Citrem Modulates Internal Nanostructure of Glyceryl Monooleate Dispersions and Bypasses Complement Activation: Towards Development of Safe Tunable Intravenous Lipid Nanocarriers
Research output: Contribution to journal › Journal article › Research › peer-review
Lyotropic non-lamellar liquid crystalline (LLC) aqueous nanodispersions hold a great promise in drug solubilization and delivery, but these nanosystems often induce severe hemolysis and complement activation, which limit their applications for safe intravenous administration. Here, we engineer and characterize LLC aqueous nanodispersions from a binary lipid mixture consisting of 2,3-dihydroxypropyl oleate (glyceryl monooleate) and medium-chain triglyceride with tunable internal nanostructures and improved hemocompatibility controlled by citrem as stabilizer. Citrem, in a concentration-dependent manner, modulates the internal nanostructure of LLC dispersions from a biphasic H2/L2 feature to a neat L2 phase, where the latter resembles 'thread-like' swollen micelles. Citrem stabilization totally overcomes hemolysis and complement activation, thus realizing the potential of the engineered LLC aqueous nanodispersions for exploitation in intravenous delivery of drugs and contrast agents.
Original language | English |
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Journal | Nanomedicine: Nanotechnology, Biology and Medicine |
Volume | 11 |
Issue number | 8 |
Pages (from-to) | 1909-14 |
Number of pages | 6 |
ISSN | 1549-9634 |
DOIs | |
Publication status | Published - 5 Sep 2015 |
ID: 144154781