Dried blood spots on carboxymethyl cellulose sheets: Rapid sample preparation based on dissolution and precipitation

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Dried blood spots on carboxymethyl cellulose sheets: Rapid sample preparation based on dissolution and precipitation. / Skoglund Ask, Kristine; Pedersen-Bjergaard, Stig; Gjelstad, Astrid.

In: Chromatographia, Vol. 79, No. 7, 2016, p. 509-514.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Skoglund Ask, K, Pedersen-Bjergaard, S & Gjelstad, A 2016, 'Dried blood spots on carboxymethyl cellulose sheets: Rapid sample preparation based on dissolution and precipitation', Chromatographia, vol. 79, no. 7, pp. 509-514. https://doi.org/10.1007/s10337-016-3039-7

APA

Skoglund Ask, K., Pedersen-Bjergaard, S., & Gjelstad, A. (2016). Dried blood spots on carboxymethyl cellulose sheets: Rapid sample preparation based on dissolution and precipitation. Chromatographia, 79(7), 509-514. https://doi.org/10.1007/s10337-016-3039-7

Vancouver

Skoglund Ask K, Pedersen-Bjergaard S, Gjelstad A. Dried blood spots on carboxymethyl cellulose sheets: Rapid sample preparation based on dissolution and precipitation. Chromatographia. 2016;79(7):509-514. https://doi.org/10.1007/s10337-016-3039-7

Author

Skoglund Ask, Kristine ; Pedersen-Bjergaard, Stig ; Gjelstad, Astrid. / Dried blood spots on carboxymethyl cellulose sheets: Rapid sample preparation based on dissolution and precipitation. In: Chromatographia. 2016 ; Vol. 79, No. 7. pp. 509-514.

Bibtex

@article{9ded59ce86fb49e5a4c702f41ecee8aa,
title = "Dried blood spots on carboxymethyl cellulose sheets: Rapid sample preparation based on dissolution and precipitation",
abstract = "This short communication describes the use of carboxymethyl cellulose sheets as sampling material for dried blood spots. Whole blood, spiked with quetiapine, a hydrophobic and basic small molecule drug substance, was spotted on the sheet and subsequently dried. The dried spot was then almost completely dissolved in acidified aqueous solution. It was shown that the dissolved polymer, together with major blood components can easily be precipitated and removed with acetonitrile. The presented sampling on a water-soluble biopolymer derivative followed by precipitation resulted in a simple protocol and around 100 % recovery of the analyte prior to liquid chromatography—tandem mass spectrometry.",
author = "{Skoglund Ask}, Kristine and Stig Pedersen-Bjergaard and Astrid Gjelstad",
year = "2016",
doi = "10.1007/s10337-016-3039-7",
language = "English",
volume = "79",
pages = "509--514",
journal = "Chromatographia",
issn = "0009-5893",
publisher = "Springer",
number = "7",

}

RIS

TY - JOUR

T1 - Dried blood spots on carboxymethyl cellulose sheets: Rapid sample preparation based on dissolution and precipitation

AU - Skoglund Ask, Kristine

AU - Pedersen-Bjergaard, Stig

AU - Gjelstad, Astrid

PY - 2016

Y1 - 2016

N2 - This short communication describes the use of carboxymethyl cellulose sheets as sampling material for dried blood spots. Whole blood, spiked with quetiapine, a hydrophobic and basic small molecule drug substance, was spotted on the sheet and subsequently dried. The dried spot was then almost completely dissolved in acidified aqueous solution. It was shown that the dissolved polymer, together with major blood components can easily be precipitated and removed with acetonitrile. The presented sampling on a water-soluble biopolymer derivative followed by precipitation resulted in a simple protocol and around 100 % recovery of the analyte prior to liquid chromatography—tandem mass spectrometry.

AB - This short communication describes the use of carboxymethyl cellulose sheets as sampling material for dried blood spots. Whole blood, spiked with quetiapine, a hydrophobic and basic small molecule drug substance, was spotted on the sheet and subsequently dried. The dried spot was then almost completely dissolved in acidified aqueous solution. It was shown that the dissolved polymer, together with major blood components can easily be precipitated and removed with acetonitrile. The presented sampling on a water-soluble biopolymer derivative followed by precipitation resulted in a simple protocol and around 100 % recovery of the analyte prior to liquid chromatography—tandem mass spectrometry.

U2 - 10.1007/s10337-016-3039-7

DO - 10.1007/s10337-016-3039-7

M3 - Journal article

VL - 79

SP - 509

EP - 514

JO - Chromatographia

JF - Chromatographia

SN - 0009-5893

IS - 7

ER -

ID: 160124219