Hanne Mørck Nielsen
Professor
Drug Delivery and Biophysics of Biopharmaceuticals
Universitetsparken 2
2100 København Ø
- 2024
- Published
Nanogel delivery systems for cationic peptides: More than a ‘One Size Fits All’ solution
Kłodzińska, S. N., Wang, Qiuyue, Molchanova, N., Mahmoudi, N., Vallooran, J. J., Hansen, Paul Robert, Jenssen, H. & Nielsen, Hanne Mørck, 2024, In: Journal of Colloid and Interface Science. 663, p. 449-457Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neonatal intestinal mucus barrier changes in response to maturity, inflammation, and sodium decanoate supplementation
Mortensen, Janni Støvring, Bohr, S. S. R., Krog, Lasse Skjoldborg, Bøtker, Johan Peter, Kapousidou, V., Saaby, Lasse, Hatzakis, Nikos, Nielsen, Hanne Mørck, Nguyen, Duc Ninh & Rønholt, Stine, 2024, In: Scientific Reports. 14, 1, 17 p., 7665.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Ca2+-Responsive Glyco-insulin
Wu, S., Østergaard, M., Fredholt, Freja, Christensen, Niels Johan, Sørensen, K. K., Mishra, N. K., Nielsen, Hanne Mørck & Jensen, Knud Jørgen, 2023, In: Bioconjugate Chemistry. 34, 3, p. 518–528Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Carrier peptide interactions with liposome membranes induce reversible clustering by surface adsorption and shape deformation
Diedrichsen, Ragna Guldsmed, Vetri, V., Prévost, S., Foderà, Vito & Nielsen, Hanne Mørck, 2023, In: Journal of Colloid and Interface Science. 650, Part B, p. 1821-1832Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell-Penetrating Peptides as Tools to Facilitate Oral Delivery of Biopharmaceuticals
Asgreen, Camilla Jantzen, Fredholt, Freja, Nielsen, Hanne Mørck & Kristensen, Mie, 2023, Cell-Penetrating Peptides: Design, Development and Applications. Oba, M. & Demizu, Y. (eds.). Wiley-VCH, p. 331-354Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Corrigendum to "Polysorbate 80 controls Morphology, structure and stability of human insulin Amyloid-Like spherulites" [J. Colloid Interface Sci. 606(Part 2) (2022) 1928-1939]
Zhou, X., Galparsoro, D. F., Madsen, Anders Østergaard, Vetri, V., van de Weert, Marco, Nielsen, Hanne Mørck & Foderà, Vito, 2023, In: Journal of Colloid and Interface Science. 640, p. 917Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of prophylactic antibiotics administration on barrier properties of intestinal mucosa and mucus from preterm born piglets
Mortensen, Janni Støvring, Nguyen, Duc Ninh, Nielsen, Hanne Mørck & Rønholt, Stine, 2023, In: Drug Delivery and Translational Research. 13, p. 1456–1469Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Encapsulation in oleyl-modified hyaluronic acid nanogels substantially improves the clinical potential of the antimicrobial peptides SAAP-148 and Ab-Cath
van Gent, M. E., Klodzinska, S. N., Drijfhout, J. W., Nielsen, Hanne Mørck & Nibbering, P. H., 2023, In: European Journal of Pharmaceutics and Biopharmaceutics. 193, p. 254-261Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Encapsulation into hyaluronic acid-based nanogels improves the selectivity index of the snake cathelicidin Ab-Cath
van Gent, M. E., Kłodzińska, S. N., Severin, M., Ali, M., van Doodewaerd, B. R., Bos, E., Koning, R. I., Drijfhout, J. W., Nielsen, Hanne Mørck & Nibbering, P. H., 2023, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 52, 11 p., 102694.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Encapsulation of SAAP-148 in Octenyl Succinic Anhydride-Modified Hyaluronic Acid Nanogels for Treatment of Skin Wound Infections
van Gent, M. E., van Baaren, T., Kłodzińska, S. N., Ali, M., Dolezal, N., van Doodewaerd, B. R., Bos, E., de Waal, A. M., Koning, R. I., Drijfhout, J. W., Nielsen, Hanne Mørck & Nibbering, P. H., 2023, In: Pharmaceutics. 15, 2, 20 p., 429.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epithelium dynamics differ in time and space when exposed to the permeation enhancers penetramax and EGTA. A head-to-head mechanistic comparison
Panou, D. A., Pedersen, Stine Helene Falsig, Kristensen, Mie & Nielsen, Hanne Mørck, 2023, In: Frontiers in Drug Delivery. 3, 16 p., 1221628.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Heterogeneous and Surface-Catalyzed Amyloid Aggregation Monitored by Spatially Resolved Fluorescence and Single Molecule Microscopy
Zhou, X., Sinkjær, Anders Wilgaard, Zhang, Min, Pinholt, H. D., Nielsen, Hanne Mørck, Hatzakis, Nikos, van de Weert, Marco & Foderà, Vito, 2023, In: The Journal of Physical Chemistry Letters. 14, 4, p. 912-919Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mucoadhesive Dendrons Conjugated to Mesoporous Silica Nanoparticles as a Drug Delivery Approach for Orally Administered Biopharmaceuticals
Tollemeto, M., Huang, Z., Christensen, Jørn Bolstad, Nielsen, Hanne Mørck & Rønholt, Stine, 2023, In: ACS Applied Materials and Interfaces. 15, 7, p. 8798–8810Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mucoadhesive chitosan- and cellulose derivative-based nanofiber-on-foam-on-film system for non-invasive peptide delivery
Stie, Mai Bay, Öblom, H., Hansen, Anders Christian Nørgaard, Jacobsen, Jette, Chronakis, I. S., Rantanen, Jukka, Nielsen, Hanne Mørck & Genina, Natalja, 2023, In: Carbohydrate Polymers. 303, 120429.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stereochemistry and Intermolecular Interactions Influence Carrier Peptide-Mediated Insulin Delivery
Diedrichsen, Ragna Guldsmed, Tuelung, P. S., Foderà, Vito & Nielsen, Hanne Mørck, 2023, In: Molecular Pharmaceutics. 20, 2, p. 1202–1212Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stereoisomer-Dependent Membrane Association and Capacity for Insulin Delivery Facilitated by Penetratin
Birch, D., Sayers, E. J., Christensen, M. V., Jones, A. T., Franzyk, Henrik & Nielsen, Hanne Mørck, 2023, In: Pharmaceutics. 15, 6, 15 p., 1672.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Barrier properties of ex vivo porcine intestinal mucus are highly independent of isolation and storage conditions
Mortensen, Janni Støvring, Saaby, Lasse, Rønholt, Stine & Nielsen, Hanne Mørck, 2022, In: European Journal of Pharmaceutics and Biopharmaceutics. 174, p. 106-110Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell-Penetrating Peptides as Carriers for Transepithelial Drug Delivery
Panou, D. A., Diedrichsen, Ragna Guldsmed, Kristensen, Mie & Nielsen, Hanne Mørck, 2022, Cell Penetrating Peptides: Methods and Protocols. Langel, Ü. (ed.). Springer, p. 371-384 (Methods in Molecular Biology, Vol. 2383).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Direct observations of drug nanocarrier interactions and mobility within biological interfaces
Bohr, S. S. R., Streck, S., Pinholt, H., Wan, F., Mcdowell, A., Nielsen, Hanne Mørck & Hatzakis, Nikos, 2022, In: Biophysical Journal. 121, 3, p. 72a-73a 2 p., 355-Pos.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Investigating the effect of graphene oxide in chitosan/alginate-based foams on the release and antifungal activity of clotrimazole in vitro
Huang, Jianfei, Jacobsen, Jette, Genina, Natalja, Larsen, Susan Weng, Nielsen, Hanne Mørck, Mullertz, Anette & Mu, Huiling, 2022, In: European Journal of Pharmaceutical Sciences. 174, 9 p., 106204.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mucoadhesive Electrospun Nanofiber-Based Hybrid System with Controlled and Unidirectional Release of Desmopressin
Stie, Mai Bay, Gätke, J. R., Chronakis, I. S., Jacobsen, Jette & Nielsen, Hanne Mørck, 2022, In: International Journal of Molecular Sciences. 23, 3, 9 p., 1458.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Physical and barrier changes in gastrointestinal mucus induced by the permeation enhancer sodium 8-[(2-hydroxybenzoyl)amino]octanoate (SNAC)
Mortensen, Janni Støvring, Bohr, S. S. R., Rønholt, Stine, Hatzakis, Nikos, Saaby, Lasse & Nielsen, Hanne Mørck, 2022, In: Journal of Controlled Release. 352, p. 163-178 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polysorbate 80 controls Morphology, structure and stability of human insulin Amyloid-Like spherulites
Zhou, X., Fennema Galparsoro, D., Madsen, Anders Østergaard, Vetri, V., van de Weert, Marco, Nielsen, Hanne Mørck & Foderà, Vito, 2022, In: Journal of Colloid and Interface Science. 606, Pt 2, p. 1928-1939Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Topical niclosamide (ATx201) reduces Staphylococcus aureus colonization and increases Shannon diversity of the skin microbiome in atopic dermatitis patients in a randomized, double-blind, placebo-controlled Phase 2 trial
Weiss, A., Delavenne, E., Matias, C., Lagler, H., Simon, D., Li, P., Hansen, J. U., Dos Santos, T. P., Jana, B., Priemel, P., Bangert, C., Bauer, M., Eberl, S., Nussbaumer-Pröll, A., Anne Österreicher, Z., Matzneller, P., Quint, T., Weber, M., Nielsen, H. M., Rades, T. & 17 others, , 2022, In: Clinical and Translational Medicine. 12, 5, e790.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Polysorbate 80 Controls Morphology, Structure and Stability of Human Insulin Amyloid-Like Spherulites
Zhou, X., Galparsoro, D. F., Madsen, Anders Østergaard, Vetri, V., van de Weert, Marco, Nielsen, Hanne Mørck & Foderà, Vito, 10 Aug 2021, bioRxiv, 52 p.Research output: Working paper › Preprint › Research
- Published
Additive manufacturing of polymeric scaffolds for biomimetic cell membrane engineering
Rovira, D. S., Nielsen, Hanne Mørck, Taboryski, R. & Bunea, A., 2021, In: Materials and Design. 201, 11 p., 109486.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Controlling the fractal dimension in self-assembly of terpyridine modified insulin by Fe2+ and Eu3+ to direct in vivo effects
Mishra, N. K., Østergaard, M., Midtgaard, S. R., Strindberg, S. S., Winkler, S., Wu, S., Sørensen, Thomas Just, Hassenkam, Tue, Poulsen, Jens-Christian Navarro, Lo Leggio, Leila, Nielsen, Hanne Mørck, Arleth, Lise, Christensen, Niels Johan, Thulstrup, Peter Waaben & Jensen, Knud Jørgen, 2021, In: Nanoscale. 13, 18, p. 8467–8473 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design of a self-unfolding delivery concept for oral administration of macromolecules
Jørgensen, J. R., Thamdrup, L. H. E., Kamguyan, K., Nielsen, L. H., Nielsen, Hanne Mørck, Boisen, A., Rades, Thomas & Mullertz, Anette , 2021, In: Journal of Controlled Release. 329, p. 948-954Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interactions of Cell-Penetrating Peptide-Modified Nanoparticles with Cells Evaluated Using Single Particle Tracking
Streck, S., Bohr, S. S., Birch, D., Rades, Thomas, Hatzakis, Nikos, McDowell, A. & Nielsen, Hanne Mørck, 2021, In: ACS Applied Bio Materials. 4, 4, p. 3155-3165 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nanoparticle-mediated pulmonary drug delivery: state of the art towards efficient treatment of recalcitrant respiratory tract bacterial infections
Huang, Z., Klodzinska, S. N., Wan, F. & Nielsen, Hanne Mørck, 2021, In: Drug Delivery and Translational Research. 11, p. 1634–1654Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Overcoming the Mucus barrier
Mortensen, Janni Støvring, Stie, Mai Bay, Rønholt, Stine & Nielsen, Hanne Mørck, 2021, Organelle and Molecular Targeting. Milane, L. S. & Amiji, M. M. (eds.). CRC Press, p. 355-379 25 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Peptide-Membrane Interactions Monitored by Fluorescence Lifetime Imaging: A Study Case of Transportan 10
Anselmo, S., Sancataldo, G., Nielsen, Hanne Mørck, Foderà, Vito & Vetri, V., 2021, In: Langmuir. 37, 44, p. 13148-13159Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Revealing the importance of carrier-cargo association in delivery of insulin and lipidated insulin
Diedrichsen, Ragna Guldsmed, Rønholt, Stine, Werner, U., Besenius, M., Leberer, E., Kristensen, Mie & Nielsen, Hanne Mørck, 2021, In: Journal of Controlled Release. 338, p. 8-21Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Swelling of mucoadhesive electrospun chitosan/polyethylene oxide nanofibers facilitates adhesion to the sublingual mucosa
Stie, Mai Bay, Gätke, J. R., Wan, F., Chronakis, I. S., Jacobsen, Jette & Nielsen, Hanne Mørck, 15 Aug 2020, In: Carbohydrate Polymers. 242, 10 p., 116428.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
EJP18 peptide derived from the juxtamembrane domain of epidermal growth factor receptor represents a novel membrane-active cell-penetrating peptide
Eissa, N. G., Sayers, E. J., Birch, D., Patel, S. G., Tsai, Y. H., Nielsen, Hanne Mørck & Jones, A. T., 8 Jan 2020, In: Biochemical Journal. 477, 1, p. 45-60 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In Vitro, Ex Vivo and In Vivo Evaluation of Microcontainers for Oral Delivery of Insulin
Jørgensen, J. R., Yu, F., Ramakrishnan, V., Nielsen, L. H., Nielsen, Hanne Mørck, Boisen, A., Rades, Thomas & Mullertz, Anette , 7 Jan 2020, In: Pharmaceutics. 12, 1, 14 p., 48.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A free-floating mucin layer to investigate the effect of the local microenvironment in lungs on mucin-nanoparticle interactions
Wan, F., Herzberg, M., Huang, Z., Hassenkam, Tue & Nielsen, Hanne Mørck, 2020, In: Acta Biomaterialia. 104, 1, p. 115-123Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Electrospun α-lactalbumin nanofibers for site-specific and fast-onset delivery of nicotine in the oral cavity: an in vitro, ex vivo and tissue spatial distribution study
Kalouta, Kleopatra, Stie, Mai Bay, Janfelt, Christian, Chronakis, I. S., Jacobsen, Jette, Nielsen, Hanne Mørck & Foderà, Vito, 2020, In: Molecular Pharmaceutics. 17, 11, p. 4189-4200Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Graphene oxide as a functional excipient in buccal films for delivery of clotrimazole: effect of molecular interactions on drug release and antifungal activity in vitro
Huang, Jianfei, Jacobsen, Jette, Larsen, Susan Weng, Genina, Natalja, van de Weert, Marco, Mullertz, Anette , Nielsen, Hanne Mørck & Mu, Huiling, 2020, In: International Journal of Pharmaceutics. 589, p. 1-9 119811.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Increased Carrier Peptide Stability through pH Adjustment Improves Insulin and PTH(1-34) Delivery In Vitro and In Vivo Rather than by Enforced Carrier Peptide-Cargo Complexation
Kristensen, Mie, Diedrichsen, Ragna Guldsmed, Vetri, V., Foderà, Vito & Nielsen, Hanne Mørck, 2020, In: Pharmaceutics. 12, 10, 18 p., 993.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Membrane interactions in drug delivery: Model cell membranes and orthogonal techniques
Bunea, A., Rønholt, Stine, Taboryski, R. & Nielsen, Hanne Mørck, 2020, In: Advances in Colloid and Interface Science. 281, 15 p., 102177.Research output: Contribution to journal › Review › Research › peer-review
- Published
Monosized Polymeric Microspheres Designed for Passive Lung Targeting: Biodistribution and Pharmacokinetics after Intravenous Administration
Agnoletti, M., Rodríguez-Rodríguez, C., Klodzinska, S. N., Esposito, T., Saatchi, K., Nielsen, Hanne Mørck & Häfeli, U. O., 2020, In: ACS Nano. 14, p. 6693-6706Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Shuffled lipidation pattern and degree of lipidation determines the membrane interaction behavior of a linear cationic membrane-active peptide
Hedegaard, S. F., Bruhn, D. S., Khandelia, H., Cardenas, M. & Nielsen, Hanne Mørck, 2020, In: Journal of Colloid and Interface Science. 578, p. 584-597 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of carbon quantum dot-poly lactic-co-glycolic acid hybrid nanoparticles for chemo-photothermal therapy against bacterial biofilms
Huang, Z., Zhou, T., Yuan, Y., Klodziska, S. N., Zheng, T., Sternberg, C., Nielsen, Hanne Mørck, Sun, Y. & Wan, F., 2020, In: Journal of Colloid and Interface Science. 577, p. 66-74 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ultrasmall TPGS-PLGA Hybrid Nanoparticles for Site-Specific Delivery of Antibiotics into Pseudomonas aeruginosa Biofilms in Lungs
Wan, F., Bohr, S. S. R., Kłodzińska, S. N., Jumaa, H., Huang, Z., Nylander, T., Thygesen, Mikkel Boas, Sørensen, K. K., Jensen, Knud Jørgen, Sternberg, C., Hatzakis, Nikos & Nielsen, Hanne Mørck, 2020, In: ACS Applied Materials and Interfaces. 12, p. 380-389Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Waterborne Electrospinning of α-Lactalbumin Generates Tunable and Biocompatible Nanofibers for Drug Delivery
Stie, Mai Bay, Corezzi, M., Juncos Bombin, A. D., Ajalloueian, F., Attrill, E., Pagliara, S., Jacobsen, Jette, Chronakis, I. S., Nielsen, Hanne Mørck & Foderà, Vito, 2020, In: ACS Applied Nano Materials. 3, 2, p. 1910–1921Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Comparison of bulk and microfluidics methods for the formulation of poly-lactic-co-glycolic acid (PLGA) nanoparticles modified with cell-penetrating peptides of different architectures
Streck, S., Neumann, H., Nielsen, Hanne Mørck, Rades, Thomas & McDowell, A., Dec 2019, In: International Journal of Pharmaceutics: X. 1, 9 p., 100030.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The distribution of cell-penetrating peptides on polymeric nanoparticles prepared using microfluidics and elucidated with small angle X-ray scattering
Streck, S., Clulow, A. J., Nielsen, Hanne Mørck, Rades, Thomas, Boyd, B. J. & McDowell, A., 1 Nov 2019, In: Journal of Colloid and Interface Science. 555, p. 438-448 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Utilizing nanoparticles for improving anti-biofilm effects of azithromycin: A head-to-head comparison of modified hyaluronic acid nanogels and coated poly (lactic-co-glycolic acid) nanoparticles
Kłodzińska, S. N., Wan, F., Jumaa, H., Sternberg, C., Rades, Thomas & Nielsen, Hanne Mørck, 1 Nov 2019, In: Journal of Colloid and Interface Science. 555, p. 595-606 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mucoadhesive Electrospun Patch Delivery of Lidocaine to the Oral Mucosa and Investigation of Spatial Distribution in a Tissue Using MALDI-Mass Spectrometry Imaging
Clitherow, K. H., Murdoch, C., Spain, S. G., Handler, A. M., Colley, H. E., Stie, Mai Bay, Nielsen, Hanne Mørck, Janfelt, Christian, Hatton, P. V. & Jacobsen, Jette, Sep 2019, In: Molecular Pharmaceutics. 16, 9, p. 3948-3956Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Repurposing Azithromycin and Rifampicin Against Gram-Negative Pathogens by Combination With Peptidomimetics
Baker, K. R., Jana, B., Hansen, A. M., Nielsen, Hanne Mørck, Franzyk, Henrik & Guardabassi, Luca, 2 Jul 2019, In: Frontiers in Cellular and Infection Microbiology. 9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acids ‘generally recognized as safe’ affect morphology and biocompatibility of electrospun chitosan/polyethylene oxide nanofibers
Stie, Mai Bay, Jones, M., Sørensen, H. O., Jacobsen, Jette, Chronakis, I. S. & Nielsen, Hanne Mørck, 1 Jul 2019, In: Carbohydrate Polymers. 215, p. 253-262Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interaction of Laponite with Membrane Components-Consequences for Bacterial Aggregation and Infection Confinement
Malekkhaiat Häffner, S., Nyström, L., Browning, K. L., Nielsen, Hanne Mørck, Strömstedt, A. A., van der Plas, Mariena J.A., Schmidtchen, A. & Malmsten, Martin, 1 May 2019, In: A C S Applied Materials and Interfaces. 11, 17, p. 15389-15400 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Qualitative and quantitative analysis of the biophysical interaction of inhaled nanoparticles with pulmonary surfactant by using quartz crystal microbalance with dissipation monitoring
Wan, F., Nylander, T., Foged, Camilla, Yang, Mingshi, Baldursdottir, S. G. & Nielsen, Hanne Mørck, 1 Mar 2019, In: Journal of Colloid and Interface Science. 545, p. 162-171 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exploring the mucoadhesive behavior of sucrose acetate isobutyrate: a novel excipient for oral delivery of biopharmaceuticals
Rønholt, Stine, Fliervoet, L. A. L., Fano, M., Schmitt, M., Antopolski, M., Urtti, A. & Nielsen, Hanne Mørck, 1 Jan 2019, In: Drug Delivery. 26, 1, p. 532-541Research output: Contribution to journal › Journal article › Research › peer-review
- Published
19F-substituted amino acids as an alternative to fluorophore labels: monitoring of degradation and cellular uptake of analogues of penetratin by 19F NMR
Christensen, M. V., Kongstad, Kenneth Thermann, Sondergaard, T. E., Stærk, Dan, Nielsen, Hanne Mørck, Franzyk, Henrik & Wimmer, R., 2019, In: Journal of Biomolecular N M R. 73, p. 167-182Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antimicrobial Activity of α-Peptide/β-Peptoid Lysine-Based Peptidomimetics Against Colistin-Resistant Pseudomonas aeruginosa Isolated From Cystic Fibrosis Patients
Molchanova, N., Wang, H., Hansen, Paul Robert, Høiby, Niels, Nielsen, Hanne Mørck & Franzyk, Henrik, 2019, In: Frontiers in Microbiology. 10, 9 p., 275.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hyaluronic acid-based nanogels improve in vivo compatibility of the anti-biofilm peptide DJK-5
Kłodzińska, S. N., Pletzer, D., Rahanjam, N., Rades, Thomas, Hancock, R. E. W. & Nielsen, Hanne Mørck, 2019, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 20, 102022.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of capacity-limited binding on recombinant factor VIII and von Willebrand factor pharmacokinetics in hemophilia A rats
Vargas Christensen, I., Loftager, M., Rode, F., Nielsen, Hanne Mørck, Kreilgaard, M. & Larsen, M. S., 2019, In: Journal of Thrombosis and Haemostasis. 17, 6, p. 964-974 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipidoid-Polymer Hybrid Nanoparticles Loaded with TNF siRNA Suppress Inflammation after Intra-articular Administration in a Murine Experimental Arthritis Model
Jansen, M. A. A., Klausen, L. H., Thanki, K., Lyngsø, J., Skov Pedersen, J., Franzyk, Henrik, Nielsen, Hanne Mørck, van Eden, W., Dong, M., Broere, F., Foged, Camilla & Zeng, X., 2019, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 142, p. 38-48Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanistic profiling of the release kinetics of siRNA from lipidoid-polymer hybrid nanoparticles in vitro and in vivo after pulmonary administration
Thanki, K., van Eetvelde, D., Geyer, A., Fraire, J., Hendrix, R., Van Eygen, H., Putteman, E., Sami, H., de Souza Carvalho-Wodarz, C., Franzyk, Henrik, Nielsen, Hanne Mørck, Braeckmans, K., Lehr, C., Ogris, M. & Foged, Camilla, 2019, In: Journal of controlled release : official journal of the Controlled Release Society. 310, p. 82-93Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Microcontainers for oral insulin delivery - in vitro studies of permeation enhancement
Rune Jørgensen, J., Leth Jepsen, M., Hagner Nielsen, L., Dufva, M., Nielsen, Hanne Mørck, Rades, Thomas, Boisen, A. & Mullertz, Anette , 2019, In: European Journal of Pharmaceutics and Biopharmaceutics. 143, p. 98-105Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Non-aqueous topical compositions comprising a halogenated salicylanilide
Sommer, M., Li, P., Frandsen, C. H., Nielsen, Hanne Mørck, Priemel, P. A. & Rades, Thomas, 2019, Patent No. US20190151231A1Research output: Patent
- Published
Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators
Baker, K. R., Jana, B., Hansen, A. M., Vissing, K. J., Nielsen, Hanne Mørck, Franzyk, Henrik & Guardabassi, Luca, 2019, In: International Journal of Antimicrobial Agents. 53, p. 868-872 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Poly(ethylene carbonate)-containing polylactic acid microparticles with rifampicin improve drug delivery to macrophages
Priemel, P. A., Wang, Y., Bohr, A., Water, J. J., Yang, Mingshi & Nielsen, Hanne Mørck, Aug 2018, In: Journal of Pharmacy and Pharmacology. 70, 8, p. 1009-1021Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biopolymer nanogels improve antibacterial activity and safety profile of a novel lysine-based α-peptide/β-peptoid peptidomimetic
Kłodzińska, S. N., Molchanova, N., Franzyk, Henrik, Hansen, Paul Robert, Damborg, Peter Panduro & Nielsen, Hanne Mørck, Jul 2018, In: European Journal of Pharmaceutics and Biopharmaceutics. 128, p. 1-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design
de Groot, A. M., Thanki, K., Gangloff, M., Falkenberg, E., Zeng, X., van Bijnen, D. C. J., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck, Broere, F., Gay, N. J., Foged, Camilla & Sijts, A. J. A. M., 1 Jun 2018, In: Molecular Therapy - Nucleic Acids. 11, p. 159-169 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluation of drug permeation under fed state conditions using mucus-covered Caco-2 cell epithelium
Birch, D., Diedrichsen, Ragna Guldsmed, Christophersen, P. C., Mu, Huiling & Nielsen, Hanne Mørck, Jun 2018, In: European Journal of Pharmaceutical Sciences. 118, p. 144-153Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stereochemistry as a determining factor for the effect of a cell-penetrating peptide on cellular viability and epithelial integrity
Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 24 May 2018, In: Biochemical Journal. 475, 10, p. 1773-1788 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In Vitro ADME Properties of Two Novel Antimicrobial Peptoid-Based Compounds as Potential Agents against Canine Pyoderma
Greco, I., Hummel, B. D., Vasir, J., Watts, J. L., Koch, J., Hansen, J. E., Nielsen, Hanne Mørck, Damborg, Peter Panduro & Hansen, Paul Robert, 10 Mar 2018, In: Molecules. 23, 3, 15 p., 630.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipid shell-enveloped polymeric nanoparticles with high integrity of lipid shells improve mucus penetration and interaction with cystic fibrosis-related bacterial biofilms
Wan, F., Nylander, T., Klodzinska, S. N., Foged, Camilla, Yang, Mingshi, Baldursdottir, S. G. & Nielsen, Hanne Mørck, 23 Feb 2018, In: A C S Applied Materials and Interfaces. 10, 13, p. 10678–10687Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing
Liu, X., Nielsen, L. H., Klodzinska, S. N., Nielsen, Hanne Mørck, Qu, H., Christensen, L. P., Rantanen, Jukka & Yang, Mingshi, Feb 2018, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 123, p. 42-49Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Combining diagnostic methods for antimicrobial susceptibility testing – A comparative approach
Klodzinska, S. N., Priemel, P. A., Rades, Thomas & Nielsen, Hanne Mørck, Jan 2018, In: Journal of Microbiological Methods. 144, p. 177-185Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles
García-Díaz, M., Birch, D., Wan, F. & Nielsen, Hanne Mørck, Jan 2018, In: Advanced Drug Delivery Reviews. 124, p. 107-124Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cellular effects and delivery propensity of penetratin is influenced by conjugation to parathyroid hormone fragment 1-34 in synergy with pH
Kristensen, Mie, Nielsen, L. H., Zor, K., Boisen, A., Christensen, M. V., Berthelsen, J. & Nielsen, Hanne Mørck, 2018, In: Bioconjugate Chemistry. 29, 2, p. 371-381Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing
Nielsen, Hanne Mørck, 2018, In: European Journal of Pharmaceutics and Biopharmaceutics.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparative study of the drug delivery mechanism of L-penetratin and D-penetratin
Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 2018.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Fluorophore labeling of a cell-penetrating peptide significantly alters the mode and degree of biomembrane interaction
Hedegaard, S. F., Derbas, M. S., Lind, T. K., Kasimova, M. R., Christensen, M. V., Michaelsen, M. H., Campbell, R. A., Jørgensen, Lene, Franzyk, Henrik, Cárdenas, M. & Nielsen, Hanne Mørck, 2018, In: Scientific Reports. 8, 1, 14 p., 6327.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipid-polymer hybrid nanoparticles (LPNs) for efficient pulmonary delivery of nucleic acids: Lessons learnt from quality-by-design based optimization, immunogenicity studies, in vitro release experiments, in vivo biodistribution and efficacy studies
Thanki, K., Thakur, A., de Groot, A. M., Geyer, A., Fraire, J., Falkenberg, E., Van Eygen, H., Putteman, E., Van Bijnen, D. C. J., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, H., Broere, F., van Eden, W., Sijts, A. J. A. M., Ogris, M., Nielsen, H. M., Braeckmans, K. & 1 others, , 2018.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
The role of mucus as an invisible cloak to transepithelial drug delivery by nanoparticles
Nielsen, Hanne Mørck, 2018, In: Advanced Drug Delivery Reviews.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Animal models for evaluation of oral delivery of biopharmaceuticals
Rønholt, Stine, Nielsen, L. H. & Nielsen, Hanne Mørck, Dec 2017, In: Journal of Controlled Release. 268, p. 57-71 15 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
The impact of particle preparation methods and polymorphic stability of lipid excipients on protein distribution in microparticles
Liu, J., Christophersen, P. C., Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, Dec 2017, In: Drug Development and Industrial Pharmacy. 43, 12, p. 2032-2042 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Engineering of small interfering RNA-loaded lipidoid-poly(DL-lactic-co-glycolic acid) hybrid nanoparticles for highly efficient and safe gene silencing: A quality by design-based approach
Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Van Driessche, E., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, Nov 2017, In: European Journal of Pharmaceutics and Biopharmaceutics. 120, p. 22-33 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nanoparticle compositions comprising PLGA derivatives and a lipid for delivery of drugs, in particular nucleic acids, especially siRNA
Foged, Camilla, Franzyk, Henrik, Zeng, X., Nielsen, Hanne Mørck & Thanki, K., 21 Sep 2017, IPC No. A61K31/713, A61K47/18, A61K47/34, A61K9/51, A61P25/00, A61P29/00, A61P35/00, Patent No. WO2017158093-A1, 16 Mar 2017, Priority date 17 Mar 2016, Priority No. EP 2016-160931Research output: Patent
- Published
Innovative Methods and Applications in Mucoadhesion Research
Mackie, A. R., Goycoolea, F. M., Menchicchi, B., Caramella, C. M., Saporito, F., Lee, S., Stephansen, K., Chronakis, I. S., Hiorth, M., Adamczak, M., Waldner, M., Nielsen, Hanne Mørck & Marcelloni, L., Aug 2017, In: Macromolecular Bioscience. 17, 8, 32 p., 1600534.Research output: Contribution to journal › Review › Research › peer-review
- Published
Assessment of mucoadhesion using small deformation rheology revisited
Rønholt, Stine, Vissing, K. J. & Nielsen, Hanne Mørck, Apr 2017, In: Nordic Rheology Society Annual Transactions. 25, p. 63 7 p.Research output: Contribution to journal › Conference article › Research › peer-review
- Published
An approach to identify clinically relevan, non-toxic peptide-antimicrobial combinations that eliminate intrinsic resistance in Gram-negative pathogens
Baker, K. R., Jana, B., Nielsen, Hanne Mørck, Franzyk, Henrik & Guardabassi, Luca, 2017. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research
- Published
Efficient Pulmonary Delivery of siRNA Using Lipid-polymer Hybrid Nanoparticles (LPNs): A quality-by-design approach for highly systematic optimization of LPNs
Thanki, K., Zeng, X., Justesen, S., Tejlmann, S., Falkenberg, E., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.Research output: Contribution to conference › Poster › Research
- Published
Fluorophore labeling of a cell-penetrating peptide induces differential effects on its cellular distribution and affects cell viability
Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 2017, In: B B A - Biomembranes. 1859, 12, p. 2483-2494Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lysine-Based α-peptide/β-peptoid peptidomimetics: Influence of hydrophobicity, fluorination and distribution of cationic charge on antimicrobial activity and cytotoxicity
Molchanova, N., Hansen, Paul Robert, Damborg, Peter Panduro, Nielsen, Hanne Mørck & Franzyk, Henrik, 2017, In: ChemMedChem. 12, p. 312-318 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quality-by-design in nanomedicine: Highly systematic optimization of lipid-polymer hybrid nanoparticles for efficacious and safe intracellular delivery of cargo siRNA
Zeng, X., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.Research output: Contribution to conference › Conference abstract for conference › Research
- Published
Synthesis and Characterisation of an Array of Lipidoid Analogues for RNA Interference Therapy
Falkenberg, E., de Groot, A. M., Sijts, A. J. A. M., Thanki, K., Zeng, X., Nielsen, Hanne Mørck, Franzyk, Henrik & Foged, Camilla, 2017.Research output: Contribution to conference › Poster › Research
- 2016
- Published
Inhalable Antimicrobials for Treatment of Bacterial Biofilm-Associated Sinusitis in Cystic Fibrosis Patients: Challenges and Drug Delivery Approaches
Klodzinska, S. N., Priemel, P. A., Rades, Thomas & Nielsen, Hanne Mørck, 9 Oct 2016, In: International Journal of Molecular Sciences . 17, 10, 19 p., 1688.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of lipid-based drug delivery systems on the transport and uptake of insulin across Caco-2 Cell monolayers
Li, P., Nielsen, Hanne Mørck & Mullertz, Anette , Sep 2016, In: Journal of Pharmaceutical Sciences. 105, 9, p. 2743-51 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Delivery of siRNA Complexed with Palmitoylated α-Peptide/β-Peptoid Cell-Penetrating Peptidomimetics: Membrane Interaction and Structural Characterization of a Lipid-Based Nanocarrier System.
Jing, X., Foged, Camilla, Martin-Bertelsen, Birte, Yaghmur, Anan, Knapp, K. M., Malmsten, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 6 Jun 2016, In: Molecular Pharmaceutics. 13, 6, p. 1739-1749 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interactions between Surfactants in Solution and Electrospun Protein Fibers: Effects on Release Behavior and Fiber Properties
Stephansen, K., García-Díaz, M., Jessen, F., Chronakis, I. S. & Nielsen, Hanne Mørck, 7 Mar 2016, In: Molecular Pharmaceutics. 13, 3, p. 748-55 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell-Penetrating Peptides as Carriers for Oral Delivery of Biopharmaceuticals
Kristensen, Mie & Nielsen, Hanne Mørck, Feb 2016, In: Basic & Clinical Pharmacology & Toxicology Online. 118, 2, p. 99-106 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Applications and Challenges for Use of Cell-Penetrating Peptides as Delivery Vectors for Peptide and Protein Cargos
Kristensen, Mie, Birch, D. & Nielsen, Hanne Mørck, 30 Jan 2016, In: International Journal of Molecular Sciences . 17, 2, p. 1-17 17 p., 185.Research output: Contribution to journal › Review › Research › peer-review
- Published
Cell-penetrating peptides as tools to enhance non-injectable delivery of biopharmaceuticals
Kristensen, Mie & Nielsen, Hanne Mørck, 2016, In: Tissue Barriers. 4, 2, 15 p., e1178369.Research output: Contribution to journal › Review › Research › peer-review
- Published
Efficient Pulmonary Delivery of siRNA Using Lipid-Polymer Hybrid Nanoparticles (LPNs): Insights into Formulation, Transfection and In Vivo Biodistribution Using NIR-based Spatio-Temporal Tracking.
Thanki, K., Geyer, A., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, Henrik, Ogris, M., Nielsen, Hanne Mørck & Foged, Camilla, 2016.Research output: Contribution to conference › Poster › Research
Efficient Pulmonary Delivery of siRNA Using Lipid-Polymer Hybrid Nanoparticles (LPNs): Insights into Formulation, Transfection and In Vivo Biodistribution Using NIR-based Spatio-Temporal Tracking.
Thanki, K., Geyer, A., Zeng, X., Sami, H., Gehrig, S., Justesen, S., Franzyk, H., Ogris, M., Nielsen, Hanne Mørck & Foged, C., 2016.Research output: Contribution to conference › Poster › Research
- Published
Large-scale biophysical evaluation of protein PEGylation effects: in vitro properties of 61 protein entities
Vernet, E., Popa, G., Pozdnyakova, I., Rasmussen, J. E., Grohganz, Holger, Giehm, L., Jensen, M. H., Wang, H., Plesner, B., Nielsen, Hanne Mørck, Jensen, Knud Jørgen, Berthelsen, J., Sundström, M. & van de Weert, Marco, 2016, In: Molecular Pharmaceutics. 13, 5, p. 1587-1598 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quantification of pharmaceutical peptides in human plasma by LC-ICP-MS sulfur detection
Møller, L. H., Macherius, A., Hansen, Thomas Hesselhøj, Nielsen, Hanne Mørck, Cornett, Claus, Østergaard, Jesper, Stürup, Stefan & Gammelgaard, Bente, 2016, In: Journal of Analytical Atomic Spectrometry. 31, p. 1877-1884 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Soft hydrogels interpenetrating silicone – a polymer network for drug releasing medical devices
Steffensen, S. L., Merete H., V., Møller, E. H., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2016, In: Journal of Biomedical Materials Research. Part B: Applied Biomaterials. 104, 2, p. 402-410 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Antimicrobial activity of GN peptides and their mode of action
Godballe, T., Mojsoska, B., Nielsen, Hanne Mørck & Jenssen, H., 13 Dec 2015, In: Biopolymers. 106, 2, p. 172–183 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bioactive protein-based nanofibers interact with intestinal biological components resulting in transepithelial permeation of a therapeutic protein
Stephansen, K., García-Díaz, M., Jessen, F., Chronakis, I. S. & Nielsen, Hanne Mørck, 10 Nov 2015, In: International Journal of Pharmaceutics. 495, 1, p. 58-66 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Steric and interactive barrier properties of intestinal mucus elucidated by particle diffusion and peptide permeation
Bøgh, M., García-Díaz, M., Mullertz, Anette & Nielsen, Hanne Mørck, Sep 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 94, Part A, p. 136–143 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hyaluronic Acid-Based Nanogels Produced by Microfluidics-Facilitated Self-Assembly Improves the Safety Profile of the Cationic Host Defense Peptide Novicidin
Water, J. J., Kim, Y., Maltesen, M. J., Franzyk, Henrik, Foged, Camilla & Nielsen, Hanne Mørck, Aug 2015, In: Pharmaceutical Research. 32, 8, p. 2727-35 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conjugation of a cell-penetrating peptide to parathyroid hormone affects its structure, potency, and transepithelial permeation
Kristensen, Mie, de Groot, A. M., Berthelsen, J., Franzyk, Henrik, Sijts, A. & Nielsen, Hanne Mørck, 18 Mar 2015, In: Bioconjugate Chemistry. 26, p. 477-488 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanistic profiling of the siRNA delivery dynamics of lipid-polymer hybrid nanoparticles
Colombo, S., Cun, D., Remaut, K., Bunker, M., Zhang, J., Martin-Bertelsen, Birte, Yaghmur, Anan, Braeckmans, K., Nielsen, Hanne Mørck & Foged, Camilla, 10 Mar 2015, In: Journal of Controlled Release. 201, p. 22-31 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mucus as a Barrier to Drug Delivery: Understanding and Mimicking the Barrier Properties
Bøgh, M. & Nielsen, Hanne Mørck, Mar 2015, In: Basic & Clinical Pharmacology & Toxicology. 116, 3, p. 179-186 8 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Nanoparticle-mediated delivery of the antimicrobial peptide plectasin against Staphylococcus aureus in infected epithelial cells
Water, J. J., Smart, S., Franzyk, Henrik, Foged, Camilla & Nielsen, Hanne Mørck, 18 Feb 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 92, p. 65-73 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selenium as an alternative peptide label - comparison to fluorophore-labelled penetratin
Hyrup Møller, L., Bahnsen, J. S., Nielsen, Hanne Mørck, Østergaard, Jesper, Stürup, Stefan & Gammelgaard, Bente, 25 Jan 2015, In: European Journal of Pharmaceutical Sciences. 67, p. 76-84 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
End Group Modification: Efficient Tool for Improving Activity of Antimicrobial Peptide Analogues towards Gram-Positive Bacteria
Jahnsen, R. O., Sandberg-Schaal, A., Frimodt-Møller, N., Nielsen, Hanne Mørck & Franzyk, Henrik, 23 Jan 2015, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 95, Part A, p. 40–46 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Three-Dimensional Printing of Drug-Eluting Implants: Preparation of an Antimicrobial Polylactide Feedstock Material
Water, J. J., Bohr, A., Bøtker, Johan Peter, Aho, J., Sandler, N., Nielsen, Hanne Mørck & Rantanen, Jukka, 15 Jan 2015, In: Journal of Pharmaceutical Sciences. p. 1099–1107 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Investigation of protein distribution in solid lipid particles and its impact on protein release using coherent anti-Stokes Raman scattering microscopy
Christophersen, P. C., Birch, D., Saarinen, J., Isomäki, A., Nielsen, Hanne Mørck, Yang, Mingshi, Strachan, C. J. & Mu, Huiling, 10 Jan 2015, In: Journal of Controlled Release. 197, p. 111-120 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Carrier peptide-mediated transepithelial permeation of biopharmaceuticals: Effect of co-administration versus direct conjugation
Kristensen, Mie & Nielsen, Hanne Mørck, 2015.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections
Bahnsen, J. S., Franzyk, Henrik, Sayers, E. J., Jones, A. T. & Nielsen, Hanne Mørck, 2015, In: Pharmaceutical Research. 32, 5, p. 1546-56 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cell-penetrating peptides as carriers for transepithelial drug delivery in vitro
Rønholt, Stine, Kristensen, Mie & Nielsen, Hanne Mørck, 2015, Cell-penetrating peptides : Methods and Protocols. Langel, Ü. (ed.). Vol. 1324. p. 261-277 17 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Cell-penetrating peptides as carriers for transepithelial drug delivery in vitro
Rønholt, Stine, Kristensen, Mie & Nielsen, Hanne Mørck, 2015, In: Methods in Molecular Biology. 1324, p. 261-277 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of particulate drug delivery systems for oral delivery of Peptide and protein drugs
Christophersen, P. C., Fano, M., Saaby, Lasse, Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, 2015, In: Current Pharmaceutical Design. 21, 19, p. 2611-28 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Improved insulin loading in poly (lactic-co-glycolic) acid (PLGA) nanoparticles upon self-assembly with lipids
Garcia Diaz, M., Foged, Camilla & Nielsen, Hanne Mørck, 2015, In: International Journal of Pharmaceutics. 482, p. 84-91 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Intact penetratin metabolite permeates across Caco-2 monolayers
Birch, D., Christensen, M. V., Stærk, D., Franzyk, H. & Nielsen, Hanne Mørck, 2015.Research output: Contribution to conference › Poster › Research
- Published
Intact penetratin metabolite permeates across Caco-2 monolayers
Birch, D., Christensen, M. V., Stærk, Dan, Franzyk, Henrik & Nielsen, Hanne Mørck, 2015.Research output: Contribution to conference › Poster › Research
- Published
Investigation of skin permeation, ex vivo inhibition of venom-induced tissue destruction, and wound healing of African plants used against snakebites
Schmidt, M. M., Stærk, Dan, Nielsen, Hanne Mørck, Brandner, J. M., Diallo, D., Kusamba Zacharie, C., Van Staden, J. & Jäger, A., 2015, In: Journal of Ethnopharmacology. 165, p. 1-8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Penetratin-Mediated Transepithelial Insulin Permeation: Importance of Cationic Residues and pH for Complexation and Permeation
Kristensen, Mie, Franzyk, Henrik, Klausen, M. T., Iversen, A., Bahnsen, J. S., Skyggebjerg, R. B., Foderà, Vito & Nielsen, Hanne Mørck, 2015, In: A A P S Journal. 17, 5, p. 1200-1209 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Penetratin-Mediated Transepithelial Insulin Permeation: Importance of Cationic Residues and pH for Complexation and Permeation
Kristensen, M., Franzyk, H., Klausen, M. T., Iversen, A., Bahnsen, J. S., Skyggebjerg, R. B., Foderà, V. & Nielsen, Hanne Mørck, 2015, In: A A P S Journal. 17, 5, p. 1200-1209 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reversible tight junction modulation using an enterotoxin-derived peptide as enhancer for delivery of biopharmaceuticals across biobarriers
Kristensen, M. & Nielsen, Hanne Mørck, 2015.Research output: Contribution to conference › Poster › Research › peer-review
- Published
- Published
Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: Enhanced gene silencing and reduced adversed effects in vitro
Zeng, X., de Groot, A. M., Sijts, A., Blenke, E. O., Colombo, S., van Eden, W., Franzyk, Henrik, Nielsen, Hanne Mørck & Foged, Camilla, 2015, In: Nanoscale. 7, 46, p. 19687-19698 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sustained prevention of biofilm formation on a novel silicone matrix suitable for medical devices
Steffensen, S. L., Merete H., V., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 94, p. 305-311Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Self-nanoemulsifying drug delivery systems for oral insulin delivery: In vitro and in vivo evaluations of enteric coating and drug loading
Li, P., Tan, A., Prestidge, C. A., Nielsen, Hanne Mørck & Mullertz, Anette , 30 Dec 2014, In: International Journal of Pharmaceutics. 477, 1-2, p. 390-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Epithelial permeation and absorption mechanisms of biopharmaceuticals
Nielsen, Hanne Mørck, 1 Oct 2014, Mucosal Delivery of Biopharmaceuticals: Biology, Challenges and Strategies. Springer US, Vol. 9781461495246. p. 99-122 24 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
The surface charge of liposomal adjuvants is decisive for their interactions with the Calu-3 and A549 airway epithelial cell culture models
Ingvarsson, P. T., Rasmussen, I. S., Viaene, M., Irlik, P. J., Nielsen, Hanne Mørck & Foged, Camilla, Aug 2014, In: European Journal of Pharmaceutics and Biopharmaceutics. 87, 3, p. 480-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin
Christophersen, P. C., Vaghela, D., Mullertz, Anette , Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, Jul 2014, In: A A P S Journal. 16, 4, p. 875-83 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
AMP mimics with bactericidal activity against Staphylococci and Pseudomonas as novel drugs for topical use in veterinary medicine
Greco, I., Damborg, Peter Panduro, Guardabassi, Luca, Nielsen, Hanne Mørck & Hansen, Paul Robert, 4 Jun 2014.Research output: Contribution to conference › Poster › Research › peer-review
AMP mimics with bactericidal activity against Staphylococci and Pseudomonas as novel drugs for topical use in veterinary medicine
Greco, I., Damborg, P. P., Guardabassi, L., Nielsen, Hanne Mørck & Hansen, P. R., 4 Jun 2014.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Tailoring Cytotoxicity of Antimicrobial Peptidomimetics with High Activity against Multidrug-Resistant Escherichia coli
Jahnsen, R. D., Sandberg-Schaal, A., Vissing, K. J., Nielsen, Hanne Mørck, Frimodt-Møller, N. & Franzyk, Henrik, 20 Mar 2014, In: Journal of Medicinal Chemistry. 57, 7, p. 2864-2873Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid Lipid Particles for Oral Delivery of Peptide and Protein Drugs II - The Digestion of Trilaurin Protects Desmopressin from Proteolytic Degradation
Christophersen, P. C., Zhang, L., Mullertz, Anette , Nielsen, Hanne Mørck, Yang, Mingshi & Mu, Huiling, 13 Mar 2014, In: Pharmaceutical Research. 31, 9, p. 2420-28 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Property profiling of biosimilar mucus in a novel mucus-containing in vitro model for assessment of intestinal drug absorption
Bøgh, M., Baldursdóttir, S. G., Mullertz, Anette & Nielsen, Hanne Mørck, 8 Jan 2014, In: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 87, p. 227-235 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of PTH-CPP fusion peptides for oral delivery
Kristensen, Mie, Berthelsen, J. & Nielsen, Hanne Mørck, 2014.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Improving the safety profile of an antimicrobial peptide: Self-assembly into hydrogel nanoparticles using microfluidics
Water, J. J., Maltesen, M. J., Foged, C., Franzyk, H. & Nielsen, Hanne Mørck, 2014.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Improving the safety profile of an antimicrobial peptide: Self-assembly into hydrogel nanoparticles using microfluidics
Water, J. J., Maltesen, M. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2014.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Parathyroid hormone coupled to cell-penetrating peptides for oral delivery
Kristensen, Mie & Nielsen, Hanne Mørck, 2014.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Silicone embedded nanogels for prolonged resistance against biofilm formation
Steffensen, S. L., Vestergaard, M. H., Jensen, M. G., Alm, M., Franzyk, H. & Nielsen, Hanne Mørck, 2014.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Silicone embedded nanogels for prolonged resistance against biofilm formation
Steffensen, S. L., Vestergaard, M. H., Jensen, M. G., Alm, M., Franzyk, Henrik & Nielsen, Hanne Mørck, 2014.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Trilaurin diminishes food effect on the release of desmopressin from solid lipid microparticles
Christophersen, P., Vaghela, D., Mullertz, Anette , Yang, Mingshi, Nielsen, Hanne Mørck & Mu, Huiling, 2014.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Trilaurin diminishes food effect on the release of desmopressin from solid lipid microparticles
Christophersen, P., Vaghela, D., Müllertz, A., Yang, M., Nielsen, Hanne Mørck & Mu, H., 2014.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- 2013
- Published
Buccal delivery of metformin: TR146 cell culture model evaluating the use of bioadhesive chitosan discs for drug permeability enhancement
Sander, C., Nielsen, Hanne Mørck & Jacobsen, Jette, 31 Dec 2013, In: International Journal of Pharmaceutics. 458, 2, p. 254-61 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of spray dried bioadhesive metformin microparticles for oromucosal administration
Sander, C., Madsen, K. D., Hyrup, B., Nielsen, Hanne Mørck, Rantanen, Jukka & Jacobsen, Jette, Nov 2013, In: European Journal of Pharmaceutics and Biopharmaceutics. 85, 3 Pt A, p. 682-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design and characterization of core-shell mPEG-PLGA composite microparticles for development of cell-scaffold constructs
Wen, Y., Gallego, M. R., Nielsen, L. F., Jørgensen, Lene, Møller, E. H. & Nielsen, Hanne Mørck, Sep 2013, In: European Journal of Pharmaceutics and Biopharmaceutics. 85, 1, p. 87-98 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Solid lipid particles for oral delivery of peptide and protein drugs I - Elucidating the release mechanism of lysozyme during lipolysis
Christophersen, P. C. B., Zhang, L., Yang, Mingshi, Nielsen, Hanne Mørck, Mullertz, Anette & Mu, Huiling, 2 Aug 2013, In: European Journal of Pharmaceutics and Biopharmaceutics. 85, 3, part A, p. 473-480Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preparation and characterization of insulin-surfactant complexes for loading into lipid-based drug delivery systems
Li, P., Nielsen, Hanne Mørck, Fano, M. & Mullertz, Anette , Aug 2013, In: Journal of Pharmaceutical Sciences. 102, 8, p. 2689-98 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Peptide-peptoid hybrids active against methicillin-resistant Staphylococci and Pseudomonas aeruginosa
Greco, I., Damborg, P. P., Guardabassi, L., Nielsen, Hanne Mørck & Hansen, P. R., 7 Jul 2013.Research output: Contribution to conference › Poster › Research › peer-review
- Published
- Published
Engineering of an Inhalable DDA/TDB Liposomal Adjuvant: A Quality-by-Design Approach Towards Optimization of the Spray Drying Process
Ingvarsson, P. T., Yang, Mingshi, Mulvad, H., Nielsen, Hanne Mørck, Rantanen, Jukka & Foged, Camilla, 22 Jun 2013, In: Pharmaceutical Research. 30, 11, p. 2772-2784Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Designing CAF-adjuvanted dry powder vaccines: spray drying preserves the adjuvant activity of CAF01
Ingvarsson, P. T., Schmidt, S. T., Christensen, D., Larsen, N. B., Hinrichs, W. L. J., Andersen, P., Rantanen, Jukka, Nielsen, Hanne Mørck, Yang, Mingshi & Foged, Camilla, 8 Feb 2013, In: Journal of Controlled Release. 167, 3, p. 256-264Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluation of carrier-mediated siRNA delivery: lessons for the design of a stem-loop qPCR-based approach for quantification of intracellular full-length siRNA
Colombo, S., Nielsen, Hanne Mørck & Foged, Camilla, 11 Jan 2013, In: Journal of Controlled Release. 166, 3, p. 220-226 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Models to predict intestinal absorption of therapeutic peptides and proteins
Antunes, F., Andrade, F., Ferreira, D., Nielsen, Hanne Mørck & Sarmento, B., Jan 2013, In: Current Drug Metabolism. 14, 1, p. 4-20 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure
Bahnsen, J. S., Franzyk, Henrik, Sandberg-Schaal, A. & Nielsen, Hanne Mørck, 2013, In: B B A - Biomembranes. 1828, 2, p. 223-232 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Biologiske lægemidler - fra molekyle til medicin
Nielsen, Hanne Mørck, Foged, C., Jørgensen, L. & Frøkjær, S., 2013, In: Lægemiddelforskning. p. 12-14Research output: Contribution to journal › Journal article › Research
- Published
Biologiske lægemidler - fra molekyle til medicin
Nielsen, Hanne Mørck, Foged, Camilla, Jørgensen, Lene & Frøkjær, Sven, 2013, In: Lægemiddelforskning. p. 12-14Research output: Contribution to journal › Journal article › Research
- Published
Cell-penetrating Peptides Targeting Intracellular Infections
Bahnsen, J. S., Franzyk, Henrik, Sandberg-Schaal, A. & Nielsen, Hanne Mørck, 2013.Research output: Contribution to conference › Poster › Research › peer-review
Cell-penetrating Peptides Targeting Intracellular Infections
Bahnsen, J. S., Franzyk, H., Sandberg-Schaal, A. & Nielsen, Hanne Mørck, 2013.Research output: Contribution to conference › Poster › Research › peer-review
Development and rheological profiling of biosimilar mucus
Bøgh, M., Baldursdottir, S. G., Nielsen, M. H., Müllertz, A. & Nielsen, Hanne Mørck, 2013, In: Nordic Rheology Society Annual Transactions. 21, p. 233-240Research output: Contribution to journal › Conference article › Research › peer-review
- Published
Development and rheological profiling of biosimilar mucus
Bøgh, M., Baldursdottir, S. G., Nielsen, M. H., Mullertz, Anette & Nielsen, Hanne Mørck, 2013, In: Nordic Rheology Society Annual Transactions. 21, p. 233-240Research output: Contribution to journal › Conference article › Research › peer-review
- Published
Loading of an antimicrobial peptide into PLGA nanoparticles increases its efficacy against intracellular Staphylococcus aureus infection in the Calu-3 bronchial epithelial cell line
Water, J. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2013.Research output: Contribution to conference › Poster › Research › peer-review
Loading of an antimicrobial peptide into PLGA nanoparticles increases its efficacy against intracellular Staphylococcus aureus infection in the Calu-3 bronchial epithelial cell line
Water, J. J., Foged, C., Franzyk, H. & Nielsen, Hanne Mørck, 2013.Research output: Contribution to conference › Poster › Research › peer-review
Mucosal drug delivery: barriers, in vitro models and formulation strategies
Bøgh, M., Foged, C., Müllertz, A. & Nielsen, Hanne Mørck, 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 383-391Research output: Contribution to journal › Review › Research › peer-review
- Published
Mucosal drug delivery: barriers, in vitro models and formulation strategies
Bøgh, M., Foged, Camilla, Mullertz, Anette & Nielsen, Hanne Mørck, 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 383-391Research output: Contribution to journal › Review › Research › peer-review
- Published
Novel Silicone Composite for Prolonged Release of Antimicrobial Peptides
Steffensen, S. L., Møller, E. H., Franzyk, Henrik, Jensen, M. G., Alm, M. & Nielsen, Hanne Mørck, 2013.Research output: Contribution to conference › Poster › Research › peer-review
Novel Silicone Composite for Prolonged Release of Antimicrobial Peptides
Steffensen, S. L., Møller, E. H., Franzyk, H., Jensen, M. G., Alm, M. & Nielsen, Hanne Mørck, 2013.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Peptide-enhanced oral delivery of therapeutic peptides and proteins
Kristensen, Mie, Foged, Camilla, Berthelsen, J. & Nielsen, Hanne Mørck, 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 365-373 9 p.Research output: Contribution to journal › Review › Research › peer-review
Peptide-enhanced oral delivery of therapeutic peptides and proteins
Kristensen, M., Foged, C., Berthelsen, J. & Nielsen, Hanne Mørck, 2013, In: Journal of Drug Delivery Science and Technology. 23, 4, p. 365-373 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Vaccination i slimhinderne skal forhindre sygdomsfremkaldende mikroorganismer at nå ind i kroppen
Foged, Camilla, Ingvarsson, P. T., Follmann, F., Christensen, D. & Nielsen, Hanne Mørck, 2013, In: Lægemiddelforskning. 2013, p. 41-43Research output: Contribution to journal › Journal article › Research
Vaccination i slimhinderne skal forhindre sygdomsfremkaldende mikroorganismer at nå ind i kroppen
Foged, C., Ingvarsson, P. T., Follmann, F., Christensen, D. & Nielsen, Hanne Mørck, 2013, In: Lægemiddelforskning. 2013, p. 41-43Research output: Contribution to journal › Journal article › Research
- 2012
Cytotoxicity and in vivo efficacy of a novel antimicrobial peptoid against Staphylococcus pseudintermedius
Damborg, P. P., Skindersø, M. E., Hansen, P. R., Bahnsen, J. S., Nielsen, Hanne Mørck & Guardabassi, L., Aug 2012.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Cytotoxicity and in vivo efficacy of a novel antimicrobial peptoid against Staphylococcus pseudintermedius
Damborg, Peter Panduro, Skindersø, M. E., Hansen, Paul Robert, Bahnsen, J. S., Nielsen, Hanne Mørck & Guardabassi, Luca, Aug 2012.Research output: Contribution to conference › Poster › Research › peer-review
- Published
Comparison of polymeric siRNA nanocarriers in murine LPS-activated macrophage cell line: Gene silencing, toxicity and off-target gene expression
Jensen, L. B., Griger, J., Naeye, B., Varkouhi, A. K., Raemdonck, K., Schiffelers, R., Lammers, T., Storm, G., Smedt, S. C. D., Sproat, B. S., Nielsen, Hanne Mørck & Foged, Camilla, 2012, In: Pharmaceutical Research. 29, p. 669-682Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cyclodextrins: efficient biocompatible solubilizing excipients for bromhexine liquid and semi-solid drug delivery systems
Stojanov, M., Nielsen, Hanne Mørck & Larsen, K. L., 2012, In: International Journal of Pharmaceutics. 422, 1-2, p. 349-355Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Delivery of dermatan sulfate from polyelectrolyte complex-containing alginate composite microspheres for tissue regeneration
Wen, Y., Grøndahl, L., Gallego, M. R., Jørgensen, Lene, Møller, E. H. & Nielsen, Hanne Mørck, 2012, In: Biomacromolecules. 13, p. 905-917Research output: Contribution to journal › Journal article › Research › peer-review
Delivery of dermatan sulfate from polyelectrolyte complex-containing alginate composite microspheres for tissue regeneration
Wen, Y., Grøndahl, L., Gallego, M. R., Jørgensen, L., Møller, E. H. & Nielsen, Hanne Mørck, 2012, In: Biomacromolecules. 13, p. 905-917Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Design of an inhalable dry powder formulation of DOTAP-modified PLGA nanoparticles loaded with siRNA
Jensen, D. M. K., Jensen, L. B., Koocheki, S., Cun, D., Nielsen, Hanne Mørck, Foged, Camilla & Bengtson, L., 2012, In: Journal of Controlled Release. 157, 1, p. 141-148Research output: Contribution to journal › Journal article › Research › peer-review
Håb om at ramme latente bakterier i deres skjul
Bahnsen, J. S., Water, J. J., Foged, C., Franzyk, H. & Nielsen, Hanne Mørck, 2012, In: Lægemiddelforskning 2012. 2012, p. 12-14Research output: Contribution to journal › Journal article › Research
- Published
Håb om at ramme latente bakterier i deres skjul
Bahnsen, J. S., Water, J. J., Foged, Camilla, Franzyk, Henrik & Nielsen, Hanne Mørck, 2012, In: Lægemiddelforskning 2012. 2012, p. 12-14Research output: Contribution to journal › Journal article › Research
- Published
In vitro placental model optimization for nanoparticle transport studies
Cartwright, L., Poulsen, M. S., Nielsen, Hanne Mørck, Pojana, G., Knudsen, Lisbeth E., Saunders, M. & Rytting, E., 2012, In: International Journal of Nanomedicine (Print). 7, p. 497-510 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vitro placental model optimization for nanoparticle transport studies
Cartwright, L., Poulsen, M. S., Nielsen, Hanne Mørck, Pojana, G., Knudsen, Lisbeth E., Saunders, M. & Rytting, E., 2012, In: International Journal of Nanomedicine (Online). 7, p. 497-510Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MRI-assessed therapeutic effects of locally administered PLGA nanoparticles loaded with anti-inflammatory siRNA in a murine arthritis model
Te Boekhorst, B. C. M., Jensen, L. B., Colombo, S., Varkouhi, A. K., Schiffelers, R. M., Lammers, T., Storm, G., Nielsen, Hanne Mørck, Strijkers, G. J., Foged, Camilla & Nicolay, K., 2012, In: Journal of controlled release : official journal of the Controlled Release Society. 161, 3, p. 772-80 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Membrane adsorption and binding, cellular uptake and cytotoxicity of cell-penetrating peptidomimetics with α-peptide/β-peptoid backbone: effects of hydrogen bonding and α-chirality in the β-peptoid residues
Jing, X., Yang, M., Kasimova, M. R., Malmsten, M., Franzyk, Henrik, Jørgensen, Lene, Foged, Camilla & Nielsen, Hanne Mørck, 2012, In: BBA General Subjects. 1818, 11, p. 2660-2668 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oral delivery of peptides and proteins using lipid-based drug delivery systems
Li, P., Nielsen, Hanne Mørck & Mullertz, Anette , 2012, In: Expert Opinion on Drug Delivery. 9, 10, p. 1289-304 16 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Solid-phase route to Fmoc-protected cationic amino acid building blocks
Clausen, J. D., Linderoth, L., Nielsen, Hanne Mørck & Franzyk, Henrik, 2012, In: Amino Acids. 43, 4, p. 1633-41 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure of immune stimulating complex matrices and immune stimulating complexes in suspension determined by small-angle X-ray scattering
Pedersen, J. S., Oliveira, C. L. P. D., Madsen, H. B., Arleth, Lise, Manniche, S., Kirkby, N. & Nielsen, Hanne Mørck, 2012, In: Biophysical Journal. 102, 10, p. 2372-2380Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The antimicrobial and cell-penetrating effects of the CPP penetratin and derived analogues.
Bahnsen, J. S., Franzyk, Henrik & Nielsen, Hanne Mørck, 2012.Research output: Contribution to conference › Poster › Research
The antimicrobial and cell-penetrating effects of the CPP penetratin and derived analogues.
Bahnsen, J. S., Franzyk, H. & Nielsen, Hanne Mørck, 2012.Research output: Contribution to conference › Poster › Research
- 2011
- Published
Gendannelse af ødelagt væv med stamceller
Møller, E. H., Wen, Y. & Nielsen, Hanne Mørck, Dec 2011, In: Lægemiddelforskning. 2011, p. 13-15Research output: Contribution to journal › Journal article › Communication
Gendannelse af ødelagt væv med stamceller
Møller, E. H., Wen, Y. & Nielsen, Hanne Mørck, Dec 2011, In: Lægemiddelforskning. 2011, p. 13-15Research output: Contribution to journal › Journal article › Communication
Genetisk nanomedicin til behandling af leddegigt
Foged, C., Jensen, L. B. & Nielsen, Hanne Mørck, Dec 2011, In: Lægemiddelforskning. p. 7-9Research output: Contribution to journal › Journal article › Communication
- Published
Genetisk nanomedicin til behandling af leddegigt
Foged, Camilla, Jensen, L. B. & Nielsen, Hanne Mørck, Dec 2011, In: Lægemiddelforskning. p. 7-9Research output: Contribution to journal › Journal article › Communication
- Published
Development of biodegradable nanocomposite scaffolds for autologous cell therapy
Wen, Y., Gallego, M. R., Nielsen, L. F., Jørgensen, Lene, Everland, H., Møller, E. H. & Nielsen, Hanne Mørck, 1 Jan 2011, In: European Cells and Materials. 21, SUPPL.1, 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vitro penetration properties of solid lipid nanoparticles in intact and barrier-impaired skin
Jensen, L. B., Petersson, K. & Nielsen, Hanne Mørck, 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 79, 1, p. 68-75Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biodegradable nanocomposite microparticles as drug delivering injectable cell scaffolds
Wen, Y., Gallego, M. R., Nielsen, L. F., Jørgensen, Lene, Everland, H., Møller, E. H. & Nielsen, Hanne Mørck, 2011, In: Journal of Controlled Release. 156, 1, p. 11-20Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Elucidating the molecular mechanism of PAMAM-siRNA dendriplex self-assembly: Effect of dendrimer charge density
Jensen, L. B., Pavan, G. M., Kasimova, M. R., Rutherford, S., Danani, A., Nielsen, Hanne Mørck & Foged, Camilla, 2011, In: International Journal of Pharmaceutics. 416, 2, p. 410-418Research output: Contribution to journal › Journal article › Research › peer-review
High loading efficiency and sustained release of siRNA encapsulated in PLGA nanoparticles: quality by design optimization and characterization
Cun, D., Jensen, D. M. K., Maltesen, M. J., Bunker, M., Whitside, P., Scurr, D., Foged, C. & Nielsen, Hanne Mørck, 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 77, 1, p. 26-35Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High loading efficiency and sustained release of siRNA encapsulated in PLGA nanoparticles: quality by design optimization and characterization
Cun, D., Jensen, D. M. K., Maltesen, M. J., Bunker, M., Whitside, P., Scurr, D., Foged, Camilla & Nielsen, Hanne Mørck, 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 77, 1, p. 26-35Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Immunity by formulation design: induction of high CD8+ T-cell responses by poly (I:C) incorporated into the CAF01 adjuvant via a double emulsion method
Nordly, P. J., Rose, F., Christensen, D., Nielsen, Hanne Mørck, Andersen, P., Agger, E. M. & Foged, Camilla, 2011, In: Journal of Controlled Release. 150, 3, p. 307-317Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In vivo clearance and metabolism of recombinant activated factor VII (rFVIIa) and its complexes with plasma protease inhibitors in the liver
Johansen, T. S., Appa, R. S., Christensen, E. I., Ioannou, Y. A., Krogh, T. N., Karpf, D. M. & Nielsen, Hanne Mørck, 2011, In: Thrombosis Research. 127, 4, p. 356-362Research output: Contribution to journal › Journal article › Research › peer-review
In vivo clearance and metabolism of recombinant activated factor VII (rFVIIa) and its complexes with plasma protease inhibitors in the liver
Johansen, T. S., Appa, R. S., Christensen, E. I., Ioannou, Y. A., Krogh, T. N., Karpf, D. M. & Nielsen, Hanne Mørck, 2011, In: Thrombosis Research. 127, 4, p. 356-362Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Incorporation of a synthetic mycobacterial monomycoloyl glycerol analogue stabilizes dimethyldioctadecylammonium liposomes and potentiates their adjuvant effect in vivo
Nordly, P. J., Korsholm, K. S., Pedersen, E. A., Khilji, T. S., Franzyk, Henrik, Jørgensen, Lene, Nielsen, Hanne Mørck, Agger, E. M. & Foged, Camilla, 2011, In: European Journal of Pharmaceutics and Biopharmaceutics. 77, 1, p. 89-98Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Incorporation of the TLR4 agonist monophosphoryl lipid A into the bilayer of DDA/DTDB liposomes : physico-chemical characterization and induction of CD8+ T-Cell responses in vivo
Nordly, P. J., Agger, E. M., Andersen, P., Nielsen, Hanne Mørck & Foged, Camilla, 2011, In: Pharmaceutical Research. 28, 3, p. 553-562Research output: Contribution to journal › Journal article › Research › peer-review
On the temperature dependence of complex formation between chitosan and proteins
Kasimova, M. R., Valázquez-Campoy, A. & Nielsen, Hanne Mørck, 2011, In: Biomacromolecules. 12, 7, p. 2534-2543Research output: Contribution to journal › Journal article › Research › peer-review
- Published
On the temperature dependence of complex formation between chitosan and proteins
Kasimova, M. R., Valázquez-Campoy, A. & Nielsen, Hanne Mørck, 2011, In: Biomacromolecules. 12, 7, p. 2534-2543Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stabilization of liposomes during drying
Ingvarsson, P. Þ., Yang, Mingshi, Nielsen, Hanne Mørck, Rantanen, Jukka & Foged, Camilla, 2011, In: Expert Opinion on Drug Delivery. 8, 3, p. 375-388Research output: Contribution to journal › Review › Research
Stabilization of liposomes during drying
Ingvarsson, P. Þ., Yang, M., Nielsen, Hanne Mørck, Rantanen, J. T. & Foged, C., 2011, In: Expert Opinion on Drug Delivery. 8, 3, p. 375-388Research output: Contribution to journal › Review › Research
- 2010
- Published
Molecular Characterization of the Interaction between siRNA and PAMAM G7 Dendrimers by SAXS, ITC, and Molecular Dynamics Simulations
Jensen, L. B., Mortensen, Kell, Pavan, G. M., Kasimova, M. R., Jensen, D. K., Gadzhyeva, V., Nielsen, Hanne Mørck & Foged, Camilla, Dec 2010, In: Biomacromolecules. 11, 12, p. 3571-3577Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Investigation of the interaction between modified ISCOMs and stratum corneum lipid model systems
Madsen, H. B., Arboe-Andersen, H. M., Rozlosnik, N., Madsen, F., Ifversen, P., Kasimova, M. R. & Nielsen, Hanne Mørck, Sep 2010, In: Biochimica et biophysica acta. 1798, 9, p. 1779-89 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antimicrobial, hemolytic, and cytotoxic activities of β-peptoid- peptide hybrid oligomers: Improved properties compared to natural AMPs (ChemBioChem (2010) 11, (152-160))
Olsen, Christian Adam, Ziegler, H. L., Nielsen, Hanne Mørck, Frimodt-Møller, N., Jaroszewski, J. W. & Franzyk, Henrik, 16 Aug 2010, In: ChemBioChem. 11, 12, 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
A synthetic mycobacterial monomycoloyl glycerol analogue stabilizes DDA liposomes
Nordly, P. J., Pedersen, E. A., Khiljii, T. S., Agger, E. M., Jørgensen, Lene, Nielsen, Hanne Mørck, Korsholm, K. S., Franzyk, Henrik & Foged, Camilla, 2010, In: CRS Newsletter. 27, 2, p. 12 14 p.Research output: Contribution to journal › Journal article › Research
- Published
Antimicrobial, hemolytic, and cytotoxic activities of ß-peptoid-peptide hybrid oligomers: Improved properties compared to natural AMPs
Olsen, Christian Adam, Ziegler, H. L., Nielsen, Hanne Mørck, Frimodt-Møller, N., Jaroszewski, J. W. & Franzyk, Henrik, 2010, In: ChemBioChem. 11, 10, p. 1356-1360Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CAF01 liposomes as a mucosal vaccine adjuvant: In vitro and in vivo investigations
Christensen, D., Foged, Camilla, Rosenkrands, I., Lundberg, C. V., Andersen, P., Agger, E. M. & Nielsen, Hanne Mørck, 2010, In: Internation Journal of Pharmaceutics. 390, p. 19-24Research output: Contribution to journal › Journal article › Research › peer-review
Cell-penetrating peptides for cytosolic delivery of biomacromolecules
Foged, C., Jing, X. & Nielsen, Hanne Mørck, 2010, Organelle-specific pharmaceutical nanotechnology. Weissig, V. & D'Souza, G. G. M. (eds.). Hoboken: Wiley, p. 403-432Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Cell-penetrating peptides for cytosolic delivery of biomacromolecules
Foged, Camilla, Jing, X. & Nielsen, Hanne Mørck, 2010, Organelle-specific pharmaceutical nanotechnology. Weissig, V. & D'Souza, G. G. M. (eds.). Hoboken: Wiley, p. 403-432Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
Cellular and intracellular distribution of recombinant activated factor VII in the rat liver
Johansen, T. S., Nielsen, Hanne Mørck, Christensen, E. I. & Appa, R. S., 2010, In: Thrombosis and Haemostasis. 103, 4, p. 860-862Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cellular and intracellular distribution of recombinant activated factor VII in the rat liver
Johansen, T. S., Nielsen, Hanne Mørck, Christensen, E. I. & Appa, R. S., 2010, In: Thrombosis and Haemostasis. 103, 4, p. 860-862Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Corticosteroid solubility and lilpid polarity control release from solid lipid nanoparticles
Jensen, L. B., Magnusson, E., Gunnarsson, L., Vermehren, C., Nielsen, Hanne Mørck & Petersson, K., 2010, In: Internation Journal of Pharmaceutics. 390, 1, p. 53-60Research output: Contribution to journal › Journal article › Research › peer-review
Influence of skin barrier on in-vitro penetration properties of solid lipid nanoparticles
Jensen, L. B., Nielsen, Hanne Mørck & Petersson, K., 2010, In: Journal of Pharmacy and Pharmacology. p. 793-794Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Influence of skin barrier on in-vitro penetration properties of solid lipid nanoparticles
Jensen, L. B., Nielsen, Hanne Mørck & Petersson, K., 2010, In: Journal of Pharmacy and Pharmacology. p. 793-794Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Investigation of the interaction between modified ISCOMs and stratum corneum lipid model systems
Madsen, H. B., Arboe-Andersen, H. M., Rozlosnik, N., Madsen, F., Ifversen, P., Kasimova, M. R. & Nielsen, Hanne Mørck, 2010, In: Biochimica et Biophysica Acta - Biomembranes. 1798, p. 1779-1789Research output: Contribution to journal › Journal article › Research › peer-review
Investigation of the interaction between modified ISCOMs and stratum corneum lipid model systems
Madsen, H. B., Arboe-Andersen, H. M., Rozlosnik, N., Madsen, F., Ifversen, P., Kasimova, M. R. & Nielsen, Hanne Mørck, 2010, In: Biochimica et Biophysica Acta - Biomembranes. 1798, p. 1779-1789Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Issues in Development of Biodrug Delivery Systems
Jørgensen, Lene, Frøkjær, Sven & Nielsen, Hanne Mørck, 2010, Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development. Morishita, M. & Park, K. (eds.). 1 ed. Informa Healthcare, p. 13-25Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Issues in development of biodrug delivery systems
Jørgensen, Lene, Frøkjær, Sven & Nielsen, Hanne Mørck, 2010, Biodrug delivery systems: fundamentals, applications and clinical development. Morishita, M. & Park, K. (eds.). New York: Informa Healthcare, p. 13-25Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
Kan nanopartikler bruges i behandlingen af hudsygdomme?
Jensen, L. B., Knudsen, N. Ø., Foged, C. & Nielsen, Hanne Mørck, 2010, In: Lægemiddelforskning. 2010, p. 10-12Research output: Contribution to journal › Journal article › Communication
- Published
Kan nanopartikler bruges i behandlingen af hudsygdomme?
Jensen, L. B., Knudsen, N. Ø., Foged, Camilla & Nielsen, Hanne Mørck, 2010, In: Lægemiddelforskning. 2010, p. 10-12Research output: Contribution to journal › Journal article › Communication
- Published
Microcalorimetric and spectroscopic studies on the mechanism of interaction between novel peptidomimetics and lipid bilayers
Nielsen, Hanne Mørck, Jing, X., Simonsen, A., Kasimova, M. R., Malmsten, M., Franzyk, Henrik & Foged, Camilla, 2010, In: Journal of Peptide Science. 16, s1, p. 151 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
Microcalorimetric and spectroscopic studies on the mechanism of interaction between novel peptidomimetics and lipid bilayers
Nielsen, Hanne Mørck, Jing, X., Simonsen, A., Kasimova, M. R., Malmsten, M., Franzyk, H. & Foged, C., 2010, In: Journal of Peptide Science. 16, s1, p. 151 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Microcalorimetric and spectroscopic studies on the mechanism of interaction between novel peptoids and lipid bilayers - effect of length, charge and N-terminal end group
Jing, X., Simonsen, A. H., Kasimova, M. R., Franzyk, Henrik, Foged, Camilla & Nielsen, Hanne Mørck, 2010, In: Drug Discovery Today. 15, 23/24, p. 1109Research output: Contribution to journal › Conference abstract in journal › Research
Microcalorimetric and spectroscopic studies on the mechanism of interaction between novel peptoids and lipid bilayers - effect of length, charge and N-terminal end group
Jing, X., Simonsen, A. H., Kasimova, M. R., Franzyk, H., Foged, C. & Nielsen, Hanne Mørck, 2010, In: Drug Discovery Today. 15, 23/24, p. 1109Research output: Contribution to journal › Conference abstract in journal › Research
Modulation of the adjuvant activity of DDA/TDB liposomes with immunostimulators
Nordly, P. J., Foged, C., Christensen, D., Lindenstrøm, T., Nielsen, Hanne Mørck & Agger, E., 2010.Research output: Contribution to conference › Poster › Research
- Published
Modulation of the adjuvant activity of DDA/TDB liposomes with immunostimulators
Nordly, P. J., Foged, Camilla, Christensen, D., Lindenstrøm, T., Nielsen, Hanne Mørck & Agger, E., 2010.Research output: Contribution to conference › Poster › Research
- Published
Molecular characterization of the interaction between siRNA and PAMAM G7 dendrimers by SAXS, ITC, and molecular dynamics simultations
Jensen, L. B., Mortensen, Kell, Pavan, G. M., Kasimova, M. R., Jensen, D. K., Gadzhyeva, V., Nielsen, Hanne Mørck & Foged, Camilla, 2010, In: Biomacromolecules. 11, 12, p. 3571-3577Research output: Contribution to journal › Journal article › Research › peer-review
Molecular characterization of the interaction between siRNA and PAMAM G7 dendrimers by SAXS, ITC, and molecular dynamics simultations
Jensen, L. B., Mortensen, K., Pavan, G. M., Kasimova, M. R., Jensen, D. K., Gadzhyeva, V., Nielsen, Hanne Mørck & Foged, C., 2010, In: Biomacromolecules. 11, 12, p. 3571-3577Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preparation and characterization of poly (DL-lactide-co-glycolide) nanoparticles for siRNA delivery
Cun, D., Foged, Camilla, Yang, Mingshi, Frøkjær, Sven & Nielsen, Hanne Mørck, 2010, In: Internation Journal of Pharmaceutics. 390, 1, p. 70-75Research output: Contribution to journal › Journal article › Research › peer-review
Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation
Jensen, D. M. K., Cun, D., Maltesen, M. J., Frøkjær, S., Nielsen, Hanne Mørck & Foged, C., 2010, In: Journal of Controlled Release. 142, p. 138-145Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Spray drying of siRNA-containing PLGA nanoparticles intended for inhalation
Jensen, D. M. K., Cun, D., Maltesen, M. J., Frøkjær, Sven, Nielsen, Hanne Mørck & Foged, Camilla, 2010, In: Journal of Controlled Release. 142, p. 138-145Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Studies towards improved cell-penetrating peptide-promoted macromolecular drug delivery
Dahlqvist Clausen, J. A., Linderoth, L., Andersen, R. B., Franzyk, Henrik & Nielsen, Hanne Mørck, 2010, In: Drug Discovery Today. 15, 23-24, p. 1109 1 p., A81.Research output: Contribution to journal › Conference abstract in journal › Research
Studies towards improved stability and permeability of a cell-penetrating peptide
Dahlqvist Clausen, J. A., Linderoth, L., Andersen, R. B., Franzyk, H. & Nielsen, Hanne Mørck, 2010, In: Journal of Peptide Science. 16, p. 148 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Studies towards improved stability and permeability of a cell-penetrating peptide
Dahlqvist Clausen, J. A., Linderoth, L., Andersen, R. B., Franzyk, Henrik & Nielsen, Hanne Mørck, 2010, In: Journal of Peptide Science. 16, p. 148 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
The unsialylated subpopulation of recombinant activated factor VII binds to the asialo-glycoprotein receptor (ASGPR) on primary rat hepatocytes
Johansen, T. S., Nielsen, Hanne Mørck, Christensen, E. I. & Appa, R. S., 2010, In: Thrombosis and Haemostasis. 104, 6, p. 1166-1173Research output: Contribution to journal › Journal article › Research › peer-review
The unsialylated subpopulation of recombinant activated factor VII binds to the asialo-glycoprotein receptor (ASGPR) on primary rat hepatocytes
Johansen, T. S., Nielsen, Hanne Mørck, Christensen, E. I. & Appa, R. S., 2010, In: Thrombosis and Haemostasis. 104, 6, p. 1166-1173Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Challenges in Delivery of Biopharmaceuticals; the Need for Advanced Delivery Systems
Nielsen, Hanne Mørck & Jørgensen, Lene, 11 Dec 2009, Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines. John Wiley & Sons, Ltd, p. 1-8 8 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
In Vitro cutaneous application of ISCOMs on human skin enhances delivery of hydrophobic model compounds through the stratum corneum
Madsen, H. B., Ifversen, P., Madsen, F., Larsen, Birger Brodin, Hausser, I. & Nielsen, Hanne Mørck, 2009, In: The AAPS Journal. 11, 4, p. 728-739Research output: Contribution to journal › Journal article › Research › peer-review
In Vitro cutaneous application of ISCOMs on human skin enhances delivery of hydrophobic model compounds through the stratum corneum
Madsen, H. B., Ifversen, P., Madsen, F., Larsen, B. B., Hausser, I. & Nielsen, Hanne Mørck, 2009, In: The AAPS Journal. 11, 4, p. 728-739Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biotechnology-based pharmaceuticals
Jørgensen, Lene, Nielsen, Hanne Mørck & Frøkjær, Sven, 2009, Modern pharmaceutics: applications and advances. Florence, A. T. & Siepmann, J. (eds.). 5 ed. New York: Informa Healthcare, Vol. 2. p. 259-293 (Drugs and the Pharmaceutical Sciences, Vol. 188).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
Biotechnology-based pharmaceuticals
Jørgensen, L., Nielsen, Hanne Mørck & Frøkjær, S., 2009, Modern pharmaceutics: applications and advances. Florence, A. T. & Siepmann, J. (eds.). 5 ed. New York: Informa Healthcare, Vol. 2. p. 259-293 (Drugs and the Pharmaceutical Sciences, Vol. 188).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Delivery technologies for biopharmaceuticals: Peptides, proteins, nucleic acids and vaccines
Jørgensen, Lene & Nielsen, Hanne Mørck, 2009, Wiley. 413 p.Research output: Book/Report › Book › Research › peer-review
Delivery technologies for biopharmaceuticals: Peptides, proteins, nucleic acids and vaccines
Jørgensen, L. & Nielsen, Hanne Mørck, 2009, Wiley. 413 p.Research output: Book/Report › Book › Research › peer-review
- Published
Innovativt nanopartikeldesign bag skræddersyede vacciner
Nordly, P. J., Agger, E. M., Nielsen, Hanne Mørck & Foged, Camilla, 2009, In: Lægemiddelforskning. p. 19-21Research output: Contribution to journal › Journal article › Research
Innovativt nanopartikeldesign bag skræddersyede vacciner
Nordly, P. J., Agger, E. M., Nielsen, Hanne Mørck & Foged, C., 2009, In: Lægemiddelforskning. p. 19-21Research output: Contribution to journal › Journal article › Research
Status and future prospects of lipid-based particulate delivery systems as vaccine adjuvants and their combination with immunostimulators
Nordly, P. J., Madsen, H. B., Nielsen, Hanne Mørck & Foged, C., 2009, In: Expert Opinion on Drug Delivery. 6, 7, p. 1-16Research output: Contribution to journal › Review › Research
- Published
Status and future prospects of lipid-based particulate delivery systems as vaccine adjuvants and their combination with immunostimulators
Nordly, P. J., Madsen, H. B., Nielsen, Hanne Mørck & Foged, Camilla, 2009, In: Expert Opinion on Drug Delivery. 6, 7, p. 1-16Research output: Contribution to journal › Review › Research
- 2008
- Published
Cell-penetrating peptides for drug delivery across membrane barriers
Foged, Camilla & Nielsen, Hanne Mørck, 2008, In: Expert Opinion on Drug Delivery. 5, 1, p. 105-17 12 p.Research output: Contribution to journal › Review › Research
- Published
Cellular uptake and membrane-destabilising properties of a-peptide/ß-peptoid chimeras: lessons for the design of new cell-penetrating peptides
Foged, Camilla, Franzyk, Henrik, Bahrami, S., Frøkjær, Sven, Jaroszewski, J. W., Nielsen, Hanne Mørck & Olsen, Christian Adam, 2008, In: BBA General Subjects. 1778, 11, p. 2487-2495Research output: Contribution to journal › Journal article › Research › peer-review
Dendritiske nanostrukturer som transportører af genestisk medicin
Jensen, L. B., Nielsen, Hanne Mørck & Foged, C., 2008, In: Lægemiddelforskning. p. 13-15Research output: Contribution to journal › Journal article › Communication
- Published
Dendritiske nanostrukturer som transportører af genestisk medicin
Jensen, L. B., Nielsen, Hanne Mørck & Foged, Camilla, 2008, In: Lægemiddelforskning. p. 13-15Research output: Contribution to journal › Journal article › Communication
Metabolic cleavage and translocation efficiency of selected cell penetrating peptides: A comparative study with epithelial cell cultures
Foerg, C., Weller, K. M., Rechsteiner, H., Nielsen, Hanne Mørck, Fernandez-Carneado, J., Brunisholz, R., Giralt, E. & Merkle, H. P., 2008, In: The AAPS Journal. 10, 2, p. 349-359Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolic cleavage and translocation efficiency of selected cell penetrating peptides: A comparative study with epithelial cell cultures
Foerg, C., Weller, K. M., Rechsteiner, H., Nielsen, Hanne Mørck, Fernandez-Carneado, J., Brunisholz, R., Giralt, E. & Merkle, H. P., 2008, In: The AAPS Journal. 10, 2, p. 349-359Research output: Contribution to journal › Journal article › Research › peer-review
- Published
NIR transmission spectroscopy for rapid determination of lipid and lyoprotector content in liposomal vaccine adjuvant system CAF01
Christensen, D., Allesø, M., Rosenkrands, I., Rantanen, Jukka, Foged, Camilla, Agger, E. M., Andersen, P. & Nielsen, Hanne Mørck, 2008, In: European Journal of Pharmaceutics and Biopharmaceutics. 70, 3, p. 914-920Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polymeric nanocarriers for siRNA delivery: challenges and future prospects
Cun, D., Jensen, L. B., Nielsen, Hanne Mørck, Moghimi, S. M. & Foged, Camilla, 2008, In: Journal of Biomedical Nanotechnology. 4, 3, p. 258-275Research output: Contribution to journal › Review › Research
Polymeric nanocarriers for siRNA delivery: challenges and future prospects
Cun, D., Jensen, L. B., Nielsen, Hanne Mørck, Moghimi, S. M. & Foged, C., 2008, In: Journal of Biomedical Nanotechnology. 4, 3, p. 258-275Research output: Contribution to journal › Review › Research
- Published
a, a´- trehalose 6,6´- dibehenate in non-phospholipid-based liposomes enables direct interaction with trehalose, offering stability during freeze-drying
Christensen, D., Kirby, D., Foged, Camilla, Agger, E. M., Andersen, P., Perrie, Y. & Nielsen, Hanne Mørck, 2008, In: Biochimica et Biophysica Acta - Biomembranes. 1778, 5, p. 1365-1373Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Farvel til sprøjten: udvikling af vaccineplaster med nanopartikler
Madsen, H. B., Ifversen, P., Madsen, F., Manniche, S. & Nielsen, Hanne Mørck, 2007, In: Lægemiddelforskning. p. 12-13Research output: Contribution to journal › Journal article › Communication
Farvel til sprøjten: udvikling af vaccineplaster med nanopartikler
Madsen, H. B., Ifversen, P., Madsen, F., Manniche, S. & Nielsen, Hanne Mørck, 2007, In: Lægemiddelforskning. p. 12-13Research output: Contribution to journal › Journal article › Communication
- Published
Liposomes for phospholipase A2 triggered siRNA release: preparation and in vitro test
Foged, Camilla, Nielsen, Hanne Mørck & Frøkjær, Sven, 2007, In: Internation Journal of Pharmaceutics. 331, 2, p. 160-166Research output: Contribution to journal › Journal article › Research › peer-review
Phospholipase A2 sensitive liposomes for delivery of small interfering RNA (siRNA)
Foged, C., Nielsen, Hanne Mørck & Frøkjær, S., 2007, In: Journal of Liposome Research. 17, 3-4Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phospholipase A2 sensitive liposomes for delivery of small interfering RNA (siRNA)
Foged, Camilla, Nielsen, Hanne Mørck & Frøkjær, Sven, 2007, In: Journal of Liposome Research. 17, 3-4Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Trehalose preserves DDA/TDB liposomes and their adjuvant effect during freeze-drying
Christensen, D., Foged, Camilla, Rosenkrands, I., Nielsen, Hanne Mørck, Andersen, P. & Agger, E. M., 2007, In: BBA General Subjects. 1768, 9, p. 2120-2129Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Cellular uptake but low permeation of human calcitonin-derived cell penetrating peptides and Tat(47-57) through well-differentiated epithelial models
Tréhin, R., Krauss, U., Beck-Sickinger, A. G., Merkle, H. P. & Nielsen, Hanne Mørck, 2004, In: Pharmaceutical Research. 21, 7, p. 1248-56 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of oil-in-water emulsions on 5-aminolevulinic acid uptake and metabolism to PpIX in cultured MCF-7 cells
Nielsen, Hanne Mørck, Aemisegger, C., Burmeister, G., Schuchter, U. & Gander, B., 2004, In: Pharmaceutical Research. 21, 12, p. 2253-60 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluation of different toxicity assays applied to proliferating cells and to stratified epithelium in relation to permeability enhancement with glycocholate
Eirheim, H. U., Bundgaard, C. & Nielsen, Hanne Mørck, 2004, In: Toxicology in Vitro. 18, 5, p. 649-57 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metabolic cleavage of cell-penetrating peptides in contact with epithelial models: human calcitonin (hCT)-derived peptides, Tat(47-57) and penetratin(43-58)
Tréhin, R., Nielsen, Hanne Mørck, Jahnke, H., Krauss, U., Beck-Sickinger, A. G. & Merkle, H. P., 2004, In: Biochemical Journal. 382, Pt 3, p. 945-56 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
Nicotine permeability across the buccal TR146 cell culture model and porcine buccal mucosa in vitro: effect of pH and concentration
Nielsen, Hanne Mørck & Rassing, M. R., 2002, In: European Journal of Pharmaceutical Sciences. 16, 3, p. 151-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The potential of chitosan in enhancing peptide and protein absorption across the TR146 cell culture model-an in vitro model of the buccal epithelium
Portero, A., Remuñán-López, C. & Nielsen, Hanne Mørck, 2002, In: Pharmaceutical Research. 19, 2, p. 169-74 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
- Published
TR146 cells grown on filters as a model of human buccal epithelium: IV. Permeability of water, mannitol, testosterone and beta-adrenoceptor antagonists. Comparison to human, monkey and porcine buccal mucosa
Nielsen, H. M., Rassing, M. R. & Nielsen, Hanne Mørck, 2000, In: International Journal of Pharmaceutics. 194, 2, p. 155-67 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TR146 cells grown on filters as a model of human buccal epithelium: V. Enzyme activity of the TR146 cell culture model, human buccal epithelium and porcine buccal epithelium, and permeability of leu-enkephalin
Mørck Nielsen, H., Rømer Rassing, M. & Nielsen, Hanne Mørck, 2000, In: International Journal of Pharmaceutics. 200, 2, p. 261-70 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
- Published
TR146 cells grown on filters as a model of human buccal epithelium: III. Permeability enhancement by different pH values, different osmolality values, and bile salts
Nielsen, Hanne Mørck & Rassing, M. R., 1999, In: International Journal of Pharmaceutics. 185, 2, p. 215-25 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TR146 cells grown on filters as a model of human buccal epithelium: permeability of fluorescein isothiocyanate-labelled dextrans in the presence of sodium glycocholate
Nielsen, Hanne Mørck, Verhoef, J. C., Ponec, M. & Rassing, M. R., 1999, In: Journal of Controlled Release. 60, 2-3, p. 223-33 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1996
- Published
Drug delivery studies in Caco-2 monolayers V. Ethyl glucoside esters as a novel type of absorption enhancers
Nielsen, Hanne Mørck, Brøndsted, H., Frøkjær, Sven & Hovgaard, L., 1 Mar 1996, In: S.T.P. Pharma Sciences. 6, 2, p. 157-161 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Drug delivery studies in Caco-2 monolayers. IV. Ethyl glycoside esters as a novel type of absorption enhancers.
Nielsen, Hanne Mørck, Brøndsted, H., Frøkjær, S. & Hovgaard, L., 1996, In: STP pharma sciences. p. 157-161Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Drug delivery studies in Caco-2 monolayers. IV. Ethyl glycoside esters as a novel type of absorption enhancers.
Nielsen, Hanne Mørck, Brøndsted, H., Frøkjær, Sven & Hovgaard, L., 1996, In: STP pharma sciences. p. 157-161Research output: Contribution to journal › Journal article › Research › peer-review
- 1995
- Published
Drug delivery studies in Caco-2 monolayers. II. Absorption enhancer effects of lysophosphatidylcholines
Hovgaard, L., Brøndsted, H. & Nielsen, Hanne Mørck, 14 Feb 1995, In: International Journal of Pharmaceutics. 114, 2, p. 141-149 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Drug delivery studies in Caco-2 monolayers. III. Intestinal transport of various vasopressin analogues in the presence of lysophosphatidylcholine
Brøndsted, H., Nielsen, Hanne Mørck & Hovgaard, L., 14 Feb 1995, In: International Journal of Pharmaceutics. 114, 2, p. 151-157 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of PTH-CPP fusion peptides for oral delivery
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Published