jan 2018, In : European Journal of Pharmaceutical Sciences. 111, p. 311-319 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  90. Published

    Supersaturation of zafirlukast in fasted and fed state intestinal media with and without precipitation inhibitors

    Madsen, C. M., Boyd, B., Rades, Thomas & Mullertz, Anette , 25 Aug 2016, In : European Journal of Pharmaceutical Sciences. 91, p. 31-39 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    Dissolution enhancement of griseofulvin from griseofulvin-sodium dodecyl sulfate discs investigated by UV imaging

    Madelung, P., Bertelsen, P., Jacobsen, Jette, Mullertz, Anette & Østergaard, Jesper, Jun 2017, In : Journal of Drug Delivery Science and Technology. 39, p. 516-522

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published

    Impact of sodium dodecyl sulphate on the dissolution of poorly soluble drug into biorelevant medium from drug-surfactant discs

    Madelung, P., Østergaard, Jesper, Bertelsen, P., Jørgensen, E. V., Jacobsen, Jette & Mullertz, Anette , 2 Mar 2014, In : International Journal of Pharmaceutics. 467, 1-2, p. 1-8

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. Published

    Cellulose Nanopaper and Nanofoam for Patient-Tailored Drug Delivery

    Löbmann, Korbinian, Wohlert, J., Mullertz, Anette , Wågberg, L. & Svagan, A. J., May 2017, In : Advanced Materials Interfaces. 4, 9, 11 p., 1600655.

    Research output: Contribution to journalJournal articleResearchpeer-review

  94. Published

    Hydrolysed pea proteins mitigate in vitro wheat starch digiestibility

    López-Barón , N., Sagnelli, D., Blennow, Andreas, Holse, M., Gao, J., Saaby, L., Mullertz, Anette , Jespersen, Birthe P Møller & Vasanthan, T., 2018, In : Food Hydrocolloids. 79, p. 117-126 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. Published

    Using biorelevant dissolution to obtain IVIVC of solid dosage forms containing a poorly-soluble model compound

    Lue, B., Nielsen, F. S., Magnussen, T., Schou, H. M., Kristensen, K., Jacobsen, L. O. & Mullertz, Anette , 2008, In : European Journal of Pharmaceutics and Biopharmaceutics. 69, 2, p. 648-657

    Research output: Contribution to journalJournal articleResearchpeer-review

  96. Published

    Enzymatic characterization of lipid-based drug delivery systems

    Ljusberg-Wahren, H., Seier Nielsen, F., Brogård, M., Troedsson, E. & Mullertz, Anette , 2005, In : Internation Journal of Pharmaceutics. 298, 2, p. 328-32 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    SEDDS for intestinal absorption of insulin: Application of Caco-2 and Caco-2/HT29 co-culture monolayers and intra-jejunal instillation in rats

    Liu, J., Werner, U., Funke, M., Besenius, M., Saaby, L., Fano, M., Mu, Huiling & Mullertz, Anette , 5 Apr 2019, In : International Journal of Pharmaceutics. 560, p. 377-384

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80

    Lind, M. L., Jacobsen, Jette, Holm, R. & Mullertz, Anette , 2008, In : European Journal of Pharmaceutical Sciences. 35, 3, p. 211-218

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    Development of simulated intestinal fluids containing nutrients as transport media in the Caco-2 cell culture model: assessment of cell viability, monolayer integrity and transport of a poorly aqueous soluble drug and a substrate of efflux mechanisms

    Lind, M. L., Jacobsen, Jette, Holm, R. & Mullertz, Anette , 2007, In : European Journal of Pharmaceutical Sciences. 32, 4-5, p. 261-270

    Research output: Contribution to journalJournal articleResearchpeer-review

  100. Published

    Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading

    Li, P., Tan, A., Prestidge, C. A., Nielsen, Hanne Mørck & Mullertz, Anette , 30 Dec 2014, In : International Journal of Pharmaceutics. 477, 1-2, p. 390-8 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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