Anette Müllertz

Anette Müllertz

Professor


  1. 2021
  2. Published

    Hot punching for loading of biodegradable microcontainers with budesonide-Soluplus film

    Abid, Z., Andreoli, F., Kristensen, M. N., Petersen, R. S., Mullertz, Anette , Boisen, A. & Keller, S. S., Sep 2021, In: Biomedical Microdevices. 23, 3, 37.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Exploring Porcine Gastric and Intestinal Fluids using Microscopic and Solubility Estimates: Impact of Placebo Self-Emulsifying Drug Delivery System Administration to Inform Bio-Predictive in vitro Tools

    Bennett-Lenane, H., Jørgensen, Jacob Rune, Koehl, N. J., Henze, L. J., O'Shea, J. P., Mullertz, Anette & Griffin, B. T., 2021, In: European Journal of Pharmaceutical Sciences. 161, 11 p., 105778.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    In vitro and in vivo comparison of microcontainers and microspheres for oral drug delivery

    Christfort, J. F., Strindberg, Sophie , Al-khalili, S., Bar-Shalom, Daniel, Boisen, A., Nielsen, L. H. & Mullertz, Anette , 2021, In: International Journal of Pharmaceutics. 600, 9 p., 120516.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Fasted and fed state human duodenal fluids: Characterization, drug solubility, and comparison to simulated fluids and with human bioavailability

    Dahlgren, D., Venczel, M., Ridoux, J. P., Skjöld, C., Mullertz, Anette , Holm, R., Augustijns, P., Hellström, P. M. & Lennernäs, H., Jun 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 163, p. 240-251 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Predicting Oral Absorption of fenofibrate in Lipid-Based Drug Delivery Systems by Combining In Vitro Lipolysis with the Mucus-PVPA Permeability Model

    Falavigna, M., Klitgaard, Mette, Berthelsen, Ragna, Mullertz, Anette & Flaten, G. E., 2021, In: Journal of Pharmaceutical Sciences. 110, 1, p. 208-216 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Towards analyzing the potential of exosomes to deliver microRNA therapeutics

    Giassafaki, L. N., Siqueira, S., Panteris, E., Psatha, K., Chatzopoulou, F., Aivaliotis, M., Tzimagiorgis, G., Mullertz, Anette , Fatouros, D. G. & Vizirianakis, I. S., 2021, In: Journal of Cellular Physiology. 236, 2, p. 1529-1544 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    INFOGEST inter-laboratory recommendations for assaying gastric and pancreatic lipases activities prior to in vitro digestion studies

    Grundy, M. M. L., Abrahamse, E., Almgren, A., Alminger, M., Andres, A., Ariëns, R. M. C., Bastiaan-Net, S., Bourlieu-Lacanal, C., Brodkorb, A., Bronze, M. R., Comi, I., Couëdelo, L., Dupont, D., Durand, A., El, S. N., Grauwet, T., Heerup, Christine Kopka, Heredia, A., Infantes Garcia, M. R., Jungnickel, C., Kłosowska-Chomiczewska, I. E., Létisse, M., Macierzanka, A., Mackie, A. R., McClements, D. J., Menard, O., Meynier, A., Michalski, M. C., Mulet-Cabero, A. I., Mullertz, Anette , Payeras Perelló, F. M., Peinado, I., Robert, M., Secouard, S., Serra, A. T., Silva, S. D., Thomassen, G., Tullberg, C., Undeland, I., Vaysse, C., Vegarud, G. E., Verkempinck, S. H. E., Viau, M., Zahir, M., Zhang, R. & Carrière, F., 2021, In: Journal of Functional Foods. 82, 104497.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Effects of recombinant human gastric lipase and pancreatin during in vitro pediatric gastro-intestinal digestion

    Heerup, Christine Kopka, Ebbesen, M. F., Geng, X., Madsen, Sofie Falkenløve, Berthelsen, Ragna & Mullertz, Anette , 2021, In: Food & Function. 12, 7, p. 2938-2949 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Dairy-derived emulsifiers in infant formula show marginal effects on the plasma lipid profile and brain structure in preterm piglets relative to soy lecithin

    Henriksen, Nicole Lind, Aasmul-Olsen, Karoline, Ramakrishnan, Venkatasubramanian, Nygaard, M. K. E., Sprenger, R. R., Heckmann, A. B., Ostenfeld, M. S., Ejsing, C. S., Eskildsen, S. F., Mullertz, Anette , Sangild, Per Torp, Bering, Stine Brandt & Thymann, Thomas, 2021, In: Nutrients. 13, 3, p. 1-18 18 p., 718.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Development of gastro-resistant coated probiotic granulates and evaluation of viability and release during simulated upper gastrointestinal transit

    Jacobsen, N. M. Y., Nedergaard, H. B., Kock, A., Caglayan, I., Laursen, M. M., Lange, E., Marcial-Coba, M. S., Bar-Shalom, Daniel, Nielsen, Dennis Sandris & Mullertz, Anette , 2021, In: LWT. 144, 9 p., 111174.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Design of a self-unfolding delivery concept for oral administration of macromolecules

    Jørgensen, Jacob Rune, Thamdrup, L. H. E., Kamguyan, K., Nielsen, L. H., Nielsen, Hanne Mørck, Boisen, A., Rades, Thomas & Mullertz, Anette , 2021, In: Journal of Controlled Release. 329, p. 948-954

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Design and optimization of self-nanoemulsifying drug delivery systems of clove oil for efficacy enhancement in fish anesthesia

    Kheawfu, Pikulkaew, Rades, Thomas, Mullertz, Anette , Jørgensen, Louise von Gersdorff & Okonogi, 2021, In: Journal of Drug Delivery Science and Technology. 61, 9 p., 102241.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Formulation optimization, anesthetic activity, skin permeation, and transportation pathway of Alpinia galanga oil SNEDDS in zebrafish (Danio rerio)

    Khumpirapang, N., Jørgensen, Louise von Gersdorff, Mullertz, Anette , Rades, Thomas & Okonogi, S., 2021, In: European Journal of Pharmaceutics and Biopharmaceutics. 165, p. 193-202 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Accepted/In press

    X-ray Imaging for Gastrointestinal Tracking of Microscale Oral Drug Delivery Devices

    Kjeldsen, R. B., Kristensen, M. N., Gundlach, C., Thamdrup, L. H. E., Mullertz, Anette , Rades, Thomas, Nielsen, L. H., Zór, K. & Boisen, A., 2021, (Accepted/In press) In: ACS Biomaterials Science and Engineering.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Estimating the Oral Absorption from Self-Nanoemulsifying Drug Delivery Systems Using an In Vitro Lipolysis-Permeation Method

    Klitgaard, Mette, Mullertz, Anette & Berthelsen, Ragna, 2021, In: Pharmaceutics. 13, 4, 14 p., 489.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Bovine Milk-Derived Emulsifiers Increase Triglyceride Absorption in Newborn Formula-Fed Pigs

    Knudsen, K. B. K., Heerup, Christine Kopka, Jensen, T. R. S., Geng, X., Drachmann, N., Nordby, P., Jeppesen, Palle Bekker, Ifaoui, I., Mullertz, Anette , Sangild, Per Torp, Ostenfeld, M. S. & Thymann, Thomas, 2021, In: Nutrients. 13, 2, 15 p., 410.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Drug solubilization during simulated pediatric gastro-intestinal digestion

    Kofoed-Djursner, C., Jamil, A., Selen, A., Mullertz, Anette & Berthelsen, Ragna, 2021, In: European Journal of Pharmaceutical Sciences. 162, 8 p., 105828.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Oligonucleotide Delivery across the Caco-2 Monolayer: The Design and Evaluation of Self-Emulsifying Drug Delivery Systems (SEDDS)

    Kubackova, J., Holas, O., Zbytovska, J., Vranikova, B., Zeng, G., Pavek, P. & Mullertz, Anette , Apr 2021, In: Pharmaceutics. 13, 4, 27 p., 459.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Exploring the Impact of Intestinal Fluid Components on the Solubility and Supersaturation of Danazol

    Madsen, C. M., Plum, J., Hens, B., Augustijns, P., Mullertz, Anette & Rades, Thomas, 2021, In: Journal of Pharmaceutical Sciences. 110, 6, p. 2479-2488 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    The Influence of Solidification on the in vitro Solubilisation of Blonanserin Loaded Supersaturated Lipid-Based Oral Formulations

    Moller, A., Schultz, H. B., Meola, T. R., Mullertz, Anette & Prestidge, C. A., 2021, In: European Journal of Pharmaceutical Sciences. 157, 10 p., 105640.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Development of Self-Nanoemulsifying Drug Delivery Systems Containing 4-Allylpyrocatechol for Treatment of Oral Infections Caused by Candida albicans

    Okonogi, S., Phumat, P., Khongkhunthian, S., Chaijareenont, P., Rades, Thomas & Mullertz, Anette , 2021, In: Pharmaceutics. 13, 2, 16 p., 167.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Integrated Multi-stakeholder Systems Thinking Strategy: Decision-making with Biopharmaceutics Risk Assessment Roadmap (BioRAM) to Optimize Clinical Performance of Drug Products

    Selen, A., Mullertz, Anette , Kesisoglou, F., Ho, R. J. Y., Cook, J. A., Dickinson, P. A. & Flanagan, T., 3 Jan 2021, In: AAPS Journal. 23, 1, 7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Accepted/In press

    Visualizing the Journey of Fenofibrate through the Rat Gastrointestinal Tract by Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging

    Strindberg, Sophie , Plum, J., Bagger, C., Janfelt, Christian & Mullertz, Anette , 2021, (Accepted/In press) In: Molecular Pharmaceutics.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

    Vinarov, Z., Abrahamsson, B., Artursson, P., Batchelor, H., Berben, P., Bernkop-Schnurch, A., Butler, J., Ceulemans, J., Davies, N., Dupont, D., Flaten, G. E., Fotaki, N., Griffin, B. T., Jannin, V., Keemink, J., Kesisoglou, F., Koziolek, M., Kuentz, M., Mackie, A., Melendez-Martinez, A. J., McAllister, M., Mullertz, Anette , O'Driscoll, C. M., Parrott, N., Paszkowska, J., Pavek, P., Porter, C. J. H., Reppas, C., Stillhart, C., Sugano, K., Toader, E., Valentova, K., Vertzoni, M., De Wildt, S. N., Wilson, C. G. & Augustijns, P., 2021, In: Advanced Drug Delivery Reviews. 171, p. 289-331 43 p.

    Research output: Contribution to journalReviewResearchpeer-review

  26. 2020
  27. Published

    Six years of progress in the oral biopharmaceutics area – A summary from the IMI OrBiTo project

    Abrahamsson, B., Mcallister, M., Augustijns, P., Zane, P., Butler, J., Holm, R., Langguth, P., Lindahl, A., Mullertz, Anette , Pepin, X., Rostami-hodjegan, A., Sjögren, E., Berntsson, M. & Lennernäs, H., 1 Jul 2020, In: European Journal of Pharmaceutics and Biopharmaceutics. 152, p. 236-247 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Improving the drug load and in vitro performance of supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS) using polymeric precipitation inhibitors

    Bannow, J., Yorulmaz, Y., Löbmann, Korbinian, Mullertz, Anette & Rades, Thomas, 2020, In: International Journal of Pharmaceutics. 575, 1188960.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Milk osteopontin retains integrin-binding activity after in vitro gastrointestinal transit

    Christensen, B., Karlsen, N. J., Jorgensen, S. D. S., Jacobsen, L. N., Ostenfeld, M. S., Petersen, S. V., Mullertz, Anette & Sorensen, E. S., Jan 2020, In: Journal of Dairy Science. 103, 1, p. 42-51

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Evaluating side-by-side diffusion models for studying drug supersaturation in an absorptive environment: a case example of fenofibrate and felodipine

    Eliasen, J. N., Berthelsen, Ragna, Slot, A. L. & Mullertz, Anette , 2020, In: Journal of Pharmacy and Pharmacology. 72, 3, p. 371-384

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published
  32. Published

    Achieving delayed release of freeze-dried probiotic strains by extrusion, spheronization and fluid bed coating - evaluated using a three-step in vitro model

    Jacobsen, N. M. Y., Caglayan, I., Caglayan, A., Bar-Shalom, Daniel & Mullertz, Anette , 2020, In: International Journal of Pharmaceutics. 591, 7 p., 120022.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    In Vitro, Ex Vivo and In Vivo Evaluation of Microcontainers for Oral Delivery of Insulin

    Jørgensen, Jacob Rune, Yu, F., Ramakrishnan, Venkatasubramanian, Nielsen, L. H., Nielsen, Hanne Mørck, Boisen, A., Rades, Thomas & Mullertz, Anette , 7 Jan 2020, In: Pharmaceutics. 12, 1, 14 p., 48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Adding a Gastric Step to the Intestinal In Vitro Digestion Model Improves the Prediction of Pharmacokinetic Data in Beagle Dogs of Two Lipid-Based Drug Delivery Systems

    Klitgaard, Mette, Beilles, S., Sassene, P. J., Berthelsen, Ragna & Mullertz, Anette , 2020, In: Molecular Pharmaceutics. 17, 9, p. 3214-3222 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B

    Kontogiannidou, E., Meikopoulos, T., Gika, H., Panteris, E., Vizirianakis, I. S., Mullertz, Anette & Fatouros, D. G., 2020, In: Pharmaceutics. 12, 8, 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Towards the development of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) containing trimethyl chitosan for the oral delivery of amphotericin B: In vitro assessment and cytocompatibility studies

    Kontogiannidou, E., Meikopoulos, T., Virgiliou, C., Bouropoulos, N., Gika, H., Vizirianakis, I. S., Mullertz, Anette & Fatouros, D. G., Apr 2020, In: Journal of Drug Delivery Science and Technology. 56, 9 p., 101524.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Evaluation of self -emulsifying drug delivery systems for oral insulin delivery using an in vitro model simulating the intestinal proteolysis

    Liu, J., Hirschberg, C., Fano, M., Mu, Huiling & Mullertz, Anette , 2020, In: European Journal of Pharmaceutical Sciences. 147, 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Effect of centrifugation speed on the measured equilibrium solubility of poorly water-soluble compounds in viscous solvents

    Liu, X., Mullertz, Anette , Bar-Shalom, Daniel & Berthelsen, Ragna, 2020, In: Journal of Drug Delivery Science and Technology. 59, 8 p., 101853.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Enhancing Stability and Tooth Bleaching Activity of Carbamide Peroxide by Electrospun Nanofibrous Film

    Okonogi, S., Kaewpinta, A., Rades, Thomas, Mullertz, Anette , Yang, Mingshi, Khongkhunthian, S. & Chaijareenont, P., 2020, In: Pharmaceuticals. 13, 11, 20 p., 381.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Comparison of induction methods for supersaturation: Amorphous dissolution versus solvent shift

    Plum, J., Bavnhoj, C. G., Eliasen, Jannik Nicklas, Rades, Thomas & Mullertz, Anette , 2020, In: European Journal of Pharmaceutics and Biopharmaceutics. 152, p. 35-43 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Comparison of induction methods for supersaturation: pH shift versus solvent shift

    Plum, J., Bavnhoj, C., Palmelund, H., Perez Alos, Laura, Mullertz, Anette & Rades, Thomas, 5 Jan 2020, In: International Journal of Pharmaceutics. 573, 8 p., 118862.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Integrated Multi-stakeholder Systems Thinking Strategy: Decision-making with Biopharmaceutics Risk Assessment Roadmap (BioRAM) to Optimize Clinical Performance of Drug Products

    Selen, A., Mullertz, Anette , Kesisoglou, F., Ho, R. J. Y., Cook, J. A., Dickinson, P. A. & Flanagan, T., 2020, In: AAPS Journal. 22, 5, 20 p., 97.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Poorly soluble drugs

    Siepmann, J., Rades, Thomas, Mullertz, Anette & Loftsson, T., 15 Mar 2020, In: International Journal of Pharmaceutics. 577, 119055.

    Research output: Contribution to journalEditorialResearch

  44. Published

    Impact of gastrointestinal physiology on drug absorption in special populations??An UNGAP review

    Stillhart, C., Vucicevic, K., Augustijns, P., Basit, A. W., Batchelor, H., Flanagan, T. R., Gesquiere, I., Greupink, R., Keszthelyi, D., Koskinen, M., Madla, C. M., Matthys, C., Miljus, G., Mooij, M. G., Parrott, N., Ungell, A. -., de Wildt, S. N., Orlu, M., Klein, S. & Mullertz, Anette , 2020, In: European Journal of Pharmaceutical Sciences. 147, 28 p., 105280.

    Research output: Contribution to journalReviewResearchpeer-review

  45. Published

    Effect of supersaturation on absorption of indomethacin and tadalafil in a single pass intestinal perfusion rat model, in the absence and presence of a precipitation inhibitor

    Strindberg, Sophie , Plum, J., Stie, Mai Bay, Christiansen, M. L., Nielsen, L. H., Rades, Thomas & Mullertz, Anette , Jun 2020, In: European Journal of Pharmaceutics and Biopharmaceutics. 151, p. 108-115

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems

    Tran, T., Bonlokke, P., Rodriguez-Rodriguez, C., Nosrati, Z., Esquinas, P. L., Borkar, N., Plum, J., Strindberg, Sophie , Karagiozov, S., Rades, Thomas, Mullertz, Anette , Saatchi, K. & Hafeli, U. O., 2020, In: Journal of Controlled Release. 317, p. 375-384

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Formulation of co-amorphous systems from naproxen and naproxen sodium and in situ monitoring of physicochemical state changes during dissolution testing by Raman spectroscopy

    Ueda, H., Bøtker, Johan Peter, Edinger, M., Löbmann, Korbinian, Grohganz, Holger, Mullertz, Anette , Rades, Thomas & Østergaard, Jesper, 2020, In: International Journal of Pharmaceutics. 587, 119662.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. 2019
  49. Published

    Biodegradable microcontainers-towards real life applications of microfabricated systems for oral drug delivery

    Abid, Z., Strindberg, Sophie , Javed, M. M., Mazzoni, C., Vaut, L., Nielsen, L. H., Gundlach, C., Petersen, R. S., Mullertz, Anette , Boisen, A. & Keller, S. S., 2019, In: Lab on a Chip. 19, 17, p. 2905-2914 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery

    Abid, Z., Dalskov Mosgaard, M., Manfroni, G., Singh Petersen, R., Hagner Nielsen, L., Mullertz, Anette , Boisen, A. & Sylvest Keller, S., Nov 2019, In: Polymers. 11, 10 p., 1828.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects

    Bergstrom, C. A. S., Box, K., Holm, R., Matthews, W., McAllister, M., Mullertz, Anette , Rades, Thomas, Schaefer, K. J. & Teleki, A., Jun 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 139, p. 101-114

    Research output: Contribution to journalReviewResearchpeer-review

  52. Published

    Self-emulsifying drug delivery systems (SEDDS) – The splendid comeback of an old technology

    Bernkop-Schnürch, A., Mullertz, Anette & Rades, Thomas, 2019, In: Advanced Drug Delivery Reviews. 142, p. 1-2 2 p.

    Research output: Contribution to journalEditorialResearchpeer-review

  53. Published

    In vitro digestion models to evaluate lipid based drug delivery systems; present status and current trends

    Berthelsen, Ragna, Klitgaard, Mette, Rades, Thomas & Mullertz, Anette , 29 Jun 2019, In: Advanced Drug Delivery Reviews. 142, p. 35-49 15 p.

    Research output: Contribution to journalReviewResearchpeer-review

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