Drug Delivery and Biophysics of Biopharmaceuticals

  1. Published

    Morphological integrity of insulin amyloid-like aggregates depends on preparation methods and post-production treatments

    Thorlaksen, C., Stanciu, A., Neergaard, M. B., Hatzakis, Nikos, Foderà, Vito & Groenning, M., 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 179, p. 147-155 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    In vitro and in vivo immunogenicity assessment of protein aggregate characteristics

    Thorlaksen, C., Schultz, H. S., Gammelgaard, S. K., Jiskoot, W., Hatzakis, Nikos, Nielsen, F. S., Solberg, H., Foderà, Vito, Bartholdy, C. & Groenning, M., 2023, In: International Journal of Pharmaceutics. 631, 122490.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Reproducible Formation of Insulin Superstructures: Amyloid-Like Fibrils, Spherulites, and Particulates

    Thorlaksen, C., Neergaard, M. B., Groenning, M. & Foderà, Vito, 2023, Protein Aggregation: Methods in Molecular Biology. Stanisław Cieplak, A. (ed.). Humana Press, p. 297-309 (Methods in Molecular Biology, Vol. 2551).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  4. Published

    Subtle pH variation around pH 4.0 affects aggregation kinetics and aggregate characteristics of recombinant human insulin

    Thorlaksen, C., Stanciu, A., Neergaard, M. B., Jiskoot, W., Groenning, M. & Foderà, Vito, 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 179, p. 166-172

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Mucoadhesive Dendrons Conjugated to Mesoporous Silica Nanoparticles as a Drug Delivery Approach for Orally Administered Biopharmaceuticals

    Tollemeto, M., Huang, Z., Christensen, Jørn Bolstad, Nielsen, Hanne Mørck & Rønholt, Stine, 2023, In: ACS Applied Materials and Interfaces. 15, 7, p. 8798–8810

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems

    Tran, T., Bonlokke, P., Rodriguez-Rodriguez, C., Nosrati, Z., Esquinas, P. L., Borkar, N., Plum, J., Strindberg, S., Karagiozov, S., Rades, Thomas, Mullertz, Anette , Saatchi, K. & Hafeli, U. O., 2020, In: Journal of Controlled Release. 317, p. 375-384

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Erratum: Fluorescence quenching to study protein-ligand binding: Common errors (Journal of Fluorescence (2010) 20 (625-629)DOI 10.1007/s10895-009-0572- x)

    van de Weert, Marco, 29 Aug 2011, In: Journal of Fluorescence. 21, 6, 1 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  8. Published

    Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques

    van de Weert, Marco, Van 'T Hof, R., Van Der Weerd, J., Heeren, R. M. A., Posthuma, G., Hennink, W. E. & Crommelin, D. J. A., 31 Jul 2000, In: Journal of Controlled Release. 68, 1, p. 31-40 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Impact of capacity-limited binding on recombinant factor VIII and von Willebrand factor pharmacokinetics in hemophilia A rats

    Vargas Christensen, I., Loftager, M., Rode, F., Nielsen, Hanne Mørck, Kreilgaard, M. & Larsen, M. S., 2019, In: Journal of Thrombosis and Haemostasis. 17, 6, p. 964-974 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    The route to protein aggregate superstructures: Particulates and amyloid-like spherulites

    Vetri, V. & Foderà, Vito, 14 Sep 2015, In: FEBS Letters. 589, 19 Pt A, p. 2448-63 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Ethanol Controls the Self-Assembly and Mesoscopic Properties of Human Insulin Amyloid Spherulites

    Vetri, V., Piccirilli, F., Krausser, J., Buscarino, G., Łapińska, U., Vestergaard, Bente, Zaccone, A. & Foderà, Vito, 29 Mar 2018, In: The Journal of Physical Chemistry B. 122, 12, p. 3101-3112

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Bioinformatic and experimental analysis of the secondary structure of amelogenin

    Vilhjalmsson, B., Rasmussen, Anne, Fabi, B., van de Weert, Marco, Hamelryck, Thomas Wim & Lemoult, S., 1 Nov 2007, In: European Cells and Materials. 14, SUPPL.2, 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Insight into Nanoscale Network of Spray-dried Polymeric Particles: Role of Polymer Molecular Conformation

    Wan, F., Larsen, F. H., Nunes Bordallo, Heloisa, Foged, Camilla, Rantanen, Jukka & Yang, Mingshi, 2018, In: A C S Applied Materials and Interfaces. 10, 43, p. 36686-36692

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Qualitative and quantitative analysis of the biophysical interaction of inhaled nanoparticles with pulmonary surfactant by using quartz crystal microbalance with dissipation monitoring

    Wan, F., Nylander, T., Foged, Camilla, Yang, Mingshi, Baldursdottir, S. G. & Nielsen, Hanne Mørck, 1 Mar 2019, In: Journal of Colloid and Interface Science. 545, p. 162-171 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    One-Step Production of Protein-Loaded PLGA Microparticles via Spray Drying Using 3-Fluid Nozzle

    Wan, F., Maltesen, M. J., Andersen, S. K., Bjerregaard, S., Foged, Camilla, Rantanen, Jukka & Yang, Mingshi, 19 Feb 2014, In: Pharmaceutical Research. 31, 8, p. 1969-1977 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    A free-floating mucin layer to investigate the effect of the local microenvironment in lungs on mucin-nanoparticle interactions

    Wan, F., Herzberg, M., Huang, Z., Hassenkam, Tue & Nielsen, Hanne Mørck, 2020, In: Acta Biomaterialia. 104, 1, p. 115-123

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Ultrasmall TPGS-PLGA Hybrid Nanoparticles for Site-Specific Delivery of Antibiotics into Pseudomonas aeruginosa Biofilms in Lungs

    Wan, F., Bohr, S. S. R., Kłodzińska, S. N., Jumaa, H., Huang, Z., Nylander, T., Thygesen, Mikkel Boas, Sørensen, K. K., Jensen, Knud Jørgen, Sternberg, C., Hatzakis, Nikos & Nielsen, Hanne Mørck, 2020, In: ACS Applied Materials and Interfaces. 12, p. 380-389

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Lipid shell-enveloped polymeric nanoparticles with high integrity of lipid shells improve mucus penetration and interaction with cystic fibrosis-related bacterial biofilms

    Wan, F., Nylander, T., Klodzinska, S. N., Foged, Camilla, Yang, Mingshi, Baldursdottir, S. G. & Nielsen, Hanne Mørck, 23 Feb 2018, In: A C S Applied Materials and Interfaces. 10, 13, p. 10678–10687

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Design of PLGA-based depot delivery systems for biopharmaceuticals prepared by spray drying

    Wan, F. & Yang, Mingshi, 10 Feb 2016, In: International Journal of Pharmaceutics. 498, 1-2, p. 82-95 14 p.

    Research output: Contribution to journalReviewResearchpeer-review

  20. Published

    Proinflammatory and amyloidogenic S100A9 induced by traumatic brain injury in mouse model

    Wang, C., Iashchishyn, I. A., Kara, J., Foderà, Vito, Vetri, V., Sancataldo, G., Marklund, N. & Morozova-Roche, L. A., 23 Apr 2019, In: Neuroscience Letters. 699, p. 199-205

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Risk assessment of exposure to 12 kinds of mycotoxins through consumption of Pericarpium Citri Reticulatae collected from Three Gorges Reservoir area of China

    Wang, W., Yuan, Y., Ma, Y., Wu, R., He, S. & He, L., 2024, In: Toxicon. 243, 107745.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Three-Dimensional Printing of Drug-Eluting Implants: Preparation of an Antimicrobial Polylactide Feedstock Material

    Water, J. J., Bohr, A., Bøtker, Johan Peter, Aho, J., Sandler, N., Nielsen, Hanne Mørck & Rantanen, Jukka, 15 Jan 2015, In: Journal of Pharmaceutical Sciences. p. 1099–1107 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Topical niclosamide (ATx201) reduces Staphylococcus aureus colonization and increases Shannon diversity of the skin microbiome in atopic dermatitis patients in a randomized, double-blind, placebo-controlled Phase 2 trial

    Weiss, A., Delavenne, E., Matias, C., Lagler, H., Simon, D., Li, P., Hansen, J. U., Dos Santos, T. P., Jana, B., Priemel, P., Bangert, C., Bauer, M., Eberl, S., Nussbaumer-Pröll, A., Anne Österreicher, Z., Matzneller, P., Quint, T., Weber, M., Nielsen, H. M., Rades, T. & 17 others, Johansen, Helle Krogh, Westh, Henrik T., Kim, W., Mylonakis, E., Friis, C., Guardabassi, Luca, Pace, J., Lundberg, C. V., M'Zali, F., Butty, P., Sørensen, N., Nielsen, H. B., Toft-Kehler, R., Guttman-Yassky, E., Stingl, G., Zeitlinger, M. & Sommer, M., 2022, In: Clinical and Translational Medicine. 12, 5, e790.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Development of biodegradable nanocomposite scaffolds for autologous cell therapy

    Wen, Y., Gallego, M. R., Nielsen, L. F., Jørgensen, Lene, Everland, H., Møller, E. H. & Nielsen, Hanne Mørck, 1 Jan 2011, In: European Cells and Materials. 21, SUPPL.1, 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Effect of excipients on encapsulation and release of insulin from spray-dried solid lipid microparticles

    Wu, C., van de Weert, Marco, Baldursdottir, S. G., Yang, Mingshi & Mu, Huiling, 25 Oct 2018, In: International Journal of Pharmaceutics. 550, 1-2, p. 439-446

    Research output: Contribution to journalJournal articleResearchpeer-review