Marco van de Weert

Marco van de Weert

Associate Professor


  1. Published

    Determination of dissociation constants between polyelectrolytes and proteins by affinity capillary electrophoresis

    Anderot, M., Nilsson, M., Végvári, Á., Møller, E. H., van de Weert, Marco & Isaksson, R., 2009, In : Journal of Chromatography - B. 877, p. 892-896

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    A reassessment of synchronous fluorescence in the separation of Trp and Tyr contributions in protein emission and in the determination of conformational changes

    Bobone, S., van de Weert, Marco & Stella, L., 5 Dec 2014, In : Journal of Molecular Structure: THEOCHEM. 1077, p. 68-76 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    On the purported "backbone fluorescence" in protein three-dimensional fluorescence spectra

    Bortolotti, A., Wong, Y. H., Korsholm, S. S., Bahring, N. H. B., Bobone, S., Tayyab, S., van de Weert, Marco & Stella, L., 2016, In : RSC Advances. 6, 114, p. 112870-112876 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    MEDICINES AUTHORITY REGULATOR AND INDUSTRY PERCEPTIONS OF BIOSIMILAR INTERCHANGEABILITY

    Druedahl, Louise C., De Bruin, Marie Louise (Marieke), Hoogland, H., Minssen, Timo, van de Weert, Marco, Kälvemark Sporrong, Sofia & Almarsdóttir, Anna Birna, Dec 2019, p. E45-E46.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  5. Published

    Rapid Conformational Analysis of Protein Drugs in Formulation by Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS)

    Esmail Nazari, Z., van de Weert, Marco, Bou-Assaf, G., Houde, D., Weiskopf, A. & Rand, Kasper Dyrberg, 1 Jul 2016, In : Journal of Pharmaceutical Sciences. 105, 11, p. 3269–3277 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Ionic strength-dependent denaturation ofThermomyces lanuginosus llipase induced by SDS

    Fanø, M., van de Weert, Marco, Møller, E. H., Kruse, N. A. & Frøkjær, Sven, 2011, In : Archives of Biochemistry and Biophysics. 506, 1, p. 92-98

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Secondary nucleation and accessible surface in insulin amyloid fibril formation

    Foderà, Vito, Librizzi, F., Jensen, M. G., van de Weert, Marco & Leone, M., 2008, In : Journal of Physical Chemistry B. 112, 12, p. 3853-3858

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Thioflavin T hydroxylation at basic pH and its effect on amyloid fibril detection

    Foderà, Vito, Jensen, M. G., Vetri, V., Librizzi, F., Spagnolo, S., Cornett, Claus, Olsen, L., van de Weert, Marco & Leone, M., 2008, In : Journal of Physical Chemistry. 112, 47, p. 15174-15181

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Large-scale polymorphism and auto-catalytic effect in insulin fibrillogenesis

    Foderà, Vito, van de Weert, Marco & Vestergaard, Bente, 2010, In : Soft Matter. 6, 18, p. 4413-4419

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Co-encapsulation of lyoprotectants improves the stability of protein-loaded PLGA nanoparticles upon lyophilization

    Fonte, P., Araújo, F., Seabra, V., Reis, S., van de Weert, Marco & Sarmento, B., 30 Dec 2015, In : International Journal of Pharmaceutics. 496, 2, p. 850-62 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Effect of the Freezing Step in the Stability and Bioactivity of Protein-Loaded PLGA Nanoparticles Upon Lyophilization

    Fonte, P., Andrade, F., Azevedo, C., Pinto, J., Seabra, V., van de Weert, Marco, Reis, S. & Sarmento, B., 2016, In : Pharmaceutical Research. 33, 11, p. 2777–2793

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Formulation, stability and characterization of protein and peptide drugs

    Frøkjær, Sven, Hovgaard, L. & van de Weert, Marco, 2004, Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids. Mahato, R. I. (ed.). Boca Raton: CRC Press, p. 378-401

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  13. Published

    Protein adsorption at charged surfaces: the role of electrostatic interactions and interfacial charge regulation

    Hartvig, R. A., van de Weert, Marco, Østergaard, Jesper, Jørgensen, Lene & Jensen, Henrik Elvang, 15 Mar 2011, In : Langmuir. 27, 6, p. 2634-2643 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Formation of dielectric layers and charge regulation in protein adsorption at biomimetic interfaces

    Hartvig, R. A., van de Weert, Marco, Østergaard, Jesper, Jørgensen, Lene & Jensen, Henrik, 2012, In : Langmuir. 28, 3, p. 1804-1815

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Interfacial complexes between a protein and lipophilic ions at an oil - water interface

    Hartvig, R. A., Méndez, M. A., van de Weert, Marco, Jørgensen, Lene, Østergaard, Jesper, Girault, H. H. & Jensen, Henrik, 2010, In : Analytical Chemistry. 82, 18, p. 7699-7705

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Protein adsorption at charged surfaces: The role of electrostatic interactions and interacial charge regulation

    Hartvig, R. A., van de Weert, Marco, Østergaard, Jesper, Jørgensen, Lene & Jensen, H., 2011, In : Langmuir. 27, p. 2634-2643

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Forced degradation of therapeutic proteins

    Hawe, A., Wiggenhorn, M., van de Weert, Marco, Garbe, J. H. O., Mahler, H. & Jiskoot, W., 2012, In : Journal of Pharmaceutical Sciences. 101, 3, p. 895-913

    Research output: Contribution to journalReviewResearchpeer-review

  18. Published

    Lipidation effect on surface adsorption and associated fibrillation of the model protein insulin

    Hedegaard, S. C. F., Cardenas Gomez, M., Barker, R., Jørgensen, Lene & van de Weert, Marco, 2016, In : Langmuir. 32, 28, p. 7241–7249 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Development of poly(ortho esters) and their application for bovine serum albumin and bupivacaine delivery

    Heller, J., Barr, J., Ng, S., Shen, H., Gurny, R., Schwach-Abdelaoui, K., Rothen-Weinhold, A. & van de Weert, Marco, 17 Jan 2002, In : Journal of controlled release : official journal of the Controlled Release Society. 78, 1-3, p. 133-41 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Preferential interactions and the effect of protein PEGylation

    Holm, L. S., Thulstrup, Peter Waaben, Kasimova, M. R. & van de Weert, Marco, 2015, In : PLOS ONE. 10, 7, 18 p., e0133584.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    The Effect of Protein PEGylation on Physical Stability in Liquid Formulation

    Holm, L. S., Mcumber, A., Rasmussen, J. E., Obiols-Rabasa, M., Thulstrup, Peter Waaben, Kasimova, M. R., Randolph, T. W. & van de Weert, Marco, 21 Aug 2014, In : Journal of Pharmaceutical Sciences. 103, 10, p. 3043-3054 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Chemical and thermal stability of insulin: effects of zinc and ligand binding to the insulin zinc-hexamer

    Huus, K., Havelund, S., Olsen, H. B., van de Weert, Marco & Frøkjær, Sven, Nov 2006, In : Pharmaceutical Research. 23, 11, p. 2611-20 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Ligand binding and thermostability of different allosteric states of the insulin zinc-hexamer

    Huus, K., Havelund, S., Olsen, H. B., Sigurskjold, B. W., van de Weert, Marco & Frøkjær, Sven, 28 Mar 2006, In : Biochemistry. 45, 12, p. 4014-4024 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Thermal dissociation and unfolding of insulin

    Huus, K., Havelund, S., Olsen, H. B., van de Weert, Marco & Frøkjær, Sven, 23 Aug 2005, In : Biochemistry. 44, 33, p. 11171-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Manipulating Aggregation Behavior of the Uncharged Peptide Carbetocin

    Høgstedt, U. B., Østergaard, Jesper, Weiss, T., Sjögren, H. & van de Weert, Marco, Mar 2018, In : Journal of Pharmaceutical Sciences. 107, 3, p. 838-847 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Taylor Dispersion Analysis as a promising tool for assessment of peptide-peptide interactions

    Høgstedt, U. B., Schwach, G., van de Weert, Marco & Østergaard, Jesper, 25 Jul 2016, In : European Journal of Pharmaceutical Sciences. 93, p. 21-28 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Small angle X-ray scattering-based elucidation of the self-association mechanism of human insulin analogue lys(B29)(N(e)¿-carboxyheptadecanoyl) des(B30)

    Jensen, M. H., Wahlund, P., Toft, K. N., Jacobsen, J. K., Steensgaard, D. B., van de Weert, Marco, Havelund, S. & Vestergaard, Bente, 15 Jan 2013, In : Biochemistry. 52, 2, p. 282-94 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Self-association of long-acting insulin analogues studied by size exclusion chromatography coupled to multi-angle light scattering

    Jensen, M. H., Wahlund, P., Jacobsen, J. K., Vestergaard, Bente, van de Weert, Marco & Havelund, S., 2011, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879, 28, p. 2945-2951

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Binding mode of Thioflavin T in insulin amyloid fibrils

    Jensen, M. G., Norrman, M., Flink, J. M., van de Weert, Marco, Bukrinsky, J. T., Schluckebier, G. & Frøkjær, Sven, 2007, In : Journal of Structural Biology. 159, 3, p. 483-497

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Study on the binding of Thioflavin T to ß-sheet-rich and non-ß-sheet cavities

    Jensen, M. G., Olsen, L., van de Weert, Marco, Flink, J. M., Frøkjær, Sven & Jørgensen, Flemming Steen, 2007, In : Journal of Structural Biology. 158, 3, p. 358-369

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Gennembrud i forståelsen af insulinfibrillering

    Jensen, M. G., Vestergaard, Bente, Frøkjær, Sven, Gajhede, Michael, Flink, J. M., van de Weert, Marco, Kastrup, Jette Sandholm Jensen & Svergun, D. I., 2007, In : Lægemiddelforskning. p. 10-11

    Research output: Contribution to journalJournal articleCommunication

  32. Published

    Investigation of factors affecting the stability of lysozyme spray dried from ethanol-water solutions

    Ji, S., Thulstrup, Peter Waaben, Mu, Huiling, Hansen, S. H., van de Weert, Marco, Rantanen, Jukka & Yang, Mingshi, 2017, In : International Journal of Pharmaceutics. 534, 1-2, p. 263-271 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Effect of ethanol as a co-solvent on the aerosol performance and stability of spray-dried lysozyme

    Ji, S., Thulstrup, Peter Waaben, Mu, Huiling, Hansen, S. H., van de Weert, Marco, Rantanen, Jukka & Yang, Mingshi, 2016, In : International Journal of Pharmaceutics. 513, 1-2, p. 175-182 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Preparing and evaluating delivery systems for proteins

    Jorgensen, L., Moeller, E. H., van de Weert, Marco, Nielsen, H. M. & Frøkjær, Sven, 2006, In : European Journal of Pharmaceutical Sciences. 29, 3-4, p. 174-82 9 p.

    Research output: Contribution to journalReviewResearchpeer-review

  35. Published

    The challenges in and importance of analysing protein structure and physical stability in complex formulations

    Jørgensen, Lene, Jensen, M. G., Roest, N., Pinholt, C. & van de Weert, Marco, 1 Jul 2013, In : Journal of Drug Delivery Science and Technology. 23, 4, p. 347-353 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  36. Published

    Probing structural changes of proteins incorporated into water-in-oil emulsions

    Jørgensen, Lene, van de Weert, Marco, Vermehren, C., Bjerregaard, S. & Frøkjær, Sven, Jul 2004, In : Journal of Pharmaceutical Sciences. 93, 7, p. 1847-59 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Analysis of protein physical stability in lipid based delivery systems: the challenges of lipid drug delivery systems

    Jørgensen, Lene, Martins, S. & van de Weert, Marco, 2009, In : Journal of Biomedical Nanotechnology. 5, 4, p. 401-408

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Competitive adsorption of monoclonal antibodies and nonionic surfactants at solid hydrophobic surfaces

    Kapp, S. J., Larsson, I., van de Weert, Marco, Cardenas Gomez, M. & Jørgensen, Lene, 2015, In : Journal of Pharmaceutical Sciences. 104, 2, p. 593-601 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Erratum: Kapp SJ, Larsson I, Van De Weert M, Ćardenas M, Jorgensen L. 2015. Competitive Adsorption of Monoclonal Antibodies and Nonionic Surfactants at Solid Hydrophobic Surfaces. 2015. J Pharm Sci 104:593-601

    Kapp, S. J., Larsson, I., van de Weert, Marco, Ćardenas, M. & Jørgensen, Lene, Oct 2015, In : Journal of Pharmaceutical Sciences. 104, 10, p. 3587 1 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  40. Published

    Influence of Tableting on the Conformation and Thermal Stability of Trypsin as a Model Protein

    Klukkert, M., van de Weert, Marco, Fanø, M., Rades, Thomas & Leopold, C. S., 2015, In : Journal of Pharmaceutical Sciences. 104, 12, p. 4314–4321 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Identification of oxidized methionine in peptides

    Lagerwerf, F. M., van de Weert, Marco, Heerma, W. & Haverkamp, J., 1996, In : Rapid Communications in Mass Spectrometry. 10, p. 1905-1910

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Screening of plants used in the European traditional medicine to treat memory disorders for acetylcholinesterase inhibitory activity and anti amyloidogenic activity

    Lobbens, E. S. B., Vissing, K. J., Jørgensen, Lene, van de Weert, Marco & Jäger, A. K., 22 Mar 2017, In : Journal of Ethnopharmacology. 200, p. 66-73 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Mechanistic study of the inhibitory activity of Geum urbanum extract against α-Synuclein fibrillation

    Lobbens, E. S., Breydo, L., Pedersen, Thomas Skamris, Vestergaard, Bente, Jäger, A. K., Jørgensen, Lene, Uversky, V. & van de Weert, Marco, 21 Jun 2016, In : B B A - Proteins and Proteomics. 1864, 9, p. 1160-1169 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    The Inhibitory Effect of Natural Products on Protein Fibrillation May Be Caused by Degradation Products – A Study Using Aloin and Insulin

    Lobbens, E. S., Foderà, Vito, Nyberg, N., Andersen, K., Jäger, A. K., Jørgensen, Lene & van de Weert, Marco, 16 Feb 2016, In : PloS one. 11, 2, p. 1-16 16 p., e0149148.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Correlation between enzyme activity an stability of a protease, an alpha-amaylase and a lipase in a simplified liquid laundry detergent system, determined by differential scanning calorimetry

    Lund, H., Kaasgaard, S. G., Skagerlind, P., Jørgensen, Lene, Jørgensen, C. I. & van de Weert, Marco, 2012, In : Journal of Surfactants and Detergents. 15, p. 9-21

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Protease and amylase stability in the presence of chelators used in laundry detergent applications: correlation between chelator properties and enzyme stability in liquid detergents

    Lund, H., Kaasgaard, S. G., Skagerlind, P., Jørgensen, Lene, Jørgensen, C. I. & van de Weert, Marco, 2012, In : Journal of Surfactants and Detergents. 15, 3, p. 265-276

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Design of experiments-based monitoring of critical quality attributes for the spray-drying process of insulin by NIR spectroscopy

    Maltesen, M. J., van de Weert, Marco & Grohganz, Holger, 2012, In : A A P S PharmSciTech. 13, 3, p. 747-55 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Drying methods for protein pharmaceuticals

    Maltesen, M. J. & van de Weert, Marco, 2008, In : Drug Discovery Today: Technologies. 5, 2-3, p. 81-88

    Research output: Contribution to journalReviewResearchpeer-review

  49. Published

    Erratum to: Design of experiments-based monitoring of critical quality attributes for the spray-drying process of insulin by NIR spectroscopy

    Maltesen, M. J., van de Weert, Marco & Grohganz, Holger, 21 Feb 2013, In : A A P S PharmSciTech. 14, 2, p. 901 1 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  50. Published

    Multivariate analysis of phenol in freeze-dried and spray-dried insulin formulations by NIR and FTIR

    Maltesen, M. J., Bjerregaard, S., Hovgaard, L., Havelund, S., van de Weert, Marco & Grohganz, Holger, 2011, In : A A P S PharmSciTech. 12, 2, p. 627-635

    Research output: Contribution to journalJournal articleResearchpeer-review

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