Anette Müllertz
Anette Müllertz

Professor


  1. Published

    Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery

    Abid, Z., Dalskov Mosgaard, M., Manfroni, G., Singh Petersen, R., Hagner Nielsen, L., Mullertz, Anette , Boisen, A. & Sylvest Keller, S., Nov 2019, In : Polymers. 11, 10 p., 1828.

    Research output: Contribution to journalJournal article

  2. Published

    Interlaboratory validation of small-scale solubility and dissolution measurements of poorly water-soluble drugs

    Andersson, S. B. E., Alvebratt, C., Bevernage, J., Bonneau, D., Mathews, C. D. C., Dattani, R., Edueng, K., He, Y., Holm, R., Madsen, C. M., Müller, T., Muenster, U., Mullertz, Anette , Ojala, K., Rades, Thomas, Sieger, P. & Bergström, C. A. S., Sep 2016, In : Journal of Pharmaceutical Sciences. 105, 9, p. 2864-72 9 p.

    Research output: Contribution to journalJournal article

  3. Published

    Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase

    Bakala-N'Goma, J., Williams, H. D., Sassene, P. J., Kleberg, K., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Mullertz, Anette , Pouton, C. W., Porter, C. J. H. & Carriere, F., Apr 2015, In : Pharmaceutical Research. 32, 4, p. 1279-1287 9 p.

    Research output: Contribution to journalJournal article

  4. Published

    Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects

    Bergstrom, C. A. S., Box, K., Holm, R., Matthews, W., McAllister, M., Mullertz, Anette , Rades, Thomas, Schaefer, K. J. & Teleki, A., Jun 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 139, p. 101-114

    Research output: Contribution to journalReview

  5. Published

    Early pharmaceutical profiling to predict oral drug absorption: current status and unmet needs

    Bergström, C. A. S., Holm, R., Jørgensen, S. A., Andersson, S. B. E., Artursson, P., Beato, S., Borde, A., Box, K., Brewster, M., Dressman, J., Feng, K., Halbert, G., Kostewicz, E., McAllister, M., Muenster, U., Thinnes, J., Taylor, R. & Mullertz, Anette , 16 Jun 2014, In : European Journal of Pharmaceutical Sciences. 57, p. 173-99 27 p.

    Research output: Contribution to journalJournal article

  6. Published

    In vitro digestion models to evaluate lipid based drug delivery systems; present status and current trends

    Berthelsen, Ragna, Klitgaard, Mette, Rades, Thomas & Mullertz, Anette , 29 Jun 2019, In : Advanced Drug Delivery Reviews. 142, p. 35-49 15 p.

    Research output: Contribution to journalReview

  7. Published

    Combining in vitro and in silico methods for better prediction of surfactant effects on the absorption of poorly water soluble drugs-a fenofibrate case example

    Berthelsen, Ragna, Sjögren, E., Jacobsen, Jette, Kristensen, J., Holm, R., Abrahamsson, B. & Mullertz, Anette , 2 Jul 2014, In : International Journal of Pharmaceutics. 473, 1-2, p. 356-365 10 p.

    Research output: Contribution to journalJournal article

  8. Published

    Dissolution Model Development: Formulation Effects and Filter Complications

    Berthelsen, Ragna, Holm, R., Jacobsen, Jette, Kristensen, J., Abrahamsson, B. & Mullertz, Anette , Feb 2016, In : Dissolution Technologies. 23, 1, p. 6-12 7 p.

    Research output: Contribution to journalJournal article

  9. Published

    Kolliphor surfactants affect solubilization and bioavailability of fenofibrate. Studies of in vitro digestion and absorption in rats.

    Berthelsen, Ragna, Holm, R., Jacobsen, Jette, Kristensen, J., Abrahamsson, B. & Mullertz, Anette , 6 Apr 2015, In : Molecular Pharmaceutics. 12, 4, p. 1062-1071 10 p.

    Research output: Contribution to journalJournal article

  10. Published

    Development of a μDissolution-Permeation model with in situ drug concentration monitoring

    Berthelsen, Ragna, Byrialsen, J. P., Holm, R., Jacobsen, Jette, Abrahamsson, B., Saabye, L., Madelung, P. & Mullertz, Anette , 1 Oct 2016, In : Journal of Drug Delivery Science and Technology. 35, p. 223-233 11 p.

    Research output: Contribution to journalJournal article

  11. Published

    The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers

    Blaabjerg, L. I., Grohganz, Holger, Lindenberg, E., Löbmann, Korbinian, Mullertz, Anette & Rades, Thomas, 21 Sep 2018, In : Pharmaceutics. 10, 4, 14 p., 164.

    Research output: Contribution to journalJournal article

  12. Published

    Insights into the early dissolution events of amlodipine using UV imaging and Raman spectroscopy

    Bøtker, Johan Peter, Savolainen, M., Koradia, V., Tian, F., Rades, Thomas, Mullertz, Anette , Cornett, Claus, Rantanen, Jukka & Østergaard, Jesper, 2011, In : Molecular Pharmaceutics. 8, 4, p. 1372-1380 9 p.

    Research output: Contribution to journalJournal article

  13. Published

    Apomorphine and its esters: Differences in Caco-2 cell permeability and chylomicron affinity

    Borkar, N., Chen, Z., Saaby, L., Mullertz, Anette , Håkansson, A. E., Schönbeck, C., Yang, Mingshi, Holm, R. & Mu, Huiling, 6 Jun 2016, In : International Journal of Pharmaceutics. 509, 1-2, p. 499–506 8 p.

    Research output: Contribution to journalJournal article

  14. Published

    Efficacy of oral lipid-based formulations of apomorphine and its diester in a Parkinson's disease rat model

    Borkar, N., Andersson, D. R., Yang, Mingshi, Mullertz, Anette , Holm, R. & Mu, Huiling, Sep 2017, In : Journal of Pharmacy and Pharmacology. 69, 9, p. 1110-1115

    Research output: Contribution to journalJournal article

  15. Published

    Lipophilic prodrugs of apomorphine I: Preparation, characterisation, and in vitro enzymatic hydrolysis in biorelevant media.

    Borkar, N. N., Li, B., Holm, R., Håkansson, A., Mullertz, Anette , Yang, Mingshi & Mu, Huiling, 2015, In : European Journal of Pharmaceutics and Biopharmaceutics. 89, p. 216-223 8 p.

    Research output: Contribution to journalJournal article

  16. Published

    In vivo evaluation of lipid-based formulations for oral delivery of apomorphine and its diester prodrugs

    Borkar, N. N., Holm, R., Yang, Mingshi, Mullertz, Anette & Mu, Huiling, 9 Sep 2016, In : International Journal of Pharmaceutics. 513, 1-2, p. 211-217 7 p.

    Research output: Contribution to journalJournal article

  17. Published

    Investigating the correlation between in vivo absorption and in vitro release of fenofibrate from lipid matrix particles in biorelevant medium

    Borkar, N. N., Xia, D., Holm, R., Gan, Y., Mullertz, Anette , Yang, Mingshi & Mu, Huiling, 2014, In : European Journal of Pharmaceutical Sciences. 51, p. 204-10 7 p.

    Research output: Contribution to journalJournal article

  18. Published

    In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration

    Butler, J., Hens, B., Vertzoni, M., Brouwers, J., Berben, P., Dressman, J., Andreas, C. J., Schaefer, K. J., Mann, J., McAllister, M., Jamei, M., Kostewicz, E., Kesisoglou, F., Langguth, P., Minekus, M., Mullertz, Anette , Schilderink, R., Koziolek, M., Jedamzik, P., Weitschies, W., Reppas, C. & Augustijns, P., Mar 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 136, p. 70-83

    Research output: Contribution to journalJournal article

  19. Published

    Steric and interactive barrier properties of intestinal mucus elucidated by particle diffusion and peptide permeation

    Bøgh, M., García-Díaz, M., Mullertz, Anette & Nielsen, Hanne Mørck, Sep 2015, In : European Journal of Pharmaceutics and Biopharmaceutics. 94, Part A, p. 136–143 8 p.

    Research output: Contribution to journalJournal article

  20. Published

    Development and rheological profiling of biosimilar mucus

    Bøgh, M., Baldursdottir, S. G., Nielsen, M. H., Mullertz, Anette & Nielsen, Hanne Mørck, 2013, In : Nordic Rheology Society Annual Transactions. 21, p. 233-240

    Research output: Contribution to journalConference article

  21. Published

    Property profiling of biosimilar mucus in a novel mucus-containing in vitro model for assessment of intestinal drug absorption

    Bøgh, M., Baldursdóttir, S. G., Mullertz, Anette & Nielsen, Hanne Mørck, 8 Jan 2014, In : European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 87, p. 227-235 9 p.

    Research output: Contribution to journalJournal article

  22. Published

    Mucosal drug delivery: barriers, in vitro models and formulation strategies

    Bøgh, M., Foged, Camilla, Mullertz, Anette & Nielsen, Hanne Mørck, 2013, In : Journal of Drug Delivery Science and Technology. 23, 4, p. 383-391

    Research output: Contribution to journalReview

  23. Published

    Anhydrate to hydrate solid-state transformations of carbamazepine and nitrofurantoin in biorelevant media studied in situ using time-resolved synchrotron X-ray diffraction

    Bøtker, Johan Peter, Rantanen, Jukka, Arnfast, L., Doreth, M., Raijada, D. K., Löbmann, Korbinian, Madsen, C. M., Khan, J., Rades, Thomas, Mullertz, Anette , Hawley, A., Thomas, D. & Boyd, B. J., Mar 2016, In : European Journal of Pharmaceutics and Biopharmaceutics. 100, p. 119-127 9 p.

    Research output: Contribution to journalJournal article

  24. Published

    A new approach to dissolution testing by UV imaging and finite element simulations

    Bøtker, Johan Peter, Rantanen, Jukka, Rades, Thomas, Mullertz, Anette , Østergaard, Jesper & Jensen, Henrik, 2013, In : Pharmaceutical Research. 30, 5, p. 1328-1337

    Research output: Contribution to journalJournal article

  25. Published

    Milk osteopontin retains integrin-binding activity after in vitro gastrointestinal transit

    Christensen, B., Karlsen, N. J., Siqueira Jørgensen, Scheyla Daniela, Jacobsen, L. N., Ostenfeld, M. S., Petersen, S. V., Mullertz, Anette & Sorensen, E. S., Jan 2020, In : Journal of Dairy Science. 103, 1, p. 42-51

    Research output: Contribution to journalJournal article

  26. Published

    Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols

    Christensen, J. Ø., Schultz, K., Mollgaard, B., Kristensen, H. G. & Mullertz, Anette , 2004, In : European Journal of Pharmaceutical Sciences. 23, 3, p. 287-96 9 p.

    Research output: Contribution to journalJournal article

  27. Published

    Effect of food intake and co-administration of placebo self-nanoemulsifying drug delivery systems on the absorption of cinnarizine in healthy human volunteers

    Christiansen, M. L., Holm, R., Abrahamsson, B., Jacobsen, Jette, Kristensen, J., Andersen, Jens Rikardt & Mullertz, Anette , 2016, In : European Journal of Pharmaceutical Sciences. 84, p. 77-82 6 p.

    Research output: Contribution to journalJournal article

  28. Published

    Evaluation of the use of Göttingen minipigs to predict food effects on the oral absorption of drugs in humans

    Christiansen, M. L., Mullertz, Anette , Garmer, M., Kristensen, J., Jacobsen, Jette, Abrahamsson, B. & Holm, R., Jan 2015, In : Journal of Pharmaceutical Sciences. 104, 1, p. 135-143 9 p.

    Research output: Contribution to journalJournal article

  29. Published

    Cinnarizine food-effects in beagle dogs can be avoided by administration in a Self Nano Emulsifying Drug Delivery System (SNEDDS)

    Christiansen, M. L., Holm, R., Kristensen, J., Kreilgaard, M., Jacobsen, Jette, Abrahamsson, B. & Mullertz, Anette , 2014, In : European Journal of Pharmaceutical Sciences. 57, p. 164-172

    Research output: Contribution to journalJournal article

  30. Published

    Trilaurin diminishes food effect on the release of desmopressin from solid lipid microparticles

    Christophersen, P., Vaghela, D., Mullertz, Anette , Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, 2014.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  31. Published

    Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin

    Christophersen, P. C., Vaghela, D., Mullertz, Anette , Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, Jul 2014, In : A A P S Journal. 16, 4, p. 875-83 9 p.

    Research output: Contribution to journalJournal article

  32. Published

    Solid Lipid Particles for Oral Delivery of Peptide and Protein Drugs II - The Digestion of Trilaurin Protects Desmopressin from Proteolytic Degradation

    Christophersen, P. C., Zhang, L., Mullertz, Anette , Nielsen, Hanne Mørck, Yang, Mingshi & Mu, Huiling, 13 Mar 2014, In : Pharmaceutical Research. 31, 9, p. 2420-28 9 p.

    Research output: Contribution to journalJournal article

  33. Published

    Solid lipid particles for oral delivery of peptide and protein drugs I - Elucidating the release mechanism of lysozyme during lipolysis

    Christophersen, P. C. B., Zhang, L., Yang, Mingshi, Nielsen, Hanne Mørck, Mullertz, Anette & Mu, Huiling, 2 Aug 2013, In : European Journal of Pharmaceutics and Biopharmaceutics. 85, 3, part A, p. 473-480

    Research output: Contribution to journalJournal article

  34. Published

    Fed and fasted state gastro-intestinal in vitro lipolysis: In vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS

    Christophersen, P. C. B., Christiansen, M. L., Holm, R., Kristensen, J., Jacobsen, Jette, Abrahamsson, B. & Mullertz, Anette , 2014, In : European Journal of Pharmaceutical Sciences. 57, p. 232-239

    Research output: Contribution to journalJournal article

  35. Published

    In vitro digestion testing of lipid-based delivery systems: calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the solubilization capacity of colloidal digestion products

    Devraj, R., Williams, H. D., Warren, D. B., Mullertz, Anette , Porter, C. J. H. & Pouton, C. W., 2012, In : International Journal of Pharmaceutics. 441, 1-2, p. 323-333

    Research output: Contribution to journalJournal article

  36. Published

    Optimizing clinical drug product performance: applying Biopharmaceutics Risk Assessment Roadmap (BioRAM) and the BioRAM Scoring Grid

    Dickinson, P. A., Kesisoglou, F., Flanagan, T., Martinez, M. N., Mistry, H. B., Crison, J. R., Polli, J. E., Cruañes, M. T., Serajuddin, A. T. M., Mullertz, Anette , Cook, J. A. & Selen, A., Nov 2016, In : Journal of Pharmaceutical Sciences. 105, 11, p. 3243-3255 13 p.

    Research output: Contribution to journalJournal article

  37. Published

    A fast and novel internal calibration method for quantitative Raman measurements on aqueous solutions

    Duraipandian, S., Knopp, M. M., Pollard, M. R., Kerdoncuff, H., Petersen, J. C. & Mullertz, Anette , 7 Aug 2018, In : Analytical Methods. 10, 29, p. 3589-3593

    Research output: Contribution to journalJournal article

  38. Published

    Impact of lipolysis on absorption of a poorly soluble model drug formulated in SMEDDS - an in vitro study

    Eriksson, A. H., Refsgaard, L., Larsen, A. T., Mullertz, Anette & Olesen, P. H., Nov 2010.

    Research output: Contribution to conferencePosterResearch

  39. Published

    Dynamisk model for fordøjelse af lipidbaserede lægemidler i tarmen

    Fatouros, D., Larsen, A., Pedersen, B. L., Jacobsen, Jette & Mullertz, Anette , 2007, In : Lægemiddelforskning. p. 20-21

    Research output: Contribution to journalJournal article

  40. Published

    Clinical studies with oral lipid based formulations of poorly soluble compounds

    Fatouros, D., Karpf, D. M., Nielsen, Flemming Steen & Mullertz, Anette , 2007, In : Therapeutics and Clinical Risk Management. 3, 4, p. 591-604 13 p.

    Research output: Contribution to journalJournal article

  41. Published

    In vitro lipid digestion models in design of drug delivery systems for enhancing oral bioavailability

    Fatouros, D. & Mullertz, Anette , 2008, In : Expert Opinion on Drug Metabolism & Toxicology. 4, 1, p. 65-76

    Research output: Contribution to journalReview

  42. Published

    Physicochemical characterization of simulated intestinal fed-state fluids containing lyso-phosphatidylcholine and cholesterol

    Fatouros, D., Walrand, I., Bergenstahl, B. & Mullertz, Anette , 2009, In : Dissolution Technologies. 16, 3, p. 47-50

    Research output: Contribution to journalJournal article

  43. Published

    Colloidal structures in media simulating intestinal fed state conditions with and without lipolysis products

    Fatouros, D., Walrand, I., Bergenstahl, B. & Mullertz, Anette , 2009, In : Pharmaceutical Research. 26, 2, p. 361-374

    Research output: Contribution to journalJournal article

  44. Published

    In vitro-in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networks

    Fatouros, D. G., Nielsen, F. S., Douroumis, D., Hadjileontiadis, L. J. & Mullertz, Anette , 2008, In : European Journal of Pharmaceutics and Biopharmaceutics. 69, 3, p. 887-898

    Research output: Contribution to journalJournal article

  45. Published

    Structural development of self nano emulsifying drug delivery systems (SNEDDS) during in vitro lipid digestion monitored by small-angle X-ray scattering

    Fatouros, D. G., Deen, R., Arleth, Lise, Bergenstahl, B., Nielsen, F. S., Pedersen, J. S. & Mullertz, Anette , 2007, In : Pharmaceutical Research. 24, 10, p. 1844-1853 10 p.

    Research output: Contribution to journalJournal article

  46. Published

    Morphological observations on a lipid-based drug delivery system during in vitro digestion

    Fatouros, D. G., Bergenstahl, B. & Mullertz, Anette , 2007, In : European Journal of Pharmaceutical Sciences. 31, 2, p. 85-94

    Research output: Contribution to journalJournal article

  47. Published

    Colloid structures in media simulating intestinal fed state conditions with and without lipolysis products

    Fatourus, D., Walrand, I., Bergenstahl, B. & Mullertz, Anette , 2008.

    Research output: Contribution to conferencePosterResearch

  48. Published

    Development of a Video-Microscopic Tool To Evaluate the Precipitation Kinetics of Poorly Water Soluble Drugs: A Case Study with Tadalafil and HPMC

    Fjelrad Christfort, J., Christensen, J. P., Madsen, C. M., Nielsen, L. H., Sandau, M., Andersen, K., Mullertz, Anette & Rades, Thomas, 2017, In : Molecular Pharmaceutics. 14, 12, p. 4154-4160

    Research output: Contribution to journalJournal article

  49. Published

    Real-time dissolution behavior of furosemide in biorelevant media as determined by UV imaging

    Gordon, S., Naelapää, K., Rantanen, Jukka, Selen, A., Mullertz, Anette & Østergaard, Jesper, 2013, In : Pharmaceutical Development and Technology. 18, 6, p. 1407-16 10 p.

    Research output: Contribution to journalJournal article

  50. Published

    Refining stability and dissolution rate of amorphous drug formulations

    Grohganz, Holger, Priemel, P. A., Löbmann, Korbinian, Nielsen, L. H., Laitinen, R., Mullertz, Anette , Van den Mooter, G. & Rades, Thomas, Jun 2014, In : Expert Opinion on Drug Delivery. 11, 6, p. 977-89 13 p.

    Research output: Contribution to journalJournal article

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