Drug Delivery and Biophysics of Biopharmaceuticals

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  1. 2016
  2. Published

    Nano-self-assemblies based on synthetic analogues of mycobacterial monomycoloyl glycerol and DDA: Supramolecular structure and adjuvant efficacy

    Martin-Bertelsen, Birte, Korsholm, K. S., Christensen, D., Franzyk, Henrik, Yaghmur, Anan & Foged, Camilla, 2016, In: Molecular Pharmaceutics. 13, 8, p. 2771-2781 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    On the purported "backbone fluorescence" in protein three-dimensional fluorescence spectra

    Bortolotti, A., Wong, Y. H., Korsholm, S. S., Bahring, N. H. B., Bobone, S., Tayyab, S., van de Weert, Marco & Stella, L., 2016, In: RSC Advances. 6, 114, p. 112870-112876 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Rhamnogalacturonan-I based microcapsules for targeted drug release

    Svagan, A. J., Kusic, A., De Gobba, Cristian, Larsen, F. H., Sassene, P., Zhou, Q., van de Weert, Marco, Mullertz, Anette , Jørgensen, Bodil & Ulvskov, Peter, 2016, In: P L o S One. 11, 12, 13 p., e0168050.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Soft hydrogels interpenetrating silicone – a polymer network for drug releasing medical devices

    Steffensen, S. L., Merete H., V., Møller, E. H., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2016, In: Journal of Biomedical Materials Research. Part B: Applied Biomaterials. 104, 2, p. 402-410 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. 2015
  7. Published

    Co-encapsulation of lyoprotectants improves the stability of protein-loaded PLGA nanoparticles upon lyophilization

    Fonte, P., Araújo, F., Seabra, V., Reis, S., van de Weert, Marco & Sarmento, B., 30 Dec 2015, In: International Journal of Pharmaceutics. 496, 2, p. 850-62 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Antimicrobial activity of GN peptides and their mode of action

    Godballe, T., Mojsoska, B., Nielsen, Hanne Mørck & Jenssen, H., 13 Dec 2015, In: Biopolymers. 106, 2, p. 172–183 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Bioactive protein-based nanofibers interact with intestinal biological components resulting in transepithelial permeation of a therapeutic protein

    Stephansen, K., García-Díaz, M., Jessen, F., Chronakis, I. S. & Nielsen, Hanne Mørck, 10 Nov 2015, In: International Journal of Pharmaceutics. 495, 1, p. 58-66 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Thioflavin T templates amyloid β(1-40) conformation and aggregation pathway

    Di Carlo, M. G., Minicozzi, V., Foderà, Vito, Militello, V., Vetri, V., Morante, S. & Leone, M., Nov 2015, In: Biophysical Chemistry. 206, p. 1-11 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    The route to protein aggregate superstructures: Particulates and amyloid-like spherulites

    Vetri, V. & Foderà, Vito, 14 Sep 2015, In: FEBS Letters. 589, 19 Pt A, p. 2448-63 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Steric and interactive barrier properties of intestinal mucus elucidated by particle diffusion and peptide permeation

    Bøgh, M., García-Díaz, M., Mullertz, Anette & Nielsen, Hanne Mørck, Sep 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 94, Part A, p. 136–143 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Intracellular siRNA delivery dynamics of integrin-targeted, PEGylated chitosan-poly(ethylene imine) hybrid nanoparticles: A mechanistic insight

    Ragelle, H., Colombo, S., Pourcelle, V., Vanvarenberg, K., Vandermeulen, G., Bouzin, C., Marchand-Brynaert, J., Feron, O., Foged, Camilla & Préat, V., 10 Aug 2015, In: Journal of Controlled Release. 211, p. 1-9 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Nanotechnology for photodynamic therapy: a perspective from the Laboratory of Dr. Michael R. Hamblin in the Wellman Center for Photomedicine at Massachusetts General Hospital and Harvard Medical School

    Hamblin, M. R., Chiang, L. Y., Lakshmanan, S., Huang, Y., Garcia-Diaz, M., Karimi, M., de Souza Rastelli, A. N. & Chandran, R., Aug 2015, In: Nanotechnology Reviews. 4, 4, p. 359-372 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Mechanistic profiling of the siRNA delivery dynamics of lipid-polymer hybrid nanoparticles

    Colombo, S., Cun, D., Remaut, K., Bunker, M., Zhang, J., Martin-Bertelsen, Birte, Yaghmur, Anan, Braeckmans, K., Nielsen, Hanne Mørck & Foged, Camilla, 10 Mar 2015, In: Journal of Controlled Release. 201, p. 22-31 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Mucus as a Barrier to Drug Delivery: Understanding and Mimicking the Barrier Properties

    Bøgh, M. & Nielsen, Hanne Mørck, Mar 2015, In: Basic & Clinical Pharmacology & Toxicology. 116, 3, p. 179-186 8 p.

    Research output: Contribution to journal › Review › Research › peer-review

  17. Published

    Three-Dimensional Printing of Drug-Eluting Implants: Preparation of an Antimicrobial Polylactide Feedstock Material

    Water, J. J., Bohr, A., Bøtker, Johan Peter, Aho, J., Sandler, N., Nielsen, Hanne Mørck & Rantanen, Jukka, 15 Jan 2015, In: Journal of Pharmaceutical Sciences. p. 1099–1107 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Carrier peptide-mediated transepithelial permeation of biopharmaceuticals: Effect of co-administration versus direct conjugation

    Kristensen, Mie & Nielsen, Hanne Mørck, 2015.

    Research output: Contribution to conference › Poster › Research › peer-review

  19. Published

    Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections

    Bahnsen, J. S., Franzyk, Henrik, Sayers, E. J., Jones, A. T. & Nielsen, Hanne Mørck, 2015, In: Pharmaceutical Research. 32, 5, p. 1546-56 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Cell-penetrating peptides as carriers for transepithelial drug delivery in vitro

    Rønholt, Stine, Kristensen, Mie & Nielsen, Hanne Mørck, 2015, Cell-penetrating peptides : Methods and Protocols. Langel, Ü. (ed.). Vol. 1324. p. 261-277 17 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  21. Published

    Cell-penetrating peptides as carriers for transepithelial drug delivery in vitro

    Rønholt, Stine, Kristensen, Mie & Nielsen, Hanne Mørck, 2015, In: Methods in Molecular Biology. 1324, p. 261-277 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Cell-penetrating peptides as carriers for transepithelial permeation of therapeutic peptides and proteins

    Kristensen, Mie, 2015

    Research output: Book/Report › Ph.D. thesis › Research

  23. Published

    Classification of vaccines

    Kallerup, R. S. & Foged, Camilla, 2015, Subunit vaccine delivery. Foged, C., Rades, T., Perrie, Y. & Hooks, S. (eds.). Springer, p. 15-29 15 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  24. Published

    Engineering of a novel adjuvant based on lipid-polymer hybrid nanoparticles: A quality-by-design approach

    Rose, F., Wern, J. E., Ingvarsson, P. T., van de Weert, Marco, Andersen, P., Follmann, F. & Foged, Camilla, 2015, In: Journal of controlled release : official journal of the Controlled Release Society. 210, p. 48-57 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Erratum: Kapp SJ, Larsson I, Van De Weert M, Ćardenas M, Jorgensen L. 2015. Competitive Adsorption of Monoclonal Antibodies and Nonionic Surfactants at Solid Hydrophobic Surfaces. 2015. J Pharm Sci 104:593-601

    Kapp, S. J., Larsson, I., van de Weert, Marco, Ćardenas, M. & Jørgensen, Lene, 2015, In: Journal of Pharmaceutical Sciences. 104, 10, p. 3587 1 p.

    Research output: Contribution to journal › Comment/debate › Research

  26. Published

    Formulation Strategies and Particle Engineering Technologies for Pulmonary Delivery of Biopharmaceuticals

    Cun, D., Wan, F. & Yang, Mingshi, 2015, In: Current Pharmaceutical Design. 21, 19, p. 2599-2610 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Improved insulin loading in poly (lactic-co-glycolic) acid (PLGA) nanoparticles upon self-assembly with lipids

    Garcia Diaz, M., Foged, Camilla & Nielsen, Hanne Mørck, 2015, In: International Journal of Pharmaceutics. 482, p. 84-91 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Influence of Tableting on the Conformation and Thermal Stability of Trypsin as a Model Protein

    Klukkert, M., van de Weert, Marco, Fanø, M., Rades, Thomas & Leopold, C. S., 2015, In: Journal of Pharmaceutical Sciences. 104, 12, p. 4314–4321 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Penetratin-mediated transepithelial insulin pemeation: Importance of complexation?

    Kristensen, Mie, Foderà, Vito & Nielsen, Hanne Mørck, 2015.

    Research output: Contribution to conference › Poster › Research › peer-review

  30. Published

    Preferential interactions and the effect of protein PEGylation

    Holm, L. S., Thulstrup, Peter Waaben, Kasimova, M. R. & van de Weert, Marco, 2015, In: PLOS ONE. 10, 7, 18 p., e0133584.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Reversible tight junction modulation using an enterotoxin-derived peptide as enhancer for delivery of biopharmaceuticals across biobarriers

    Kristensen, Mie & Nielsen, Hanne Mørck, 2015.

    Research output: Contribution to conference › Poster › Research › peer-review

  32. Published

    Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: Enhanced gene silencing and reduced adversed effects in vitro

    Zeng, X., de Groot, A. M., Sijts, A., Blenke, E. O., Colombo, S., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck & Foged, Camilla, 2015, In: Nanoscale. 7, 46, p. 19687-19698 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. 2014
  34. Published

    Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading

    Li, P., Tan, A., Prestidge, C. A., Nielsen, Hanne Mørck & Mullertz, Anette , 30 Dec 2014, In: International Journal of Pharmaceutics. 477, 1-2, p. 390-8 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Epithelial permeation and absorption mechanisms of biopharmaceuticals

    Nielsen, Hanne Mørck, 1 Oct 2014, Mucosal Delivery of Biopharmaceuticals: Biology, Challenges and Strategies. Springer US, Vol. 9781461495246. p. 99-122 24 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  36. Published

    Observation of the Early Structural Changes Leading to the Formation of Protein Superstructures

    Foderà, Vito, Vetri, V., Wind, T. S., Noppe, W., Cornett, Claus, Donald, A. M., Morozova-Roche, L. A. & Vestergaard, Bente, 18 Sep 2014, In: Journal of Physical Chemistry Letters. 5, 18, p. 3254-3258 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    The Effect of Protein PEGylation on Physical Stability in Liquid Formulation

    Holm, L. S., Mcumber, A., Rasmussen, J. E., Obiols-Rabasa, M., Thulstrup, Peter Waaben, Kasimova, M. R., Randolph, T. W. & van de Weert, Marco, 21 Aug 2014, In: Journal of Pharmaceutical Sciences. 103, 10, p. 3043-3054 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    The surface charge of liposomal adjuvants is decisive for their interactions with the Calu-3 and A549 airway epithelial cell culture models

    Ingvarsson, P. T., Rasmussen, I. S., Viaene, M., Irlik, P. J., Nielsen, Hanne Mørck & Foged, Camilla, Aug 2014, In: European Journal of Pharmaceutics and Biopharmaceutics. 87, 3, p. 480-8 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Tailoring Cytotoxicity of Antimicrobial Peptidomimetics with High Activity against Multidrug-Resistant Escherichia coli

    Jahnsen, R. D., Sandberg-Schaal, A., Vissing, K. J., Nielsen, Hanne Mørck, Frimodt-Møller, N. & Franzyk, Henrik, 20 Mar 2014, In: Journal of Medicinal Chemistry. 57, 7, p. 2864-2873

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    One-Step Production of Protein-Loaded PLGA Microparticles via Spray Drying Using 3-Fluid Nozzle

    Wan, F., Maltesen, M. J., Andersen, S. K., Bjerregaard, S., Foged, Camilla, Rantanen, Jukka & Yang, Mingshi, 19 Feb 2014, In: Pharmaceutical Research. 31, 8, p. 1969-1977 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Property profiling of biosimilar mucus in a novel mucus-containing in vitro model for assessment of intestinal drug absorption

    Bøgh, M., Baldursdóttir, S. G., Mullertz, Anette & Nielsen, Hanne Mørck, 8 Jan 2014, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 87, p. 227-235 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Stability of monoclonal antibodies at high-concentration: head-to-head comparison of the IgG1 and IgG4 subclass

    Neergaard, M. S., Nielsen, A. D., Parshad, H. & van de Weert, Marco, Jan 2014, In: Journal of Pharmaceutical Sciences. 103, 1, p. 115-27 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Characterization of PTH-CPP fusion peptides for oral delivery

    Kristensen, Mie, Berthelsen, J. & Nielsen, Hanne Mørck, 2014.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  44. Published

    Parathyroid hormone coupled to cell-penetrating peptides for oral delivery

    Kristensen, Mie & Nielsen, Hanne Mørck, 2014.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  45. 2013
  46. Published

    Models to predict intestinal absorption of therapeutic peptides and proteins

    Antunes, F., Andrade, F., Ferreira, D., Nielsen, Hanne Mørck & Sarmento, B., Jan 2013, In: Current Drug Metabolism. 14, 1, p. 4-20 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. 2011
  48. Published

    Erratum: Fluorescence quenching to study protein-ligand binding: Common errors (Journal of Fluorescence (2010) 20 (625-629)DOI 10.1007/s10895-009-0572- x)

    van de Weert, Marco, 29 Aug 2011, In: Journal of Fluorescence. 21, 6, 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  49. Published

    Development of biodegradable nanocomposite scaffolds for autologous cell therapy

    Wen, Y., Gallego, M. R., Nielsen, L. F., Jørgensen, Lene, Everland, H., Møller, E. H. & Nielsen, Hanne Mørck, 1 Jan 2011, In: European Cells and Materials. 21, SUPPL.1, 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. 2010
  51. Published

    Antimicrobial, hemolytic, and cytotoxic activities of β-peptoid- peptide hybrid oligomers: Improved properties compared to natural AMPs (ChemBioChem (2010) 11, (152-160))

    Olsen, Christian Adam, Ziegler, H. L., Nielsen, Hanne Mørck, Frimodt-Møller, N., Jaroszewski, J. W. & Franzyk, Henrik, 16 Aug 2010, In: ChemBioChem. 11, 12, 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  52. Published

    Issues in Development of Biodrug Delivery Systems

    Jørgensen, Lene, Frøkjær, Sven & Nielsen, Hanne Mørck, 2010, Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development. Morishita, M. & Park, K. (eds.). 1 ed. Informa Healthcare, p. 13-25

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  53. 2009
  54. Published

    Challenges in Delivery of Biopharmaceuticals; the Need for Advanced Delivery Systems

    Nielsen, Hanne Mørck & Jørgensen, Lene, 11 Dec 2009, Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines. John Wiley & Sons, Ltd, p. 1-8 8 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  55. 2007
  56. Published

    Bioinformatic and experimental analysis of the secondary structure of amelogenin

    Vilhjalmsson, B., Rasmussen, Anne, Fabi, B., van de Weert, Marco, Hamelryck, Thomas Wim & Lemoult, S., 1 Nov 2007, In: European Cells and Materials. 14, SUPPL.2, 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Published

    Liposomes for phospholipase A2 triggered siRNA release: preparation and in vitro test

    Foged, Camilla, Nielsen, Hanne Mørck & Frøkjær, Sven, 2007, In: Internation Journal of Pharmaceutics. 331, 2, p. 160-166

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. 2000
  59. Published

    Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques

    van de Weert, Marco, Van 'T Hof, R., Van Der Weerd, J., Heeren, R. M. A., Posthuma, G., Hennink, W. E. & Crommelin, D. J. A., 31 Jul 2000, In: Journal of Controlled Release. 68, 1, p. 31-40 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. 1996
  61. Published

    Drug delivery studies in Caco-2 monolayers V. Ethyl glucoside esters as a novel type of absorption enhancers

    Nielsen, Hanne Mørck, Brøndsted, H., Frøkjær, Sven & Hovgaard, L., 1 Mar 1996, In: S.T.P. Pharma Sciences. 6, 2, p. 157-161 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  62. 1995
  63. Published

    Drug delivery studies in Caco-2 monolayers. II. Absorption enhancer effects of lysophosphatidylcholines

    Hovgaard, L., Brøndsted, H. & Nielsen, Hanne Mørck, 14 Feb 1995, In: International Journal of Pharmaceutics. 114, 2, p. 141-149 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    Drug delivery studies in Caco-2 monolayers. III. Intestinal transport of various vasopressin analogues in the presence of lysophosphatidylcholine

    Brøndsted, H., Nielsen, Hanne Mørck & Hovgaard, L., 14 Feb 1995, In: International Journal of Pharmaceutics. 114, 2, p. 151-157 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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