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The microbiota residing in the lower part of the gastrointestinal tract (GIT) is important for the health and wellbeing of humans. Some diseases and conditions have been connected with a certain microbiota composition in colon and it can therefore be beneficial to manipulate this composition by delivery of specific probiotics.
When probiotics are administered through the oral route it is necessary that the bacteria survive the passage through the stomach and small intestine. Furthermore targeted delivery of probiotics to the lower gastro intestinal tract may improve there beneficial effects.
The aim of my current research is therefor to develop and validate an oral delivery system which is able to carry a large load of probiotics and delivering these to the ileum or colon alive. To validate the delivery systems biorelevant in vitro models are being developed and tested.
-Lipid and polymer coatings for colonic delivery of API or probiotics.
-Development of biorelevant in vitro models for validation of targeting delivery systems