Kasper Dyrberg Rand

Kasper Dyrberg Rand

Professor


  1. Spatially resolved protein hydrogen exchange measured by matrix-assisted laser desorption ionization in-source decay

    Rand, Kasper Dyrberg, Bache, N., Nedertoft, M. M. & Jørgensen, T., 2011, In: Analytical Chemistry. 83, 23, p. 8859-62 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Gas-phase fragmentation of peptides to increase the spatial resolution of the Hydrogen Exchange Mass Spectrometry experiment

    Jensen, P. F. & Rand, Kasper Dyrberg, Mar 2016, Hydrogen Exchange Mass Spectrometry of Proteins: Fundamentals, Methods and Applications. Weis, D. (ed.). Wiley, p. 127-148 22 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  3. Published

    Hydrogen exchange: A sensitive analytical window into protein conformation and dynamics

    Jensen, P. F. & Rand, Kasper Dyrberg, Mar 2016, Hydrogen Exchange Mass Spectrometry of protein: Fundamentals, Methods and Applications. Weis, D. (ed.). Wiley, p. 1-17 17 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  4. Published

    A simple sheathless CE-MS interface with a sub-micrometer electrical contact fracture for sensitive analysis of peptide and protein samples

    Nguyen, T. T. T. N., Petersen, Nickolaj J. & Rand, Kasper Dyrberg, 2016, In: Analytica Chimica Acta. 936, p. 157–167 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Probing the Dissociation of Protein Complexes by Means of Gas-Phase H/D Exchange Mass Spectrometry

    Mistarz, U. H., Chandler, S. A., Brown, J. M., Benesch, J. L. P. & Rand, Kasper Dyrberg, 15 Jan 2019, In: Journal of the American Society for Mass Spectrometry. 30, 1, p. 45-57 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Conformational characterization of nerve growth factor-β reveals that its regulatory pro-part domain stabilizes three loop regions in its mature part

    Trabjerg, Esben, Kartberg, F., Christensen, S. & Rand, Kasper Dyrberg, 6 Oct 2017, In: Journal of Biological Chemistry. 292, 40, p. 16665-16676 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Conformational Analysis of Proteins in Highly Concentrated Solutions by Dialysis-Coupled Hydrogen/Deuterium Exchange Mass Spectrometry

    Houde, D., Esmail Nazari, Z., Bou-Assaf, G. M., Weiskopf, A. S. & Rand, Kasper Dyrberg, 9 Feb 2016, In: Journal of the American Society for Mass Spectrometry. 27, 4, p. 669–676 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Substrate- and Cofactor-independent Inhibition of Histone Demethylase KDM4C

    Leurs, U., Lohse, B., Rand, Kasper Dyrberg, Ming, S., Riise, E. S., Cole, P. A., Kristensen, Jesper Langgaard & Clausen, Rasmus Prætorius, 11 Jul 2014, In: A C S Chemical Biology. 9, 9, p. 2131-2138 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    An intact C-terminal end of albumin is required for its long half-life in humans

    Nilsen, J., Trabjerg, Esben, Grevys, A., Azevedo, C., Brennan, S. O., Stensland, M., Wilson, J., Sand, K. M. K., Bern, M., Dalhus, B., Roopenian, D. C., Sandlie, I., Rand, Kasper Dyrberg & Andersen, J. T., 20 Apr 2020, In: Communications Biology. 3, 1, 11 p., 181.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Partial Unwinding of Transmembrane Helices Facilitates Alternating Access in the Neurotransmitter: Sodium Symporter LeuT

    Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 28 Jun 2017

    Research output: Other contributionResearch

  11. Published

    Photodissociation Mass Spectrometry Accurately Localizes Sites of Backbone Deuteration in Peptides

    Mistarz, U. H., Bellina, B., Jensen, P. F., Brown, J. M., Barran, P. E. & Rand, Kasper Dyrberg, 14 Nov 2017

    Research output: Other contributionResearch

  12. Published

    Benzisothiazolinone derivatives as potent allosteric monoacylglycerol lipase inhibitors that functionally mimic sulfenylation of regulatory cysteines

    Castelli, R., Scalvini, L., Vacondio, F., Lodola, A., Anselmi, M., Vezzosi, S., Carmi, C., Bassi, M., Ferlenghi, F., Rivara, S., Möller, I. R., Rand, K. D., Daglian, J., Wei, D., Dotsey, E. Y., Ahmed, F., Jung, K-M., Stella, N., Singh, S., Mor, M. & 1 others, Piomelli, D., 2020, In: Journal of Medicinal Chemistry. 63, 3, p. 1261-1280

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Structural Dynamics and Catalytic Properties of a Multimodular Xanthanase

    Moroz, O. V., Jensen, P. F., Mcdonald, S. P., Mcgregor, N., Blagova, E., Comamala, G., Segura, D. R., Anderson, L., Vasu, S. M., Rao, V. P., Giger, L., Sørensen, T. H., Monrad, R. N., Svendsen, A., Nielsen, J. E., Henrissat, B., Davies, G. J., Brumer, H., Rand, Kasper Dyrberg & Wilson, K. S., 6 Jul 2018, In: ACS Catalysis. 8, 7, p. 6021-6034

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Gas-phase hydrogen/deuterium exchange in a traveling wave ion guide for the examination of protein conformations

    Rand, Kasper Dyrberg, Pringle, S. D., Murphy, J. P., Fadgen, K. E., Brown, J. & Engen, J. R., 2009, In: Analytical Chemistry. 81, 24, p. 10019-28 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Revealing the dynamic allosteric changes required for formation of the cysteine synthase complex by hydrogen-deuterium exchange mass spectrometry

    Rosa, B., Dickinson, E. R., Marchetti, M., Campanini, B., Pioselli, B., Bettati, S. & Rand, Kasper Dyrberg, 2021, In: Molecular and Cellular Proteomics. 20, 12 p., 100098.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Investigating the utility of minimized sample preparation and high-resolution mass spectrometry for quantification of monoclonal antibody drugs

    Nguyen, T. T. T. N., Mistarz, U. H., Costa, N., Herbet, A., Boquet, D., Becher, F. & Rand, Kasper Dyrberg, 10 Sep 2018, In: Journal of Pharmaceutical and Biomedical Analysis. 159, p. 384-392

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT: Recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Robert Vandenberg

    Merkle, P. S., Gotfryd, K., Cuendet, M. A., Leth-Espensen, K. Z., Gether, Ulrik, Loland, Claus Juul & Rand, Kasper Dyrberg, 2018, In: Science Advances. 4, 5, 12 p., eaar6179.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published
  19. Published

    Construct design, production, and characterization of Plasmodium falciparum 48/45 R0.6C subunit protein produced in Lactococcus lactis as candidate vaccine

    Singh, S. K., Roeffen, W., Mistarz, U. H., Chourasia, B. K., Yang, F., Rand, Kasper Dyrberg, Sauerwein, R. W. & Theisen, Michael, 2017, In: Microbial Cell Factories. 16, 1, 11 p., 97.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Thiol-ene Monolithic Pepsin Microreactor with a 3D-Printed Interface for Efficient UPLC-MS Peptide Mapping Analyses

    Jönsson, A., Svejdal, R. R., Bøgelund, N., Nguyen, T. T. T. N., Flindt, H., Kutter, Jörg P., Rand, Kasper Dyrberg & Lafleur, J. P., 21 Mar 2017, In: Analytical Chemistry. 89, 8, p. 4573-4580 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    The extraordinary thermal stability of EstA from S. islandicus is independent of post translational modifications

    Stiefler-Jensen, D., Schwarz-Linnet, T., de Lichtenberg, C., Nguyen, T. T. T. N., Rand, Kasper Dyrberg, Huang, L., She, Q. & Teilum, Kaare, Sep 2017, In: Protein Science. 26, 9, p. 1819-1827 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    UV Photodissociation Mass Spectrometry Accurately Localize Sites of Backbone Deuteration in Peptides

    Mistarz, U. H., Bellina, B., Jensen, P. F., Brown, J. M., Barran, P. E. & Rand, Kasper Dyrberg, 2018, In: Analytical Chemistry. 90, 2, p. 1077-1080 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Conformationally Restricted Glycopeptide Backbone Inhibits Gas-Phase H/D Scrambling between Glycan and Peptide Moieties

    Code, C., Qiu, D., Solov'yov, I. A., Lee, J., Shin, H., Roland, C., Sagui, C., Houde, D., Rand, Kasper Dyrberg & Jørgensen, T. J. D., 2023, In: Journal of the American Chemical Society. 145, 44, p. 23925-23938

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Conformational analysis of large and highly disulfide-stabilized proteins by integrating online electrochemical reduction into an optimized H/D exchange mass spectrometry workflow

    Trabjerg, Esben, Jakobsen, R. U., Mysling, S., Christensen, S., Jørgensen, T. J. D. & Rand, Kasper Dyrberg, 6 Aug 2015, In: Analytical Chemistry. 87, 17, p. 8880–8888 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Measuring the binding interfaces of protein complexes by gas-phase hydrogen/deuterium exchange mass spectrometry (gas-phase HDX-MS)

    Mistarz, U. H., Brown, J. M., Haselmann, K. F. & Rand, Kasper Dyrberg, 2015.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  26. Published

    Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) Centroid Data Measured between 3.6 degrees C and 25.4 degrees C for the Fab Fragment of NISTmAb

    Hudgens, J. W., Gallagher, E. S., Karageorgos, I., Anderson, K. W., Huang, R. Y-C., Chen, G., Bou-Assaf, G. M., Espada, A., Chalmers, M. J., Harguindey, E., Zhang, H-M., Walters, B. T., Zhang, J., Venable, J., Steckler, C., Park, I., Brock, A., Lu, X., Pandey, R., Chandramohan, A. & 16 others, Anand, G. S., Nirudodhi, S. N., Sperry, J. B., Rouse, J. C., Carroll, J. A., Rand, Kasper Dyrberg, Leurs, U., Weis, D. D., Al-Naqshabandi, M. A., Hageman, T. S., Deredge, D., Wintrode, P. L., Papanastasiou, M., Lambris, J. D., Li, S. & Urata, S., 2 May 2019, In: Journal of Research of the National Institute of Standards and Technology. 124, 7 p., 124009.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Investigating the Conformational Response of the Sortilin Receptor upon Binding Endogenous Peptide- and Protein Ligands by HDX-MS

    Trabjerg, Esben, Abu-Asad, N., Wan, Z., Kartberg, F., Christensen, S. & Rand, Kasper Dyrberg, 2 Jul 2019, In: Structure. 27, 7, p. 1103-1113.e3

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. A combined structural dynamics approach identifies a putative switch in factor VIIa employed by tissue factor to initiate blood coagulation

    Olsen, O. H., Rand, Kasper Dyrberg, Østergaard, H. & Persson, E., 2007, In: Protein Science. 16, 4, p. 671-82 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. False EX1 signatures caused by sample carryover during HX MS analyses

    Fang, J., Rand, Kasper Dyrberg, Beuning, P. J. & Engen, J. R., 2011, In: International Journal of Mass Spectrometry. 302, 1-3, p. 19-25 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Massespektrometri viser vejen til forbedrede proteinlægemidler

    Song, H. & Rand, Kasper Dyrberg, 2012, In: Lægemiddelforskning. 2012, p. 43-46

    Research output: Contribution to journalJournal articleCommunication

  31. Published

    Glycine Perturbs Local and Global Conformational Flexibility of a Transmembrane Helix

    Högel, P., Götz, A., Kuhne, F., Ebert, M., Stelzer, W., Rand, Kasper Dyrberg, Scharnagl, C. & Langosch, D., 27 Feb 2018, In: Biochemistry. 57, 8, p. 1326-1337 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Analytical Techniques in the Pharmaceutical Sciences

    Leurs, U., Mistarz, U. H. & Rand, Kasper Dyrberg, 2016, Analytical Techniques in the Pharmaceutical Sciences. Müllertz, A., Perrie, Y. & Rades, T. (eds.). Springer Publishing Company, p. 253-289 36 p. (Advances in Delivery Science and Technology).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  33. Published

    Rapid Conformational Analysis of Protein Drugs in Formulation by Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS)

    Esmail Nazari, Z., van de Weert, Marco, Bou-Assaf, G., Houde, D., Weiskopf, A. & Rand, Kasper Dyrberg, 1 Jul 2016, In: Journal of Pharmaceutical Sciences. 105, 11, p. 3269–3277 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Direct coupling of a flow-flow electromembrane extraction probe to LC-MS

    Fuchs, D., Gabel-Jensen, C., Jensen, H., Rand, Kasper Dyrberg, Pedersen-Bjergaard, Stig, Hansen, S. H. & Petersen, Nickolaj J., 2016, In: Analytica Chimica Acta. 905, p. 93-99 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Structure and Dynamics of a Promiscuous Xanthan Lyase from Paenibacillus nanensis and the Design of Variants with Increased Stability and Activity

    Jensen, P. F., Kadziola, Anders, Comamala, G., Segura, D. R., Anderson, L., Poulsen, Jens-Christian Navarro, Rasmussen, K. K., Agarwal, S., Sainathan, R. K., Monrad, R. N., Svendsen, A., Nielsen, J. E., Lo Leggio, Leila & Rand, Kasper Dyrberg, 2019, In: Cell Chemical Biology. 26, 2, p. 191-202.e1-e6 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed β2-Microglobulin through Distinct Binding Sites

    Merkle, P. S., Irving, M., Hongjian, S., Ferber, M., Jørgensen, T. J. D., Scholten, K., Luescher, I., Coukos, G., Zoete, V., Cuendet, M. A., Michielin, O. & Rand, Kasper Dyrberg, 1 Aug 2017, In: Biochemistry. 56, 30, p. 3945-3961 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Sites involved in intra- and interdomain allostery associated with the activation of factor VIIa pinpointed by hydrogen-deuterium exchange and electron transfer dissociation mass spectrometry

    Song, H., Olsen, O. H., Persson, E. & Rand, Kasper Dyrberg, 24 Oct 2014, In: The Journal of Biological Chemistry. 289, p. 35388-96 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Conformational heterogeneity of Savinase from NMR, HDX-MS and X-ray diffraction analysis

    Wu, S., Nguyen, T. T. T. N., Moroz, O. V., Turkenburg, J. P., Nielsen, J. E., Wilson, K. S., Rand, Kasper Dyrberg & Teilum, Kaare, 2020, In: PeerJ. 8, 17 p., e9408.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Hydrogen/deuterium exchange mass spectrometry with improved electrochemical reduction enables comprehensive epitope mapping of a therapeutic antibody to the cysteine-knot containing vascular endothelial growth factor

    Comamala, G., Wagner, C., de la Torre, P. S., Jakobsen, R. U., Hilger, M., Brouwer, H. & Rand, Kasper Dyrberg, 8 Jun 2020, In: Analytica Chimica Acta. 1115, p. 41-51 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Epitope mapping of a blood-brain barrier crossing antibody targeting the cysteine-rich region of IGF1R using hydrogen-exchange mass spectrometry enabled by electrochemical reduction

    Sheff, J., Kelly, J., Foss, M., Brunette, E., Kemmerich, K., van Faassen, H., Raphael, S., Hussack, G., Comamala, G., Rand, Kasper Dyrberg & Stanimirovic, D. B., 2023, In: Journal of Biochemistry. 173, 2, p. 95-105

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Getting to the core of protein pharmaceuticals – comprehensive structure analysis by mass spectrometry

    Leurs, U., Mistarz, U. H. & Rand, Kasper Dyrberg, 2015, In: European Journal of Pharmaceutics and Biopharmaceutics. 93, p. 95-109 15 p.

    Research output: Contribution to journalReviewResearchpeer-review

  42. Published

    The First Community-Wide, Comparative Cross-linking Mass Spectrometry Study

    Iacobucci, C., Piotrowski, C., Aebersold, R., Amaral, B. C., Andrews, P. C., Bernfur, K., Borchers, C. H., Brodie, N. I., Bruce, J. E., Cao, Y., Chaignepain, S., Chavez, J. D., Claverol, S., Cox, J., Davis, T. N., Degliesposti, G., Dong, M-Q., Edinger, N., Emanuelsson, C., Gay, M. & 53 others, Gomes-Neto, F., Gozzo, F. C., Gutierrez, C. B., Haupt, C., Heck, A. J. R., Herzog, F., Huang, L., Hoopmann, M. R., Kalisman, N., Klykov, O., Kukačka, Z., Liu, F., MacCoss, M. J., Mechtler, K., Mesika, R., Moritz, R. L., Nagaraj, N., Nesati, V., Neves-Fereira, A. G. C., Ninnis, R., Novák, P., O'Reilly, F. J., Pelzing, M., Petrotchenko, E. V., Piersimoni, L., Plasencia, M., Pukala, T. L., Rand, Kasper Dyrberg, Rappsilber, J., Reichman, D., Sailer, C., Sarnowski, C. P., Scheltema, R. A., Schmidt, C., Schriemer, D. C., Shi, Y., Skehel, J. M., Slavin, M., Sobott, F., Solis-Mezarino, V., Stephanowitz, H., Stengel, F., Stieger, C. E., Trabjerg, Esben, Trnka, M. J., Vilaseca, M., Viner, R., Xiang, Y., Yılmaz, Ş., Zelter, A., Ziemianowicz, D. S., Leitner, A. & Sinz, A., 2 May 2019, In: Analytical Chemistry. 91, 11, p. 6953-6961

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Substrate-Induced Conformational Dynamics of the Dopamine Transporter

    Nielsen, A. K., Moller, I. R., Rasmussen, Søren Gøgsig Faarup, Rand, Kasper Dyrberg & Loland, Claus Juul, 2019, In: Biophysical Society. Annual Meeting. Abstracts. 116, 3, p. 346A 1 p., 1714-Pos.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  44. Published

    Hydrogen atom scrambling in selectively labeled anionic peptides upon collisional activation by MALDI tandem time-of-flight mass spectrometry

    Bache, N., Rand, Kasper Dyrberg, Roepstorff, P., Ploug, Michael & Jørgensen, T., 2008, In: Journal of The American Society for Mass Spectrometry. 19, 12, p. 1719-25 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Formation of covalent di-tyrosine dimers in recombinant α-synuclein

    van Maarschalkerweerd, A., Pedersen, M., Peterson, H., Nilsson, M., Nguyen, T., Skamris, T., Rand, Kasper Dyrberg, Vetri, V., Langkilde, Annette Eva & Vestergaard, Bente, 19 Oct 2015, In: Intrinsically Disordered Proteins. 3, 1, p. 1-12 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Removal of N-Linked Glycosylations at Acidic pH by PNGase A Facilitates Hydrogen/Deuterium Exchange Mass Spectrometry Analysis of N-Linked Glycoproteins

    Jensen, P. F., Comamala Grau, G., Trelle, M. B., Madsen, J. B., Jorgensen, T. J. D. & Rand, Kasper Dyrberg, 20 Dec 2016, In: Analytical Chemistry. 88, 24, p. 12479-12488 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Probing the Conformational Dynamics of Affinity-Enhanced T Cell Receptor Variants upon Binding the Peptide-Bound Major Histocompatibility Complex by Hydrogen/Deuterium Exchange Mass Spectrometry

    Merkle, P. S., Trabjerg, Esben, Hongjian, S., Ferber, M., Cuendet, M. A., Jorgensen, T. J. D., Luescher, I., Irving, M., Zoete, V., Michielin, O. & Rand, Kasper Dyrberg, 2021, In: Biochemistry. 60, 11, p. 859-872

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Thiol-ene microfluidic chip for fast on-chip sample clean-up, separation and ESI mass spectrometry of peptides and proteins

    Svejdal, R. R., Sticker, Drago, Sønderby, C., Kutter, Jörg P. & Rand, Kasper Dyrberg, 2020, In: Analytica Chimica Acta. 1140, p. 168-177 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Conformational analysis of complex protein states by hydrogen/deuterium exchange mass spectrometry (HDX-MS): Challenges and emerging solutions

    Trabjerg, Esben, Nazari, Z. E. & Rand, Kasper Dyrberg, Sep 2018, In: Trends in Analytical Chemistry. 106, p. 125-138

    Research output: Contribution to journalReviewResearchpeer-review

  50. Published

    Mapping the interactions of selective biochemical probes of antibody conformation by hydrogen-deuterium exchange mass spectrometry

    Leurs, U., Beck, H., Bonnington, L., Lindner, I., Pol, E. & Rand, Kasper Dyrberg, 1 Jun 2017, In: ChemBioChem. 18, 11, p. 1016-1021

    Research output: Contribution to journalJournal articleResearchpeer-review

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