Process development for spray drying of sticky pharmaceuticals; case study of bioadhesive nicotine microparticles for compressed medicated chewing gum

Research output: Contribution to journalJournal articleResearchpeer-review

Camilla Sander, Henrik Stillhof Nielsen, Susanne Roslev Søgaard, Celina Støving, Mingshi Yang, Jette Jacobsen, Jukka Rantanen

Spray drying of pharmaceutical compounds with sticky properties is a challenging task and may require substantial time and resources. By including small-scale studies of single droplet drying kinetics a relatively high number of experiments with less material is allowed. This means one can construct a more robust design space according to Quality by Design (QbD) formulation development principles. In the current study we present a case study on the development of spray dried microparticles comprising nicotine bitartrate and hypromellose or alginate polymer, for incorporation into medicated chewing gum. By illustration of initial studies on single droplet drying kinetics, subsequent characterization of microparticles, and final characterization of compressed chewing gum this paper summarizes the entire development process.
Original languageEnglish
JournalInternational Journal of Pharmaceutics
Volume452
Issue number1-2
Pages (from-to)434-7
Number of pages4
ISSN0378-5173
DOIs
Publication statusPublished - 16 Aug 2013

    Research areas

  • Alginates, Chewing Gum, Desiccation, Drug Delivery Systems, Glucuronic Acid, Hexuronic Acids, Mannitol, Methylcellulose, Nicotine, Technology, Pharmaceutical

ID: 104836207