Andrea Heinz
Associate Professor - Promotion Programme
LEO Foundation Center for Cutaneous Drug Delivery
Universitetsparken 2
2100 København Ø
- Published
A comprehensive map of human elastin cross-linking during elastogenesis
Hedtke, T., Schräder, C. U., Heinz, Andrea, Hoehenwarter, W., Brinckmann, J., Groth, T. & Schmelzer, C. E. H., 2019, In: The F E B S Journal (Online). p. 3594-3610Research output: Contribution to journal › Journal article › Research › peer-review
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Analysis of solid-state transformations of pharmaceutical compounds using vibrational spectroscopy
Heinz, Andrea, Strachan, C. J., Gordon, K. C. & Rades, Thomas, Aug 2009, In: The Journal of pharmacy and pharmacology. 61, 8, p. 971-88 18 p.Research output: Contribution to journal › Review › Research › peer-review
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Better understanding of dissolution behaviour of amorphous drugs by in situ solid-state analysis using Raman spectroscopy
Savolainen, M., Kogermann, K., Heinz, Andrea, Aaltonen, J., Peltonen, L., Strachan, C. & Yliruusi, J., Jan 2009, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 71, 1, p. 71-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cadmium toxicity investigated at the physiological and biophysical levels under environmentally relevant conditions using the aquatic model plant Ceratophyllum demersum
Andresen, E., Kappel, S., Stärk, H., Riegger, U., Borovec, J., Mattusch, J., Heinz, Andrea, Schmelzer, C. E. H., Matoušková, Š., Dickinson, B. & Küpper, H., Jun 2016, In: New Phytologist. 210, 4, p. 1244-58 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of extracellular vesicles by capillary zone electrophoresis: A novel concept for characterization of a next-generation drug delivery platform
Steć, A., Heinz, Andrea & Dziomba, S., 1 May 2024, In: Journal of Pharmaceutical Analysis. p. 101004Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of novel interactions with plasma membrane NEU1 reveals new biological functions for the elastin receptor complex in vascular diseases
Tembely, D., Bocquet, O., Kawecki, C., Terryn, C., Schmelzer, C., Heinz, Andrea, Romier-Crouzet, B., Bennasroune, A., Blaise, S., Sartelet, H., Martiny, L., Duca, L. & Maurice, P., 2021, In: Atherosclerosis. 331, 1 p., E24.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Characterizing an amorphous system exhibiting trace crystallinity: A case study with saquinavir
Heinz, Andrea, Strachan, C. J., Atassi, F., Gordon, K. C. & Rades, Thomas, Jan 2008, In: Crystal Growth & Design. 8, 1, p. 119-127Research output: Contribution to journal › Journal article › Research › peer-review
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Coaxial electrospinning of polycaprolactone: A design of experiments approach
Gürtler, Anna-Lena, Linseisen, I., Grohganz, Holger & Heinz, Andrea, 2024, In: European Polymer Journal. 208, 11 p., 112886.Research output: Contribution to journal › Journal article › Research › peer-review
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Degradation of tropoelastin and skin elastin by neprilysin
Mora Huertas, A. C., Schmelzer, C. E. H., Luise, C., Sippl, W., Pietzsch, M., Hoehenwarter, W. & Heinz, Andrea, 2018, In: Biochimie. 146, p. 73-78 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Degradation of tropoelastin by matrix metalloproteinases--cleavage site specificities and release of matrikines
Heinz, Andrea, Jung, M. C., Duca, L., Sippl, W., Taddese, S., Ihling, C., Rusciani, A., Jahreis, G., Weiss, A. S., Neubert, R. H. H. & Schmelzer, C. E. H., Apr 2010, In: F E B S Journal. 277, 8, p. 1939-56 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Design and characterization of matrix metalloproteinase-responsive hydrogels for the treatment of inflammatory skin diseases
Noddeland, H. K., Lind, M., Jensen, L. B., Petersson, K., Skak-Nielsen, T., Larsen, F. H., Malmsten, Martin & Heinz, Andrea, 2023, In: Acta Biomaterialia. 157, p. 149-161Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Does human leukocyte elastase degrade intact skin elastin?
Schmelzer, C. E. H., Jung, M. C., Wohlrab, J., Neubert, R. H. H. & Heinz, Andrea, Nov 2012, In: F E B S Journal. 279, 22, p. 4191-200 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Elastases and elastokines: elastin degradation and its significance in health and disease
Heinz, Andrea, 2020, In: Critical Reviews in Biochemistry and Molecular Biology. 55, 3, p. 252-273 22 p.Research output: Contribution to journal › Review › Research › peer-review
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Elastic fibers during aging and disease
Heinz, Andrea, 2021, In: Ageing Research Reviews. 66, 19 p., 101255.Research output: Contribution to journal › Review › Research › peer-review
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Elastin
Rønnow, S. R., Kristensen, J. H., Thorlacius-Ussing, J., Karsdal, M. A. & Heinz, Andrea, 2024, Biochemistry of Collagens, Laminins and Elastin. 3 ed. Academic Press, p. 279-289Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Elastin is heterogeneously cross-linked
Schräder, C. U., Heinz, Andrea, Majovsky, P., Karaman, B., Brinckmann, J., Sippl, W. & Schmelzer, C. E. H., 2018, In: The Journal of Biological Chemistry. 293, 39, p. 15107-15119Research output: Contribution to journal › Journal article › Research › peer-review
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Elastin-derived peptides are new regulators of insulin resistance development in mice
Blaise, S., Romier, B., Kawecki, C., Ghirardi, M., Rabenoelina, F., Baud, S., Duca, L., Maurice, P., Heinz, Andrea, Schmelzer, C. E. H., Tarpin, M., Martiny, L., Garbar, C., Dauchez, M., Debelle, L. & Durlach, V., Nov 2013, In: Diabetes. 62, 11, p. 3807-16 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Elastins from patients with Williams-Beuren syndrome and healthy individuals differ on the molecular level
Heinz, Andrea, Huertas, A. C. M., Schräder, C. U., Pankau, R., Gosch, A. & Schmelzer, C. E. H., Jul 2016, In: American Journal of Medical Genetics. Part A. 170, 7, p. 1832-42 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Electrospinning Proteins for Wound Healing Purposes: Opportunities and Challenges
Akhmetova, A. & Heinz, Andrea, 2020, In: Pharmaceutics. 13, 1, 22 p., 4.Research output: Contribution to journal › Journal article › Research › peer-review
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Electrospun fibers for the treatment of skin diseases
Gürtler, Anna-Lena, Rades, Thomas & Heinz, Andrea, 2023, In: Journal of controlled release : official journal of the Controlled Release Society. 363, p. 621-640Research output: Contribution to journal › Review › Research › peer-review
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Expression of elastolytic cathepsins in human skin and their involvement in age-dependent elastin degradation
Panwar, P., Hedtke, T., Heinz, Andrea, Andrault, P., Hoehenwarter, W., Granville, D. J., Schmelzer, C. E. H. & Brömme, D., 2020, In: B B A - General Subjects. 1864, 5, 18 p., 129544.Research output: Contribution to journal › Journal article › Research › peer-review
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Extracellular Matrix Stiffness and Composition Regulate the Myofibroblast Differentiation of Vaginal Fibroblasts
Ruiz-Zapata, A. M., Heinz, Andrea, Kerkhof, M. H., van de Westerlo-van Rijt, C., Schmelzer, C. E. H., Stoop, R., Kluivers, K. B. & Oosterwijk, E., 2020, In: International Journal of Molecular Sciences . 21, 13, 15 p., 4762.Research output: Contribution to journal › Journal article › Research › peer-review
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Fingerprinting desmosine-containing elastin peptides
Schräder, C. U., Heinz, Andrea, Majovsky, P. & Schmelzer, C. E. H., May 2015, In: Journal of the American Society for Mass Spectrometry. 26, 5, p. 762-73 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Highly Elastic and Water Stable Zein Microfibers as a Potential Drug Delivery System for Wound Healing
Akhmetova, A., Lanno, G., Kogermann, K., Malmsten, Martin, Rades, Thomas & Heinz, Andrea, 2020, In: Pharmaceutics. 12, 5, 19 p., 458.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of CD36 as a new interaction partner of membrane NEU1: potential implication in the pro-atherogenic effects of the elastin receptor complex
Kawecki, C., Bocquet, O., Schmelzer, C. E. H., Heinz, Andrea, Ihling, C., Wahart, A., Romier, B., Bennasroune, A., Blaise, S., Terryn, C., Linton, K. J., Martiny, L., Duca, L. & Maurice, P., 2019, In: Cellular and molecular life sciences : CMLS. 76, 4, p. 791–807Research output: Contribution to journal › Journal article › Research › peer-review
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In Situ Imaging of Subcutaneous Drug Delivery Systems Using Microspatially Offset Low-Frequency Raman Spectroscopy
Bērziņš, Kārlis, Czyrski, Grzegorz Sebastian, Aljabbari, Anas Samir Mohammad, Heinz, Andrea & Boyd, Ben, 2024, In: Analytical Chemistry. 96, 16, p. 6408–6416Research output: Contribution to journal › Journal article › Research › peer-review
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In Situ Transformation of Electrospun Nanofibers into Nanofiber-Reinforced Hydrogels
Martin, A., Nyman, J. N., Reinholdt, R., Cai, Jun, Gürtler, Anna-Lena, van der Plas, Mariena J.A., Malmsten, Martin, Rades, Thomas & Heinz, Andrea, 2022, In: Nanomaterials. 12, 14, 2437.Research output: Contribution to journal › Journal article › Research › peer-review
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In vitro cross-linking of elastin peptides and molecular characterization of the resultant biomaterials
Heinz, Andrea, Ruttkies, C. K. H., Jahreis, G., Schräder, C. U., Wichapong, K., Sippl, W., Keeley, F. W., Neubert, R. H. H. & Schmelzer, C. E. H., Apr 2013, In: B B A - Reviews on Cancer. 1830, 4, p. 2994-3004 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Insights into the degradation of human elastin by matrilysin-1
Heinz, Andrea, Taddese, S., Sippl, W., Neubert, R. H. H. & Schmelzer, C. E. H., Feb 2011, In: Biochimie. 93, 2, p. 187-94 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Investigating the role of (2S,4R)-4-hydroxyproline in elastin model peptides
Bochicchio, B., Laurita, A., Heinz, Andrea, Schmelzer, C. E. H. & Pepe, A., 9 Dec 2013, In: Biomacromolecules. 14, 12, p. 4278-88 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Longevity of elastin in human intervertebral disc as probed by the racemization of aspartic acid
Sivan, S., Van El, B., Merkher, Y., Schmelzer, C. E. H., Zuurmond, A., Heinz, Andrea, Wachtel, E., Varga, P., Lazary, A., Brayda-Bruno, M. & Maroudas, A., Oct 2012, In: B B A - Reviews on Cancer. 1820, 10, p. 1671-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lysyl oxidase-like 2 (LOXL2)-mediated cross-linking of tropoelastin
Schmelzer, C. E. H., Heinz, Andrea, Troilo, H., Lockhart-Cairns, M. P., Jowitt, T. A., Marchand, M. F., Bidault, L., Bignon, M., Hedtke, T., Barret, A., McConnell, J. C., Sherratt, M. J., Germain, S., Hulmes, D. J. S., Baldock, C. & Muller, L., 2019, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 4, p. 5468-5481Research output: Contribution to journal › Journal article › Research › peer-review
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MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III
Taddese, S., Jung, M. C., Ihling, C., Heinz, Andrea, Neubert, R. H. H. & Schmelzer, C. E. H., Apr 2010, In: B B A - Reviews on Cancer. 1804, 4, p. 731-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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MMP-14 degrades tropoelastin and elastin
Miekus, N., Luise, C., Sippl, W., Baczek, T., Schmelzer, C. E. H. & Heinz, Andrea, 2019, In: Biochimie. p. 32-39Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
Matrix metalloproteinase landscape in the imiquimod-induced skin inflammation mouse model
Noddeland, H. K., Canbay, V., Lind, M., Savickas, S., Jensen, L. B., Petersson, K., Malmsten, Martin, Koch, J., Auf Dem Keller, U. & Heinz, Andrea, 2024, (E-pub ahead of print) In: Biochimie.Research output: Contribution to journal › Journal article › Research › peer-review
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Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms
Bultmann-Mellin, I., Conradi, A., Maul, A. C., Dinger, K., Wempe, F., Wohl, A. P., Imhof, T., Wunderlich, F. T., Bunck, A. C., Nakamura, T., Koli, K., Bloch, W., Ghanem, A., Heinz, Andrea, von Melchner, H., Sengle, G. & Sterner-Kock, A., Apr 2015, In: Disease models & mechanisms. 8, 4, p. 403-15 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular-level characterization of elastin-like constructs and human aortic elastin
Heinz, Andrea, Schräder, C. U., Baud, S., Keeley, F. W., Mithieux, S. M., Weiss, A. S., Neubert, R. H. H. & Schmelzer, C. E. H., Sep 2014, In: Matrix Biology. 38, p. 12-21 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Molecular-level insights into aging processes of skin elastin
Mora Huertas, A. C., Schmelzer, C. E. H., Hoehenwarter, W., Heyroth, F. & Heinz, Andrea, 30 Aug 2016, In: Biochimie. 128-129, p. 163-73 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Production of Elastin-Derived Peptides Contribute to the Development of Non-Alcoholic Steatohepatitis
Romier, B., Ivaldi, C., Sartelet, H., Heinz, A., Schmelzer, C. E. H., Garnotel, R., Guillot, A., Jonquet, J., Bertin, E., Guéant, J-L., Alberto, J-M., Bronowicki, J-P., Amoyel, J., Hocine, T., Duca, L., Maurice, P., Bennasroune, A., Martiny, L., Debelle, L., Durlach, V. & 1 others, , 2018, In: Diabetes. 67, p. 1604-1615Research output: Contribution to journal › Journal article › Research › peer-review
Prolyl hydroxylation in elastin is not random
Schmelzer, C. E. H., Nagel, M. B. M., Dziomba, S., Merkher, Y., Sivan, S. S. & Heinz, Andrea, Oct 2016, In: B B A - Reviews on Cancer. 1860, 10, p. 2169-77 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protease-Responsive Hydrogel Microparticles for Intradermal Drug Delivery
Noddeland, H. K., Lind, M., Petersson, K., Caruso, F., Malmsten, Martin & Heinz, Andrea, 2023, In: Biomacromolecules. 24, 7, p. 3203–3214Research output: Contribution to journal › Journal article › Research › peer-review
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Quantifying ternary mixtures of different solid-state forms of indomethacin by Raman and near-infrared spectroscopy
Heinz, Andrea, Savolainen, M., Rades, Thomas & Strachan, C. J., 2007, In: European Journal of Pharmaceutical Sciences. 32, 3, p. 182-192 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Role for Cela1 in Postnatal Lung Remodeling and AAT-deficient Emphysema
Joshi, R., Heinz, Andrea, Fan, Q., Guo, S., Monia, B., Schmelzer, C. E. H., Weiss, A. S., Batie, M., Parameshwaran, H. & Varisco, B. M., 8 Feb 2018, In: American Journal of Respiratory Cell and Molecular Biology. 59, 2, p. 167-178 0361OC .Research output: Contribution to journal › Journal article › Research › peer-review
Screening for differences in the amorphous state of indomethacin using multivariate visualization
Savolainen, M., Heinz, Andrea, Strachan, C., Gordon, K. C., Yliruusi, J., Rades, Thomas & Sandler, N., 2007, In: European Journal of Pharmaceutical Sciences. 30, 2, p. 113-123Research output: Contribution to journal › Journal article › Research › peer-review
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Structure and activity of Aspergillus nidulans copper amine oxidase
McGrath, A. P., Mithieux, S. M., Collyer, C. A., Bakhuis, J. G., van den Berg, M., Sein, A., Heinz, Andrea, Schmelzer, C., Weiss, A. S. & Guss, J. M., 28 Jun 2011, In: Biochemistry. 50, 25, p. 5718-30 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The action of neutrophil serine proteases on elastin and its precursor
Heinz, Andrea, Jung, M. C., Jahreis, G., Rusciani, A., Duca, L., Debelle, L., Weiss, A. S., Neubert, R. H. H. & Schmelzer, C. E. H., Jan 2012, In: Biochimie. 94, 1, p. 192-202 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Understanding the solid-state forms of fenofibrate - a spectroscopic and computational study
Heinz, Andrea, Gordon, K. C., McGoverin, C. M., Rades, Thomas & Strachan, C. J., 2009, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 71, 1, p. 100-108Research output: Contribution to journal › Journal article › Research › peer-review
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Unique molecular networks: Formation and role of elastin cross-links
Schmelzer, C. E. H., Hedtke, T. & Heinz, Andrea, 2020, In: IUBMB Life. 55, 3, p. 842-854 13 p.Research output: Contribution to journal › Review › Research › peer-review
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Zein-polycaprolactone core-shell nanofibers for wound healing
Martin, A., Cai, Jun, Gürtler, Anna-Lena, van der Plas, Mariena J.A., Malmsten, Martin, Rades, Thomas & Heinz, Andrea, 2022, In: International Journal of Pharmaceutics. 621, 10 p., 121809.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 165030651
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Lysyl oxidase-like 2 (LOXL2)-mediated cross-linking of tropoelastin
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
127
downloads
Identification of CD36 as a new interaction partner of membrane NEU1: potential implication in the pro-atherogenic effects of the elastin receptor complex
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
113
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Elastin is heterogeneously cross-linked
Research output: Contribution to journal › Journal article › Research › peer-review
Published