Investigation of a new mathematical model for compression of pharmaceutical powders
Research output: Contribution to journal › Journal article › Research › peer-review
A new compaction equation, the log-exp model: V=V-w log(P)+V exp(P/P) is presented. The model presumes that two compaction processes: a logarithmic and an exponential decline may be active simultaneously. Using non-linear regression techniques the model gives an excellent fit to a number of model substances with wide differences in compaction behaviour. Compared to the Kawakita equation the model covers a broader range of the compaction profile. The new model and the Cooper and Eaton equation fit the data on the same level, but the parameters derived from the log-exp model seems to have more discriminative power between substances and have a close relation to the apparent plastic or brittle densification mechanism. The log-exp model has potential as a tool in estimation of the strength of agglomerated materials. A proposal for a set-up to an iterative non-linear regression calculation in a spreadsheet program is attached.
Original language | English |
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Journal | European Journal of Pharmaceutical Sciences |
Volume | 14 |
Issue number | 2 |
Pages (from-to) | 149-157 |
Number of pages | 9 |
ISSN | 0928-0987 |
DOIs | |
Publication status | Published - 1 Jan 2001 |
ID: 62956744