Pharmaceuticals, Processes and Products
Our interdisciplinary and international team combines advanced experimental and computational methods to obtain fundamental understanding of physical, chemical and pharmaceutical engineering principles. We use this knowledge to leverage the design and production of “personalised medicines” inter alia through advanced enabling dosage form design, particle and solid-state form engineering, and continuous processing.
Our research centres on the development of novel design, formulation, and manufacturing processes for both small-molecule and biologic drugs.
Key areas of focus include:
- Fundamental Principles: Investigating the physical and chemical principles of solid-state materials that are underlying pharmaceutical engineering to enhance the design, formulation, and manufacturing of medicinal products.
- Particle and solid-state form Engineering: Enhancing the bioavailability and stability of active pharmaceutical ingredients through innovative particle and solid-state form design.
- Personalised Dosage Forms: Utilising advanced manufacturing technologies and design options to create customised dosage forms tailored to individual patient needs.
- Computational Modelling and Data Science: Leveraging computer simulations, data science, and machine learning to understand and predict system behaviour.
The 3P group is focusing on investigating fundamental principles of solid-state pharmaceutical products to leverage particle engineering and innovative solid dosage forms.
Key areas of our research include:
- Amorphous, co-amorphous and polyamorphous pharmaceuticals: Our research has unveiled the physicochemical basis of co-amorphous systems and the phenomenon of polyamorphism and its interconversions in pharmaceutical compounds. We investigate the complex nature of co-amorphous forms and polyamorphic systems and their implications for the stability and efficacy of pharmaceutical products.
- Personalised Medicine through Modular Design: We have explored the potential of tailor-made doses of pharmaceuticals using tunable modular design. This approach allows for the precise adjustment of medication dosages, thereby enhancing patient-specific treatment regimens.
- Freeze-Drying Excipients: Our investigation into the chemical space for freeze-drying excipients has provided valuable insights into the selection and optimisation of excipients for freeze-dried pharmaceutical formulations. This research contributes to the development of more stable and effective freeze-dried products.
- Particle engineering: We investigate the physical and chemical principles that govern the formation of particles via the spray drying or eletrohydrodynamic process and evaluate the impact of the obtained particles on the bio-environment or subsequent processing. This approach allows for improving drug delivery efficiency and rational design of medicinal products.
- Crystallography: We use X-ray and electron diffraction techniques to reveal structures of pharmaceutically relevant crystalline systems, in order gain a deeper understanding of stabilities and phase transitions. We leverage artificial intelligence and atomistic simulations to enhance the accuracy and efficiency of crystallographic analysis, providing new insights into crystal structures.
See an overview of all the group's publications
Associate Professor Natalja Genina
Focuses on the development, physico-chemical characterisation and non-destructive quality control of personalised dosage forms and their integration into digital health.
Associate Professor Mingshi Yang
Expert in particle engineering, pulmonary drug delivery, and regenerative medicines, with a commitment to research excellence in pharmaceutical technology.
Associate Professor Lene Jørgensen
Researches the structure and stability of biomacromolecules in pharmaceutical processes, with a focus on protein formulation and regulatory aspects.
Professor Thomas Rades
Known for his work on the design and physical characterization of drug solid dosage forms and enabling formulations.
Associate Professor Holger Grohganz
Investigates the influence of formulation and process parameters on the performance of solid-state pharmaceuticals, with a special interest in amorphous systems.
Associate Professor Inês Catarina Batista Martins
Specialises in solid-state pharmaceutics, focusing on the engineering and characterisation of complex crystalline and amorphous pharmaceutical systems.
Data Scientist Anders Støttrup Larsen
Utilises advanced atomistic simulations and machine learning to study crystalline and amorphous systems.
Associate Professor Anders Østergaard Madsen
Specialises in crystallography, scientific computing, and machine learning to understand crystal properties and improve pharmaceutical formulations.
Group members
| Name | Title | Phone | |
|---|---|---|---|
| Search in Name | Search in Title | Search in Phone | |
| Adam Svane Frahm | Laboratory Technician | +4535329409 | |
| Aleksander Scharff | Laboratory Technician | +4535331940 | |
| Aliz Kispal | Guest Researcher | ||
| Anders Støttrup Larsen | Postdoc | +4535332928 | |
| Anders Østergaard Madsen | Associate Professor | ||
| Andreas Michael Maltschik | PhD Fellow | +4535330355 | |
| Ane Begona Sancho Escribano | External | ||
| Anis Arnous | Guest Researcher | ||
| Arife Önder | Guest Researcher | +4535336518 | |
| Barbora Hrebikova | External | ||
| Diana Merkureva | Master Thesis Student | ||
| Dorthe Ørbæk | Laboratory Technician | +4535336179 | |
| Holger Grohganz | Associate Professor | +4535336473 | |
| Inês Catarina Batista Martins | Associate Professor | ||
| Izaro Oiarbide Beain | Guest Researcher | ||
| JIRASIT INTHORN | Guest Researcher | ||
| Jing Zhang | PhD Student | ||
| Jonathan Grønlund | Master Thesis Student | ||
| Jumana Mustafa Merchant | Guest Researcher | ||
| Jørn Sonnergaard | Associate Professor Emeritus | ||
| Korbinian Löbmann | External | +4535320541 | |
| Lasse Fabian Rademacker Jensen | Guest Researcher | ||
| Lene Jørgensen | Associate Professor | +4535336369 | |
| Marianna Boraschi | PhD Student | ||
| Masoud Pazhman | Master Student | ||
| Mingshi Yang | Associate Professor - Promotion Programme | +4535336141 | |
| Natalja Genina | Associate Professor | +4535337923 | |
| Neha Aftab | Master Thesis Student | ||
| Nuzhat Shaheen | Laboratory Technician | +4535336571 | |
| Paola Ferrarazzo | External | ||
| Philipp Hans | Postdoc | +4535334376 | |
| Rong Di | Guest Researcher | +4591999558 | |
| Sudeshna Roy | Visiting PhD Student | ||
| Thomas Rades | Professor | +4535336032 | |
| Uxue Martinez de Zuazo San Pedro | Guest Researcher | ||
| Viktor Kristian Winsløv Jeppesen | Master Thesis Student | ||
| Wuzhong He | PhD Student | ||
| Xiaoxiao Liang | Visiting PhD Student |
Research group leader
Anders Østergaard Madsen
Associate Professor
Phone +45 35 32 02 83
a.madsen@sund.ku.dk