Pharmaceutical Analytical Chemistry

Our research group provides analytical chemical tools for tackling many challenges in pharmaceutical and medical research, especially in situations where sample amount is scarce, where the molecules of interest are only present in small concentrations, or where a large number of samples needs to be processed in a short time frame. To enable this cutting-edge analysis, we develop and apply technologies such as micro-nano engineering, microfluidics, and polymer science for next generation high-throughput workflows, e.g., in bioanalysis, biophysical characterization of peptides, proteins and new drug modalities, drug transport studies, and drug delivery.

We have a stronghold in qualitative and (validated) quantitative analytical chemistry. We are developing new ways to perform chemical analysis and physical chemical profiling of drug substances, while pushing traditional approaches to their limits.

Main focal areas of the group are modern separation techniques (e.g. LC, CE, TDA/FIDA) coupled to mass spectrometry, advanced sample preparation methods (e.g., µSPE, µEME), and a range of microfluidics-driven techniques (e.g., droplets, micro-nano particle fabrication, microphysiological in vitro models). We develop and apply CE and TDA-based approaches for physical chemical profiling and biophysical characterization of biologics as well as nanoparticles; furthermore, we develop concepts for in vitro release testing with an outset in chromatography and separation sciences.

Research in the Pharmaceutical Analytical Chemistry group is highly multidisciplinary and builds heavily on strong collaborative efforts. Our research group is dedicated to creating a supportive atmosphere for students and emerging researchers, fostering their development into highly desirable professionals in the community.