Anette Müllertz

Anette Müllertz

Professor


  1. 2020
  2. Published

    Improving the drug load and in vitro performance of supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS) using polymeric precipitation inhibitors

    Bannow, Jacob, Yorulmaz, Y., Löbmann, Korbinian, Mullertz, Anette & Rades, Thomas, 2020, In : International Journal of Pharmaceutics. 575, 1188960.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Milk osteopontin retains integrin-binding activity after in vitro gastrointestinal transit

    Christensen, B., Karlsen, N. J., Siqueira Jørgensen, Scheyla Daniela, Jacobsen, L. N., Ostenfeld, M. S., Petersen, S. V., Mullertz, Anette & Sorensen, E. S., Jan 2020, In : Journal of Dairy Science. 103, 1, p. 42-51

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Evaluating side-by-side diffusion models for studying drug supersaturation in an absorptive environment: a case example of fenofibrate and felodipine

    Eliasen, J. N., Berthelsen, Ragna, Slot, A. L. & Mullertz, Anette , 2020, In : Journal of Pharmacy and Pharmacology. 72, 3, p. 371-384

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. E-pub ahead of print

    Towards analyzing the potential of exosomes to deliver microRNA therapeutics

    Giassafaki, L. N., Siqueira, S., Panteris, E., Psatha, K., Chatzopoulou, F., Aivaliotis, M., Tzimagiorgis, G., Mullertz, Anette , Fatouros, D. G. & Vizirianakis, I. S., 2020, In : Journal of Cellular Physiology. 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published
  7. Published

    In Vitro, Ex Vivo and In Vivo Evaluation of Microcontainers for Oral Delivery of Insulin

    Jørgensen, Jacob Rune, Yu, F., Ramakrishnan, Venkatasubramanian, Nielsen, L. H., Nielsen, Hanne Mørck, Boisen, A., Rades, Thomas & Mullertz, Anette , 7 Jan 2020, In : Pharmaceutics. 12, 1, 14 p., 48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B

    Kontogiannidou, E., Meikopoulos, T., Gika, H., Panteris, E., Vizirianakis, I. S., Mullertz, Anette & Fatouros, D. G., 2020, In : Pharmaceutics. 12, 8, 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Towards the development of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) containing trimethyl chitosan for the oral delivery of amphotericin B: In vitro assessment and cytocompatibility studies

    Kontogiannidou, E., Meikopoulos, T., Virgiliou, C., Bouropoulos, N., Gika, H., Vizirianakis, I. S., Mullertz, Anette & Fatouros, D. G., Apr 2020, In : Journal of Drug Delivery Science and Technology. 56, 9 p., 101524.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Evaluation of self -emulsifying drug delivery systems for oral insulin delivery using an in vitro model simulating the intestinal proteolysis

    Liu, J., Hirschberg, C., Fano, M., Mu, Huiling & Mullertz, Anette , 2020, In : European Journal of Pharmaceutical Sciences. 147, 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Comparison of induction methods for supersaturation: pH shift versus solvent shift

    Plum, J., Bavnhoj, C., Palmelund, Henrik Brogaard, Perez Alos, Laura, Mullertz, Anette & Rades, Thomas, 5 Jan 2020, In : International Journal of Pharmaceutics. 573, 8 p., 118862.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Integrated Multi-stakeholder Systems Thinking Strategy: Decision-making with Biopharmaceutics Risk Assessment Roadmap (BioRAM) to Optimize Clinical Performance of Drug Products

    Selen, A., Mullertz, Anette , Kesisoglou, F., Ho, R. J. Y., Cook, J. A., Dickinson, P. A. & Flanagan, T., 2020, In : AAPS Journal. 22, 5, 20 p., 97.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Poorly soluble drugs

    Siepmann, J., Rades, Thomas, Mullertz, Anette & Loftsson, T., 15 Mar 2020, In : International Journal of Pharmaceutics. 577, 119055.

    Research output: Contribution to journalEditorialResearchpeer-review

  14. Published

    Impact of gastrointestinal physiology on drug absorption in special populations??An UNGAP review

    Stillhart, C., Vucicevic, K., Augustijns, P., Basit, A. W., Batchelor, H., Flanagan, T. R., Gesquiere, I., Greupink, R., Keszthelyi, D., Koskinen, M., Madla, C. M., Matthys, C., Miljus, G., Mooij, M. G., Parrott, N., Ungell, A. -., de Wildt, S. N., Orlu, M., Klein, S. & Mullertz, Anette , 2020, In : European Journal of Pharmaceutical Sciences. 147, 28 p., 105280.

    Research output: Contribution to journalReviewResearchpeer-review

  15. Published

    Effect of supersaturation on absorption of indomethacin and tadalafil in a single pass intestinal perfusion rat model, in the absence and presence of a precipitation inhibitor

    Strindberg, Sophie , Plum, J., Stie, Mai Bay, Christiansen, M. L., Nielsen, L. H., Rades, Thomas & Mullertz, Anette , Jun 2020, In : European Journal of Pharmaceutics and Biopharmaceutics. 151, p. 108-115

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems

    Tran, T., Bonlokke, P., Rodriguez-Rodriguez, C., Nosrati, Z., Esquinas, P. L., Borkar, N., Plum, J., Strindberg, Sophie , Karagiozov, S., Rades, Thomas, Mullertz, Anette , Saatchi, K. & Häfeli, Urs Otto, 2020, In : Journal of Controlled Release. 317, p. 375-384

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Formulation of co-amorphous systems from naproxen and naproxen sodium and in situ monitoring of physicochemical state changes during dissolution testing by Raman spectroscopy

    Ueda, H., Bøtker, Johan Peter, Edinger, M., Löbmann, Korbinian, Grohganz, Holger, Mullertz, Anette , Rades, Thomas & Østergaard, Jesper, 25 Sep 2020, In : International Journal of Pharmaceutics. 587, 119662.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. 2019
  19. Published

    Biodegradable microcontainers-towards real life applications of microfabricated systems for oral drug delivery

    Abid, Z., Strindberg, Sophie , Javed, M. M., Mazzoni, C., Vaut, L., Nielsen, L. H., Gundlach, C., Petersen, R. S., Mullertz, Anette , Boisen, A. & Keller, S. S., 2019, In : Lab on a Chip. 19, 17, p. 2905-2914 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery

    Abid, Z., Dalskov Mosgaard, M., Manfroni, G., Singh Petersen, R., Hagner Nielsen, L., Mullertz, Anette , Boisen, A. & Sylvest Keller, S., Nov 2019, In : Polymers. 11, 10 p., 1828.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects

    Bergstrom, C. A. S., Box, K., Holm, R., Matthews, W., McAllister, M., Mullertz, Anette , Rades, Thomas, Schaefer, K. J. & Teleki, A., Jun 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 139, p. 101-114

    Research output: Contribution to journalReviewResearchpeer-review

  22. Published

    Self-emulsifying drug delivery systems (SEDDS) – The splendid comeback of an old technology

    Bernkop-Schnürch, A., Mullertz, Anette & Rades, Thomas, 2019, In : Advanced Drug Delivery Reviews. 142, p. 1-2 2 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  23. Published

    In vitro digestion models to evaluate lipid based drug delivery systems; present status and current trends

    Berthelsen, Ragna, Klitgaard, Mette, Rades, Thomas & Mullertz, Anette , 29 Jun 2019, In : Advanced Drug Delivery Reviews. 142, p. 35-49 15 p.

    Research output: Contribution to journalReviewResearchpeer-review

  24. Published

    Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

    Boyd, B. J., Bergström, C. A. S., Vinarov, Z., Kuentz, M., Brouwers, J., Augustijns, P., Brandl, M., Bernkop-Schnürch, A., Shrestha, N., Préat, V., Mullertz, Anette , Bauer-Brandl, A. & Jannin, V., 2019, In : European Journal of Pharmaceutical Sciences. 137, 27 p., 104967.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration

    Butler, J., Hens, B., Vertzoni, M., Brouwers, J., Berben, P., Dressman, J., Andreas, C. J., Schaefer, K. J., Mann, J., McAllister, M., Jamei, M., Kostewicz, E., Kesisoglou, F., Langguth, P., Minekus, M., Mullertz, Anette , Schilderink, R., Koziolek, M., Jedamzik, P., Weitschies, W., Reppas, C. & Augustijns, P., Mar 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 136, p. 70-83

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Developing a predictive in vitro dissolution model based on gastrointestinal fluid characterisation in rats

    Christfort, J. F., Strindberg, Sophie , Plum, J., Hall-Andersen, J., Janfelt, Christian, Nielsen, L. H. & Mullertz, Anette , 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 142, p. 307-314 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Ex vivo intestinal perfusion model for investigating mucoadhesion of microcontainers

    Dalskov Mosgaard, M., Strindberg, Sophie , Abid, Z., Singh Petersen, R., Højlund Eklund Thamdrup, L., Joukainen Andersen, A., Sylvest Keller, S., Mullertz, Anette , Hagner Nielsen, L. & Boisen, A., 2019, In : International Journal of Pharmaceutics. 570, 118658.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Exploring the utility of the Chasing-rinciple: influence of drug-free SNEDDS composition on solubilization of carvedilol, cinnarizine and R3040 in aqueous suspension

    Siqueira Jørgensen, Scheyla Daniela, Rades, Thomas, Mu, Huiling, Graeser, K. & Mullertz, Anette , Jan 2019, In : Acta Pharmaceutica Sinica B. 9, 1, p. 194-201

    Research output: Contribution to journalLetterResearchpeer-review

  29. Published

    SEDDS for intestinal absorption of insulin: Application of Caco-2 and Caco-2/HT29 co-culture monolayers and intra-jejunal instillation in rats

    Liu, J., Werner, U., Funke, M., Besenius, M., Saaby, L., Fano, M., Mu, Huiling & Mullertz, Anette , 5 Apr 2019, In : International Journal of Pharmaceutics. 560, p. 377-384

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Polymeric Lids for Microcontainers for Oral Protein Delivery

    Mazzoni, C., Jacobsen, R. D., Mortensen, J., Jørgensen, Jacob Rune, Vaut, L., Jacobsen, Jette, Gundlach, C., Mullertz, Anette , Nielsen, L. H. & Boisen, A., 2019, In : Macromolecular Bioscience. 19, 5, 1900004.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Fenofibrate oral absorption from SNEDDS and super-SNEDDS is not significantly affected by lipase inhibition in rats

    Michaelsen, M. H., Siqueira Jørgensen, Scheyla Daniela, Abdi, I. M., Wasan, K. M., Rades, Thomas & Mullertz, Anette , 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 142, p. 258-264 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Microcontainers for oral insulin delivery - in vitro studies of permeation enhancement

    Jørgensen, Jacob Rune, Leth Jepsen, M., Hagner Nielsen, L., Dufva, M., Nielsen, Hanne Mørck, Rades, Thomas, Boisen, A. & Mullertz, Anette , 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 143, p. 98-105

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    In vivo models and decision trees for formulation development in early drug development: A review of current practices and recommendations for biopharmaceutical development

    Zane, P., Gieschen, H., Kersten, E., Mathias, N., Ollier, C., Johansson, P., Van den Bergh, A., Van Hemelryck, S., Reichel, A., Rotgeri, A., Schäfer, K., Mullertz, Anette & Langguth, P., 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 142, p. 222-231 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. 2018
  35. Published

    The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers

    Blaabjerg, L. I., Grohganz, Holger, Lindenberg, E., Löbmann, Korbinian, Mullertz, Anette & Rades, Thomas, 21 Sep 2018, In : Pharmaceutics. 10, 4, 14 p., 164.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    A fast and novel internal calibration method for quantitative Raman measurements on aqueous solutions

    Duraipandian, S., Knopp, M. M., Pollard, M. R., Kerdoncuff, H., Petersen, J. C. & Mullertz, Anette , 7 Aug 2018, In : Analytical Methods. 10, 29, p. 3589-3593

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Characterization of the hydrodynamics in a miniaturized dissolution apparatus

    Johansson, Kristoffer Enøe, Plum, J., Mosleh, M., Madsen, C. M., Rades, Thomas & Mullertz, Anette , 2018, In : Journal of Pharmaceutical Sciences. 107, 4, p. 1095-1103 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    The ability of two in vitro lipolysis models reflecting the human and rat gastro-intestinal conditions to predict the in vivo performance of SNEDDS dosing regimens

    Siqueira Jørgensen, Scheyla Daniela, Al Sawaf, M., Graeser, K., Mu, Huiling, Mullertz, Anette & Rades, Thomas, Mar 2018, In : European Journal of Pharmaceutics and Biopharmaceutics. 124, p. 116-124

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Development and characterization of clove oil nanoemulsions and self-microemulsifying drug delivery systems

    Kheawfu, K., Pikulkaew, S., Rades, Thomas, Mullertz, Anette & Okonogi, S., 2018, In : Journal of Drug Delivery Science and Technology. 46, p. 330-338 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    In vivo anesthetic effect and mechanism of action of active compounds from Alpinia galanga oil on Cyprinus carpio (koi carp)

    Khumpirapang, N., Chaichit, S., Jiranusornkul, S., Pikulkaew, S., Mullertz, Anette & Okonogi, S., 1 Nov 2018, In : Aquaculture. 496, p. 176-184

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Hydrolysed pea proteins mitigate in vitro wheat starch digiestibility

    López-Barón , N., Sagnelli, D., Blennow, Andreas, Holse, M., Gao, J., Saaby, L., Mullertz, Anette , Jespersen, Birthe P Møller & Vasanthan, T., 2018, In : Food Hydrocolloids. 79, p. 117-126 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Effect of composition of simulated intestinal media on the solubility of poorly soluble compounds investigated by design of experiments

    Madsen, C. M., Feng, K., Leithead, A., Canfield, N., Jørgensen, S. A., Mullertz, Anette & Rades, Thomas, Jan 2018, In : European Journal of Pharmaceutical Sciences. 111, p. 311-319 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Formulation of self-nanoemulsifying drug delivery systems containing monoacyl phosphatidylcholine and Kolliphor® RH40 using experimental design

    Tran, T., Rades, Thomas & Mullertz, Anette , 2018, In : Asian Journal of Pharmaceutical Sciences. 13, p. 536-545

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Using Potentiometric Free Drug Sensors to Determine the Free Concentration of Ionizable Drugs in Colloidal Systems

    Tran, T., Chakraborty, A., Xi, X., Bohets, H., Cornett, Claus, Tsinman, K., Rades, Thomas & Mullertz, Anette , Jan 2018, In : Journal of Pharmaceutical Sciences. 107, 1, p. 103-112

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and L-Arginine

    Ueda, H., Wu, W., Löbmann, Korbinian, Grohganz, Holger, Mullertz, Anette & Rades, Thomas, May 2018, In : Molecular Pharmaceutics. 15, 5, p. 2036-2044

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Are phytosomes a superior nanodelivery system for the antioxidant rutin?

    Vu, H. T. H., Hook, S. M., Siqueira Jørgensen, Scheyla Daniela, Mullertz, Anette , Rades, Thomas & McDowell, A., 2018, In : International Journal of Pharmaceutics. 548, 1, p. 82-91 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. 2017
  48. Published

    Efficacy of oral lipid-based formulations of apomorphine and its diester in a Parkinson's disease rat model

    Borkar, N., Andersson, D. R., Yang, Mingshi, Mullertz, Anette , Holm, R. & Mu, Huiling, Sep 2017, In : Journal of Pharmacy and Pharmacology. 69, 9, p. 1110-1115

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Development of a Video-Microscopic Tool To Evaluate the Precipitation Kinetics of Poorly Water Soluble Drugs: A Case Study with Tadalafil and HPMC

    Fjelrad Christfort, J., Christensen, J. P., Madsen, C. M., Nielsen, L. H., Sandau, M., Andersen, K., Mullertz, Anette & Rades, Thomas, 2017, In : Molecular Pharmaceutics. 14, 12, p. 4154-4160

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Amorphous is not always better—A dissolution study on solid state forms of carbamazepine

    Jensen, L. G., Skautrup, F. B., Mullertz, Anette , Abrahamsson, B., Rades, Thomas & Priemel, P. A., 30 Apr 2017, In : International Journal of Pharmaceutics. 522, 1-2, p. 74-79 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    In Vitro Model Simulating Gastro-Intestinal Digestion in the Pediatric Population (Neonates and Young Infants)

    Kamstrup, D., Berthelsen, Ragna, Sassene, P. J., Selen, A. & Mullertz, Anette , Feb 2017, In : A A P S PharmSciTech. 18, 2, p. 317-329 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Self-microemulsifying drug delivery system and nanoemulsion for enhancing aqueous miscibility of Alpinia galanga oil

    Khumpirapang, N., Pikulkaew, S., Mullertz, Anette , Rades, Thomas & Okonogi, S., 2017, In : PLOS ONE. 12, 11, 18 p., e0188848.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Studying furosemide solubilization using an in vitro model simulating gastrointestinal digestion and drug solubilization in neonates and young infants

    Klitgaard, Mette, Sassene, P. J., Selen, A., Mullertz, Anette & Berthelsen, Ragna, 15 Nov 2017, In : European Journal of Pharmaceutical Sciences. 109, p. 191-199 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Solution or suspension - Does it matter for lipid based systems? In vivo studies of chase dosing lipid vehicles with aqueous suspensions of a poorly soluble drug

    Larsen, A. T., Holm, R. & Mullertz, Anette , Aug 2017, In : European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 117, p. 308-314 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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