Drug Delivery and Biophysics of Biopharmaceuticals

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  1. 2022
  2. Published

    Investigating the effect of graphene oxide in chitosan/alginate-based foams on the release and antifungal activity of clotrimazole in vitro

    Huang, Jianfei, Jacobsen, Jette, Genina, Natalja, Larsen, Susan Weng, Nielsen, Hanne Mørck, Mullertz, Anette & Mu, Huiling, 2022, In: European Journal of Pharmaceutical Sciences. 174, 9 p., 106204.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Ion-Mediated Morphological Diversity in Protein Amyloid Systems

    Chaaban, Hussein Forsberg, Vallooran, J. J., van de Weert, Marco & Foderà, Vito, 2022, In: Journal of Physical Chemistry Letters. 13, 16, p. 3586-3593

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Morphological integrity of insulin amyloid-like aggregates depends on preparation methods and post-production treatments

    Thorlaksen, C., Stanciu, A., Neergaard, M. B., Hatzakis, Nikos, Foderà, Vito & Groenning, M., 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 179, p. 147-155 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin

    Stie, Mai Bay, Gätke, J. R., Chronakis, I. S., Jacobsen, Jette & Nielsen, Hanne Mørck, 2022, In: International Journal of Molecular Sciences. 23, 3, 9 p., 1458.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Physical and barrier changes in gastrointestinal mucus induced by the permeation enhancer sodium 8-[(2-hydroxybenzoyl)amino]octanoate (SNAC)

    Mortensen, Janni Støvring, Bohr, S. S. R., Rønholt, Stine, Hatzakis, Nikos, Saaby, Lasse & Nielsen, Hanne Mørck, 2022, In: Journal of Controlled Release. 352, p. 163-178 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Polysorbate 80 controls Morphology, structure and stability of human insulin Amyloid-Like spherulites

    Zhou, X., Fennema Galparsoro, D., Madsen, Anders Østergaard, Vetri, V., van de Weert, Marco, Nielsen, Hanne Mørck & Foderà, Vito, 2022, In: Journal of Colloid and Interface Science. 606, Pt 2, p. 1928-1939

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Preanalytical Stability of Flucloxacillin, Piperacillin, Tazobactam, Meropenem, Cefalexin, Cefazolin, and Ceftazidime in Therapeutic Drug Monitoring: A Structured Review

    Mortensen, Janni Støvring, Jensen, B. P. & Doogue, M., 2022, In: Therapeutic Drug Monitoring. 44, 6, p. 709-719

    Research output: Contribution to journal › Review › Research › peer-review

  9. Published

    Prevalence of antibiotic resistance genes in Pangasianodon hypophthalmus and Oreochromis niloticus aquaculture production systems in Bangladesh

    Lassen, Simon Bo, Ahsan, M. E., Islam, S. R., Zhou, X. Y., Razzak, M. A., Su, J. Q. & Brandt, Kristian Koefoed, 2022, In: Science of the Total Environment. 813, 151915.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Protein materials as sustainable non- and minimally invasive strategies for biomedical applications

    Stie, Mai Bay, Kalouta, Kleopatra, Vetri, V. & Foderà, Vito, 2022, In: Journal of Controlled Release. 344, p. 12-25

    Research output: Contribution to journal › Review › Research › peer-review

  11. Published

    Radiolabeling of a polypeptide polymer for intratumoral delivery of alpha-particle emitter, 225Ac, and beta-particle emitter, 177Lu

    Shalgunov, Vladimir, Engudar, G., Bohrmann, L., Wharton, L., Maskell, K., Johann, K., Barz, M., Schaffer, P., Herth, Matthias Manfred & Radchenko, V., 2022, In: Nuclear Medicine and Biology. 104-105, p. 11-21

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Recommendations for addressing the translational gap between experimental and clinical research on amyloid diseases

    Solomon, M., Foderà, Vito, Langkilde, Annette Eva, Elliott, P., Tagliavini, F., Forsyth, V. T., Klementieva, O. & Bellotti, V., 2022, In: Journal of Translational Medicine. 20, 1, 7 p., 213.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin

    Kabedev, A., Zhuo, Xuezhi, Leng, D., Foderà, Vito, Zhao, M., Larsson, P., Bergström, C. A. S. & Löbmann, Korbinian, 2022, In: Molecular Pharmaceutics. 19, 11, p. 3922–3933

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Subtle pH variation around pH 4.0 affects aggregation kinetics and aggregate characteristics of recombinant human insulin

    Thorlaksen, C., Stanciu, A., Neergaard, M. B., Jiskoot, W., Groenning, M. & Foderà, Vito, 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 179, p. 166-172

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Sustainable strategies for waterborne electrospinning of biocompatible nanofibers based on soy protein isolate

    Stie, Mai Bay, Kalouta, Kleopatra, Cunha, Cristiana, Feroze, H. M., Vetri, V. & Foderà, Vito, 2022, In: Sustainable Materials and Technologies. 34, 11 p., e00519.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Topical niclosamide (ATx201) reduces Staphylococcus aureus colonization and increases Shannon diversity of the skin microbiome in atopic dermatitis patients in a randomized, double-blind, placebo-controlled Phase 2 trial

    Weiss, A., Delavenne, E., Matias, C., Lagler, H., Simon, D., Li, P., Hansen, J. U., Dos Santos, T. P., Jana, B., Priemel, P., Bangert, C., Bauer, M., Eberl, S., Nussbaumer-Pröll, A., Anne Österreicher, Z., Matzneller, P., Quint, T., Weber, M., Nielsen, H. M., Rades, T. & 17 others, Johansen, Helle Krogh, Westh, Henrik T., Kim, W., Mylonakis, E., Friis, C., Guardabassi, Luca, Pace, J., Lundberg, C. V., M'Zali, F., Butty, P., Sørensen, N., Nielsen, H. B., Toft-Kehler, R., Guttman-Yassky, E., Stingl, G., Zeitlinger, M. & Sommer, M., 2022, In: Clinical and Translational Medicine. 12, 5, e790.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    α-casein micelles-membranes interaction: Flower-like lipid protein coaggregates formation

    Anselmo, S., Sancataldo, G., Foderà, Vito & Vetri, V., 2022, In: Biochimica et Biophysica Acta - General Subjects. 1866, 10, 11 p., 130196.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. 2023
  19. Published

    Application of Low-Frequency Raman Spectroscopy to Probe Dynamics of Lipid Mesophase Transformations upon Hydration

    Krog, Lasse Skjoldborg, Kirkensgaard, Jacob Judas Kain, Foderà, Vito, Boyd, Ben & Bērziņš, Kārlis, 2023, In: Journal of Physical Chemistry B. 127, 14, p. 3223-3230

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Ca2+-Responsive Glyco-insulin

    Wu, S., Østergaard, M., Fredholt, Freja, Christensen, Niels Johan, Sørensen, K. K., Mishra, N. K., Nielsen, Hanne Mørck & Jensen, Knud Jørgen, 2023, In: Bioconjugate Chemistry. 34, 3, p. 518–528

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Carrier peptide interactions with liposome membranes induce reversible clustering by surface adsorption and shape deformation

    Diedrichsen, Ragna Guldsmed, Vetri, V., Prévost, S., Foderà, Vito & Nielsen, Hanne Mørck, 2023, In: Journal of Colloid and Interface Science. 650, Part B, p. 1821-1832

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Cell-Penetrating Peptides as Tools to Facilitate Oral Delivery of Biopharmaceuticals

    Asgreen, Camilla Jantzen, Fredholt, Freja, Nielsen, Hanne Mørck & Kristensen, Mie, 2023, Cell-Penetrating Peptides: Design, Development and Applications. Oba, M. & Demizu, Y. (eds.). Wiley-VCH, p. 331-354

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  23. Published

    Corrigendum to "Polysorbate 80 controls Morphology, structure and stability of human insulin Amyloid-Like spherulites" [J. Colloid Interface Sci. 606(Part 2) (2022) 1928-1939]

    Zhou, X., Galparsoro, D. F., Madsen, Anders Østergaard, Vetri, V., van de Weert, Marco, Nielsen, Hanne Mørck & Foderà, Vito, 2023, In: Journal of Colloid and Interface Science. 640, p. 917

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Editorial: Microbe-nanoparticle interactions: a mechanistic approach

    Kumari, M., Klodzinska, S. N. & Chifiriuc, M. C., 2023, In: Frontiers in Microbiology. 14, 2 p., 1273364.

    Research output: Contribution to journal › Editorial › Research › peer-review

  25. Published

    Effects of prophylactic antibiotics administration on barrier properties of intestinal mucosa and mucus from preterm born piglets

    Mortensen, Janni Støvring, Nguyen, Duc Ninh, Nielsen, Hanne Mørck & Rønholt, Stine, 2023, In: Drug Delivery and Translational Research. 13, p. 1456–1469

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Encapsulation in oleyl-modified hyaluronic acid nanogels substantially improves the clinical potential of the antimicrobial peptides SAAP-148 and Ab-Cath

    van Gent, M. E., Klodzinska, S. N., Drijfhout, J. W., Nielsen, Hanne Mørck & Nibbering, P. H., 2023, In: European Journal of Pharmaceutics and Biopharmaceutics. 193, p. 254-261

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Encapsulation into hyaluronic acid-based nanogels improves the selectivity index of the snake cathelicidin Ab-Cath

    van Gent, M. E., Kłodzińska, S. N., Severin, M., Ali, M., van Doodewaerd, B. R., Bos, E., Koning, R. I., Drijfhout, J. W., Nielsen, Hanne Mørck & Nibbering, P. H., 2023, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 52, 11 p., 102694.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Encapsulation of SAAP-148 in Octenyl Succinic Anhydride-Modified Hyaluronic Acid Nanogels for Treatment of Skin Wound Infections

    van Gent, M. E., van Baaren, T., Kłodzińska, S. N., Ali, M., Dolezal, N., van Doodewaerd, B. R., Bos, E., de Waal, A. M., Koning, R. I., Drijfhout, J. W., Nielsen, Hanne Mørck & Nibbering, P. H., 2023, In: Pharmaceutics. 15, 2, 20 p., 429.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Epithelium dynamics differ in time and space when exposed to the permeation enhancers penetramax and EGTA. A head-to-head mechanistic comparison

    Panou, D. A., Pedersen, Stine Helene Falsig, Kristensen, Mie & Nielsen, Hanne Mørck, 2023, In: Frontiers in Drug Delivery. 3, 16 p., 1221628.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    From dilute to concentrated solutions of intrinsically disordered proteins: Interpretation and analysis of collected data

    Lenton, Samuel John, Fagerberg, E., Tully, M. & Skepö, M., 2023, In: Methods in Enzymology. 678, p. 299-330

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Heterogeneous and Surface-Catalyzed Amyloid Aggregation Monitored by Spatially Resolved Fluorescence and Single Molecule Microscopy

    Zhou, X., Sinkjær, Anders Wilgaard, Zhang, Min, Pinholt, H. D., Nielsen, Hanne Mørck, Hatzakis, Nikos, van de Weert, Marco & Foderà, Vito, 2023, In: The Journal of Physical Chemistry Letters. 14, 4, p. 912-919

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Identifying Biological and Biophysical Features of Different Maturation States of α-Synuclein Amyloid Fibrils

    Skamris, T., Vestergaard, Bente, Madsen, Kenneth Lindegaard, Langkilde, Annette Eva & Foderà, Vito, 2023, In: Methods in molecular biology (Clifton, N.J.). 2551, p. 321-344 24 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    In vitro and in vivo immunogenicity assessment of protein aggregate characteristics

    Thorlaksen, C., Schultz, H. S., Gammelgaard, S. K., Jiskoot, W., Hatzakis, Nikos, Nielsen, F. S., Solberg, H., Foderà, Vito, Bartholdy, C. & Groenning, M., 2023, In: International Journal of Pharmaceutics. 631, 122490.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Insights into the mechanisms of interaction between inhalable lipid-polymer hybrid nanoparticles and pulmonary surfactant

    Xu, Y., Parra-Ortiz, E., Wan, F., Cañadas, O., Garcia-Alvarez, B., Thakur, A., Franzyk, Henrik, Pérez-Gil, J., Malmsten, Martin & Foged, Camilla, 2023, In: Journal of Colloid and Interface Science. 633, p. 511-525

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Mechanisms of Drug Solubility Enhancement Induced by β-Lactoglobulin-Based Amorphous Solid Dispersions

    Zhuo, Xuezhi, Sener, Z., Kabedev, A., Zhao, M., Arnous, A., Leng, D., Foderà, Vito & Löbmann, Korbinian, 2023, In: Molecular Pharmaceutics. 20, 10, p. 5206–5213

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Molecularly Imprinted Polymers for Targeting Lipopolysaccharides and Photothermal Inactivation of Pseudomonas aeruginosa

    Zhang, Q., Zhang, M., Huang, Z., Sun, Y. & Ye, L., 2023, In: ACS Applied Polymer Materials. 5, 4, p. 3055–3064

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Mucoadhesive Dendrons Conjugated to Mesoporous Silica Nanoparticles as a Drug Delivery Approach for Orally Administered Biopharmaceuticals

    Tollemeto, M., Huang, Z., Christensen, Jørn Bolstad, Nielsen, Hanne Mørck & Rønholt, Stine, 2023, In: ACS Applied Materials and Interfaces. 15, 7, p. 8798–8810

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Mucoadhesive chitosan- and cellulose derivative-based nanofiber-on-foam-on-film system for non-invasive peptide delivery

    Stie, Mai Bay, Öblom, H., Hansen, Anders Christian Nørgaard, Jacobsen, Jette, Chronakis, I. S., Rantanen, Jukka, Nielsen, Hanne Mørck & Genina, Natalja, 2023, In: Carbohydrate Polymers. 303, 120429.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Quantitative Evaluation of a Multimodal Aptamer-Targeted Long-Circulating Polymer for Tumor Targeting

    Bohrmann, L., Burghardt, T., Rodríguez-Rodríguez, C., Herth, Matthias Manfred, Saatchi, K. & Häfeli, U. O., 2023, In: ACS Omega. 8, 12, p. 11003-11020

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Reproducible Formation of Insulin Superstructures: Amyloid-Like Fibrils, Spherulites, and Particulates

    Thorlaksen, C., Neergaard, M. B., Groenning, M. & Foderà, Vito, 2023, Protein Aggregation: Methods in Molecular Biology. Stanisław Cieplak, A. (ed.). Humana Press, p. 297-309 (Methods in Molecular Biology, Vol. 2551).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  41. Published

    Stereochemistry and Intermolecular Interactions Influence Carrier Peptide-Mediated Insulin Delivery

    Diedrichsen, Ragna Guldsmed, Tuelung, P. S., Foderà, Vito & Nielsen, Hanne Mørck, 2023, In: Molecular Pharmaceutics. 20, 2, p. 1202–1212

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Stereoisomer-Dependent Membrane Association and Capacity for Insulin Delivery Facilitated by Penetratin

    Birch, D., Sayers, E. J., Christensen, M. V., Jones, A. T., Franzyk, Henrik & Nielsen, Hanne Mørck, 2023, In: Pharmaceutics. 15, 6, 15 p., 1672.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Sustainable soy protein microsponges for efficient removal of lead (II) from aqueous environments

    Anselmo, S., Avola, T., Kalouta, Kleopatra, Cataldo, S., Sancataldo, G., Muratore, N., Foderà, Vito, Vetri, V. & Pettignano, A., 2023, In: International Journal of Biological Macromolecules. 239, 14 p., 124276.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Unleashing the healing potential: Exploring next-generation regenerative protein nanoscaffolds for burn wound recovery

    Si, L., Guo, X., Bera, H., Chen, Y., Xiu, F., Liu, P., Zhao, C., Abbasi, Y. F., Tang, X., Foderà, Vito, Cun, D. & Yang, Mingshi, 2023, In: Asian Journal of Pharmaceutical Sciences. 18, 6, 13 p., 100856.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Variation in prognosis and treatment outcome in juvenile myoclonic epilepsy: a Biology of Juvenile Myoclonic Epilepsy Consortium proposal for a practical definition and stratified medicine classifications

    BIOJUME Consortium, B. C., 2023, In: Brain Communications. 5, 3, 18 p., fcad182.

    Research output: Contribution to journal › Review › Research › peer-review

  46. 2024
  47. Published

    Analysis of stabilization mechanisms in β-lactoglobulin-based amorphous solid dispersions by experimental and computational approaches

    Zhuo, Xuezhi, Foderà, Vito, Larsson, P., Schaal, Z., Bergström, C. A. S., Löbmann, Korbinian & Kabedev, A., 2024, In: European Journal of Pharmaceutical Sciences. 192, 13 p., 106639.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Defect engineering to tailor structure-activity relationship in biodegradable nanozymes for tumor therapy by dual-channel death strategies

    Su, Y., Lv, M., Huang, Z., An, N., Chen, Y., Wang, H., Li, Z., Wu, S., Ye, F., Shen, J. & Li, A., 2024, In: Journal of Controlled Release. 367, p. 557-571

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Development of a 99mTc-labeled tetrazine for pretargeted SPECT imaging using an alendronic acid-based bone targeting model

    Bohrmann, L., Poulie, Christian Bernard Matthijs, Rodríguez-Rodríguez, C., Karagiozov, S., Saatchi, K., Herth, Matthias Manfred & Häfeli, U. O., 2024, In: PLoS ONE. 19, 4, 18 p., e0300466.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Development of an immunosuppressed orthotopic hepatocellular carcinoma rat model for the evaluation of chemo- and radioembolization therapies

    Charles, L., Sekar, S., Osooly, M., Javed, S., Williams, K. C., Welch, I., Barta, I., Saatchi, K. & Häfeli, U. O., 2024, In: European Journal of Pharmaceutics and Biopharmaceutics. 196, 9 p., 114180.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Electrosprayed Poly-butyl-succinate microparticles for sustained release of Ciprofloxacin as an antimicrobial delivery system

    Foderà, Vito, Terracina, F., Catania, V., Sciré, S., Schillaci, D. & Licciardi, M., 2024, In: Powder Technology. 432, 10 p., 119152.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Exploring the effect of protein secondary structure on the solid state and physical stability of protein-based amorphous solid dispersions

    Zhuo, Xuezhi, Ochner, J., Leng, D., Foderà, Vito & Löbmann, Korbinian, 2024, In: European Journal of Pharmaceutics and Biopharmaceutics. 198, 8 p., 114274.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Investigating the influence of protein secondary structure on the dissolution behavior of β-lactoglobulin-based amorphous solid dispersions

    Zhuo, Xuezhi, Tozzetti, M., Arnous, A., Leng, D., Foderà, Vito & Löbmann, Korbinian, 2024, In: International Journal of Pharmaceutics. 653, 8 p., 123887.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Nanogel delivery systems for cationic peptides: More than a ‘One Size Fits All’ solution

    Kłodzińska, S. N., Wang, Qiuyue, Molchanova, N., Mahmoudi, N., Vallooran, J. J., Hansen, Paul Robert, Jenssen, H. & Nielsen, Hanne Mørck, 2024, In: Journal of Colloid and Interface Science. 663, p. 449-457

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation

    Mortensen, Janni Støvring, Bohr, S. S. R., Krog, Lasse Skjoldborg, Bøtker, Johan Peter, Kapousidou, V., Saaby, Lasse, Hatzakis, Nikos, Nielsen, Hanne Mørck, Nguyen, Duc Ninh & Rønholt, Stine, 2024, In: Scientific Reports. 14, 1, 17 p., 7665.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Risk assessment of exposure to 12 kinds of mycotoxins through consumption of Pericarpium Citri Reticulatae collected from Three Gorges Reservoir area of China

    Wang, W., Yuan, Y., Ma, Y., Wu, R., He, S. & He, L., 2024, In: Toxicon. 243, 107745.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Accepted/In press

    Versatile Mechanically Tunable Hydrogels for Therapeutic Delivery Applications

    Sun, Q., Tao, S., Bovone, G., Han, G., Deshmukh, D., Tibbitt, M. W., Ren, Q., Bertsch, Pascal Peter, Siqueira, G. & Fischer, P., 2024, (Accepted/In press) In: Advanced Healthcare Materials.

    Research output: Contribution to journal › Journal article › Research › peer-review

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