Marco van de Weert

Marco van de Weert

Associate Professor


  1. Published

    Viscosity of high concentration protein formulations of monoclonal antibodies of the IgG1 and IgG4 subclass - Prediction of viscosity through protein-protein interaction measurements

    Neergaard, M. S., Kalonia, D. S., Parshad, H., Nielsen, A., Møller, E. H., van de Weert, Marco & Nielsen, A. D., 26 Apr 2013, In : European Journal of Pharmaceutical Sciences. 49, 3, p. 400-410 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Thioflavin T hydroxylation at basic pH and its effect on amyloid fibril detection

    Foderà, Vito, Jensen, M. G., Vetri, V., Librizzi, F., Spagnolo, S., Cornett, Claus, Olsen, L., van de Weert, Marco & Leone, M., 2008, In : Journal of Physical Chemistry. 112, 47, p. 15174-15181

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Thermal dissociation and unfolding of insulin

    Huus, K., Havelund, S., Olsen, H. B., van de Weert, Marco & Frøkjær, Sven, 23 Aug 2005, In : Biochemistry. 44, 33, p. 11171-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Thermal and acid denaturation of bovine lens a-crystallin

    Rasmussen, T., van de Weert, Marco, Jiskoot, W. & Kasimova, M. R., 2011, In : Proteins - Structure Function and Bioinformatics. 79, 6, p. 1747-1758

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    The molecular chaperone a-crystallin as an excipient in an insulin formulation

    Rasmussen, T., Tantipolphan, R., van de Weert, Marco & Jiskoot, W., 2010, In : Pharmaceutical Research. 27, p. 1337-1347

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    The effect of a water/organic solvent interface on the structural stability of lysozyme

    van de Weert, Marco, Hoechstetter, J., Hennink, W. E. & Crommelin, D. J. A., 2000, In : Journal of Controlled Release. p. 351-359

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The dangers of citing papers you did not read or understand

    van de Weert, Marco & Stella, L., 15 Jun 2019, In : Journal of Molecular Structure: THEOCHEM. 1186, p. 102-103 2 p.

    Research output: Contribution to journalJournal articleCommunication

  8. Published

    The chaperone-like protein a-crystallin dissociates insulin dimers and hexamers

    Rasmussen, T., Kasimova, M. R., Jiskoot, W. & van de Weert, Marco, 2009, In : Biochemistry. 48, p. 9313-9320

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The challenges in and importance of analysing protein structure and physical stability in complex formulations

    Jørgensen, Lene, Jensen, M. G., Roest, N., Pinholt, C. & van de Weert, Marco, 1 Jul 2013, In : Journal of Drug Delivery Science and Technology. 23, 4, p. 347-353 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  10. Published

    The Inhibitory Effect of Natural Products on Protein Fibrillation May Be Caused by Degradation Products – A Study Using Aloin and Insulin

    Lobbens, E. S., Foderà, Vito, Nyberg, N., Andersen, K., Jäger, A. K., Jørgensen, Lene & van de Weert, Marco, 16 Feb 2016, In : PloS one. 11, 2, p. 1-16 16 p., e0149148.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The Effect of Protein PEGylation on Physical Stability in Liquid Formulation

    Holm, L. S., Mcumber, A., Rasmussen, J. E., Obiols-Rabasa, M., Thulstrup, Peter Waaben, Kasimova, M. R., Randolph, T. W. & van de Weert, Marco, 21 Aug 2014, In : Journal of Pharmaceutical Sciences. 103, 10, p. 3043-3054 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Taylor Dispersion Analysis as a promising tool for assessment of peptide-peptide interactions

    Høgstedt, U. B., Schwach, G., van de Weert, Marco & Østergaard, Jesper, 25 Jul 2016, In : European Journal of Pharmaceutical Sciences. 93, p. 21-28 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Study on the binding of Thioflavin T to ß-sheet-rich and non-ß-sheet cavities

    Jensen, M. G., Olsen, L., van de Weert, Marco, Flink, J. M., Frøkjær, Sven & Jørgensen, Flemming Steen, 2007, In : Journal of Structural Biology. 158, 3, p. 358-369

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Studies on human insulin adsorption kinetics at an organic-aqueous interface determined using a label-free electroanalytical approach

    Thomsen, A. E., Jensen, Henrik, Jørgensen, Lene, van de Weert, Marco & Østergaard, Jesper, 2008, In : Colloids and Surfaces B: Biointerfaces. 63, 2, p. 243-248

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Stability of pharmaceutical proteins in particulate carriers

    van de Weert, Marco, van 't Hof, R., Hennink, W. E. & Crommelin, D. J. A., 1998, Alfred Benzon Symposium proceedings. Frøkjær, S., Christrup, L. & Krogsgaard-Larsen, P. (eds.). Copenhagen: Munksgaard , Vol. 43. p. 359-375

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  16. Published

    Stability of monoclonal antibodies at high-concentration: head-to-head comparison of the IgG1 and IgG4 subclass

    Neergaard, M. S., Nielsen, A. D., Parshad, H. & van de Weert, Marco, Jan 2014, In : Journal of Pharmaceutical Sciences. 103, 1, p. 115-27 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Stability aspects of salmon calcitonin entrapped in poly(ether-ester) sustained release systems

    van Dijkhuizen-Radersma, R., Nicolas, H. M., van de Weert, Marco, Blom, M., de Groot, K. & Bezemer, J. M., 6 Nov 2002, In : International Journal of Pharmaceutics. 248, 1-2, p. 229-37 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Spray dried cubosomes with ovalbumin and Quil-A as a nanoparticulate dry powder vaccine formulation

    von Halling Laier, C., Gibson, B., van de Weert, Marco, Boyd, B. J., Rades, Thomas, Boisen, A., Hook, S. & Nielsen, L. H., 25 Oct 2018, In : International Journal of Pharmaceutics. 550, 1-2, p. 35-44 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Small angle X-ray scattering-based elucidation of the self-association mechanism of human insulin analogue lys(B29)(N(e)¿-carboxyheptadecanoyl) des(B30)

    Jensen, M. H., Wahlund, P., Toft, K. N., Jacobsen, J. K., Steensgaard, D. B., van de Weert, Marco, Havelund, S. & Vestergaard, Bente, 15 Jan 2013, In : Biochemistry. 52, 2, p. 282-94 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Serial Coupling of Ion-Exchange and Size-Exclusion Chromatography to Determine Aggregation Levels in mAbs in The Presence of a Proteinaceous Excipient, Recombinant Human Serum Albumin

    Weisbjerg, P. L. G., Caspersen, M. B., Cook, K. & van de Weert, Marco, 1 Dec 2014, In : Journal of Pharmaceutical Sciences. 104, 2, p. 548-556 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Semisolid, self-catalyzed poly(ortho ester)s as controlled-release systems: protein release and protein stability issues

    van de Weert, Marco, van Steenbergen, M. J., Cleland, J. L., Heller, J., Hennink, W. E. & Crommelin, D. J. A., Apr 2002, In : Journal of Pharmaceutical Sciences. 91, 4, p. 1065-74 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Self-association of long-acting insulin analogues studied by size exclusion chromatography coupled to multi-angle light scattering

    Jensen, M. H., Wahlund, P., Jacobsen, J. K., Vestergaard, Bente, van de Weert, Marco & Havelund, S., 2011, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879, 28, p. 2945-2951

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Secondary nucleation and accessible surface in insulin amyloid fibril formation

    Foderà, Vito, Librizzi, F., Jensen, M. G., van de Weert, Marco & Leone, M., 2008, In : Journal of Physical Chemistry B. 112, 12, p. 3853-3858

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Screening of plants used in the European traditional medicine to treat memory disorders for acetylcholinesterase inhibitory activity and anti amyloidogenic activity

    Lobbens, E. S. B., Vissing, K. J., Jørgensen, Lene, van de Weert, Marco & Jäger, A. K., 22 Mar 2017, In : Journal of Ethnopharmacology. 200, p. 66-73 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Rhamnogalacturonan-I based microcapsules for targeted drug release

    Svagan, A. J., Kusic, A., De Gobba, Cristian, Larsen, F. H., Sassene, P., Zhou, Q., van de Weert, Marco, Mullertz, Anette , Jørgensen, Bodil & Ulvskov, Peter, 2016, In : P L o S One. 11, 12, 13 p., e0168050.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Reversible aggregation of lysozyme in a biodegradable amphiphilic multiblock copolymer

    van de Weert, Marco, van Dijkhuizen-Radersma, R., Bezemer, J. M., Hennink, W. E. & Crommelin, D. J. A., Jul 2002, In : European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 54, 1, p. 89-93 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Rapid Conformational Analysis of Protein Drugs in Formulation by Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS)

    Esmail Nazari, Z., van de Weert, Marco, Bou-Assaf, G., Houde, D., Weiskopf, A. & Rand, Kasper Dyrberg, 1 Jul 2016, In : Journal of Pharmaceutical Sciences. 105, 11, p. 3269–3277 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Quality by design: Spray drying of insulin intended for inhalation

    Maltesen, M. J., Bjerregaard, S., Hovgaard, L., Havelund, S. & van de Weert, Marco, 2008, In : European Journal of Pharmaceutics and Biopharmaceutics. 70, 3, p. 828-838

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Protein pharmaceuticals

    van de Weert, Marco & Møller, E. H., 2008, In : Drug Discovery Today: Technologies. 5, 2-3, p. 35-36

    Research output: Contribution to journalEditorialResearch

  30. Protein instability in poly(lactic-co-glycolic acid) microparticles

    van de Weert, Marco, Jiskoot, W. & Hennink, W. E., 2000, In : Pharmaceutical Research. 17, p. 1159-1167

    Research output: Contribution to journalReviewResearchpeer-review

  31. Published

    Protein adsorption at charged surfaces: The role of electrostatic interactions and interacial charge regulation

    Hartvig, R. A., van de Weert, Marco, Østergaard, Jesper, Jørgensen, Lene & Jensen, H., 2011, In : Langmuir. 27, p. 2634-2643

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Protein adsorption at charged surfaces: the role of electrostatic interactions and interfacial charge regulation

    Hartvig, R. A., van de Weert, Marco, Østergaard, Jesper, Jørgensen, Lene & Jensen, Henrik Elvang, 15 Mar 2011, In : Langmuir. 27, 6, p. 2634-2643 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Protease and amylase stability in the presence of chelators used in laundry detergent applications: correlation between chelator properties and enzyme stability in liquid detergents

    Lund, H., Kaasgaard, S. G., Skagerlind, P., Jørgensen, Lene, Jørgensen, C. I. & van de Weert, Marco, 2012, In : Journal of Surfactants and Detergents. 15, 3, p. 265-276

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Probing structural changes of proteins incorporated into water-in-oil emulsions

    Jørgensen, Lene, van de Weert, Marco, Vermehren, C., Bjerregaard, S. & Frøkjær, Sven, Jul 2004, In : Journal of Pharmaceutical Sciences. 93, 7, p. 1847-59 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Probing insulin's secondary structure after entrapment into alginate/chitosan nanoparticles

    Sarmento, B., Ferreira, D. C., Jørgensen, Lene & van de Weert, Marco, 2007, In : European Journal of Pharmaceutics and Biopharmaceutics. 65, 1, p. 10-17

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Preparing and evaluating delivery systems for proteins

    Jorgensen, L., Moeller, E. H., van de Weert, Marco, Nielsen, H. M. & Frøkjær, Sven, 2006, In : European Journal of Pharmaceutical Sciences. 29, 3-4, p. 174-82 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  37. Published

    Preferential interactions and the effect of protein PEGylation

    Holm, L. S., Thulstrup, Peter Waaben, Kasimova, M. R. & van de Weert, Marco, 2015, In : PLOS ONE. 10, 7, 18 p., e0133584.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Preface

    van de Weert, Marco & Møller, E. H., 2008, Immunogenicity of biopharmaceuticals. van de Weert, M. & Møller, E. H. (eds.). 1 ed. New York: Springer, p. v-vi

    Research output: Chapter in Book/Report/Conference proceedingPreface/postscriptResearch

  39. Published

    Physical Instability of Peptides and Proteins

    van de Weert, Marco & Randolph, T. W., 2013, Pharmaceutical Formulation Development of Peptides and Proteins. Hovgaard, L., Frokjaer, S. & van de Weert, M. (eds.). 2 ed. Boca Raton: CRC Press, p. 107-130

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  40. Published

    On the purported "backbone fluorescence" in protein three-dimensional fluorescence spectra

    Bortolotti, A., Wong, Y. H., Korsholm, S. S., Bahring, N. H. B., Bobone, S., Tayyab, S., van de Weert, Marco & Stella, L., 2016, In : RSC Advances. 6, 114, p. 112870-112876 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Multivariate analysis of phenol in freeze-dried and spray-dried insulin formulations by NIR and FTIR

    Maltesen, M. J., Bjerregaard, S., Hovgaard, L., Havelund, S., van de Weert, Marco & Grohganz, Holger, 2011, In : A A P S PharmSciTech. 12, 2, p. 627-635

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Mechanistic study of the inhibitory activity of Geum urbanum extract against α-Synuclein fibrillation

    Lobbens, E. S., Breydo, L., Pedersen, T. S., Vestergaard, Bente, Jäger, A. K., Jørgensen, Lene, Uversky, V. & van de Weert, Marco, 21 Jun 2016, In : B B A - Proteins and Proteomics. 1864, 9, p. 1160-1169 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Mass spectrometric analysis of oxidized tryptophan

    van de Weert, Marco, Lagerwerf, F. M., Haverkamp, J. & Heerma, W., 1998, In : Journal of Mass Spectrometry. 33, p. 884-891

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Manipulating Aggregation Behavior of the Uncharged Peptide Carbetocin

    Høgstedt, U. B., Østergaard, Jesper, Weiss, T., Sjögren, H. & van de Weert, Marco, Mar 2018, In : Journal of Pharmaceutical Sciences. 107, 3, p. 838-847 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    MEDICINES AUTHORITY REGULATOR AND INDUSTRY PERCEPTIONS OF BIOSIMILAR INTERCHANGEABILITY

    Druedahl, Louise C., De Bruin, Marie Louise (Marieke), Hoogland, H., Minssen, Timo, van de Weert, Marco, Kälvemark Sporrong, Sofia & Almarsdóttir, Anna Birna, Dec 2019, p. E45-E46.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  46. Published

    Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques

    van de Weert, Marco, Van 'T Hof, R., Van Der Weerd, J., Heeren, R. M. A., Posthuma, G., Hennink, W. E. & Crommelin, D. J. A., 31 Jul 2000, In : Journal of Controlled Release. 68, 1, p. 31-40 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Lipidation effect on surface adsorption and associated fibrillation of the model protein insulin

    Hedegaard, S. C. F., Cardenas Gomez, M., Barker, R., Jørgensen, Lene & van de Weert, Marco, 2016, In : Langmuir. 32, 28, p. 7241–7249 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Ligand binding and thermostability of different allosteric states of the insulin zinc-hexamer

    Huus, K., Havelund, S., Olsen, H. B., Sigurskjold, B. W., van de Weert, Marco & Frøkjær, Sven, 28 Mar 2006, In : Biochemistry. 45, 12, p. 4014-4024 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Large-scale polymorphism and auto-catalytic effect in insulin fibrillogenesis

    Foderà, Vito, van de Weert, Marco & Vestergaard, Bente, 2010, In : Soft Matter. 6, 18, p. 4413-4419

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Large-scale biophysical evaluation of protein PEGylation effects: in vitro properties of 61 protein entities

    Vernet, E., Popa, G., Pozdnyakova, I., Rasmussen, J. E., Grohganz, Holger, Giehm, L., Jensen, M. H., Wang, H., Plesner, B., Nielsen, Hanne Mørck, Jensen, Knud Jørgen, Berthelsen, J., Sundström, M. & van de Weert, Marco, 2016, In : Molecular Pharmaceutics. 13, 5, p. 1587-1598 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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