Marco van de Weert

Marco van de Weert

Associate Professor


  1. 2011
  2. Published

    Thermal and acid denaturation of bovine lens a-crystallin

    Rasmussen, T., van de Weert, Marco, Jiskoot, W. & Kasimova, M. R., 2011, In : Proteins - Structure Function and Bioinformatics. 79, 6, p. 1747-1758

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2010
  4. Published

    Fluorescence quenching to study protein-ligand binding: Common errors

    van de Weert, Marco, 2010, In : Journal of Fluorescence. 20, p. 625-629

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Interfacial complexes between a protein and lipophilic ions at an oil - water interface

    Hartvig, R. A., Méndez, M. A., van de Weert, Marco, Jørgensen, Lene, Østergaard, Jesper, Girault, H. H. & Jensen, Henrik, 2010, In : Analytical Chemistry. 82, 18, p. 7699-7705

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Large-scale polymorphism and auto-catalytic effect in insulin fibrillogenesis

    Foderà, Vito, van de Weert, Marco & Vestergaard, Bente, 2010, In : Soft Matter. 6, 18, p. 4413-4419

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The molecular chaperone a-crystallin as an excipient in an insulin formulation

    Rasmussen, T., Tantipolphan, R., van de Weert, Marco & Jiskoot, W., 2010, In : Pharmaceutical Research. 27, p. 1337-1347

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2009
  9. Published

    Analysis of insulin allostery in solution and solid state with FTIR

    Maltesen, M. J., Bjerregaard, S., Hovgaard, L., Havelund, S. & van de Weert, Marco, 2009, In : Journal of Pharmaceutical Sciences. 98, 9, p. 3265-3277

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Analysis of protein physical stability in lipid based delivery systems: the challenges of lipid drug delivery systems

    Jørgensen, Lene, Martins, S. & van de Weert, Marco, 2009, In : Journal of Biomedical Nanotechnology. 5, 4, p. 401-408

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Delivery technologies for biopharmaceuticals: a critical assessment

    van de Weert, Marco, 2009, Delivery technologies for biopharmaceuticals: Peptides, proteins, nucleic acids and vaccines. Jørgensen, L. & Mørck Nielsen, H. (eds.). Chichester: Wiley, p. 407-411

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  12. Published

    Determination of dissociation constants between polyelectrolytes and proteins by affinity capillary electrophoresis

    Anderot, M., Nilsson, M., Végvári, Á., Møller, E. H., van de Weert, Marco & Isaksson, R., 2009, In : Journal of Chromatography - B. 877, p. 892-896

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Infrared spectroscopy of protein pharmaceuticals

    van de Weert, Marco & Jørgensen, Lene, 2009, Advances in Biomedical Spectroscopy: Biological and Biomedical Infrared Spectrocopy. Barth, A. & Haris, P. I. (eds.). Amsterdam: IOS Press, Vol. 2. p. 168-177

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  14. Published

    The chaperone-like protein a-crystallin dissociates insulin dimers and hexamers

    Rasmussen, T., Kasimova, M. R., Jiskoot, W. & van de Weert, Marco, 2009, In : Biochemistry. 48, p. 9313-9320

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. 2008
  16. Published

    Drying methods for protein pharmaceuticals

    Maltesen, M. J. & van de Weert, Marco, 2008, In : Drug Discovery Today: Technologies. 5, 2-3, p. 81-88

    Research output: Contribution to journalReviewResearchpeer-review

  17. Published

    Immunogenicity of biopharmaceuticals: methods to reduce immunogenicity and biosimilars

    van de Weert, Marco & Møller, E. H., 2008, Immunogenicity of biopharmaceuticals. van de Weert, M. & Møller, E. H. (eds.). 1 ed. New York: Springer, p. 97-111

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  18. Published

    Preface

    van de Weert, Marco & Møller, E. H., 2008, Immunogenicity of biopharmaceuticals. van de Weert, M. & Møller, E. H. (eds.). 1 ed. New York: Springer, p. v-vi

    Research output: Chapter in Book/Report/Conference proceedingPreface/postscriptResearch

  19. Published

    Protein pharmaceuticals

    van de Weert, Marco & Møller, E. H., 2008, In : Drug Discovery Today: Technologies. 5, 2-3, p. 35-36

    Research output: Contribution to journalEditorialResearch

  20. Published

    Quality by design: Spray drying of insulin intended for inhalation

    Maltesen, M. J., Bjerregaard, S., Hovgaard, L., Havelund, S. & van de Weert, Marco, 2008, In : European Journal of Pharmaceutics and Biopharmaceutics. 70, 3, p. 828-838

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Secondary nucleation and accessible surface in insulin amyloid fibril formation

    Foderà, Vito, Librizzi, F., Jensen, M. G., van de Weert, Marco & Leone, M., 2008, In : Journal of Physical Chemistry B. 112, 12, p. 3853-3858

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Studies on human insulin adsorption kinetics at an organic-aqueous interface determined using a label-free electroanalytical approach

    Thomsen, A. E., Jensen, Henrik, Jørgensen, Lene, van de Weert, Marco & Østergaard, Jesper, 2008, In : Colloids and Surfaces B: Biointerfaces. 63, 2, p. 243-248

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Thioflavin T hydroxylation at basic pH and its effect on amyloid fibril detection

    Foderà, Vito, Jensen, M. G., Vetri, V., Librizzi, F., Spagnolo, S., Cornett, Claus, Olsen, L., van de Weert, Marco & Leone, M., 2008, In : Journal of Physical Chemistry. 112, 47, p. 15174-15181

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. 2007
  25. Published

    Bioinformatic and experimental analysis of the secondary structure of amelogenin

    Vilhjalmsson, B., Rasmussen, Anne, Fabi, B., van de Weert, Marco, Hamelryck, Thomas Wim & Lemoult, S., 1 Nov 2007, In : European Cells and Materials. 14, SUPPL.2, 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils

    Vestergaard, Bente, Jensen, M. G., Roessle, M., Kastrup, Jette Sandholm Jensen, van de Weert, Marco, Flink, J. M., Frøkjær, Sven, Gajhede, Michael & Svergun, D. I., 2007, In : PLoS - Biology. 5, 5, p. 1089-1097

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Binding mode of Thioflavin T in insulin amyloid fibrils

    Jensen, M. G., Norrman, M., Flink, J. M., van de Weert, Marco, Bukrinsky, J. T., Schluckebier, G. & Frøkjær, Sven, 2007, In : Journal of Structural Biology. 159, 3, p. 483-497

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Characterisation and physical stability of PEGylated glucagon

    Stigsnæs, P., Frøkjær, Sven, Bjerregaard, S., van de Weert, Marco, Kingshott, P. & Møller, E. H., 2007, In : Internation Journal of Pharmaceutics. 330, 1-2, p. 89-98

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Characterisation of salmon calcitonin in spray-dried powder for inhalation. Effect of chitosan

    Yang, Mingshi, Velaga, S., Yamamoto, H., Takeuchi, H., Kawashima, Y., Hovgaard, L., van de Weert, Marco & Frøkjær, Sven, 2007, In : Internation Journal of Pharmaceutics. 331, 2, p. 176-181

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Characterization of a cyclosporine solid dispersion for inhalation

    Zijlstra, G. S., Rijkeboer, M., van Drooge, D. J., Sutter, M., Jiskoot, W., van de Weert, Marco, Hinrichs, W. L. J. & Frijlink, H. W., 2007, In : The AAPS journal. 9, 2, p. E190-E199

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Gennembrud i forståelsen af insulinfibrillering

    Jensen, M. G., Vestergaard, Bente, Frøkjær, Sven, Gajhede, Michael, Flink, J. M., van de Weert, Marco, Kastrup, Jette Sandholm Jensen & Svergun, D. I., 2007, In : Lægemiddelforskning. p. 10-11

    Research output: Contribution to journalJournal articleCommunication

  32. Published

    Probing insulin's secondary structure after entrapment into alginate/chitosan nanoparticles

    Sarmento, B., Ferreira, D. C., Jørgensen, Lene & van de Weert, Marco, 2007, In : European Journal of Pharmaceutics and Biopharmaceutics. 65, 1, p. 10-17

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Study on the binding of Thioflavin T to ß-sheet-rich and non-ß-sheet cavities

    Jensen, M. G., Olsen, L., van de Weert, Marco, Flink, J. M., Frøkjær, Sven & Jørgensen, Flemming Steen, 2007, In : Journal of Structural Biology. 158, 3, p. 358-369

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. 2006
  35. Published

    Chemical and thermal stability of insulin: effects of zinc and ligand binding to the insulin zinc-hexamer

    Huus, K., Havelund, S., Olsen, H. B., van de Weert, Marco & Frøkjær, Sven, Nov 2006, In : Pharmaceutical Research. 23, 11, p. 2611-20 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Ligand binding and thermostability of different allosteric states of the insulin zinc-hexamer

    Huus, K., Havelund, S., Olsen, H. B., Sigurskjold, B. W., van de Weert, Marco & Frøkjær, Sven, 28 Mar 2006, In : Biochemistry. 45, 12, p. 4014-4024 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Preparing and evaluating delivery systems for proteins

    Jorgensen, L., Moeller, E. H., van de Weert, Marco, Nielsen, H. M. & Frøkjær, Sven, 2006, In : European Journal of Pharmaceutical Sciences. 29, 3-4, p. 174-82 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  38. 2005
  39. Published

    Factors of importance for a successful delivery system for proteins

    van de Weert, Marco, Jørgensen, Lene, Horn Moeller, E. & Frøkjær, Sven, Nov 2005, In : Expert Opinion on Drug Delivery. 2, 6, p. 1029-37 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  40. Published

    Thermal dissociation and unfolding of insulin

    Huus, K., Havelund, S., Olsen, H. B., van de Weert, Marco & Frøkjær, Sven, 23 Aug 2005, In : Biochemistry. 44, 33, p. 11171-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Complex coacervation with heparin results in decreased lysozyme stability

    van de Weert, Marco, Bendix Andersen, M. & Frøkjær, Sven, 3 Jan 2005, In : Journal of controlled release : official journal of the Controlled Release Society. 101, 1-3, p. 361-2 2 p.

    Research output: Contribution to journalConference abstract in journalResearch

  42. Published

    Evaluation of statistical design/modeling for prediction of the effect of amino acids on agitation-induced aggregation of human growth hormone and human insulin

    Soenderkaer, S., van de Weert, Marco, Lindgaard Hansen, L., Flink, J. & Frøkjær, Sven, 2005, In : Journal of Drug Delivery Science and Technology. 15, 6, p. 427-434 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Fourier transform infrared spectroscopy of protein formulations

    van de Weert, Marco, Hering, J. A. & Haris, P. I., 2005, Methods for Structural Analysis of Protein Pharmaceuticals. Jiskoot, W. & Crommelin, D. (eds.). Arlington: Springer Science+Business Media, p. 131-166

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  44. 2004
  45. Published

    Complex coacervation of lysozyme and heparin: complex characterization and protein stability

    van de Weert, Marco, Andersen, M. B. & Frøkjær, Sven, Dec 2004, In : Pharmaceutical Research. 21, 12, p. 2354-9 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Probing structural changes of proteins incorporated into water-in-oil emulsions

    Jørgensen, Lene, van de Weert, Marco, Vermehren, C., Bjerregaard, S. & Frøkjær, Sven, Jul 2004, In : Journal of Pharmaceutical Sciences. 93, 7, p. 1847-59 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Effects of sucrose on rFVIIa aggregation and methionine oxidation

    Soenderkaer, S., Carpenter, J. F., van de Weert, Marco, Hansen, L. L., Flink, J. & Frøkjær, Sven, Apr 2004, In : European Journal of Pharmaceutical Sciences. 21, 5, p. 597-606 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Formulation, stability and characterization of protein and peptide drugs

    Frøkjær, Sven, Hovgaard, L. & van de Weert, Marco, 2004, Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids. Mahato, R. I. (ed.). Boca Raton: CRC Press, p. 378-401

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  49. 2002
  50. Stability aspects of salmon calcitonin entrapped in poly(ether-ester) sustained release systems

    van Dijkhuizen-Radersma, R., Nicolas, H. M., van de Weert, Marco, Blom, M., de Groot, K. & Bezemer, J. M., 6 Nov 2002, In : International Journal of Pharmaceutics. 248, 1-2, p. 229-37 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Reversible aggregation of lysozyme in a biodegradable amphiphilic multiblock copolymer

    van de Weert, Marco, van Dijkhuizen-Radersma, R., Bezemer, J. M., Hennink, W. E. & Crommelin, D. J. A., Jul 2002, In : European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 54, 1, p. 89-93 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Influence of neutron irradiation on holmium acetylacetonate loaded poly(L-lactic acid) microspheres

    Nijsen, J. F., van Het Schip, A. D., van Steenbergen, M. J., Zielhuis, S. W., Kroon-Batenburg, L. M. J., van de Weert, Marco, van Rijk, P. P. & Hennink, W. E., Apr 2002, In : Biomaterials. 23, 8, p. 1831-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Semisolid, self-catalyzed poly(ortho ester)s as controlled-release systems: protein release and protein stability issues

    van de Weert, Marco, van Steenbergen, M. J., Cleland, J. L., Heller, J., Hennink, W. E. & Crommelin, D. J. A., Apr 2002, In : Journal of Pharmaceutical Sciences. 91, 4, p. 1065-74 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Development of poly(ortho esters) and their application for bovine serum albumin and bupivacaine delivery

    Heller, J., Barr, J., Ng, S., Shen, H., Gurny, R., Schwach-Abdelaoui, K., Rothen-Weinhold, A. & van de Weert, Marco, 17 Jan 2002, In : Journal of controlled release : official journal of the Controlled Release Society. 78, 1-3, p. 133-41 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. 2001
  56. Fourier transform infrared spectrometric analysis of protein conformation: effect of sampling method and stress factors

    van de Weert, Marco, Haris, P. I., Hennink, W. E. & Crommelin, D. J., 15 Oct 2001, In : Analytical Biochemistry. 297, 2, p. 160-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Characterization of poly(L-lactic acid) microspheres loaded with holmium acetylacetonate

    Nijsen, J. F. W., van Steenbergen, M. J., Kooijman, H., Talsma, H., Kroon-Batenburg, L. M. J., van de Weert, Marco, van Rijk, P. P., de Witte, A., van het Schip, A. D. & Hennink, W. E., 2001, In : Biomaterials. 22, p. 3073-3081

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. 2000
  59. Published

    Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques

    van de Weert, Marco, Van 'T Hof, R., Van Der Weerd, J., Heeren, R. M. A., Posthuma, G., Hennink, W. E. & Crommelin, D. J. A., 31 Jul 2000, In : Journal of Controlled Release. 68, 1, p. 31-40 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Protein instability in poly(lactic-co-glycolic acid) microparticles

    van de Weert, Marco, Jiskoot, W. & Hennink, W. E., 2000, In : Pharmaceutical Research. 17, p. 1159-1167

    Research output: Contribution to journalReviewResearchpeer-review

  61. Published

    The effect of a water/organic solvent interface on the structural stability of lysozyme

    van de Weert, Marco, Hoechstetter, J., Hennink, W. E. & Crommelin, D. J. A., 2000, In : Journal of Controlled Release. p. 351-359

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 1302800