Hanne Mørck Nielsen
Professor
Drug Delivery and Biophysics of Biopharmaceuticals
Universitetsparken 2
2100 København Ø
- 2019
- Published
Repurposing Azithromycin and Rifampicin Against Gram-Negative Pathogens by Combination With Peptidomimetics
Baker, K. R., Jana, B., Hansen, A. M., Nielsen, Hanne Mørck, Franzyk, Henrik & Guardabassi, Luca, 2 Jul 2019, In: Frontiers in Cellular and Infection Microbiology. 9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acids ‘generally recognized as safe’ affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers
Stie, Mai Bay, Jones, M., Sørensen, H. O., Jacobsen, Jette, Chronakis, I. S. & Nielsen, Hanne Mørck, 1 Jul 2019, In: Carbohydrate Polymers. 215, p. 253-262Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction of Laponite with Membrane Components-Consequences for Bacterial Aggregation and Infection Confinement
Malekkhaiat Häffner, S., Nyström, L., Browning, K. L., Nielsen, Hanne Mørck, Strömstedt, A. A., van der Plas, Mariena J.A., Schmidtchen, A. & Malmsten, Martin, 1 May 2019, In: A C S Applied Materials and Interfaces. 11, 17, p. 15389-15400 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Qualitative and quantitative analysis of the biophysical interaction of inhaled nanoparticles with pulmonary surfactant by using quartz crystal microbalance with dissipation monitoring
Wan, F., Nylander, T., Foged, Camilla, Yang, Mingshi, Baldursdottir, S. G. & Nielsen, Hanne Mørck, 1 Mar 2019, In: Journal of Colloid and Interface Science. 545, p. 162-171 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exploring the mucoadhesive behavior of sucrose acetate isobutyrate: a novel excipient for oral delivery of biopharmaceuticals
Rønholt, Stine, Fliervoet, L. A. L., Fano, M., Schmitt, M., Antopolski, M., Urtti, A. & Nielsen, Hanne Mørck, 1 Jan 2019, In: Drug Delivery. 26, 1, p. 532-541Research output: Contribution to journal › Journal article › Research › peer-review
- Published
19F-substituted amino acids as an alternative to fluorophore labels: monitoring of degradation and cellular uptake of analogues of penetratin by 19F NMR
Christensen, M. V., Kongstad, Kenneth Thermann, Sondergaard, T. E., Stærk, Dan, Nielsen, Hanne Mørck, Franzyk, Henrik & Wimmer, R., 2019, In: Journal of Biomolecular N M R. 73, p. 167-182Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients
Molchanova, N., Wang, H., Hansen, Paul Robert, Høiby, Niels, Nielsen, Hanne Mørck & Franzyk, Henrik, 2019, In: Frontiers in Microbiology. 10, 9 p., 275.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hyaluronic acid-based nanogels improve in vivo compatibility of the anti-biofilm peptide DJK-5
Kłodzińska, S. N., Pletzer, D., Rahanjam, N., Rades, Thomas, Hancock, R. E. W. & Nielsen, Hanne Mørck, 2019, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 20, 102022.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of capacity-limited binding on recombinant factor VIII and von Willebrand factor pharmacokinetics in hemophilia A rats
Vargas Christensen, I., Loftager, M., Rode, F., Nielsen, Hanne Mørck, Kreilgaard, M. & Larsen, M. S., 2019, In: Journal of Thrombosis and Haemostasis. 17, 6, p. 964-974 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipidoid-Polymer Hybrid Nanoparticles Loaded with TNF siRNA Suppress Inflammation after Intra-articular Administration in a Murine Experimental Arthritis Model
Jansen, M. A. A., Klausen, L. H., Thanki, K., Lyngsø, J., Skov Pedersen, J., Franzyk, Henrik, Nielsen, Hanne Mørck, van Eden, W., Dong, M., Broere, F., Foged, Camilla & Zeng, X., 2019, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 142, p. 38-48Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration
Thanki, K., van Eetvelde, D., Geyer, A., Fraire, J., Hendrix, R., Van Eygen, H., Putteman, E., Sami, H., de Souza Carvalho-Wodarz, C., Franzyk, Henrik, Nielsen, Hanne Mørck, Braeckmans, K., Lehr, C., Ogris, M. & Foged, Camilla, 2019, In: Journal of controlled release : official journal of the Controlled Release Society. 310, p. 82-93Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Microcontainers for oral insulin delivery - in vitro studies of permeation enhancement
Rune Jørgensen, J., Leth Jepsen, M., Hagner Nielsen, L., Dufva, M., Nielsen, Hanne Mørck, Rades, Thomas, Boisen, A. & Mullertz, Anette , 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 143, p. 98-105Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Non-aqueous topical compositions comprising a halogenated salicylanilide
Sommer, M., Li, P., Frandsen, C. H., Nielsen, Hanne Mørck, Priemel, P. A. & Rades, Thomas, 2019, Patent No. US20190151231A1Research output: Patent
- Published
Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators
Baker, K. R., Jana, B., Hansen, A. M., Vissing, K. J., Nielsen, Hanne Mørck, Franzyk, Henrik & Guardabassi, Luca, 2019, In: International Journal of Antimicrobial Agents. 53, p. 868-872 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Poly(ethylene carbonate)-containing polylactic acid microparticles with rifampicin improve drug delivery to macrophages
Priemel, P. A., Wang, Y., Bohr, A., Water, J. J., Yang, Mingshi & Nielsen, Hanne Mørck, Aug 2018, In: Journal of Pharmacy and Pharmacology. 70, 8, p. 1009-1021Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biopolymer nanogels improve antibacterial activity and safety profile of a novel lysine-based α-peptide/β-peptoid peptidomimetic
Kłodzińska, S. N., Molchanova, N., Franzyk, Henrik, Hansen, Paul Robert, Damborg, Peter Panduro & Nielsen, Hanne Mørck, Jul 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 128, p. 1-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design
de Groot, A. M., Thanki, K., Gangloff, M., Falkenberg, E., Zeng, X., van Bijnen, D. C. J., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck, Broere, F., Gay, N. J., Foged, Camilla & Sijts, A. J. A. M., 1 Jun 2018, In: Molecular Therapy - Nucleic Acids. 11, p. 159-169 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluation of drug permeation under fed state conditions using mucus-covered Caco-2 cell epithelium
Birch, D., Diedrichsen, Ragna Guldsmed, Christophersen, P. C., Mu, Huiling & Nielsen, Hanne Mørck, Jun 2018, In: European Journal of Pharmaceutical Sciences. 118, p. 144-153Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stereochemistry as a determining factor for the effect of a cell-penetrating peptide on cellular viability and epithelial integrity
Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 24 May 2018, In: Biochemical Journal. 475, 10, p. 1773-1788 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In Vitro ADME Properties of Two Novel Antimicrobial Peptoid-Based Compounds as Potential Agents against Canine Pyoderma
Greco, I., Hummel, B. D., Vasir, J., Watts, J. L., Koch, J., Hansen, J. E., Nielsen, Hanne Mørck, Damborg, Peter Panduro & Hansen, Paul Robert, 10 Mar 2018, In: Molecules. 23, 3, 15 p., 630.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipid shell-enveloped polymeric nanoparticles with high integrity of lipid shells improve mucus penetration and interaction with cystic fibrosis-related bacterial biofilms
Wan, F., Nylander, T., Klodzinska, S. N., Foged, Camilla, Yang, Mingshi, Baldursdottir, S. G. & Nielsen, Hanne Mørck, 23 Feb 2018, In: A C S Applied Materials and Interfaces. 10, 13, p. 10678–10687Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing
Liu, X., Nielsen, L. H., Klodzinska, S. N., Nielsen, Hanne Mørck, Qu, H., Christensen, L. P., Rantanen, Jukka & Yang, Mingshi, Feb 2018, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 123, p. 42-49Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Combining diagnostic methods for antimicrobial susceptibility testing – A comparative approach
Klodzinska, S. N., Priemel, P. A., Rades, Thomas & Nielsen, Hanne Mørck, Jan 2018, In: Journal of Microbiological Methods. 144, p. 177-185Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles
García-Díaz, M., Birch, D., Wan, F. & Nielsen, Hanne Mørck, Jan 2018, In: Advanced Drug Delivery Reviews. 124, p. 107-124Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cellular effects and delivery propensity of penetratin is influenced by conjugation to parathyroid hormone fragment 1-34 in synergy with pH
Kristensen, Mie, Nielsen, L. H., Zor, K., Boisen, A., Christensen, M. V., Berthelsen, J. & Nielsen, Hanne Mørck, 2018, In: Bioconjugate Chemistry. 29, 2, p. 371-381Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing
Nielsen, Hanne Mørck, 2018, In: European Journal of Pharmaceutics and Biopharmaceutics.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparative study of the drug delivery mechanism of L-penetratin and D-penetratin
Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 2018.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Fluorophore labeling of a cell-penetrating peptide significantly alters the mode and degree of biomembrane interaction
Hedegaard, S. F., Derbas, M. S., Lind, T. K., Kasimova, M. R., Christensen, M. V., Michaelsen, M. H., Campbell, R. A., Jørgensen, Lene, Franzyk, Henrik, Cárdenas, M. & Nielsen, Hanne Mørck, 2018, In: Scientific Reports. 8, 1, 14 p., 6327.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies
Thanki, K., Thakur, A., de Groot, A. M., Geyer, A., Fraire, J., Falkenberg, E., Van Eygen, H., Putteman, E., Van Bijnen, D. C. J., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, H., Broere, F., van Eden, W., Sijts, A. J. A. M., Ogris, M., Nielsen, H. M., Braeckmans, K. & 1 others, , 2018.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles
Nielsen, Hanne Mørck, 2018, In: Advanced Drug Delivery Reviews.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Animal models for evaluation of oral delivery of biopharmaceuticals
Rønholt, Stine, Nielsen, L. H. & Nielsen, Hanne Mørck, Dec 2017, In: Journal of Controlled Release. 268, p. 57-71 15 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
The impact of particle preparation methods and polymorphic stability of lipid excipients on protein distribution in microparticles
Liu, J., Christophersen, P. C., Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, Dec 2017, In: Drug Development and Industrial Pharmacy. 43, 12, p. 2032-2042 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Engineering of small interfering RNA-loaded lipidoid-poly(DL-lactic-co-glycolic acid) hybrid nanoparticles for highly efficient and safe gene silencing: A quality by design-based approach
Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Van Driessche, E., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, Nov 2017, In: European Journal of Pharmaceutics and Biopharmaceutics. 120, p. 22-33 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA
Foged, Camilla, Franzyk, Henrik, Zeng, X., Nielsen, Hanne Mørck & Thanki, K., 21 Sep 2017, IPC No. A61K31/713, A61K47/18, A61K47/34, A61K9/51, A61P25/00, A61P29/00, A61P35/00, Patent No. WO2017158093-A1, 16 Mar 2017, Priority date 17 Mar 2016, Priority No. EP 2016-160931Research output: Patent
- Published
Innovative Methods and Applications in Mucoadhesion Research
Mackie, A. R., Goycoolea, F. M., Menchicchi, B., Caramella, C. M., Saporito, F., Lee, S., Stephansen, K., Chronakis, I. S., Hiorth, M., Adamczak, M., Waldner, M., Nielsen, Hanne Mørck & Marcelloni, L., Aug 2017, In: Macromolecular Bioscience. 17, 8, 32 p., 1600534.Research output: Contribution to journal › Review › Research › peer-review
- Published
Assessment of mucoadhesion using small deformation rheology revisited
Rønholt, Stine, Vissing, K. J. & Nielsen, Hanne Mørck, Apr 2017, In: Nordic Rheology Society Annual Transactions. 25, p. 63 7 p.Research output: Contribution to journal › Conference article › Research › peer-review
- Published
An approach to identify clinically relevan, non-toxic peptide-antimicrobial combinations that eliminate intrinsic resistance in Gram-negative pathogens
Baker, K. R., Jana, B., Nielsen, Hanne Mørck, Franzyk, Henrik & Guardabassi, Luca, 2017. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research
- Published
Efficient Pulmonary Delivery of siRNA Using Lipid-polymer Hybrid Nanoparticles (LPNs): A quality-by-design approach for highly systematic optimization of LPNs
Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.Research output: Contribution to conference › Poster › Research
- Published
Fluorophore labeling of a cell-penetrating peptide induces differential effects on its cellular distribution and affects cell viability
Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 2017, In: B B A - Biomembranes. 1859, 12, p. 2483-2494Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lysine-Based α-peptide/β-peptoid peptidomimetics: Influence of hydrophobicity, fluorination and distribution of cationic charge on antimicrobial activity and cytotoxicity
Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro, Nielsen, Hanne Mørck & Franzyk, Henrik, 2017, In: ChemMedChem. 12, p. 312-318 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quality-by-design in nanomedicine: Highly systematic optimization of lipid-polymer hybrid nanoparticles for efficacious and safe intracellular delivery of cargo siRNA
Zeng, X., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.Research output: Contribution to conference › Conference abstract for conference › Research
- Published
Synthesis and Characterisation of an Array of Lipidoid Analogues for RNA Interference Therapy
Falkenberg, E., de Groot, A. M., Sijts, A. J. A. M., Thanki, K., Zeng, X., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.Research output: Contribution to conference › Poster › Research
- 2016
- Published
Inhalable Antimicrobials for Treatment of Bacterial Biofilm-Associated Sinusitis in Cystic Fibrosis Patients: Challenges and Drug Delivery Approaches
Klodzinska, S. N., Priemel, P. A., Rades, Thomas & Nielsen, Hanne Mørck, 9 Oct 2016, In: International Journal of Molecular Sciences . 17, 10, 19 p., 1688.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of lipid-based drug delivery systems on the transport and uptake of insulin across Caco-2 Cell monolayers
Li, P., Nielsen, Hanne Mørck & Mullertz, Anette , Sep 2016, In: Journal of Pharmaceutical Sciences. 105, 9, p. 2743-51 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System.
Jing, X., Foged, Camilla, Martin-Bertelsen, Birte, Yaghmur, Anan, Knapp, K. M., Malmsten, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 6 Jun 2016, In: Molecular Pharmaceutics. 13, 6, p. 1739-1749 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interactions between Surfactants in Solution and Electrospun Protein Fibers: Effects on Release Behavior and Fiber Properties
Stephansen, K., García-Díaz, M., Jessen, F., Chronakis, I. S. & Nielsen, Hanne Mørck, 7 Mar 2016, In: Molecular Pharmaceutics. 13, 3, p. 748-55 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell-Penetrating Peptides as Carriers for Oral Delivery of Biopharmaceuticals
Kristensen, Mie & Nielsen, Hanne Mørck, Feb 2016, In: Basic & Clinical Pharmacology & Toxicology Online. 118, 2, p. 99-106 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Applications and Challenges for Use of Cell-Penetrating Peptides as Delivery Vectors for Peptide and Protein Cargos
Kristensen, Mie, Birch, D. & Nielsen, Hanne Mørck, 30 Jan 2016, In: International Journal of Molecular Sciences . 17, 2, p. 1-17 17 p., 185.Research output: Contribution to journal › Review › Research › peer-review
- Published
Cell-penetrating peptides as tools to enhance non-injectable delivery of biopharmaceuticals
Kristensen, Mie & Nielsen, Hanne Mørck, 2016, In: Tissue Barriers. 4, 2, 15 p., e1178369.Research output: Contribution to journal › Review › Research › peer-review
- Published
Efficient Pulmonary Delivery of siRNA Using Lipid-Polymer Hybrid Nanoparticles (LPNs): Insights into Formulation, Transfection and In Vivo Biodistribution Using NIR-based Spatio-Temporal Tracking.
Thanki, K., Geyer, A., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, Henrik, Ogris, M., Nielsen, Hanne Mørck & Foged, Camilla, 2016.Research output: Contribution to conference › Poster › Research
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Characterization of PTH-CPP fusion peptides for oral delivery
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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