Marco van de Weert

Marco van de Weert

Associate Professor


  1. Published

    A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils

    Vestergaard, Bente, Jensen, M. G., Roessle, M., Kastrup, Jette Sandholm Jensen, van de Weert, Marco, Flink, J. M., Frøkjær, Sven, Gajhede, Michael & Svergun, D. I., 2007, In : PLoS - Biology. 5, 5, p. 1089-1097

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    A reassessment of synchronous fluorescence in the separation of Trp and Tyr contributions in protein emission and in the determination of conformational changes

    Bobone, S., van de Weert, Marco & Stella, L., 5 Dec 2014, In : Journal of Molecular Structure: THEOCHEM. 1077, p. 68-76 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Analysis of insulin allostery in solution and solid state with FTIR

    Maltesen, M. J., Bjerregaard, S., Hovgaard, L., Havelund, S. & van de Weert, Marco, 2009, In : Journal of Pharmaceutical Sciences. 98, 9, p. 3265-3277

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Analysis of protein physical stability in lipid based delivery systems: the challenges of lipid drug delivery systems

    Jørgensen, Lene, Martins, S. & van de Weert, Marco, 2009, In : Journal of Biomedical Nanotechnology. 5, 4, p. 401-408

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Binding mode of Thioflavin T in insulin amyloid fibrils

    Jensen, M. G., Norrman, M., Flink, J. M., van de Weert, Marco, Bukrinsky, J. T., Schluckebier, G. & Frøkjær, Sven, 2007, In : Journal of Structural Biology. 159, 3, p. 483-497

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Bioinformatic and experimental analysis of the secondary structure of amelogenin

    Vilhjalmsson, B., Rasmussen, Anne, Fabi, B., van de Weert, Marco, Hamelryck, Thomas Wim & Lemoult, S., 1 Nov 2007, In : European Cells and Materials. 14, SUPPL.2, 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Characterisation and physical stability of PEGylated glucagon

    Stigsnæs, P., Frøkjær, Sven, Bjerregaard, S., van de Weert, Marco, Kingshott, P. & Møller, E. H., 2007, In : Internation Journal of Pharmaceutics. 330, 1-2, p. 89-98

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Characterisation of salmon calcitonin in spray-dried powder for inhalation. Effect of chitosan

    Yang, Mingshi, Velaga, S., Yamamoto, H., Takeuchi, H., Kawashima, Y., Hovgaard, L., van de Weert, Marco & Frøkjær, Sven, 2007, In : Internation Journal of Pharmaceutics. 331, 2, p. 176-181

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Characterization of Therapeutic Peptides and Proteins

    van de Weert, Marco & Arvinte, T., 2013, Pharmaceutical Formulation Development of Peptides and Proteins. Hovgaard, L., Frokjaer, S. & van de Weert, M. (eds.). 2 ed. Boca Raton: CRC Press, p. 49-78

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  10. Published

    Characterization of a cyclosporine solid dispersion for inhalation

    Zijlstra, G. S., Rijkeboer, M., van Drooge, D. J., Sutter, M., Jiskoot, W., van de Weert, Marco, Hinrichs, W. L. J. & Frijlink, H. W., 2007, In : The AAPS journal. 9, 2, p. E190-E199

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Characterization of poly(L-lactic acid) microspheres loaded with holmium acetylacetonate

    Nijsen, J. F. W., van Steenbergen, M. J., Kooijman, H., Talsma, H., Kroon-Batenburg, L. M. J., van de Weert, Marco, van Rijk, P. P., de Witte, A., van het Schip, A. D. & Hennink, W. E., 2001, In : Biomaterials. 22, p. 3073-3081

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Chemical and thermal stability of insulin: effects of zinc and ligand binding to the insulin zinc-hexamer

    Huus, K., Havelund, S., Olsen, H. B., van de Weert, Marco & Frøkjær, Sven, Nov 2006, In : Pharmaceutical Research. 23, 11, p. 2611-20 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Co-encapsulation of lyoprotectants improves the stability of protein-loaded PLGA nanoparticles upon lyophilization

    Fonte, P., Araújo, F., Seabra, V., Reis, S., van de Weert, Marco & Sarmento, B., 30 Dec 2015, In : International Journal of Pharmaceutics. 496, 2, p. 850-62 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Competitive adsorption of monoclonal antibodies and nonionic surfactants at solid hydrophobic surfaces

    Kapp, S. J., Larsson, I., van de Weert, Marco, Cardenas Gomez, M. & Jørgensen, Lene, 2015, In : Journal of Pharmaceutical Sciences. 104, 2, p. 593-601 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Complex coacervates of hyaluronic acid and lysozyme: Effect on protein structure and physical stability

    Water, J. J., Schack, M. M., Velazquez-Campoy, A., Maltesen, M. J., van de Weert, Marco & Jørgensen, Lene, 1 Jan 2014, In : European Journal of Pharmaceutics and Biopharmaceutics. 88, 2, p. 325-331 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Complex coacervation of lysozyme and heparin: complex characterization and protein stability

    van de Weert, Marco, Andersen, M. B. & Frøkjær, Sven, Dec 2004, In : Pharmaceutical Research. 21, 12, p. 2354-9 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Complex coacervation with heparin results in decreased lysozyme stability

    van de Weert, Marco, Bendix Andersen, M. & Frøkjær, Sven, 3 Jan 2005, In : Journal of controlled release : official journal of the Controlled Release Society. 101, 1-3, p. 361-2 2 p.

    Research output: Contribution to journalConference abstract in journalResearch

  18. Published

    Correlation between calculated molecular descriptors of excipient amino acids and experimentally observed thermal stability of lysozyme

    Meng-Lund, H., Friis, N., van de Weert, Marco, Rantanen, Jukka, Poso, A., Grohganz, Holger & Jørgensen, Lene, 15 May 2017, In : International Journal of Pharmaceutics. 523, 1, p. 238-245 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Correlation between enzyme activity an stability of a protease, an alpha-amaylase and a lipase in a simplified liquid laundry detergent system, determined by differential scanning calorimetry

    Lund, H., Kaasgaard, S. G., Skagerlind, P., Jørgensen, Lene, Jørgensen, C. I. & van de Weert, Marco, 2012, In : Journal of Surfactants and Detergents. 15, p. 9-21

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Delivery technologies for biopharmaceuticals: a critical assessment

    van de Weert, Marco, 2009, Delivery technologies for biopharmaceuticals: Peptides, proteins, nucleic acids and vaccines. Jørgensen, L. & Mørck Nielsen, H. (eds.). Chichester: Wiley, p. 407-411

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  21. Published

    Design of experiments-based monitoring of critical quality attributes for the spray-drying process of insulin by NIR spectroscopy

    Maltesen, M. J., van de Weert, Marco & Grohganz, Holger, 2012, In : A A P S PharmSciTech. 13, 3, p. 747-55 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Determination of dissociation constants between polyelectrolytes and proteins by affinity capillary electrophoresis

    Anderot, M., Nilsson, M., Végvári, Á., Møller, E. H., van de Weert, Marco & Isaksson, R., 2009, In : Journal of Chromatography - B. 877, p. 892-896

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Development of poly(ortho esters) and their application for bovine serum albumin and bupivacaine delivery

    Heller, J., Barr, J., Ng, S., Shen, H., Gurny, R., Schwach-Abdelaoui, K., Rothen-Weinhold, A. & van de Weert, Marco, 17 Jan 2002, In : Journal of controlled release : official journal of the Controlled Release Society. 78, 1-3, p. 133-41 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Drying methods for protein pharmaceuticals

    Maltesen, M. J. & van de Weert, Marco, 2008, In : Drug Discovery Today: Technologies. 5, 2-3, p. 81-88

    Research output: Contribution to journalReviewResearchpeer-review

  25. Published

    Effect of ethanol as a co-solvent on the aerosol performance and stability of spray-dried lysozyme

    Ji, S., Thulstrup, Peter Waaben, Mu, Huiling, Hansen, S. H., van de Weert, Marco, Rantanen, Jukka & Yang, Mingshi, 2016, In : International Journal of Pharmaceutics. 513, 1-2, p. 175-182 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Effect of excipients on encapsulation and release of insulin from spray-dried solid lipid microparticles

    Wu, C., van de Weert, Marco, Baldursdottir, S. G., Yang, Mingshi & Mu, Huiling, 6 Sep 2018, In : International Journal of Pharmaceutics. 550, 1-2, p. 439-446

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Effect of the Freezing Step in the Stability and Bioactivity of Protein-Loaded PLGA Nanoparticles Upon Lyophilization

    Fonte, P., Andrade, F., Azevedo, C., Pinto, J., Seabra, V., van de Weert, Marco, Reis, S. & Sarmento, B., 2016, In : Pharmaceutical Research. 33, 11, p. 2777–2793

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Effects of sucrose on rFVIIa aggregation and methionine oxidation

    Soenderkaer, S., Carpenter, J. F., van de Weert, Marco, Hansen, L. L., Flink, J. & Frøkjær, Sven, Apr 2004, In : European Journal of Pharmaceutical Sciences. 21, 5, p. 597-606 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Engineering of a novel adjuvant based on lipid-polymer hybrid nanoparticles: A quality-by-design approach

    Rose, F., Wern, J. E., Ingvarsson, P. T., van de Weert, Marco, Andersen, P., Follmann, F. & Foged, Camilla, 2015, In : Journal of controlled release : official journal of the Controlled Release Society. 210, p. 48-57 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Erratum: Fluorescence quenching to study protein-ligand binding: Common errors (Journal of Fluorescence (2010) 20 (625-629)DOI 10.1007/s10895-009-0572- x)

    van de Weert, Marco, 29 Aug 2011, In : Journal of Fluorescence. 21, 6, 1 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  31. Published

    Erratum to: Design of experiments-based monitoring of critical quality attributes for the spray-drying process of insulin by NIR spectroscopy

    Maltesen, M. J., van de Weert, Marco & Grohganz, Holger, 21 Feb 2013, In : A A P S PharmSciTech. 14, 2, p. 901 1 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  32. Published

    Erratum: Kapp SJ, Larsson I, Van De Weert M, Ćardenas M, Jorgensen L. 2015. Competitive Adsorption of Monoclonal Antibodies and Nonionic Surfactants at Solid Hydrophobic Surfaces. 2015. J Pharm Sci 104:593-601

    Kapp, S. J., Larsson, I., van de Weert, Marco, Ćardenas, M. & Jørgensen, Lene, Oct 2015, In : Journal of Pharmaceutical Sciences. 104, 10, p. 3587 1 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  33. Published

    Evaluation of statistical design/modeling for prediction of the effect of amino acids on agitation-induced aggregation of human growth hormone and human insulin

    Soenderkaer, S., van de Weert, Marco, Lindgaard Hansen, L., Flink, J. & Frøkjær, Sven, 2005, In : Journal of Drug Delivery Science and Technology. 15, 6, p. 427-434 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Factors of importance for a successful delivery system for proteins

    van de Weert, Marco, Jørgensen, Lene, Horn Moeller, E. & Frøkjær, Sven, Nov 2005, In : Expert Opinion on Drug Delivery. 2, 6, p. 1029-37 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  35. Published

    Fluorescence quenching and ligand binding: A critical discussion of a popular methodology

    van de Weert, Marco & Stella, L., 2011, In : Journal of Molecular Structure: THEOCHEM. 998, 1-3, p. 144-150

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Fluorescence quenching to study protein-ligand binding: Common errors

    van de Weert, Marco, 2010, In : Journal of Fluorescence. 20, p. 625-629

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Fluorescence spectroscopy and binding: Getting it right

    Stella, L., van de Weert, Marco, Burrows, H. D. & Fausto, R., 5 Dec 2014, In : Journal of Molecular Structure: THEOCHEM. 1077, p. 1-3 3 p.

    Research output: Contribution to journalEditorialResearch

  38. Published

    Forced degradation of therapeutic proteins

    Hawe, A., Wiggenhorn, M., van de Weert, Marco, Garbe, J. H. O., Mahler, H. & Jiskoot, W., 2012, In : Journal of Pharmaceutical Sciences. 101, 3, p. 895-913

    Research output: Contribution to journalReviewResearchpeer-review

  39. Published

    Formation of dielectric layers and charge regulation in protein adsorption at biomimetic interfaces

    Hartvig, R. A., van de Weert, Marco, Østergaard, Jesper, Jørgensen, Lene & Jensen, Henrik, 2012, In : Langmuir. 28, 3, p. 1804-1815

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Formulation, stability and characterization of protein and peptide drugs

    Frøkjær, Sven, Hovgaard, L. & van de Weert, Marco, 2004, Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids. Mahato, R. I. (ed.). Boca Raton: CRC Press, p. 378-401

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  41. Fourier transform infrared spectrometric analysis of protein conformation: effect of sampling method and stress factors

    van de Weert, Marco, Haris, P. I., Hennink, W. E. & Crommelin, D. J., 15 Oct 2001, In : Analytical Biochemistry. 297, 2, p. 160-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Fourier transform infrared spectroscopy of protein formulations

    van de Weert, Marco, Hering, J. A. & Haris, P. I., 2005, Methods for Structural Analysis of Protein Pharmaceuticals. Jiskoot, W. & Crommelin, D. (eds.). Arlington: Springer Science+Business Media, p. 131-166

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  43. Published

    Fuzzy Logic-based expert system for evaluating cake quality of freeze-dried formulations

    Trnka, H., Wu, J., van de Weert, Marco, Grohganz, Holger & Rantanen, Jukka, Dec 2013, In : Journal of Pharmaceutical Sciences. 102, 12, p. 4364-74 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Gennembrud i forståelsen af insulinfibrillering

    Jensen, M. G., Vestergaard, Bente, Frøkjær, Sven, Gajhede, Michael, Flink, J. M., van de Weert, Marco, Kastrup, Jette Sandholm Jensen & Svergun, D. I., 2007, In : Lægemiddelforskning. p. 10-11

    Research output: Contribution to journalJournal articleCommunication

  45. Identification of oxidized methionine in peptides

    Lagerwerf, F. M., van de Weert, Marco, Heerma, W. & Haverkamp, J., 1996, In : Rapid Communications in Mass Spectrometry. 10, p. 1905-1910

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Immunogenicity of biopharmaceuticals: methods to reduce immunogenicity and biosimilars

    van de Weert, Marco & Møller, E. H., 2008, Immunogenicity of biopharmaceuticals. van de Weert, M. & Møller, E. H. (eds.). 1 ed. New York: Springer, p. 97-111

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  47. Published

    Influence of Tableting on the Conformation and Thermal Stability of Trypsin as a Model Protein

    Klukkert, M., van de Weert, Marco, Fanø, M., Rades, Thomas & Leopold, C. S., 2015, In : Journal of Pharmaceutical Sciences. 104, 12, p. 4314–4321 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Influence of neutron irradiation on holmium acetylacetonate loaded poly(L-lactic acid) microspheres

    Nijsen, J. F., van Het Schip, A. D., van Steenbergen, M. J., Zielhuis, S. W., Kroon-Batenburg, L. M. J., van de Weert, Marco, van Rijk, P. P. & Hennink, W. E., Apr 2002, In : Biomaterials. 23, 8, p. 1831-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Infrared spectroscopy of protein pharmaceuticals

    van de Weert, Marco & Jørgensen, Lene, 2009, Advances in Biomedical Spectroscopy: Biological and Biomedical Infrared Spectrocopy. Barth, A. & Haris, P. I. (eds.). Amsterdam: IOS Press, Vol. 2. p. 168-177

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  50. Published

    Infrared spectroscopy to characterize protein aggregates

    van de Weert, Marco & Jørgensen, Lene, 2012, Analysis of aggregates and particles in protein pharmaceuticals. Mahler, H-C. & Jiskoot, W. (eds.). Hoboken: Wiley, p. 227-248

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

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