Anette Müllertz

Anette Müllertz

Professor

Member of:


    1. 2012
    2. Published

      Insights into intermediate phases of human intestinal fluids visualized by atomic force microscopy and cryo-transmission electron microscopy ex vivo

      Mullertz, Anette , Fatouros, D. G., Smith, J. R., Vertzoni, M. & Reppas, C., 2012, In: Molecular Pharmaceutics. 9, 2, p. 237-247

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Published

      Oral delivery of peptides and proteins using lipid-based drug delivery systems

      Li, P., Nielsen, Hanne Mørck & Mullertz, Anette , 2012, In: Expert Opinion on Drug Delivery. 9, 10, p. 1289-304 16 p.

      Research output: Contribution to journalReviewResearchpeer-review

    4. Published

      SNEDDS containing poorly water soluble cinnarizine; development and in Vitro characterization of dispersion, digestion and solubilization

      Larsen, A. T., Ogbonna, A., Abu-Rmaileh, R., Abrahmsson, B., Østergaard, Jesper & Mullertz, Anette , 2012, In: Pharmaceutics. 4, 4, p. 641-665

      Research output: Contribution to journalJournal articleResearchpeer-review

    5. Published

      Spatial confinement can lead to increased stability of amorphous indomethacin

      Nielsen, L. H., Keller, S. S., Gordon, K. C., Boisen, A., Rades, Thomas & Mullertz, Anette , 2012, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 81, 2, p. 418-25 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. Published

      Toward the Establishment of Standardized in Vitro Tests for Lipid-Based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I, II, IIIA, IIIB, and IV Formulations during in Vitro Digestion

      Williams, H. D., Anby, M. U., Sassene, P., Kleberg, K., Bakala-N’Goma, J., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Carrière, F., Mullertz, Anette , Pouton, C. W. & Porter, C. J. H., 2012, In: Molecular Pharmaceutics. 9, 11, p. 3286-3300 15 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    7. Published

      Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: Method parameterization and comparison of in vitro digestion profiles across a range of representative formulations

      Williams, H. D., Sassene, P., Kleberg, K., Bakala-N'Goma, J., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Carrière, F., Mullertz, Anette , Porter, C. J. H. & Pouton, C. W., 2012, In: Journal of Pharmaceutical Sciences. 101, 9, p. 3360-3380

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. Published

      Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessful

      Holm, R., Hesselkilde, J. Z., Jørgensen, E. B. & Mullertz, Anette , 2012, In: European Journal of Pharmaceutical Sciences. 47, p. 347-351

      Research output: Contribution to journalJournal articleResearchpeer-review

    9. 2011
    10. Published

      A novel excipient, 1-perfluorohexyloctane shows limited utility for the oral delivery of poorly water-soluble drugs

      Holm, R., Jørgensen, E. B., Harborg, M., Larsen, R. S., Holm, P., Mullertz, Anette & Jacobsen, Jette, 2011, In: European Journal of Pharmaceutical Sciences. 42, p. 416-422

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. Published

      Effect of bile on the oral absorption of halofantrine in polyethylene glycol 400 and polysorbate 80 formulations dosed to bile duct cannulated rats

      Tønsberg, H., Holm, R., Mu, Huiling, Boll, J. B., Jacobsen, Jette & Mullertz, Anette , 2011, In: Journal of Pharmacy and Pharmacology. 63, p. 817-824

      Research output: Contribution to journalJournal articleResearchpeer-review

    12. Published

      In vitro lipolysis models as a tool for the characterization of oral lilpid and surfactant based drug delivery systems

      Larsen, A. T., Sassene, P. & Mullertz, Anette , 2011, In: International Journal of Pharmaceutics. 417, 1-2, p. 245-255

      Research output: Contribution to journalJournal articleResearchpeer-review

    13. Published

      Insights into the early dissolution events of amlodipine using UV imaging and Raman spectroscopy

      Bøtker, Johan Peter, Savolainen, M., Koradia, V., Tian, F., Rades, Thomas, Mullertz, Anette , Cornett, Claus, Rantanen, Jukka & Østergaard, Jesper, 2011, In: Molecular Pharmaceutics. 8, 4, p. 1372-1380 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. Published

      Phase transformations of amlodipine besylate solid forms

      Koradia, V. S., Lemos, A. F. F. D., Allesø, M., Diego, H. L. D., Ringkjøbing-Elema, M., Mullertz, Anette & Rantanen, Jukka, 2011, In: Journal of Pharmaceutical Sciences. 100, 7, p. 2896-2910

      Research output: Contribution to journalJournal articleResearchpeer-review

    15. 2010
    16. Published

      Impact of lipolysis on absorption of a poorly soluble model drug formulated in SMEDDS - an in vitro study

      Eriksson, A. H., Refsgaard, L., Larsen, A. T., Mullertz, Anette & Olesen, P. H., Nov 2010.

      Research output: Contribution to conferencePosterResearch

    17. Published

      Insights into the ultrastructure of human intestinal fluids in the fed state by electron microscopy analysis

      Mullertz, Anette , Fatouros, D., Smith, J. R., Vertzoni, M. & Rappas, C., Nov 2010.

      Research output: Contribution to conferencePosterResearch

    18. Published

      Redissolution and polymorphic characterization of a poorly water-soluble drug precipitated during in vitro lipolysis from a lipid-based formulation

      Ren, S., Ogbonna, A., Koradia, V. S., Sassene, P. J., Rades, T. & Mullertz, Anette , Nov 2010.

      Research output: Contribution to conferencePosterResearch

    19. Published

      Selection of a lipase for development of an in vitro gastric lipid digestion model

      Larsen, A. T., Jensen, L. G., Hansen, K. K. & Mullertz, Anette , Nov 2010.

      Research output: Contribution to conferencePosterResearch

    20. Published

      Solid forms of amlodipine besylate: Physiochemical, structural, and thermodynamic characterization

      Koradia, V. S., Lopez de Diego, H., Frydenvang, Karla Andrea, Ringkjøbing-Elema, M., Mullertz, Anette , Bond, A. D. & Rantanen, Jukka, 28 Oct 2010, In: Crystal Growth & Design. 10, 12, p. 5279-5290

      Research output: Contribution to journalJournal articleResearchpeer-review

    21. Published

      An updated and simplified method for bile duct cannulation of rats

      Tønsberg, H., Holm, R., Bjerregaaard, T. G., Jacobsen, Jette & Mullertz, Anette , 2010, In: Laboratory Animals. 44, 4, p. 373-376

      Research output: Contribution to journalJournal articleResearchpeer-review

    22. Published

      Biorelevant media simulating fed state intestinal fluids: colloid phase characterization and impact on solubilization capacity

      Kleberg, K., Jacobsen, F., Fatouros, D. G. & Mullertz, Anette , 2010, In: Journal of Pharmaceutical Sciences. 99, 8, p. 3522-3532 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    23. Published

      Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studies

      Kleberg, K., Jacobsen, Jette & Mullertz, Anette , 2010, In: Journal of Pharmacy and Pharmacology. 62, 11, p. 1656-1668 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    24. Published

      Meeting report: applied biopharmaceutics and quality by design for dissolution/release specification setting: product quality for patient benefit

      Selen, A., Cruanes, M. T., Mullertz, Anette , Dicikinsion, P. A., Cook, J. A., Polli, J. E., Kesisoglou, F., Crison, J., Johnson, K. C., Muirhead, G. T., Schofield, T. & Tsong, Y., 2010, In: The AAPS Journal. 12, 3, p. 465-472

      Research output: Contribution to journalReviewResearch

    25. Published

      New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs

      Mullertz, Anette , Ogbonna, A., Ren, S. & Rades, Thomas, 2010, In: Journal of Pharmacy and Pharmacology. 62, 11, p. 1622-1636 15 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    26. Published

      Precipitation of a poorly soluble model drug during in vitro lilpolysis: characterization and dissolution of the precipitate

      Sassene, P. J., Knopp, Matthias Manne, Hesselkilde, J. Z., Koradia, V., Larsen, A., Rades, Thomas & Mullertz, Anette , 2010, In: Journal of Pharmaceutical Sciences. 99, 12, p. 4982-4991

      Research output: Contribution to journalJournal articleResearchpeer-review

    27. 2009
    28. Published

      Adsorption of pharmaceutical excipients onto microcrystals of siramesine hydrochloride: Effects on physicochemical properties

      Zimmermann, A., Millqvist-Fureby, A., Elema, M. R., Hansen, T., Mullertz, Anette & Hovgaard, L., 2009, In: European Journal of Pharmaceutics and Biopharmaceutics. 71, 1, p. 109-116

      Research output: Contribution to journalJournal articleResearchpeer-review

    29. Published

      Colloidal structures in media simulating intestinal fed state conditions with and without lipolysis products

      Fatouros, D., Walrand, I., Bergenstahl, B. & Mullertz, Anette , 2009, In: Pharmaceutical Research. 26, 2, p. 361-374

      Research output: Contribution to journalJournal articleResearchpeer-review

    30. Published

      Effects of polysorbate 80 on the in-vitro precipitation and oral bioavailability of halofantrine from polyethylene glycol 400 formulations in rats

      Tønsberg, H., Holm, R., Boll, J. B., Jacobsen, Jette & Mullertz, Anette , 2009, In: Journal of Pharmacy and Pharmacology. 62, 1, p. 63-70

      Research output: Contribution to journalJournal articleResearchpeer-review

    31. Published

      Influence of the solid form of siramesine hydrochloride on its behaviour in aqueous environments

      Zimmermann, A., Tian, F., Lopez de Diego, H., Ringkjøbing Elema, M., Rantanen, Jukka, Mullertz, Anette & Hovgaard, L., 2009, In: Pharmaceutical Research. 26, 4, p. 846-854

      Research output: Contribution to journalJournal articleResearchpeer-review

    32. Published

      Optimization of the in vitro lipolysis rate of SMEDDS containing cinnarizine

      Ulmann, C., Figueriedo-Larsen, M., Refsgaard, L., Hellekilde, J., Larsen, A., Nielsen, C., Olesen, P. & Mullertz, Anette , 2009.

      Research output: Contribution to conferencePosterResearch

    33. Published

      Physicochemical characterization of simulated intestinal fed-state fluids containing lyso-phosphatidylcholine and cholesterol

      Fatouros, D., Walrand, I., Bergenstahl, B. & Mullertz, Anette , 2009, In: Dissolution Technologies. 16, 3, p. 47-50

      Research output: Contribution to journalJournal articleResearchpeer-review

    34. Published

      Tabletter med "løse ender" giver forsinket afgift af lægemiddelstof

      Naelapaa, K., Mullertz, Anette , Jacobsen, Jette, Rømsing, J. & Bar-Shalom, Daniel, 2009, In: Lægemiddelforskning. p. 4-6 3 p.

      Research output: Contribution to journalJournal articleResearch

    35. Published

      Tabletter med løse ender

      Naelapaa, K., Mullertz, Anette , Jacobsen, Jette, Rømsing, J. & Bar-Shalom, Daniel, 2009, In: Lægemiddelforskning. p. 4-6

      Research output: Contribution to journalJournal articleResearch

    36. Published

      The use of biorelevant dissolution media in determining the region of microemulsion: Implications for in vitro lipid formulation assessment

      Ogbonna, A., Ren, S., Olesen, P. & Mullertz, Anette , 2009.

      Research output: Contribution to conferencePosterResearch

    37. 2008
    38. Published

      In vitro lipid digestion models in design of drug delivery systems for enhancing oral bioavailability

      Fatouros, D. & Mullertz, Anette , 2008, In: Expert Opinion on Drug Metabolism & Toxicology. 4, 1, p. 65-76

      Research output: Contribution to journalReviewResearch

    39. Published

      Bioavailability of probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state

      Nielsen, F. S., Petersen, K. & Mullertz, Anette , 2008, In: European Journal of Pharmaceutics and Biopharmaceutics. 69, 2, p. 553-562

      Research output: Contribution to journalJournal articleResearchpeer-review

    40. Published

      Characterization and physical stability of spray dried solid dispersions of probucol and PVP-K30

      Thybo, P., Pedersen, B. L., Hovgaard, L., Holm, R. & Mullertz, Anette , 2008, In: Pharmaceutical Development and Technology. 13, 5, p. 375-86 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    41. Published

      Colloid structures in media simulating intestinal fed state conditions with and without lipolysis products

      Fatourus, D., Walrand, I., Bergenstahl, B. & Mullertz, Anette , 2008.

      Research output: Contribution to conferencePosterResearch

    42. Published

      Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories

      Hayeshi, R., Hilgendorf, C., Arthursson, P., Augustijns, P., Larsen, Birger Brodin, Dehertogh, P., Fisher, K., Fossati, L., Hovenkamp, E., Korjamo, T., Masungi, C., Maubon, N., Mols, R., Mullertz, Anette , Mönkkönen, J., O´Driscoll, C., Oppers-Tiemissen, H. M., Ragnarsson, E. G. E., Rooseboom, M. & Ungell, A., 2008, In: European Journal of Pharmaceutical Sciences. 35, 5, p. 383-396

      Research output: Contribution to journalJournal articleResearchpeer-review

    43. Published

      Dynamisk model for fordøjelse af lipidbaserede lægemidler i tarmen

      Larsen, A., Fatourous, D., Jacobsen, Jette & Mullertz, Anette , 2008, In: Dansk Kemi. 89, 8, p. 30-33

      Research output: Contribution to journalJournal articleResearch

    44. Published

      In vitro-in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networks

      Fatouros, D. G., Nielsen, F. S., Douroumis, D., Hadjileontiadis, L. J. & Mullertz, Anette , 2008, In: European Journal of Pharmaceutics and Biopharmaceutics. 69, 3, p. 887-898

      Research output: Contribution to journalJournal articleResearchpeer-review

    45. Published

      Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80

      Lind, M. L., Jacobsen, Jette, Holm, R. & Mullertz, Anette , 2008, In: European Journal of Pharmaceutical Sciences. 35, 3, p. 211-218

      Research output: Contribution to journalJournal articleResearchpeer-review

    46. Published

      Lipid-based formulations for danazol containing a digestible surfactant, labrafil M2125CS: In vivo bioavailability and dynamic in vitro lipolysis

      Larsen, A., Holm, R., Pedersen, M. L. & Mullertz, Anette , 2008, In: Pharmaceutical Research. 25, 12, p. 2769-2777

      Research output: Contribution to journalJournal articleResearchpeer-review

    47. Published

      Using biorelevant dissolution to obtain IVIVC of solid dosage forms containing a poorly-soluble model compound

      Lue, B., Nielsen, F. S., Magnussen, T., Schou, H. M., Kristensen, K., Jacobsen, L. O. & Mullertz, Anette , 2008, In: European Journal of Pharmaceutics and Biopharmaceutics. 69, 2, p. 648-657

      Research output: Contribution to journalJournal articleResearchpeer-review

    48. 2007
    49. Published

      Bioavailability of seocalcitol III: administration of lipid-based formulations to minipigs in the fasted and fed state

      Grove, M., Mullertz, Anette , Pedersen, G. P. & Nielsen, J. L., 2007, In: European Journal of Pharmaceutical Sciences. 31, 1, p. 8-15

      Research output: Contribution to journalJournal articleResearchpeer-review

    50. Published

      Biorelevant dissolution media

      Mullertz, Anette , 2007, Solvent systems and their selection in pharmaceutics and biopharmaceutics: Biotechnology: Pharmaceutical aspects. Augustijns, P. & Brewster, M. E. (eds.). New York: Springer Science+Business Media, Vol. 6. p. 107-177

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

    51. Published

      Characterization of prototype self-nanoemulsifying formulations of lipophilic compounds

      Nielsen, F. S., Gibault, E., Ljusberg-Wahren, H., Arleth, Lise, Pedersen, J. S. & Mullertz, Anette , 2007, In: Journal of Pharmaceutical Sciences. 96, 4, p. 876-892 17 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    52. Published

      Clinical studies with oral lipid based formulations of poorly soluble compounds

      Fatouros, D., Karpf, D. M., Nielsen, Flemming Steen & Mullertz, Anette , 2007, In: Therapeutics and Clinical Risk Management. 3, 4, p. 591-604 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    53. Published

      Determination of surface-adsorbed excipients of various types on drug particles prepared by antisolvent precipitation using HPLC with evaporative light scattering detection

      Zimmermann, A., Elema, M. R., Hansen, T., Mullertz, Anette & Hovgaard, L., 2007, In: Journal of Pharmaceutical and Biomedical Analysis. 44, 4, p. 874-880

      Research output: Contribution to journalJournal articleResearchpeer-review

    54. Published

      Development of simulated intestinal fluids containing nutrients as transport media in the Caco-2 cell culture model: assessment of cell viability, monolayer integrity and transport of a poorly aqueous soluble drug and a substrate of efflux mechanisms

      Lind, M. L., Jacobsen, Jette, Holm, R. & Mullertz, Anette , 2007, In: European Journal of Pharmaceutical Sciences. 32, 4-5, p. 261-270

      Research output: Contribution to journalJournal articleResearchpeer-review

    55. Published

      Effect of labrafil 2125CS on the oral bioavailability of danazol, a poorly soluble drug compound

      Larsen, A., Holm, R., Pedersen, M. & Mullertz, Anette , 2007.

      Research output: Contribution to conferencePosterResearch

    56. Published

      Liquid self-microemulsifying drug delivery

      Mullertz, Anette & Grove, M., 2007, Oral lipid-based formulations: enhancing the bioavailability of poor water-soluble drugs. Hauss, D. J. (ed.). New York: Informa Healthcare, p. 107-128

      Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

    ID: 1302503