Recent advances in cryo-TEM imaging of soft lipid nanoparticles
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Recent advances in cryo-TEM imaging of soft lipid nanoparticles. / Helvig, Shen Yu; Mat Azmi, Intan Diana Binti; Moghimi, Seyed Moien; Yaghmur, Anan.
In: AIMS Biophysics, Vol. 2, No. 2, 2015, p. 116-130.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Recent advances in cryo-TEM imaging of soft lipid nanoparticles
AU - Helvig, Shen Yu
AU - Mat Azmi, Intan Diana Binti
AU - Moghimi, Seyed Moien
AU - Yaghmur, Anan
PY - 2015
Y1 - 2015
N2 - Cryo-transmission electron microscopy (Cryo-TEM), and its technological variations thereof, have become a powerful tool for detailed morphological characterization and 3D tomography of soft lipid and polymeric nanoparticles as well as biological materials such as viruses and DNA without chemical fixation. Here, we review and discuss recent advances in Cryo-TEM analysis of lipid-based drug nanocarriers with particular emphasis on morphological and internal nanostructure characterization of lyotropic liquid crystalline nanoparticles such as cubosomes and hexosomes.
AB - Cryo-transmission electron microscopy (Cryo-TEM), and its technological variations thereof, have become a powerful tool for detailed morphological characterization and 3D tomography of soft lipid and polymeric nanoparticles as well as biological materials such as viruses and DNA without chemical fixation. Here, we review and discuss recent advances in Cryo-TEM analysis of lipid-based drug nanocarriers with particular emphasis on morphological and internal nanostructure characterization of lyotropic liquid crystalline nanoparticles such as cubosomes and hexosomes.
U2 - 10.3934/biophy.2015.2.116
DO - 10.3934/biophy.2015.2.116
M3 - Journal article
VL - 2
SP - 116
EP - 130
JO - AIMS Biophysics
JF - AIMS Biophysics
SN - 2377-9098
IS - 2
ER -
ID: 144411874