Anette Müllertz

Anette Müllertz

Professor

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    ORCID: 0000-0003-3020-8892

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    1. Published

      In vivo models and decision trees for formulation development in early drug development: A review of current practices and recommendations for biopharmaceutical development

      Zane, P., Gieschen, H., Kersten, E., Mathias, N., Ollier, C., Johansson, P., Van den Bergh, A., Van Hemelryck, S., Reichel, A., Rotgeri, A., Schäfer, K., Mullertz, Anette & Langguth, P., 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 142, p. 222-231 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Influence of bile on the absorption of halofantrine from lipid-based formulations

      Holm, R., Tønsberg, H., Jørgensen, E. B., Abedinpour, P., Farsad, S. & Mullertz, Anette , 2012, In: European Journal of Pharmaceutics and Biopharmaceutics. 81, 2, p. 281-287

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Influence of drug load and physical form of cinnarizine in new SNEDDS dosing regimens: in vivo and in vitro evaluations

      Siqueira, S. D. V. S., Mullertz, Anette , Gräeser, K., Kasten, G., Mu, Huiling & Rades, Thomas, Mar 2017, In: A A P S Journal. 19, 2, p. 587-594 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Influence of lipid composition and drug load on the in vitro performance of self-nanoemulsifying drug delivery systems

      Thomas, N., Mullertz, Anette , Graf, A. & Rades, T., 2012, In: Journal of Pharmaceutical Sciences. 101, 5, p. 1721-1731

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Influence of preparation method and choice of phospholipid on co-amorphization, physical stability, and dissolution behavior of equimolar indomethacin-phospholipid systems: A case study

      Khorami, Keyoomars, Mullertz, Anette & Rades, Thomas, 2024, In: Journal of Drug Delivery Science and Technology. 93, 8 p., 105433.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Influence of the solid form of siramesine hydrochloride on its behaviour in aqueous environments

      Zimmermann, A., Tian, F., Lopez de Diego, H., Ringkjøbing Elema, M., Rantanen, Jukka, Mullertz, Anette & Hovgaard, L., 2009, In: Pharmaceutical Research. 26, 4, p. 846-854

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Influence of the type of surfactant and the degree of dispersion on the lymphatic transport of halofantrine in conscious rats

      Karpf, D. M., Holm, R., Kristensen, H. G. & Mullertz, Anette , 2004, In: Pharmaceutical Research. 21, 8, p. 1413-8 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Insights into intermediate phases of human intestinal fluids visualized by atomic force microscopy and cryo-transmission electron microscopy ex vivo

      Mullertz, Anette , Fatouros, D. G., Smith, J. R., Vertzoni, M. & Reppas, C., 2012, In: Molecular Pharmaceutics. 9, 2, p. 237-247

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Insights into the early dissolution events of amlodipine using UV imaging and Raman spectroscopy

      Bøtker, Johan Peter, Savolainen, M., Koradia, V., Tian, F., Rades, Thomas, Mullertz, Anette , Cornett, Claus, Rantanen, Jukka & Østergaard, Jesper, 2011, In: Molecular Pharmaceutics. 8, 4, p. 1372-1380 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Insights into the ultrastructure of human intestinal fluids in the fed state by electron microscopy analysis

      Mullertz, Anette , Fatouros, D., Smith, J. R., Vertzoni, M. & Rappas, C., Nov 2010.

      Research output: Contribution to conference › Poster › Research

    11. Published

      Integrated Multi-stakeholder Systems Thinking Strategy: Decision-making with Biopharmaceutics Risk Assessment Roadmap (BioRAM) to Optimize Clinical Performance of Drug Products [incl, correction]

      Selen, A., Mullertz, Anette , Kesisoglou, F., Ho, R. J. Y., Cook, J. A., Dickinson, P. A. & Flanagan, T., 2020, In: AAPS Journal. 22, 5, 20 p., 97.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Interlaboratory validation of small-scale solubility and dissolution measurements of poorly water-soluble drugs

      Andersson, S. B. E., Alvebratt, C., Bevernage, J., Bonneau, D., Mathews, C. D. C., Dattani, R., Edueng, K., He, Y., Holm, R., Madsen, C. M., Müller, T., Muenster, U., Mullertz, Anette , Ojala, K., Rades, Thomas, Sieger, P. & Bergström, C. A. S., Sep 2016, In: Journal of Pharmaceutical Sciences. 105, 9, p. 2864-72 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80

      Lind, M. L., Jacobsen, Jette, Holm, R. & Mullertz, Anette , 2008, In: European Journal of Pharmaceutical Sciences. 35, 3, p. 211-218

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Investigating the correlation between in vivo absorption and in vitro release of fenofibrate from lipid matrix particles in biorelevant medium

      Borkar, N. N., Xia, D., Holm, R., Gan, Y., Mullertz, Anette , Yang, Mingshi & Mu, Huiling, 2014, In: European Journal of Pharmaceutical Sciences. 51, p. 204-10 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Investigating the effect of graphene oxide in chitosan/alginate-based foams on the release and antifungal activity of clotrimazole in vitro

      Huang, Jianfei, Jacobsen, Jette, Genina, Natalja, Larsen, Susan Weng, Nielsen, Hanne Mørck, Mullertz, Anette & Mu, Huiling, 2022, In: European Journal of Pharmaceutical Sciences. 174, 9 p., 106204.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery

      Abid, Z., Dalskov Mosgaard, M., Manfroni, G., Singh Petersen, R., Hagner Nielsen, L., Mullertz, Anette , Boisen, A. & Sylvest Keller, S., Nov 2019, In: Polymers. 11, 10 p., 1828.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Investigation of the Intra- and Interlaboratory Reproducibility of a Small Scale Standardized Supersaturation and Precipitation Method

      Plum, J., Madsen, C. M., Teleki, A., Bevernage, J., da Costa Mathews, C., Karlsson, E. M., Carlert, S., Holm, R., Müller, T., Matthews, W., Sayers, A., Ojala, K., Tsinsman, K., Lingamaneni, R., Bergström, C. A., Rades, Thomas & Mullertz, Anette , 7 Nov 2017, In: Molecular Pharmaceutics. 14, 12, p. 4161-4169

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Kolliphor surfactants affect solubilization and bioavailability of fenofibrate. Studies of in vitro digestion and absorption in rats.

      Berthelsen, R., Holm, R., Jacobsen, Jette, Kristensen, J., Abrahamsson, B. & Mullertz, Anette , 6 Apr 2015, In: Molecular Pharmaceutics. 12, 4, p. 1062-1071 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Lipid-based formulations for danazol containing a digestible surfactant, labrafil M2125CS: In vivo bioavailability and dynamic in vitro lipolysis

      Larsen, A., Holm, R., Pedersen, M. L. & Mullertz, Anette , 2008, In: Pharmaceutical Research. 25, 12, p. 2769-2777

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Lipid-based formulations for oral administration of poorly water-soluble drugs

      Mu, Huiling, Holm, R. & Mullertz, Anette , 30 Aug 2013, In: International Journal of Pharmaceutics. 453, 1, p. 215-24 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Lipophilic prodrugs of apomorphine I: Preparation, characterisation, and in vitro enzymatic hydrolysis in biorelevant media.

      Borkar, N. N., Li, B., Holm, R., Håkansson, A., Mullertz, Anette , Yang, Mingshi & Mu, Huiling, 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 89, p. 216-223 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Liquid self-microemulsifying drug delivery

      Mullertz, Anette & Grove, M., 2007, Oral lipid-based formulations: enhancing the bioavailability of poor water-soluble drugs. Hauss, D. J. (ed.). New York: Informa Healthcare, p. 107-128

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    23. Published

      Lymphatic fatty acids in canines dosed with pharmaceutical formulations containing structured triacylglycerols

      Holm, R., Porsgaard, T., Porter, H., Høy, C., Edwards, G. A., Mullertz, Anette , Kristensen, H. G. & Charman, W. N., 2006, In: European Journal of Lipid Science and Technology. 108, 9, p. 714-722 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Mapping the intermediate digestion phases of human healthy intestinal contents from distal ileum and caecum at fasted and fed state conditions

      Tran, T., Fatouros, D. G., Vertzoni, M., Reppas, C. & Mullertz, Anette , Mar 2017, In: The Journal of pharmacy and pharmacology. 69, 3, p. 265-273 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Marine lipids and the bioavailability of omega-3 fatty acids

      Mu, Huiling & Mullertz, Anette , 2015, In: Current Nutrition and Food Science. 11, 3, p. 177-187 11 p.

      Research output: Contribution to journal › Review › Research › peer-review

    26. Published

      Meeting report: applied biopharmaceutics and quality by design for dissolution/release specification setting: product quality for patient benefit

      Selen, A., Cruanes, M. T., Mullertz, Anette , Dicikinsion, P. A., Cook, J. A., Polli, J. E., Kesisoglou, F., Crison, J., Johnson, K. C., Muirhead, G. T., Schofield, T. & Tsong, Y., 2010, In: The AAPS Journal. 12, 3, p. 465-472

      Research output: Contribution to journal › Review › Research

    27. Published

      Microcontainers for oral insulin delivery - in vitro studies of permeation enhancement

      Rune Jørgensen, J., Leth Jepsen, M., Hagner Nielsen, L., Dufva, M., Nielsen, Hanne Mørck, Rades, Thomas, Boisen, A. & Mullertz, Anette , 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 143, p. 98-105

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Milk osteopontin retains integrin-binding activity after in vitro gastrointestinal transit

      Christensen, B., Karlsen, N. J., Jorgensen, S. D. S., Jacobsen, L. N., Ostenfeld, M. S., Petersen, S. V., Mullertz, Anette & Sorensen, E. S., Jan 2020, In: Journal of Dairy Science. 103, 1, p. 42-51

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Miniaturized approach for excipient selection during the development of oral solid dosage form

      Raijada, D. K., Mullertz, Anette , Cornett, Claus, Munk, T., Sonnergaard, J. & Rantanen, Jukka, Mar 2014, In: Journal of Pharmaceutical Sciences. 103, 3, p. 900-8 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Monoacyl phosphatidylcholine inhibits the formation of lipid multilamellar structures during in vitro lipolysis of self-emulsifying drug delivery systems

      Tran, T., Siqueira, S. D. V. S., Amenitsch, H., Rades, Thomas & Mullertz, Anette , 15 Oct 2017, In: European Journal of Pharmaceutical Sciences. 108, p. 62-70

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Morphological observations on a lipid-based drug delivery system during in vitro digestion

      Fatouros, D. G., Bergenstahl, B. & Mullertz, Anette , 2007, In: European Journal of Pharmaceutical Sciences. 31, 2, p. 85-94

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Moving perfusion culture and live-cell imaging from lab to disc: proof of concept toxicity assay with AI-based image analysis

      Serioli, L., Gruzinskyte, L., Zappalà, G., Hwu, E. T., Laksafoss, T. Z., Jensen, P. L., Demarchi, D., Mullertz, Anette , Boisen, A. & Zór, K., 2023, In: Lab on a Chip. 23, p. 1603-1612

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Mucosal drug delivery: barriers, in vitro models and formulation strategies

      Bøgh, M., Foged, Camilla, Mullertz, Anette & Nielsen, Hanne Mørck, 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 383-391

      Research output: Contribution to journal › Review › Research › peer-review

    34. Published

      New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs

      Mullertz, Anette , Ogbonna, A., Ren, S. & Rades, Thomas, 2010, In: Journal of Pharmacy and Pharmacology. 62, 11, p. 1622-1636 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Oligonucleotide Delivery across the Caco-2 Monolayer: The Design and Evaluation of Self-Emulsifying Drug Delivery Systems (SEDDS)

      Kubackova, J., Holas, O., Zbytovska, J., Vranikova, B., Zeng, G., Pavek, P. & Mullertz, Anette , Apr 2021, In: Pharmaceutics. 13, 4, 27 p., 459.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Optimization of self nanoemulsifying drug delivery system for poorly water-soluble drug using response surface methodology

      Ren, S., Mu, Huiling, Alchaer, F., Chtatou, A. & Mullertz, Anette , May 2013, In: Drug Development and Industrial Pharmacy. 39, 5, p. 799-806 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Optimization of the in vitro lipolysis rate of SMEDDS containing cinnarizine

      Ulmann, C., Figueriedo-Larsen, M., Refsgaard, L., Hellekilde, J., Larsen, A., Nielsen, C., Olesen, P. & Mullertz, Anette , 2009.

      Research output: Contribution to conference › Poster › Research

    38. Published

      Optimizing clinical drug product performance: applying Biopharmaceutics Risk Assessment Roadmap (BioRAM) and the BioRAM Scoring Grid

      Dickinson, P. A., Kesisoglou, F., Flanagan, T., Martinez, M. N., Mistry, H. B., Crison, J. R., Polli, J. E., Cruañes, M. T., Serajuddin, A. T. M., Mullertz, Anette , Cook, J. A. & Selen, A., Nov 2016, In: Journal of Pharmaceutical Sciences. 105, 11, p. 3243-3255 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Oral bioavailability of cinnarizine in dogs: relation to SNEDDS droplet size, drug solubility and in vitro precipitation

      Larsen, A. T., Ohlsson, A. G., Polentarutti, B., Barker, R. A., Phillips, A. R., Abu-Rmaileh, R., Dickinson, P. A., Abrahamsson, B., Østergaard, Jesper & Mullertz, Anette , 2013, In: European Journal of Pharmaceutical Sciences. 48, 1-2, p. 339-50 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Oral delivery of peptides and proteins using lipid-based drug delivery systems

      Li, P., Nielsen, Hanne Mørck & Mullertz, Anette , 2012, In: Expert Opinion on Drug Delivery. 9, 10, p. 1289-304 16 p.

      Research output: Contribution to journal › Review › Research › peer-review

    41. Published

      Phase transformations of amlodipine besylate solid forms

      Koradia, V. S., Lemos, A. F. F. D., Allesø, M., Diego, H. L. D., Ringkjøbing-Elema, M., Mullertz, Anette & Rantanen, Jukka, 2011, In: Journal of Pharmaceutical Sciences. 100, 7, p. 2896-2910

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Physico-chemical characterization of aspirated and simulated human gastric fluids to study their influence on the intrinsic dissolution rate of cinnarizine

      Pedersen, P. B., Berthelsen, R., Rades, Thomas, Jørgensen, S. A., Vilmann, Peter, Bar-Shalom, Daniel, Baldursdottir, S. & Mullertz, Anette , 2022, In: International Journal of Pharmaceutics. 622, 7 p., 121856.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Physicochemical characterization of simulated intestinal fed-state fluids containing lyso-phosphatidylcholine and cholesterol

      Fatouros, D., Walrand, I., Bergenstahl, B. & Mullertz, Anette , 2009, In: Dissolution Technologies. 16, 3, p. 47-50

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Polymer selection for simulation of rheological properties of human gastric fluid

      Pedersen, P. B., Vilmann, P., Bar-Shalom, Daniel, Mullertz, Anette & Baldursdottir, S. G., 2013, In: Nordic Rheology Society Annual Transactions. 21, p. 241-247

      Research output: Contribution to journal › Conference article › Research

    45. Published

      Polymer-filled microcontainers for oral delivery loaded using supercritical impregnation

      Marizza, P., Keller, S. S., Mullertz, Anette & Boisen, A., 10 Jan 2014, In: Journal of controlled release : official journal of the Controlled Release Society. 173, p. 1-9 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Polymeric Lids for Microcontainers for Oral Protein Delivery

      Mazzoni, C., Jacobsen, R. D., Mortensen, J., Jørgensen, J. R., Vaut, L., Jacobsen, Jette, Gundlach, C., Mullertz, Anette , Nielsen, L. H. & Boisen, A., 2019, In: Macromolecular Bioscience. 19, 5, 1900004.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Polymeric microcontainers improve oral bioavailability of furosemide

      Nielsen, L. H., Melero, A., Keller, S. S., Jacobsen, Jette, Garrigues, T., Rades, Thomas, Mullertz, Anette & Boisen, A., 17 May 2016, In: International Journal of Pharmaceutics. 504, 1-2, p. 98-109 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Poorly soluble drugs

      Siepmann, J., Rades, Thomas, Mullertz, Anette & Loftsson, T., 15 Mar 2020, In: International Journal of Pharmaceutics. 577, 119055.

      Research output: Contribution to journal › Editorial › Research

    49. Published

      Precipitation of a poorly soluble model drug during in vitro lilpolysis: characterization and dissolution of the precipitate

      Sassene, P. J., Knopp, Matthias Manne, Hesselkilde, J. Z., Koradia, V., Larsen, A., Rades, Thomas & Mullertz, Anette , 2010, In: Journal of Pharmaceutical Sciences. 99, 12, p. 4982-4991

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Predicting Oral Absorption of fenofibrate in Lipid-Based Drug Delivery Systems by Combining In Vitro Lipolysis with the Mucus-PVPA Permeability Model

      Falavigna, M., Klitgaard, Mette, Berthelsen, R., Mullertz, Anette & Flaten, G. E., 2021, In: Journal of Pharmaceutical Sciences. 110, 1, p. 208-216 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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