Drug Delivery and Biophysics of Biopharmaceuticals

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  1. Published

    Mucoadhesive Dendrons Conjugated to Mesoporous Silica Nanoparticles as a Drug Delivery Approach for Orally Administered Biopharmaceuticals

    Tollemeto, M., Huang, Z., Christensen, Jørn Bolstad, Nielsen, Hanne Mørck & Rønholt, Stine, 2023, In: ACS Applied Materials and Interfaces. 15, 7, p. 8798–8810

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Morphological integrity of insulin amyloid-like aggregates depends on preparation methods and post-production treatments

    Thorlaksen, C., Stanciu, A., Neergaard, M. B., Hatzakis, Nikos, Foderà, Vito & Groenning, M., 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 179, p. 147-155 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    In vitro and in vivo immunogenicity assessment of protein aggregate characteristics

    Thorlaksen, C., Schultz, H. S., Gammelgaard, S. K., Jiskoot, W., Hatzakis, Nikos, Nielsen, F. S., Solberg, H., Foderà, Vito, Bartholdy, C. & Groenning, M., 2023, In: International Journal of Pharmaceutics. 631, 122490.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Reproducible Formation of Insulin Superstructures: Amyloid-Like Fibrils, Spherulites, and Particulates

    Thorlaksen, C., Neergaard, M. B., Groenning, M. & Foderà, Vito, 2023, Protein Aggregation: Methods in Molecular Biology. Stanisław Cieplak, A. (ed.). Humana Press, p. 297-309 (Methods in Molecular Biology, Vol. 2551).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  5. Published

    Subtle pH variation around pH 4.0 affects aggregation kinetics and aggregate characteristics of recombinant human insulin

    Thorlaksen, C., Stanciu, A., Neergaard, M. B., Jiskoot, W., Groenning, M. & Foderà, Vito, 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 179, p. 166-172

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies

    Thanki, K., Thakur, A., de Groot, A. M., Geyer, A., Fraire, J., Falkenberg, E., Van Eygen, H., Putteman, E., Van Bijnen, D. C. J., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, H., Broere, F., van Eden, W., Sijts, A. J. A. M., Ogris, M., Nielsen, H. M., Braeckmans, K. & 1 others, Foged, Camilla, 2018.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  7. Published

    Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration

    Thanki, K., van Eetvelde, D., Geyer, A., Fraire, J., Hendrix, R., Van Eygen, H., Putteman, E., Sami, H., de Souza Carvalho-Wodarz, C., Franzyk, Henrik, Nielsen, Hanne Mørck, Braeckmans, K., Lehr, C., Ogris, M. & Foged, Camilla, 2019, In: Journal of controlled release : official journal of the Controlled Release Society. 310, p. 82-93

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Dual-Isotope SPECT/CT Imaging of the Tuberculosis Subunit Vaccine H56/CAF01: Induction of Strong Systemic and Mucosal IgA and T-Cell Responses in Mice Upon Subcutaneous Prime and Intrapulmonary Boost Immunization

    Thakur, A., Rodríguez-Rodríguez, C., Saatchi, K., Rose, F., Esposito, T., Nosrati, Z., Andersen, P., Christensen, D., Häfeli, U. O. & Foged, Camilla, 2018, In: Frontiers in Immunology. 9, 21 p., 2825.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Rhamnogalacturonan-I based microcapsules for targeted drug release

    Svagan, A. J., Kusic, A., De Gobba, Cristian, Larsen, F. H., Sassene, P., Zhou, Q., van de Weert, Marco, Mullertz, Anette , Jørgensen, Bodil & Ulvskov, Peter, 2016, In: P L o S One. 11, 12, 13 p., e0168050.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Accepted/In press

    Versatile Mechanically Tunable Hydrogels for Therapeutic Delivery Applications

    Sun, Q., Tao, S., Bovone, G., Han, G., Deshmukh, D., Tibbitt, M. W., Ren, Q., Bertsch, Pascal Peter, Siqueira, G. & Fischer, P., 2024, (Accepted/In press) In: Advanced Healthcare Materials.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Hybrid Metal-Phenol Nanoparticles with Polydopamine-like Coating for PET/SPECT/CT Imaging

    Suarez-Garcia, S., Esposito, T. V. F., Neufeld-Peters, J., Bergamo, M., Yang, H., Saatchi, K., Schaffer, P., Hafeli, U. O., Ruiz-Molina, D., Rodriguez-Rodriguez, C. & Novio, F., 2021, In: A C S Applied Materials and Interfaces. 13, 9, p. 10705-10718

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Defect engineering to tailor structure-activity relationship in biodegradable nanozymes for tumor therapy by dual-channel death strategies

    Su, Y., Lv, M., Huang, Z., An, N., Chen, Y., Wang, H., Li, Z., Wu, S., Ye, F., Shen, J. & Li, A., 2024, In: Journal of Controlled Release. 367, p. 557-571

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Barrier properties of ex vivo porcine intestinal mucus are highly independent of isolation and storage conditions

    Mortensen, Janni Støvring, Saaby, Lasse, Rønholt, Stine & Nielsen, Hanne Mørck, 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 174, p. 106-110

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Effect of supersaturation on absorption of indomethacin and tadalafil in a single pass intestinal perfusion rat model, in the absence and presence of a precipitation inhibitor

    Strindberg, S., Plum, J., Stie, Mai Bay, Christiansen, M. L., Nielsen, L. H., Rades, Thomas & Mullertz, Anette , Jun 2020, In: European Journal of Pharmaceutics and Biopharmaceutics. 151, p. 108-115

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Interactions of Cell-Penetrating Peptide-Modified Nanoparticles with Cells Evaluated Using Single Particle Tracking

    Streck, S., Bohr, S. S., Birch, D., Rades, Thomas, Hatzakis, Nikos, McDowell, A. & Nielsen, Hanne Mørck, 2021, In: ACS Applied Bio Materials. 4, 4, p. 3155-3165 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Comparison of bulk and microfluidics methods for the formulation of poly-lactic-co-glycolic acid (PLGA) nanoparticles modified with cell-penetrating peptides of different architectures

    Streck, S., Neumann, H., Nielsen, Hanne Mørck, Rades, Thomas & McDowell, A., Dec 2019, In: International Journal of Pharmaceutics: X. 1, 9 p., 100030.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    The distribution of cell-penetrating peptides on polymeric nanoparticles prepared using microfluidics and elucidated with small angle X-ray scattering

    Streck, S., Clulow, A. J., Nielsen, Hanne Mørck, Rades, Thomas, Boyd, B. J. & McDowell, A., 1 Nov 2019, In: Journal of Colloid and Interface Science. 555, p. 438-448 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Protein materials as sustainable non- and minimally invasive strategies for biomedical applications

    Stie, Mai Bay, Kalouta, Kleopatra, Vetri, V. & Foderà, Vito, 2022, In: Journal of Controlled Release. 344, p. 12-25

    Research output: Contribution to journal › Review › Research › peer-review

  19. Published

    Swelling of mucoadhesive electrospun chitosan/polyethylene oxide nanofibers facilitates adhesion to the sublingual mucosa

    Stie, Mai Bay, Gätke, J. R., Wan, F., Chronakis, I. S., Jacobsen, Jette & Nielsen, Hanne Mørck, 15 Aug 2020, In: Carbohydrate Polymers. 242, 10 p., 116428.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Waterborne Electrospinning of α-Lactalbumin Generates Tunable and Biocompatible Nanofibers for Drug Delivery

    Stie, Mai Bay, Corezzi, M., Juncos Bombin, A. D., Ajalloueian, F., Attrill, E., Pagliara, S., Jacobsen, Jette, Chronakis, I. S., Nielsen, Hanne Mørck & Foderà, Vito, 2020, In: ACS Applied Nano Materials. 3, 2, p. 1910–1921

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Delivery of proteins encapsulated in chitosan-tripolyphosphate nanoparticles to human skin melanoma cells

    Stie, Mai Bay, Thoke, H. S., Issinger, O. G., Hochscherf, J., Guerra, B. & Olsen, L. F., 1 Feb 2019, In: Colloids and Surfaces B: Biointerfaces. 174, p. 216-223 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Sustainable strategies for waterborne electrospinning of biocompatible nanofibers based on soy protein isolate

    Stie, Mai Bay, Kalouta, Kleopatra, Cunha, Cristiana, Feroze, H. M., Vetri, V. & Foderà, Vito, 2022, In: Sustainable Materials and Technologies. 34, 11 p., e00519.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Acids ‘generally recognized as safe’ affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers

    Stie, Mai Bay, Jones, M., Sørensen, H. O., Jacobsen, Jette, Chronakis, I. S. & Nielsen, Hanne Mørck, 1 Jul 2019, In: Carbohydrate Polymers. 215, p. 253-262

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin

    Stie, Mai Bay, Gätke, J. R., Chronakis, I. S., Jacobsen, Jette & Nielsen, Hanne Mørck, 2022, In: International Journal of Molecular Sciences. 23, 3, 9 p., 1458.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Mucoadhesive chitosan- and cellulose derivative-based nanofiber-on-foam-on-film system for non-invasive peptide delivery

    Stie, Mai Bay, Öblom, H., Hansen, A. C. N., Jacobsen, Jette, Chronakis, I. S., Rantanen, Jukka, Nielsen, Hanne Mørck & Genina, Natalja, 2023, In: Carbohydrate Polymers. 303, 120429.

    Research output: Contribution to journal › Journal article › Research › peer-review

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