Johan Peter Bøtker

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• Research outputs
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Associate professor

Image analysis and computer vision approaches for various pharmaceutical systems. Solid state analysis (thermal analysis, Raman spectroscopy, synchrotron SAXS and WAXS diffraction, powder X-ray diffraction) with MATLAB® / Python programming and multivariate methods for extraction of the chemical relevant data for subsequent analytical purposes.

Dissolution testing using conventional methods and custom produced setups by 3D printing thereby enabling characterization of the solid forms in relation to dissolution performance.

Acoustic treatment of data and inhaled drug delivery.

Processing of pharmaceutical solids (milling, hot-melt extrusion and 3D printing).

Selected publications

1. Published

   Influence of temperature on solvent-mediated anhydrate-to-hydrate transformation kinetics

   Qu, H., Munk, T. P., Cornett, Claus, Wu, J., Bøtker, Johan Peter, Christensen, L. P., Rantanen, Jukka & Tian, F., 2011, In: Pharmaceutical Research. 28, 2, p. 364-373

   Research output: Contribution to journal › Journal article › peer-review

2. Published

   Assessment of crystalline disorder in cryo-milled samples of indomethacin using atomic pair-wise distribution functions

   Bøtker, Johan Peter, Karmwar, P., Strachan, C. J., Cornett, Claus, Tian, F., Zujovic, Z., Rantanen, Jukka & Rades, Thomas, 2011, In: International Journal of Pharmaceutics. 417, 1-2, p. 112-119 8 p.

   Research output: Contribution to journal › Journal article › peer-review

3. Published

   Polymorphic form of piroxicam influences the performance of armorphous material prepared by ball-milling

   Naelapaa, K., Bøtker, Johan Peter, Veski, P., Rantanen, Jukka, Rades, Thomas & Kogermann, K., 2012, In: International Journal of Pharmaceutics. 429, 1-2, p. 69-77

   Research output: Contribution to journal › Journal article › peer-review

4. Published

   Atomic pairwise distribution function analysis of the amorphous phase prepared by different manufacturing routes

   Bøtker, Johan Peter, Koradia, V., Rades, T., Rantanen, Jukka & Savolainen, M., 28 Aug 2012, In: Pharmaceutics. 4, 1, p. 93-103 11 p.

   Research output: Contribution to journal › Journal article › peer-review

5. Published

   Insights into the early dissolution events of amlodipine using UV imaging and Raman spectroscopy

   Bøtker, Johan Peter, Savolainen, M., Koradia, V., Tian, F., Rades, Thomas, Mullertz, Anette , Cornett, Claus, Rantanen, Jukka & Østergaard, Jesper, 2011, In: Molecular Pharmaceutics. 8, 4, p. 1372-1380 9 p.

   Research output: Contribution to journal › Journal article › peer-review

6. Published

   Investigations on the effect of different cooling rates on the stability of amorphous indomethacin

   Karmwar, P., Bøtker, Johan Peter, Graeser, K. A., Strachan, C. J., Rantanen, Jukka & Rades, T., 2011, In: European Journal of Pharmaceutical Sciences. 44, 3, p. 341-350

   Research output: Contribution to journal › Journal article › peer-review

7. Published

   Structural elucidationof rapid solution-mediatedPhase transitions in pharmaceutical solids using in situ synchrotron SAXS/WAXS

   Bøtker, Johan Peter, Rades, Thomas, Rantanen, Jukka, Hawley, A. & Boyd, B. J., 1 Aug 2012, In: Molecular Pharmaceutics. 9, 9, p. 2787-2791

   Research output: Contribution to journal › Journal article › peer-review

8. Published

   A new approach to dissolution testing by UV imaging and finite element simulations

   Bøtker, Johan Peter, Rantanen, Jukka, Rades, Thomas, Mullertz, Anette , Østergaard, Jesper & Jensen, H., 2013, In: Pharmaceutical Research. 30, 5, p. 1328-1337

   Research output: Contribution to journal › Journal article › peer-review